Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWD6_LEIIN

TriTrypDb:

LINF_150008800

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	387	391	PF00656	0.717
CLV_C14_Caspase3-7	457	461	PF00656	0.485
CLV_C14_Caspase3-7	63	67	PF00656	0.695
CLV_NRD_NRD_1	14	16	PF00675	0.557
CLV_NRD_NRD_1	143	145	PF00675	0.718
CLV_NRD_NRD_1	208	210	PF00675	0.544
CLV_NRD_NRD_1	217	219	PF00675	0.543
CLV_NRD_NRD_1	283	285	PF00675	0.530
CLV_NRD_NRD_1	286	288	PF00675	0.522
CLV_NRD_NRD_1	324	326	PF00675	0.535
CLV_NRD_NRD_1	362	364	PF00675	0.717
CLV_NRD_NRD_1	376	378	PF00675	0.665
CLV_NRD_NRD_1	393	395	PF00675	0.678
CLV_NRD_NRD_1	404	406	PF00675	0.697
CLV_PCSK_FUR_1	284	288	PF00082	0.577
CLV_PCSK_FUR_1	374	378	PF00082	0.612
CLV_PCSK_KEX2_1	14	16	PF00082	0.551
CLV_PCSK_KEX2_1	143	145	PF00082	0.718
CLV_PCSK_KEX2_1	208	210	PF00082	0.540
CLV_PCSK_KEX2_1	217	219	PF00082	0.550
CLV_PCSK_KEX2_1	283	285	PF00082	0.527
CLV_PCSK_KEX2_1	286	288	PF00082	0.524
CLV_PCSK_KEX2_1	354	356	PF00082	0.702
CLV_PCSK_KEX2_1	361	363	PF00082	0.723
CLV_PCSK_KEX2_1	376	378	PF00082	0.662
CLV_PCSK_KEX2_1	393	395	PF00082	0.728
CLV_PCSK_KEX2_1	404	406	PF00082	0.617
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.628
CLV_PCSK_SKI1_1	101	105	PF00082	0.592
CLV_PCSK_SKI1_1	190	194	PF00082	0.500
CLV_PCSK_SKI1_1	213	217	PF00082	0.571
DEG_SPOP_SBC_1	103	107	PF00917	0.614
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.650
DOC_MAPK_gen_1	325	331	PF00069	0.586
DOC_PP2B_LxvP_1	30	33	PF13499	0.540
DOC_SPAK_OSR1_1	15	19	PF12202	0.482
DOC_USP7_MATH_1	103	107	PF00917	0.618
DOC_USP7_MATH_1	126	130	PF00917	0.737
DOC_USP7_MATH_1	158	162	PF00917	0.709
DOC_USP7_MATH_1	270	274	PF00917	0.557
DOC_USP7_MATH_1	330	334	PF00917	0.720
DOC_USP7_MATH_1	392	396	PF00917	0.577
DOC_USP7_MATH_1	436	440	PF00917	0.656
DOC_WW_Pin1_4	119	124	PF00397	0.755
DOC_WW_Pin1_4	134	139	PF00397	0.652
DOC_WW_Pin1_4	146	151	PF00397	0.607
DOC_WW_Pin1_4	191	196	PF00397	0.621
DOC_WW_Pin1_4	33	38	PF00397	0.630
DOC_WW_Pin1_4	380	385	PF00397	0.785
DOC_WW_Pin1_4	91	96	PF00397	0.810
LIG_14-3-3_CanoR_1	143	150	PF00244	0.714
LIG_14-3-3_CanoR_1	164	172	PF00244	0.647
LIG_14-3-3_CanoR_1	182	191	PF00244	0.602
LIG_14-3-3_CanoR_1	304	308	PF00244	0.585
LIG_14-3-3_CanoR_1	361	366	PF00244	0.674
