Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWD7_LEIIN

TriTrypDb:

LINF_150008900

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HWD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.440
CLV_NRD_NRD_1	28	30	PF00675	0.547
CLV_NRD_NRD_1	630	632	PF00675	0.395
CLV_NRD_NRD_1	648	650	PF00675	0.373
CLV_PCSK_FUR_1	26	30	PF00082	0.569
CLV_PCSK_KEX2_1	26	28	PF00082	0.561
CLV_PCSK_KEX2_1	629	631	PF00082	0.394
CLV_PCSK_KEX2_1	648	650	PF00082	0.362
CLV_PCSK_PC7_1	22	28	PF00082	0.571
CLV_PCSK_SKI1_1	136	140	PF00082	0.680
CLV_PCSK_SKI1_1	229	233	PF00082	0.647
CLV_PCSK_SKI1_1	512	516	PF00082	0.609
CLV_PCSK_SKI1_1	523	527	PF00082	0.613
CLV_PCSK_SKI1_1	588	592	PF00082	0.719
CLV_PCSK_SKI1_1	641	645	PF00082	0.356
DEG_SPOP_SBC_1	116	120	PF00917	0.522
DEG_SPOP_SBC_1	190	194	PF00917	0.511
DOC_CDC14_PxL_1	435	443	PF14671	0.389
DOC_CKS1_1	211	216	PF01111	0.442
DOC_CYCLIN_RxL_1	226	235	PF00134	0.423
DOC_CYCLIN_RxL_1	585	593	PF00134	0.425
DOC_CYCLIN_yClb1_LxF_4	474	480	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.722
DOC_MAPK_MEF2A_6	33	42	PF00069	0.523
DOC_MAPK_MEF2A_6	497	506	PF00069	0.445
DOC_MAPK_MEF2A_6	636	644	PF00069	0.693
DOC_MAPK_RevD_3	616	630	PF00069	0.380
DOC_PP1_RVXF_1	163	170	PF00149	0.558
DOC_PP1_RVXF_1	586	592	PF00149	0.458
DOC_PP2B_LxvP_1	543	546	PF13499	0.440
DOC_PP2B_PxIxI_1	501	507	PF00149	0.401
DOC_PP4_FxxP_1	499	502	PF00568	0.394
DOC_PP4_FxxP_1	56	59	PF00568	0.348
DOC_USP7_MATH_1	115	119	PF00917	0.462
DOC_USP7_MATH_1	190	194	PF00917	0.489
DOC_USP7_MATH_1	294	298	PF00917	0.448
DOC_USP7_MATH_1	397	401	PF00917	0.437
DOC_USP7_MATH_1	553	557	PF00917	0.477
DOC_USP7_MATH_1	606	610	PF00917	0.436
DOC_USP7_MATH_1	89	93	PF00917	0.578
DOC_USP7_MATH_1	95	99	PF00917	0.445
DOC_USP7_UBL2_3	405	409	PF12436	0.412
DOC_WW_Pin1_4	148	153	PF00397	0.428
DOC_WW_Pin1_4	198	203	PF00397	0.507
DOC_WW_Pin1_4	210	215	PF00397	0.395
DOC_WW_Pin1_4	468	473	PF00397	0.479
DOC_WW_Pin1_4	599	604	PF00397	0.465
LIG_14-3-3_CanoR_1	128	138	PF00244	0.409
LIG_14-3-3_CanoR_1	165	170	PF00244	0.478
LIG_14-3-3_CanoR_1	478	486	PF00244	0.455
LIG_14-3-3_CanoR_1	491	497	PF00244	0.375
LIG_14-3-3_CanoR_1	512	517	PF00244	0.389
LIG_14-3-3_CanoR_1	52	60	PF00244	0.525
LIG_14-3-3_CanoR_1	94	103	PF00244	0.429
LIG_AP2alpha_1	56	60	PF02296	0.345
LIG_AP2alpha_2	58	60	PF02296	0.412
LIG_BRCT_BRCA1_1	56	60	PF00533	0.470
LIG_eIF4E_1	226	232	PF01652	0.377
LIG_eIF4E_1	480	486	PF01652	0.456
LIG_FHA_1	198	204	PF00498	0.417
LIG_FHA_1	220	226	PF00498	0.389
LIG_FHA_1	235	241	PF00498	0.398
LIG_FHA_1	356	362	PF00498	0.411
LIG_FHA_1	430	436	PF00498	0.429
LIG_FHA_1	457	463	PF00498	0.392
LIG_FHA_1	480	486	PF00498	0.456
LIG_FHA_1	513	519	PF00498	0.359
LIG_FHA_1	585	591	PF00498	0.427
LIG_FHA_1	603	609	PF00498	0.363
LIG_FHA_2	119	125	PF00498	0.441
LIG_FHA_2	286	292	PF00498	0.450
LIG_FHA_2	360	366	PF00498	0.481
LIG_GBD_Chelix_1	610	618	PF00786	0.328
LIG_Integrin_RGD_1	323	325	PF01839	0.606
LIG_LIR_Apic_2	196	202	PF02991	0.497
