LeishMANIAdb
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Putative ecotin

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ecotin
Gene product:
Isoprenylcysteine alpha-carbonyl methylesterase - putative
Species:
Leishmania infantum
UniProt:
A4HWD4_LEIIN
TriTrypDb:
LINF_150008600
Length:
759

Annotations

Annotations by Jardim et al.

Hydrolase, ecotin LiISP3

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Phosphorylation

Amastigote: 221, 701, 718
Promastigote: 671
Promastigote/Amastigote: 676, 707, 711

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HWD4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWD4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016787 hydrolase activity 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 271 275 PF00656 0.699
CLV_C14_Caspase3-7 408 412 PF00656 0.236
CLV_C14_Caspase3-7 618 622 PF00656 0.343
CLV_C14_Caspase3-7 701 705 PF00656 0.382
CLV_C14_Caspase3-7 731 735 PF00656 0.440
CLV_MEL_PAP_1 96 102 PF00089 0.302
CLV_NRD_NRD_1 311 313 PF00675 0.383
CLV_NRD_NRD_1 347 349 PF00675 0.471
CLV_NRD_NRD_1 352 354 PF00675 0.254
CLV_NRD_NRD_1 507 509 PF00675 0.495
CLV_NRD_NRD_1 537 539 PF00675 0.566
CLV_NRD_NRD_1 648 650 PF00675 0.608
CLV_NRD_NRD_1 98 100 PF00675 0.295
CLV_PCSK_KEX2_1 346 348 PF00082 0.594
CLV_PCSK_KEX2_1 354 356 PF00082 0.278
CLV_PCSK_KEX2_1 507 509 PF00082 0.495
CLV_PCSK_KEX2_1 537 539 PF00082 0.564
CLV_PCSK_KEX2_1 648 650 PF00082 0.609
CLV_PCSK_KEX2_1 98 100 PF00082 0.295
CLV_PCSK_PC1ET2_1 346 348 PF00082 0.510
CLV_PCSK_PC1ET2_1 354 356 PF00082 0.158
CLV_PCSK_SKI1_1 119 123 PF00082 0.417
CLV_PCSK_SKI1_1 512 516 PF00082 0.489
CLV_PCSK_SKI1_1 557 561 PF00082 0.479
CLV_PCSK_SKI1_1 605 609 PF00082 0.564
CLV_PCSK_SKI1_1 64 68 PF00082 0.528
CLV_PCSK_SKI1_1 71 75 PF00082 0.426
DEG_APCC_DBOX_1 511 519 PF00400 0.312
DEG_APCC_DBOX_1 745 753 PF00400 0.397
DEG_SCF_FBW7_1 15 22 PF00400 0.276
DOC_CKS1_1 16 21 PF01111 0.276
DOC_CYCLIN_yClb5_NLxxxL_5 109 117 PF00134 0.504
DOC_CYCLIN_yCln2_LP_2 603 609 PF00134 0.372
DOC_MAPK_DCC_7 601 609 PF00069 0.383
DOC_MAPK_gen_1 350 360 PF00069 0.436
DOC_MAPK_HePTP_8 287 299 PF00069 0.505
DOC_MAPK_MEF2A_6 290 299 PF00069 0.479
DOC_MAPK_MEF2A_6 353 362 PF00069 0.436
DOC_PP1_RVXF_1 69 76 PF00149 0.260
DOC_PP2B_LxvP_1 297 300 PF13499 0.483
DOC_USP7_MATH_1 265 269 PF00917 0.700
DOC_USP7_MATH_1 300 304 PF00917 0.563
DOC_USP7_MATH_1 482 486 PF00917 0.302
DOC_USP7_MATH_1 565 569 PF00917 0.323
DOC_USP7_MATH_1 673 677 PF00917 0.541
DOC_USP7_MATH_1 682 686 PF00917 0.501
DOC_USP7_MATH_1 691 695 PF00917 0.416
DOC_USP7_UBL2_3 346 350 PF12436 0.759
DOC_USP7_UBL2_3 601 605 PF12436 0.403