LIG_14-3-3_CanoR_1	393	397	PF00244	0.628
LIG_14-3-3_CanoR_1	415	424	PF00244	0.668
LIG_14-3-3_CanoR_1	46	52	PF00244	0.704
LIG_14-3-3_CanoR_1	89	95	PF00244	0.612
LIG_Actin_WH2_2	168	186	PF00022	0.590
LIG_APCC_ABBA_1	16	21	PF00400	0.582
LIG_APCC_ABBAyCdc20_2	15	21	PF00400	0.583
LIG_BIR_II_1	1	5	PF00653	0.625
LIG_CaM_IQ_9	341	357	PF13499	0.607
LIG_EVH1_1	30	34	PF00568	0.543
LIG_FHA_1	105	111	PF00498	0.542
LIG_FHA_1	418	424	PF00498	0.669
LIG_FHA_1	451	457	PF00498	0.534
LIG_FHA_1	57	63	PF00498	0.622
LIG_FHA_2	385	391	PF00498	0.757
LIG_FHA_2	455	461	PF00498	0.437
LIG_LIR_Gen_1	127	138	PF02991	0.725
LIG_LIR_Nem_3	127	133	PF02991	0.727
LIG_MYND_1	232	236	PF01753	0.590
LIG_SH2_CRK	328	332	PF00017	0.671
LIG_SH2_NCK_1	130	134	PF00017	0.728
LIG_SH2_SRC	177	180	PF00017	0.565
LIG_SH2_STAP1	19	23	PF00017	0.577
LIG_SH2_STAT5	177	180	PF00017	0.576
LIG_SH2_STAT5	199	202	PF00017	0.443
LIG_SH2_STAT5	451	454	PF00017	0.402
LIG_SH2_STAT5	69	72	PF00017	0.721
LIG_SH3_1	28	34	PF00018	0.601
LIG_SH3_2	123	128	PF14604	0.710
LIG_SH3_3	120	126	PF00018	0.693
LIG_SH3_3	28	34	PF00018	0.629
LIG_SH3_3	324	330	PF00018	0.682
LIG_SH3_3	378	384	PF00018	0.730
LIG_SH3_4	402	409	PF00018	0.581
LIG_WW_3	32	36	PF00397	0.690
MOD_CDK_SPxxK_3	35	42	PF00069	0.643
MOD_CDK_SPxxK_3	91	98	PF00069	0.707
MOD_CK1_1	106	112	PF00069	0.664
MOD_CK1_1	129	135	PF00069	0.749
MOD_CK1_1	249	255	PF00069	0.706
MOD_CK1_1	303	309	PF00069	0.660
MOD_CK1_1	320	326	PF00069	0.482
MOD_CK1_1	339	345	PF00069	0.482
MOD_CK1_1	364	370	PF00069	0.703
MOD_CK1_1	418	424	PF00069	0.723
MOD_CK1_1	58	64	PF00069	0.646
MOD_CK1_1	71	77	PF00069	0.684
MOD_CK2_1	119	125	PF00069	0.549
MOD_CK2_1	165	171	PF00069	0.664
MOD_CK2_1	262	268	PF00069	0.642
MOD_CK2_1	436	442	PF00069	0.579
MOD_DYRK1A_RPxSP_1	35	39	PF00069	0.684
MOD_DYRK1A_RPxSP_1	380	384	PF00069	0.587
MOD_GlcNHglycan	167	170	PF01048	0.699
MOD_GlcNHglycan	184	187	PF01048	0.542
MOD_GlcNHglycan	251	254	PF01048	0.778
MOD_GlcNHglycan	356	359	PF01048	0.632
MOD_GlcNHglycan	366	369	PF01048	0.723
MOD_GlcNHglycan	62	65	PF01048	0.642
MOD_GlcNHglycan	70	73	PF01048	0.724
MOD_GSK3_1	142	149	PF00069	0.756
MOD_GSK3_1	153	160	PF00069	0.584
MOD_GSK3_1	22	29	PF00069	0.557
MOD_GSK3_1	299	306	PF00069	0.558
MOD_GSK3_1	336	343	PF00069	0.615