LIG_LIR_Apic_2	54	59	PF02991	0.363
LIG_LIR_Gen_1	143	154	PF02991	0.479
LIG_LIR_Gen_1	168	174	PF02991	0.477
LIG_LIR_Gen_1	301	312	PF02991	0.410
LIG_LIR_Gen_1	37	47	PF02991	0.408
LIG_LIR_Gen_1	57	67	PF02991	0.408
LIG_LIR_Gen_1	573	583	PF02991	0.423
LIG_LIR_Nem_3	143	149	PF02991	0.420
LIG_LIR_Nem_3	168	172	PF02991	0.476
LIG_LIR_Nem_3	221	226	PF02991	0.359
LIG_LIR_Nem_3	301	307	PF02991	0.393
LIG_LIR_Nem_3	37	42	PF02991	0.408
LIG_LIR_Nem_3	57	63	PF02991	0.408
LIG_LIR_Nem_3	573	578	PF02991	0.449
LIG_Pex14_2	56	60	PF04695	0.345
LIG_Rb_pABgroove_1	424	432	PF01858	0.380
LIG_SH2_CRK	199	203	PF00017	0.488
LIG_SH2_CRK	357	361	PF00017	0.382
LIG_SH2_CRK	575	579	PF00017	0.414
LIG_SH2_NCK_1	78	82	PF00017	0.398
LIG_SH2_STAP1	174	178	PF00017	0.466
LIG_SH2_STAP1	251	255	PF00017	0.479
LIG_SH2_STAP1	315	319	PF00017	0.463
LIG_SH2_STAP1	357	361	PF00017	0.455
LIG_SH2_STAP1	592	596	PF00017	0.487
LIG_SH2_STAT5	101	104	PF00017	0.398
LIG_SH2_STAT5	199	202	PF00017	0.420
LIG_SH2_STAT5	357	360	PF00017	0.425
LIG_SH2_STAT5	425	428	PF00017	0.449
LIG_SH2_STAT5	542	545	PF00017	0.361
LIG_SH2_STAT5	583	586	PF00017	0.493
LIG_SH3_3	13	19	PF00018	0.660
LIG_SH3_3	208	214	PF00018	0.430
LIG_SH3_3	290	296	PF00018	0.510
LIG_SUMO_SIM_anti_2	118	127	PF11976	0.434
LIG_SUMO_SIM_par_1	3	9	PF11976	0.757
LIG_SUMO_SIM_par_1	439	444	PF11976	0.378
LIG_SUMO_SIM_par_1	514	519	PF11976	0.446
LIG_TRAF2_1	635	638	PF00917	0.619
LIG_TYR_ITIM	540	545	PF00017	0.437
LIG_WRC_WIRS_1	591	596	PF05994	0.490
MOD_CDK_SPK_2	599	604	PF00069	0.486
MOD_CK1_1	118	124	PF00069	0.448
MOD_CK1_1	157	163	PF00069	0.518
MOD_CK1_1	191	197	PF00069	0.514
MOD_CK1_1	218	224	PF00069	0.444
MOD_CK1_1	318	324	PF00069	0.544
MOD_CK1_1	415	421	PF00069	0.411
MOD_CK1_1	449	455	PF00069	0.449
MOD_CK1_1	458	464	PF00069	0.361
MOD_CK1_1	468	474	PF00069	0.356
MOD_CK1_1	481	487	PF00069	0.324
MOD_CK1_1	54	60	PF00069	0.483
MOD_CK2_1	359	365	PF00069	0.470
MOD_CK2_1	449	455	PF00069	0.489
MOD_GlcNHglycan	111	114	PF01048	0.769
MOD_GlcNHglycan	133	136	PF01048	0.627
MOD_GlcNHglycan	234	237	PF01048	0.645
MOD_GlcNHglycan	251	254	PF01048	0.497
MOD_GlcNHglycan	258	261	PF01048	0.640
MOD_GlcNHglycan	272	275	PF01048	0.744
MOD_GlcNHglycan	278	281	PF01048	0.783
MOD_GlcNHglycan	317	320	PF01048	0.744
MOD_GlcNHglycan	48	51	PF01048	0.459
MOD_GlcNHglycan	520	523	PF01048	0.647
MOD_GlcNHglycan	53	56	PF01048	0.687
MOD_GlcNHglycan	554	558	PF01048	0.689
MOD_GlcNHglycan	8	11	PF01048	0.555
MOD_GSK3_1	140	147	PF00069	0.450
MOD_GSK3_1	156	163	PF00069	0.387
MOD_GSK3_1	184	191	PF00069	0.479
MOD_GSK3_1	215	222	PF00069	0.443
MOD_GSK3_1	234	241	PF00069	0.396
MOD_GSK3_1	265	272	PF00069	0.546
MOD_GSK3_1	34	41	PF00069	0.462
MOD_GSK3_1	355	362	PF00069	0.428
MOD_GSK3_1	379	386	PF00069	0.448
MOD_GSK3_1	397	404	PF00069	0.426
MOD_GSK3_1	415	422	PF00069	0.358
MOD_GSK3_1	446	453	PF00069	0.380
MOD_GSK3_1	512	519	PF00069	0.356
MOD_GSK3_1	563	570	PF00069	0.440
MOD_GSK3_1	595	602	PF00069	0.417
MOD_LATS_1	627	633	PF00433	0.625