DOC_WW_Pin1_4 15 20 PF00397 0.194
DOC_WW_Pin1_4 158 163 PF00397 0.704
DOC_WW_Pin1_4 4 9 PF00397 0.382
DOC_WW_Pin1_4 708 713 PF00397 0.491
DOC_WW_Pin1_4 715 720 PF00397 0.484
DOC_WW_Pin1_4 736 741 PF00397 0.371
DOC_WW_Pin1_4 90 95 PF00397 0.342
LIG_14-3-3_CanoR_1 180 187 PF00244 0.625
LIG_14-3-3_CanoR_1 244 249 PF00244 0.666
LIG_14-3-3_CanoR_1 290 294 PF00244 0.504
LIG_14-3-3_CanoR_1 312 320 PF00244 0.603
LIG_14-3-3_CanoR_1 527 531 PF00244 0.353
LIG_14-3-3_CanoR_1 677 682 PF00244 0.500
LIG_14-3-3_CanoR_1 71 76 PF00244 0.297
LIG_14-3-3_CanoR_1 722 726 PF00244 0.452
LIG_14-3-3_CanoR_1 751 756 PF00244 0.382
LIG_14-3-3_CanoR_1 98 103 PF00244 0.530
LIG_APCC_ABBA_1 559 564 PF00400 0.294
LIG_APCC_ABBAyCdc20_2 507 513 PF00400 0.324
LIG_BIR_II_1 1 5 PF00653 0.465
LIG_BRCT_BRCA1_1 26 30 PF00533 0.215
LIG_BRCT_BRCA1_1 492 496 PF00533 0.270
LIG_CaM_IQ_9 226 242 PF13499 0.617
LIG_DLG_GKlike_1 244 251 PF00625 0.560
LIG_EH1_1 495 503 PF00400 0.269
LIG_eIF4E_1 372 378 PF01652 0.366
LIG_FHA_1 105 111 PF00498 0.575
LIG_FHA_1 125 131 PF00498 0.575
LIG_FHA_1 290 296 PF00498 0.480
LIG_FHA_1 315 321 PF00498 0.556
LIG_FHA_1 404 410 PF00498 0.303
LIG_FHA_1 50 56 PF00498 0.330
LIG_FHA_1 540 546 PF00498 0.314
LIG_FHA_1 618 624 PF00498 0.307
LIG_FHA_1 676 682 PF00498 0.485
LIG_FHA_1 722 728 PF00498 0.447
LIG_FHA_2 271 277 PF00498 0.695
LIG_FHA_2 398 404 PF00498 0.236
LIG_FHA_2 616 622 PF00498 0.356
LIG_FHA_2 699 705 PF00498 0.388
LIG_FHA_2 729 735 PF00498 0.451
LIG_LIR_Apic_2 472 478 PF02991 0.329
LIG_LIR_Apic_2 720 726 PF02991 0.493
LIG_LIR_Apic_2 754 758 PF02991 0.354
LIG_LIR_Apic_2 79 85 PF02991 0.272
LIG_LIR_Gen_1 18 28 PF02991 0.479
LIG_LIR_Gen_1 29 38 PF02991 0.528
LIG_LIR_Gen_1 39 49 PF02991 0.482
LIG_LIR_Gen_1 548 559 PF02991 0.305
LIG_LIR_Gen_1 608 617 PF02991 0.297
LIG_LIR_Gen_1 74 83 PF02991 0.366
LIG_LIR_Nem_3 18 24 PF02991 0.479
LIG_LIR_Nem_3 294 299 PF02991 0.471
LIG_LIR_Nem_3 37 41 PF02991 0.529
LIG_LIR_Nem_3 393 397 PF02991 0.236
LIG_LIR_Nem_3 548 554 PF02991 0.311
LIG_LIR_Nem_3 608 614 PF02991 0.294
LIG_LIR_Nem_3 636 640 PF02991 0.333
LIG_LIR_Nem_3 724 728 PF02991 0.482
LIG_LRP6_Inhibitor_1 92 98 PF00058 0.306
LIG_NRBOX 112 118 PF00104 0.572
LIG_NRBOX 12 18 PF00104 0.195
LIG_PCNA_TLS_4 290 297 PF02747 0.477
LIG_PCNA_yPIPBox_3 375 385 PF02747 0.366
LIG_Pex14_1 367 371 PF04695 0.330
LIG_Pex14_2 218 222 PF04695 0.581
LIG_Pex14_2 38 42 PF04695 0.581
LIG_PTB_Apo_2 266 273 PF02174 0.662
LIG_SH2_CRK 475 479 PF00017 0.331
LIG_SH2_CRK 723 727 PF00017 0.477
LIG_SH2_PTP2 489 492 PF00017 0.253
LIG_SH2_PTP2 611 614 PF00017 0.312
LIG_SH2_PTP2 755 758 PF00017 0.355
LIG_SH2_SRC 296 299 PF00017 0.473
