Putative ecotin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative ecotin

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWD3_LEIIN

TriTrypDb:

LINF_150008500

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.618
CLV_NRD_NRD_1	192	194	PF00675	0.802
CLV_NRD_NRD_1	286	288	PF00675	0.746
CLV_NRD_NRD_1	4	6	PF00675	0.810
CLV_NRD_NRD_1	43	45	PF00675	0.536
CLV_NRD_NRD_1	539	541	PF00675	0.592
CLV_PCSK_FUR_1	189	193	PF00082	0.781
CLV_PCSK_KEX2_1	191	193	PF00082	0.794
CLV_PCSK_KEX2_1	286	288	PF00082	0.746
CLV_PCSK_KEX2_1	4	6	PF00082	0.810
CLV_PCSK_KEX2_1	43	45	PF00082	0.536
CLV_PCSK_KEX2_1	466	468	PF00082	0.743
CLV_PCSK_KEX2_1	538	540	PF00082	0.578
CLV_PCSK_PC1ET2_1	466	468	PF00082	0.724
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.578
CLV_PCSK_PC7_1	535	541	PF00082	0.570
CLV_PCSK_SKI1_1	266	270	PF00082	0.613
CLV_PCSK_SKI1_1	286	290	PF00082	0.618
CLV_PCSK_SKI1_1	43	47	PF00082	0.677
CLV_PCSK_SKI1_1	635	639	PF00082	0.550
DEG_APCC_DBOX_1	634	642	PF00400	0.660
DEG_MDM2_SWIB_1	643	651	PF02201	0.487
DEG_ODPH_VHL_1	579	590	PF01847	0.733
DEG_SPOP_SBC_1	276	280	PF00917	0.713
DEG_SPOP_SBC_1	281	285	PF00917	0.661
DEG_SPOP_SBC_1	346	350	PF00917	0.722
DOC_CYCLIN_yClb1_LxF_4	638	643	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	621	627	PF00134	0.591
DOC_MAPK_gen_1	191	200	PF00069	0.744
DOC_MAPK_gen_1	373	382	PF00069	0.593
DOC_MAPK_MEF2A_6	375	384	PF00069	0.587
DOC_PP1_RVXF_1	638	644	PF00149	0.595
DOC_PP2B_LxvP_1	51	54	PF13499	0.591
DOC_PP2B_LxvP_1	621	624	PF13499	0.667
DOC_USP7_MATH_1	132	136	PF00917	0.816
DOC_USP7_MATH_1	143	147	PF00917	0.732
DOC_USP7_MATH_1	276	280	PF00917	0.770
DOC_USP7_MATH_1	290	294	PF00917	0.555
DOC_USP7_MATH_1	304	308	PF00917	0.641
DOC_USP7_MATH_1	316	320	PF00917	0.528
DOC_USP7_MATH_1	346	350	PF00917	0.738
DOC_USP7_MATH_1	402	406	PF00917	0.826
DOC_USP7_MATH_1	413	417	PF00917	0.510
DOC_USP7_MATH_1	564	568	PF00917	0.739
DOC_USP7_MATH_1	77	81	PF00917	0.670
DOC_WW_Pin1_4	348	353	PF00397	0.748
DOC_WW_Pin1_4	436	441	PF00397	0.811
DOC_WW_Pin1_4	469	474	PF00397	0.726
DOC_WW_Pin1_4	487	492	PF00397	0.756
LIG_14-3-3_CanoR_1	218	225	PF00244	0.658
LIG_14-3-3_CanoR_1	232	240	PF00244	0.743
LIG_14-3-3_CanoR_1	317	325	PF00244	0.578
LIG_14-3-3_CanoR_1	347	352	PF00244	0.845
LIG_14-3-3_CanoR_1	373	382	PF00244	0.671
LIG_14-3-3_CanoR_1	4	14	PF00244	0.651
LIG_14-3-3_CanoR_1	409	418	PF00244	0.679
LIG_Actin_WH2_2	159	175	PF00022	0.625
LIG_Actin_WH2_2	620	637	PF00022	0.714
LIG_AP_GAE_1	524	530	PF02883	0.635
LIG_BIR_II_1	1	5	PF00653	0.758
LIG_BIR_III_4	213	217	PF00653	0.676
LIG_BIR_III_4	544	548	PF00653	0.561
LIG_BRCT_BRCA1_1	511	515	PF00533	0.687
LIG_CtBP_PxDLS_1	615	619	PF00389	0.584
LIG_EH_1	627	631	PF12763	0.531
LIG_FHA_1	349	355	PF00498	0.772
LIG_FHA_1	375	381	PF00498	0.580
LIG_FHA_1	508	514	PF00498	0.823
LIG_FHA_2	410	416	PF00498	0.679
LIG_LIR_Apic_2	238	243	PF02991	0.736
LIG_LIR_Gen_1	151	159	PF02991	0.611
LIG_LIR_Gen_1	199	207	PF02991	0.488
LIG_LIR_Gen_1	524	534	PF02991	0.650
LIG_LIR_Nem_3	151	155	PF02991	0.615
LIG_LIR_Nem_3	524	530	PF02991	0.664
LIG_Pex14_2	643	647	PF04695	0.691
LIG_PTAP_UEV_1	193	198	PF05743	0.712
LIG_RPA_C_Fungi	528	540	PF08784	0.634
LIG_SH2_CRK	152	156	PF00017	0.613
LIG_SH2_CRK	240	244	PF00017	0.732
LIG_SH2_NCK_1	240	244	PF00017	0.732
LIG_SH2_SRC	168	171	PF00017	0.613
LIG_SH2_STAP1	164	168	PF00017	0.733
LIG_SH2_STAP1	323	327	PF00017	0.711
LIG_SH2_STAP1	337	341	PF00017	0.534
LIG_SH2_STAP1	644	648	PF00017	0.618
LIG_SH2_STAT5	240	243	PF00017	0.832
LIG_SH2_STAT5	642	645	PF00017	0.551
LIG_SH3_1	191	197	PF00018	0.711
LIG_SH3_3	11	17	PF00018	0.726
LIG_SH3_3	137	143	PF00018	0.788
LIG_SH3_3	191	197	PF00018	0.670
LIG_SH3_3	241	247	PF00018	0.817
LIG_SH3_3	396	402	PF00018	0.715
LIG_SH3_3	449	455	PF00018	0.725
LIG_SH3_3	482	488	PF00018	0.806
LIG_SH3_3	569	575	PF00018	0.720
LIG_SH3_3	605	611	PF00018	0.714
LIG_SH3_3	63	69	PF00018	0.811
LIG_TRAF2_1	167	170	PF00917	0.612
LIG_TRAF2_1	404	407	PF00917	0.646
LIG_WW_3	344	348	PF00397	0.831
LIG_WW_3	52	56	PF00397	0.635
MOD_CDK_SPxK_1	469	475	PF00069	0.728
MOD_CK1_1	199	205	PF00069	0.766
MOD_CK1_1	208	214	PF00069	0.755
MOD_CK1_1	233	239	PF00069	0.718
MOD_CK1_1	245	251	PF00069	0.707
MOD_CK1_1	272	278	PF00069	0.700
MOD_CK1_1	280	286	PF00069	0.697
MOD_CK1_1	306	312	PF00069	0.743
MOD_CK1_1	319	325	PF00069	0.527
MOD_CK1_1	348	354	PF00069	0.769
MOD_CK1_1	456	462	PF00069	0.797
MOD_CK1_1	490	496	PF00069	0.804
MOD_CK1_1	566	572	PF00069	0.830
MOD_CK1_1	600	606	PF00069	0.676
MOD_CK1_1	619	625	PF00069	0.494
MOD_CK1_1	70	76	PF00069	0.772
MOD_CK2_1	164	170	PF00069	0.683
MOD_CK2_1	409	415	PF00069	0.736
MOD_CK2_1	551	557	PF00069	0.794
MOD_CK2_1	614	620	PF00069	0.585
MOD_GlcNHglycan	106	109	PF01048	0.576
MOD_GlcNHglycan	194	197	PF01048	0.677
MOD_GlcNHglycan	207	210	PF01048	0.486
MOD_GlcNHglycan	232	235	PF01048	0.627
MOD_GlcNHglycan	247	250	PF01048	0.752
MOD_GlcNHglycan	258	261	PF01048	0.642
MOD_GlcNHglycan	262	265	PF01048	0.635
MOD_GlcNHglycan	274	277	PF01048	0.734
MOD_GlcNHglycan	279	282	PF01048	0.759
MOD_GlcNHglycan	318	321	PF01048	0.634
MOD_GlcNHglycan	362	366	PF01048	0.790
MOD_GlcNHglycan	455	458	PF01048	0.806
MOD_GlcNHglycan	478	481	PF01048	0.785
MOD_GlcNHglycan	492	495	PF01048	0.728
MOD_GlcNHglycan	517	520	PF01048	0.719
MOD_GlcNHglycan	566	569	PF01048	0.774
MOD_GlcNHglycan	599	602	PF01048	0.693
MOD_GlcNHglycan	612	615	PF01048	0.717
MOD_GlcNHglycan	648	651	PF01048	0.589
MOD_GlcNHglycan	74	77	PF01048	0.737
MOD_GlcNHglycan	83	86	PF01048	0.485
MOD_GlcNHglycan	95	98	PF01048	0.565
MOD_GSK3_1	128	135	PF00069	0.741
MOD_GSK3_1	179	186	PF00069	0.636
MOD_GSK3_1	192	199	PF00069	0.626
MOD_GSK3_1	238	245	PF00069	0.821
MOD_GSK3_1	256	263	PF00069	0.687
MOD_GSK3_1	272	279	PF00069	0.718
MOD_GSK3_1	303	310	PF00069	0.702
MOD_GSK3_1	315	322	PF00069	0.644
MOD_GSK3_1	32	39	PF00069	0.572
MOD_GSK3_1	374	381	PF00069	0.589
MOD_GSK3_1	409	416	PF00069	0.710
MOD_GSK3_1	486	493	PF00069	0.812
MOD_GSK3_1	610	617	PF00069	0.659
MOD_GSK3_1	75	82	PF00069	0.682
MOD_N-GLC_1	548	553	PF02516	0.721
MOD_NEK2_1	184	189	PF00069	0.641
MOD_NEK2_1	198	203	PF00069	0.685
MOD_NEK2_1	262	267	PF00069	0.744
MOD_NEK2_1	269	274	PF00069	0.689
MOD_NEK2_1	515	520	PF00069	0.705
MOD_NEK2_1	646	651	PF00069	0.533
MOD_PIKK_1	177	183	PF00454	0.521
MOD_PKA_1	192	198	PF00069	0.658
MOD_PKA_1	4	10	PF00069	0.621
MOD_PKA_2	177	183	PF00069	0.659
MOD_PKA_2	192	198	PF00069	0.613
MOD_PKA_2	217	223	PF00069	0.734
MOD_PKA_2	245	251	PF00069	0.797
MOD_PKA_2	256	262	PF00069	0.678
MOD_PKA_2	316	322	PF00069	0.590
MOD_PKA_2	346	352	PF00069	0.765
MOD_PKA_2	374	380	PF00069	0.588
MOD_PKA_2	4	10	PF00069	0.758
MOD_PKA_2	497	503	PF00069	0.662
MOD_PKA_2	534	540	PF00069	0.622
MOD_Plk_1	164	170	PF00069	0.605
MOD_Plk_1	523	529	PF00069	0.652
MOD_Plk_1	619	625	PF00069	0.718
MOD_Plk_4	269	275	PF00069	0.733
MOD_ProDKin_1	348	354	PF00069	0.749
MOD_ProDKin_1	436	442	PF00069	0.808
MOD_ProDKin_1	469	475	PF00069	0.728
MOD_ProDKin_1	487	493	PF00069	0.758
MOD_SUMO_for_1	47	50	PF00179	0.702
TRG_ENDOCYTIC_2	152	155	PF00928	0.609
TRG_ER_diArg_1	188	191	PF00400	0.748
TRG_ER_diArg_1	192	194	PF00400	0.726
TRG_ER_diArg_1	286	288	PF00400	0.746
TRG_ER_diArg_1	327	330	PF00400	0.611
TRG_ER_diArg_1	355	358	PF00400	0.663
TRG_ER_diArg_1	372	375	PF00400	0.526
TRG_ER_diArg_1	42	44	PF00400	0.525
TRG_ER_diArg_1	496	499	PF00400	0.681
TRG_ER_diArg_1	633	636	PF00400	0.489
TRG_NLS_MonoExtC_3	537	543	PF00514	0.526
TRG_NLS_MonoExtN_4	535	542	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.740
TRG_Pf-PMV_PEXEL_1	401	406	PF00026	0.711
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC10	Leptomonas seymouri	32%	100%
A0A3S7WTB9	Leishmania donovani	98%	100%
A4H805	Leishmania braziliensis	60%	96%
E9AQ33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QFE9	Leishmania major	85%	100%