MOD_N-GLC_1	116	121	PF02516	0.689
MOD_N-GLC_1	188	193	PF02516	0.721
MOD_N-GLC_1	219	224	PF02516	0.609
MOD_N-GLC_1	270	275	PF02516	0.784
MOD_N-GLC_1	332	337	PF02516	0.560
MOD_N-GLC_1	389	394	PF02516	0.759
MOD_N-GLC_1	412	417	PF02516	0.692
MOD_N-GLC_1	446	451	PF02516	0.597
MOD_N-GLC_1	456	461	PF02516	0.589
MOD_N-GLC_2	467	469	PF02516	0.551
MOD_N-GLC_2	579	581	PF02516	0.583
MOD_NEK2_1	156	161	PF00069	0.480
MOD_NEK2_1	178	183	PF00069	0.418
MOD_NEK2_1	209	214	PF00069	0.506
MOD_NEK2_1	225	230	PF00069	0.263
MOD_NEK2_1	232	237	PF00069	0.378
MOD_NEK2_1	38	43	PF00069	0.403
MOD_NEK2_1	401	406	PF00069	0.436
MOD_NEK2_1	429	434	PF00069	0.452
MOD_NEK2_1	441	446	PF00069	0.335
MOD_NEK2_1	479	484	PF00069	0.341
MOD_NEK2_1	528	533	PF00069	0.454
MOD_NEK2_1	574	579	PF00069	0.352
MOD_NEK2_1	590	595	PF00069	0.442
MOD_NEK2_1	614	619	PF00069	0.371
MOD_NEK2_1	67	72	PF00069	0.394
MOD_NEK2_1	83	88	PF00069	0.397
MOD_OFUCOSY	171	176	PF10250	0.683
MOD_PIKK_1	412	418	PF00454	0.492
MOD_PIKK_1	89	95	PF00454	0.522
MOD_PK_1	446	452	PF00069	0.408
MOD_PKA_1	629	635	PF00069	0.597
MOD_PKA_2	492	498	PF00069	0.475
MOD_PKA_2	51	57	PF00069	0.691
MOD_PKA_2	546	552	PF00069	0.397
MOD_PKA_2	629	635	PF00069	0.599
MOD_PKB_1	27	35	PF00069	0.755
MOD_Plk_1	157	163	PF00069	0.525
MOD_Plk_1	178	184	PF00069	0.470
MOD_Plk_1	195	201	PF00069	0.347
MOD_Plk_1	219	225	PF00069	0.405
MOD_Plk_1	332	338	PF00069	0.399
MOD_Plk_1	348	354	PF00069	0.503
MOD_Plk_1	430	436	PF00069	0.362
MOD_Plk_1	446	452	PF00069	0.414
MOD_Plk_4	12	18	PF00069	0.814
MOD_Plk_4	140	146	PF00069	0.424
MOD_Plk_4	157	163	PF00069	0.405
MOD_Plk_4	178	184	PF00069	0.470
MOD_Plk_4	219	225	PF00069	0.405
MOD_Plk_4	310	316	PF00069	0.461
MOD_Plk_4	34	40	PF00069	0.513
MOD_Plk_4	348	354	PF00069	0.503
MOD_Plk_4	379	385	PF00069	0.372
MOD_Plk_4	397	403	PF00069	0.429
MOD_Plk_4	430	436	PF00069	0.399
MOD_Plk_4	446	452	PF00069	0.414
MOD_Plk_4	481	487	PF00069	0.388
MOD_Plk_4	570	576	PF00069	0.426
MOD_Plk_4	606	612	PF00069	0.329
MOD_Plk_4	620	626	PF00069	0.329
MOD_Plk_4	97	103	PF00069	0.423
MOD_ProDKin_1	148	154	PF00069	0.428
MOD_ProDKin_1	198	204	PF00069	0.505
MOD_ProDKin_1	210	216	PF00069	0.401
MOD_ProDKin_1	468	474	PF00069	0.479
MOD_ProDKin_1	599	605	PF00069	0.470
MOD_SUMO_for_1	635	638	PF00179	0.596
MOD_SUMO_rev_2	392	400	PF00179	0.486
TRG_DiLeu_BaEn_1	638	643	PF01217	0.620
TRG_DiLeu_LyEn_5	638	643	PF01217	0.583
TRG_ENDOCYTIC_2	251	254	PF00928	0.401
TRG_ENDOCYTIC_2	357	360	PF00928	0.382
TRG_ENDOCYTIC_2	542	545	PF00928	0.434
TRG_ENDOCYTIC_2	575	578	PF00928	0.441
TRG_ER_diArg_1	25	28	PF00400	0.758
TRG_ER_diArg_1	628	631	PF00400	0.607
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.762
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	641	645	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W1	Leptomonas seymouri	45%	100%
A0A3S5H6U2	Leishmania donovani	99%	100%
A4H809	Leishmania braziliensis	67%	100%
E9AQ37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QFE5	Leishmania major	87%	100%