LIG_SH2_SRC 516 519 PF00017 0.301
LIG_SH2_STAP1 144 148 PF00017 0.641
LIG_SH2_STAP1 528 532 PF00017 0.343
LIG_SH2_STAT3 40 43 PF00017 0.509
LIG_SH2_STAT5 296 299 PF00017 0.502
LIG_SH2_STAT5 372 375 PF00017 0.332
LIG_SH2_STAT5 387 390 PF00017 0.184
LIG_SH2_STAT5 40 43 PF00017 0.509
LIG_SH2_STAT5 489 492 PF00017 0.253
LIG_SH2_STAT5 528 531 PF00017 0.286
LIG_SH2_STAT5 533 536 PF00017 0.297
LIG_SH2_STAT5 579 582 PF00017 0.330
LIG_SH2_STAT5 611 614 PF00017 0.312
LIG_SH2_STAT5 723 726 PF00017 0.547
LIG_SH2_STAT5 755 758 PF00017 0.362
LIG_SH2_STAT5 82 85 PF00017 0.272
LIG_SH2_STAT5 90 93 PF00017 0.338
LIG_SH3_1 723 729 PF00018 0.486
LIG_SH3_3 133 139 PF00018 0.754
LIG_SH3_3 161 167 PF00018 0.734
LIG_SH3_3 258 264 PF00018 0.703
LIG_SH3_3 386 392 PF00018 0.236
LIG_SH3_3 464 470 PF00018 0.411
LIG_SH3_3 723 729 PF00018 0.486
LIG_SH3_3 737 743 PF00018 0.437
LIG_SUMO_SIM_par_1 356 361 PF11976 0.272
LIG_SUMO_SIM_par_1 405 411 PF11976 0.236
LIG_SUMO_SIM_par_1 605 610 PF11976 0.314
LIG_TRFH_1 611 615 PF08558 0.293
LIG_TRFH_1 90 94 PF08558 0.440
LIG_TYR_ITIM 609 614 PF00017 0.347
LIG_TYR_ITIM 638 643 PF00017 0.385
LIG_UBA3_1 304 313 PF00899 0.547
LIG_UBA3_1 55 64 PF00899 0.272
LIG_WRC_WIRS_1 20 25 PF05994 0.430
MOD_CDC14_SPxK_1 163 166 PF00782 0.633
MOD_CDK_SPxK_1 160 166 PF00069 0.628
MOD_CDK_SPxxK_3 715 722 PF00069 0.421
MOD_CK1_1 101 107 PF00069 0.502
MOD_CK1_1 125 131 PF00069 0.650
MOD_CK1_1 247 253 PF00069 0.635
MOD_CK1_1 26 32 PF00069 0.276
MOD_CK1_1 268 274 PF00069 0.710
MOD_CK1_1 314 320 PF00069 0.626
MOD_CK1_1 4 10 PF00069 0.382
MOD_CK1_1 445 451 PF00069 0.256
MOD_CK1_1 654 660 PF00069 0.443
MOD_CK1_1 676 682 PF00069 0.515
MOD_CK1_1 744 750 PF00069 0.463
MOD_CK2_1 247 253 PF00069 0.682
MOD_CK2_1 272 278 PF00069 0.710
MOD_CK2_1 397 403 PF00069 0.236
MOD_CK2_1 619 625 PF00069 0.350
MOD_GlcNHglycan 148 151 PF01048 0.592
MOD_GlcNHglycan 205 208 PF01048 0.402
MOD_GlcNHglycan 3 6 PF01048 0.559
MOD_GlcNHglycan 333 336 PF01048 0.534
MOD_GlcNHglycan 435 438 PF01048 0.449
MOD_GlcNHglycan 452 455 PF01048 0.488
MOD_GlcNHglycan 492 495 PF01048 0.459
MOD_GlcNHglycan 566 570 PF01048 0.508
MOD_GlcNHglycan 573 576 PF01048 0.503
MOD_GlcNHglycan 653 656 PF01048 0.614
MOD_GlcNHglycan 684 687 PF01048 0.791
MOD_GlcNHglycan 692 696 PF01048 0.698
MOD_GSK3_1 125 132 PF00069 0.659
MOD_GSK3_1 144 151 PF00069 0.767
MOD_GSK3_1 15 22 PF00069 0.276
MOD_GSK3_1 203 210 PF00069 0.654
MOD_GSK3_1 214 221 PF00069 0.596
MOD_GSK3_1 268 275 PF00069 0.657
MOD_GSK3_1 403 410 PF00069 0.321
MOD_GSK3_1 565 572 PF00069 0.325
MOD_GSK3_1 615 622 PF00069 0.368
MOD_GSK3_1 673 680 PF00069 0.538
MOD_GSK3_1 704 711 PF00069 0.488