MOD_GSK3_1	364	371	PF00069	0.740
MOD_GSK3_1	376	383	PF00069	0.666
MOD_GSK3_1	450	457	PF00069	0.507
MOD_GSK3_1	486	493	PF00069	0.547
MOD_GSK3_1	56	63	PF00069	0.673
MOD_GSK3_1	99	106	PF00069	0.655
MOD_N-GLC_1	249	254	PF02516	0.699
MOD_N-GLC_1	26	31	PF02516	0.546
MOD_N-GLC_1	293	298	PF02516	0.629
MOD_NEK2_1	293	298	PF00069	0.558
MOD_NEK2_1	416	421	PF00069	0.686
MOD_NEK2_2	480	485	PF00069	0.432
MOD_PIKK_1	199	205	PF00454	0.450
MOD_PIKK_1	270	276	PF00454	0.569
MOD_PKA_1	143	149	PF00069	0.716
MOD_PKA_1	286	292	PF00069	0.558
MOD_PKA_1	354	360	PF00069	0.705
MOD_PKA_1	361	367	PF00069	0.617
MOD_PKA_1	376	382	PF00069	0.626
MOD_PKA_2	142	148	PF00069	0.706
MOD_PKA_2	165	171	PF00069	0.663
MOD_PKA_2	286	292	PF00069	0.668
MOD_PKA_2	303	309	PF00069	0.531
MOD_PKA_2	354	360	PF00069	0.666
MOD_PKA_2	361	367	PF00069	0.655
MOD_PKA_2	376	382	PF00069	0.777
MOD_PKA_2	392	398	PF00069	0.580
MOD_PKB_1	284	292	PF00069	0.555
MOD_PKB_1	361	369	PF00069	0.677
MOD_PKB_1	374	382	PF00069	0.552
MOD_PKB_1	413	421	PF00069	0.589
MOD_Plk_1	226	232	PF00069	0.655
MOD_Plk_1	26	32	PF00069	0.547
MOD_Plk_4	418	424	PF00069	0.642
MOD_ProDKin_1	119	125	PF00069	0.759
MOD_ProDKin_1	134	140	PF00069	0.650
MOD_ProDKin_1	146	152	PF00069	0.607
MOD_ProDKin_1	191	197	PF00069	0.611
MOD_ProDKin_1	33	39	PF00069	0.632
MOD_ProDKin_1	380	386	PF00069	0.781
MOD_ProDKin_1	91	97	PF00069	0.813
MOD_SUMO_rev_2	20	30	PF00179	0.505
MOD_SUMO_rev_2	219	225	PF00179	0.557
MOD_SUMO_rev_2	395	403	PF00179	0.580
TRG_DiLeu_BaEn_1	4	9	PF01217	0.600
TRG_ENDOCYTIC_2	130	133	PF00928	0.729
TRG_ENDOCYTIC_2	19	22	PF00928	0.515
TRG_ENDOCYTIC_2	328	331	PF00928	0.676
TRG_ER_diArg_1	14	16	PF00400	0.504
TRG_ER_diArg_1	207	209	PF00400	0.540
TRG_ER_diArg_1	216	218	PF00400	0.547
TRG_ER_diArg_1	283	286	PF00400	0.530
TRG_ER_diArg_1	361	363	PF00400	0.613
TRG_ER_diArg_1	403	405	PF00400	0.713
TRG_ER_diArg_1	410	413	PF00400	0.612
TRG_NLS_MonoCore_2	400	405	PF00514	0.678
TRG_NLS_MonoExtC_3	400	405	PF00514	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I2	Leptomonas seymouri	41%	94%
A0A3Q8IIM0	Leishmania donovani	100%	100%
A0A3R7M601	Trypanosoma rangeli	26%	100%
E9AQ36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QFE6	Leishmania major	84%	100%
V5DCS2	Trypanosoma cruzi	28%	100%