MOD_GSK3_1 98 105 PF00069 0.511
MOD_LATS_1 675 681 PF00433 0.501
MOD_N-GLC_1 218 223 PF02516 0.422
MOD_N-GLC_1 268 273 PF02516 0.493
MOD_N-GLC_1 428 433 PF02516 0.503
MOD_NEK2_1 1 6 PF00069 0.403
MOD_NEK2_1 148 153 PF00069 0.766
MOD_NEK2_1 23 28 PF00069 0.276
MOD_NEK2_1 48 53 PF00069 0.346
MOD_NEK2_1 66 71 PF00069 0.375
MOD_NEK2_1 681 686 PF00069 0.484
MOD_NEK2_2 300 305 PF00069 0.563
MOD_NEK2_2 482 487 PF00069 0.305
MOD_PIKK_1 234 240 PF00454 0.645
MOD_PIKK_1 252 258 PF00454 0.745
MOD_PIKK_1 445 451 PF00454 0.236
MOD_PIKK_1 704 710 PF00454 0.424
MOD_PKA_1 98 104 PF00069 0.512
MOD_PKA_2 105 111 PF00069 0.502
MOD_PKA_2 174 180 PF00069 0.635
MOD_PKA_2 289 295 PF00069 0.506
MOD_PKA_2 311 317 PF00069 0.646
MOD_PKA_2 482 488 PF00069 0.289
MOD_PKA_2 526 532 PF00069 0.301
MOD_PKA_2 676 682 PF00069 0.499
MOD_PKA_2 721 727 PF00069 0.442
MOD_PKA_2 98 104 PF00069 0.492
MOD_Plk_1 144 150 PF00069 0.687
MOD_Plk_1 218 224 PF00069 0.652
MOD_Plk_1 268 274 PF00069 0.715
MOD_Plk_1 428 434 PF00069 0.236
MOD_Plk_2-3 174 180 PF00069 0.619
MOD_Plk_2-3 270 276 PF00069 0.699
MOD_Plk_2-3 311 317 PF00069 0.585
MOD_Plk_2-3 403 409 PF00069 0.303
MOD_Plk_4 188 194 PF00069 0.606
MOD_Plk_4 247 253 PF00069 0.574
MOD_Plk_4 300 306 PF00069 0.578
MOD_Plk_4 428 434 PF00069 0.248
MOD_Plk_4 439 445 PF00069 0.217
MOD_Plk_4 6 12 PF00069 0.379
MOD_Plk_4 619 625 PF00069 0.402
MOD_Plk_4 751 757 PF00069 0.345
MOD_ProDKin_1 15 21 PF00069 0.194
MOD_ProDKin_1 158 164 PF00069 0.705
MOD_ProDKin_1 4 10 PF00069 0.382
MOD_ProDKin_1 708 714 PF00069 0.490
MOD_ProDKin_1 715 721 PF00069 0.482
MOD_ProDKin_1 736 742 PF00069 0.373
MOD_ProDKin_1 90 96 PF00069 0.336
MOD_SUMO_for_1 121 124 PF00179 0.630
TRG_ENDOCYTIC_2 296 299 PF00928 0.473
TRG_ENDOCYTIC_2 387 390 PF00928 0.236
TRG_ENDOCYTIC_2 394 397 PF00928 0.236
TRG_ENDOCYTIC_2 489 492 PF00928 0.269
TRG_ENDOCYTIC_2 511 514 PF00928 0.305
TRG_ENDOCYTIC_2 611 614 PF00928 0.312
TRG_ENDOCYTIC_2 640 643 PF00928 0.399
TRG_ER_diArg_1 165 168 PF00400 0.624
TRG_ER_diArg_1 233 236 PF00400 0.663
TRG_ER_diArg_1 353 356 PF00400 0.502
TRG_ER_diArg_1 97 99 PF00400 0.492
TRG_NLS_MonoExtC_3 345 350 PF00514 0.765
TRG_NLS_MonoExtC_3 352 357 PF00514 0.372
TRG_NLS_MonoExtN_4 350 357 PF00514 0.414
TRG_Pf-PMV_PEXEL_1 508 513 PF00026 0.629

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJ74 Leptomonas seymouri 64% 100%
A0A1X0NTZ0 Trypanosomatidae 42% 100%
A0A3Q8IC72 Leishmania donovani 99% 100%
A0A3R7K197 Trypanosoma rangeli 49% 100%
A4H806 Leishmania braziliensis 79% 100%
E9AQ34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QFE8 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS