LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HWD1_LEIIN
TriTrypDb:
LINF_150008300
Length:
800

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWD1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWD1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 103 107 PF00656 0.715
CLV_C14_Caspase3-7 200 204 PF00656 0.511
CLV_C14_Caspase3-7 407 411 PF00656 0.321
CLV_MEL_PAP_1 292 298 PF00089 0.364
CLV_NRD_NRD_1 117 119 PF00675 0.466
CLV_NRD_NRD_1 132 134 PF00675 0.322
CLV_NRD_NRD_1 306 308 PF00675 0.398
CLV_NRD_NRD_1 323 325 PF00675 0.343
CLV_NRD_NRD_1 333 335 PF00675 0.448
CLV_NRD_NRD_1 455 457 PF00675 0.473
CLV_NRD_NRD_1 611 613 PF00675 0.575
CLV_NRD_NRD_1 614 616 PF00675 0.572
CLV_NRD_NRD_1 620 622 PF00675 0.504
CLV_NRD_NRD_1 694 696 PF00675 0.511
CLV_NRD_NRD_1 728 730 PF00675 0.612
CLV_NRD_NRD_1 731 733 PF00675 0.626
CLV_NRD_NRD_1 773 775 PF00675 0.648
CLV_NRD_NRD_1 79 81 PF00675 0.588
CLV_PCSK_FUR_1 331 335 PF00082 0.453
CLV_PCSK_FUR_1 611 615 PF00082 0.675
CLV_PCSK_FUR_1 618 622 PF00082 0.596
CLV_PCSK_FUR_1 729 733 PF00082 0.529
CLV_PCSK_FUR_1 771 775 PF00082 0.604
CLV_PCSK_KEX2_1 117 119 PF00082 0.466
CLV_PCSK_KEX2_1 132 134 PF00082 0.322
CLV_PCSK_KEX2_1 306 308 PF00082 0.405
CLV_PCSK_KEX2_1 333 335 PF00082 0.448
CLV_PCSK_KEX2_1 455 457 PF00082 0.476
CLV_PCSK_KEX2_1 610 612 PF00082 0.582
CLV_PCSK_KEX2_1 613 615 PF00082 0.592
CLV_PCSK_KEX2_1 620 622 PF00082 0.506
CLV_PCSK_KEX2_1 694 696 PF00082 0.511
CLV_PCSK_KEX2_1 727 729 PF00082 0.609
CLV_PCSK_KEX2_1 731 733 PF00082 0.622
CLV_PCSK_KEX2_1 771 773 PF00082 0.624
CLV_PCSK_KEX2_1 79 81 PF00082 0.694
CLV_PCSK_PC1ET2_1 613 615 PF00082 0.584
CLV_PCSK_PC7_1 610 616 PF00082 0.549
CLV_PCSK_PC7_1 727 733 PF00082 0.489
CLV_PCSK_PC7_1 768 774 PF00082 0.492
CLV_PCSK_SKI1_1 155 159 PF00082 0.437
CLV_PCSK_SKI1_1 26 30 PF00082 0.538
CLV_PCSK_SKI1_1 284 288 PF00082 0.368
CLV_PCSK_SKI1_1 325 329 PF00082 0.414
CLV_PCSK_SKI1_1 37 41 PF00082 0.549
CLV_PCSK_SKI1_1 4 8 PF00082 0.611
CLV_PCSK_SKI1_1 418 422 PF00082 0.355
CLV_PCSK_SKI1_1 427 431 PF00082 0.422
CLV_PCSK_SKI1_1 555 559 PF00082 0.440
CLV_PCSK_SKI1_1 732 736 PF00082 0.654
DEG_APCC_DBOX_1 712 720 PF00400 0.559
DEG_SPOP_SBC_1 197 201 PF00917 0.542
DEG_SPOP_SBC_1 652 656 PF00917 0.801
DEG_SPOP_SBC_1 745 749 PF00917 0.566
DOC_CYCLIN_RxL_1 152 161 PF00134 0.487
DOC_CYCLIN_yCln2_LP_2 28 34 PF00134 0.492
DOC_CYCLIN_yCln2_LP_2 489 495 PF00134 0.391
DOC_CYCLIN_yCln2_LP_2 593 599 PF00134 0.630
DOC_MAPK_DCC_7 155 164 PF00069 0.480
DOC_MAPK_DCC_7 284 294 PF00069 0.353
DOC_MAPK_DCC_7 471 479 PF00069 0.378
DOC_MAPK_gen_1 117 128 PF00069 0.406
DOC_MAPK_gen_1 306 312 PF00069 0.362
DOC_MAPK_gen_1 357 365 PF00069 0.341
DOC_MAPK_MEF2A_6 155 164 PF00069 0.480
DOC_MAPK_MEF2A_6 471 479 PF00069 0.378
DOC_PP1_RVXF_1 293 299 PF00149 0.459
DOC_PP1_RVXF_1 553 560 PF00149 0.570
DOC_PP2B_LxvP_1 113 116 PF13499 0.647
DOC_PP2B_LxvP_1 157 160 PF13499 0.329
DOC_PP2B_LxvP_1 365 368 PF13499 0.379
DOC_PP2B_LxvP_1 593 596 PF13499 0.517
DOC_PP2B_LxvP_1 719 722 PF13499 0.544
DOC_PP4_FxxP_1 401 404 PF00568 0.346
DOC_USP7_MATH_1 197 201 PF00917 0.533
DOC_USP7_MATH_1 244 248 PF00917 0.318
DOC_USP7_MATH_1 337 341 PF00917 0.448
DOC_USP7_MATH_1 478 482 PF00917 0.501
DOC_USP7_MATH_1 599 603 PF00917 0.570
DOC_USP7_MATH_1 605 609 PF00917 0.515
DOC_USP7_MATH_1 651 655 PF00917 0.706
DOC_USP7_MATH_1 738 742 PF00917 0.739
DOC_USP7_MATH_1 745 749 PF00917 0.586
DOC_USP7_MATH_1 98 102 PF00917 0.637
DOC_WW_Pin1_4 12 17 PF00397 0.601
DOC_WW_Pin1_4 172 177 PF00397 0.585
DOC_WW_Pin1_4 43 48 PF00397 0.594
DOC_WW_Pin1_4 469 474 PF00397 0.356
DOC_WW_Pin1_4 521 526 PF00397 0.328
DOC_WW_Pin1_4 601 606 PF00397 0.560
DOC_WW_Pin1_4 653 658 PF00397 0.570
DOC_WW_Pin1_4 734 739 PF00397 0.520
DOC_WW_Pin1_4 777 782 PF00397 0.719
LIG_14-3-3_CanoR_1 139 144 PF00244 0.410
LIG_14-3-3_CanoR_1 169 176 PF00244 0.655
LIG_14-3-3_CanoR_1 192 202 PF00244 0.492
LIG_14-3-3_CanoR_1 295 299 PF00244 0.454
LIG_14-3-3_CanoR_1 37 42 PF00244 0.628
LIG_14-3-3_CanoR_1 620 625 PF00244 0.540
LIG_Actin_WH2_2 279 297 PF00022 0.343
LIG_BIR_III_4 106 110 PF00653 0.581
LIG_CNOT1_NIM_1 205 214 PF04054 0.447
LIG_CtBP_PxDLS_1 671 675 PF00389 0.705
LIG_Dynein_DLC8_1 498 504 PF01221 0.513
LIG_eIF4E_1 226 232 PF01652 0.505
LIG_FHA_1 144 150 PF00498 0.372
LIG_FHA_1 20 26 PF00498 0.468
LIG_FHA_1 214 220 PF00498 0.425
LIG_FHA_1 271 277 PF00498 0.321
LIG_FHA_1 291 297 PF00498 0.265
LIG_FHA_1 330 336 PF00498 0.562
LIG_FHA_1 38 44 PF00498 0.443
LIG_FHA_1 441 447 PF00498 0.524
LIG_FHA_1 5 11 PF00498 0.679
LIG_FHA_1 57 63 PF00498 0.530
LIG_FHA_2 213 219 PF00498 0.425
LIG_FHA_2 405 411 PF00498 0.309
LIG_FHA_2 685 691 PF00498 0.530
LIG_FHA_2 792 798 PF00498 0.620
LIG_LIR_Gen_1 203 211 PF02991 0.476
LIG_LIR_Nem_3 151 157 PF02991 0.364
LIG_LIR_Nem_3 203 208 PF02991 0.496
LIG_LIR_Nem_3 210 214 PF02991 0.427
LIG_LIR_Nem_3 461 466 PF02991 0.311
LIG_MYND_1 156 160 PF01753 0.340
LIG_PCNA_yPIPBox_3 222 232 PF02747 0.481
LIG_SH2_CRK 211 215 PF00017 0.394
LIG_SH2_NCK_1 733 737 PF00017 0.552
LIG_SH2_PTP2 476 479 PF00017 0.364
LIG_SH2_SRC 571 574 PF00017 0.490
LIG_SH2_STAP1 205 209 PF00017 0.374
LIG_SH2_STAP1 345 349 PF00017 0.457
LIG_SH2_STAP1 361 365 PF00017 0.332
LIG_SH2_STAT3 345 348 PF00017 0.557
LIG_SH2_STAT3 397 400 PF00017 0.469
LIG_SH2_STAT5 143 146 PF00017 0.320
LIG_SH2_STAT5 239 242 PF00017 0.340
LIG_SH2_STAT5 259 262 PF00017 0.197
LIG_SH2_STAT5 476 479 PF00017 0.364
LIG_SH2_STAT5 546 549 PF00017 0.446
LIG_SH2_STAT5 571 574 PF00017 0.341
LIG_SH3_3 472 478 PF00018 0.381
LIG_SH3_3 51 57 PF00018 0.505
LIG_SH3_3 519 525 PF00018 0.383
LIG_SH3_3 589 595 PF00018 0.436
LIG_SH3_3 778 784 PF00018 0.599
LIG_SUMO_SIM_anti_2 215 221 PF11976 0.426
LIG_SUMO_SIM_anti_2 362 367 PF11976 0.311
LIG_SUMO_SIM_anti_2 380 388 PF11976 0.244
LIG_SUMO_SIM_par_1 155 161 PF11976 0.387
LIG_SUMO_SIM_par_1 215 221 PF11976 0.299
LIG_SUMO_SIM_par_1 278 285 PF11976 0.379
LIG_SUMO_SIM_par_1 308 314 PF11976 0.279
LIG_SUMO_SIM_par_1 530 536 PF11976 0.324
LIG_TRAF2_1 100 103 PF00917 0.546
LIG_TRAF2_1 640 643 PF00917 0.607
LIG_TRAF2_1 675 678 PF00917 0.691
LIG_TRAF2_1 681 684 PF00917 0.666
LIG_TYR_ITIM 209 214 PF00017 0.429
LIG_WRC_WIRS_1 240 245 PF05994 0.351
LIG_WW_1 473 476 PF00397 0.400
LIG_WW_3 1 5 PF00397 0.577
MOD_CDK_SPK_2 12 17 PF00069 0.601
MOD_CDK_SPK_2 172 177 PF00069 0.564
MOD_CDK_SPxK_1 601 607 PF00069 0.552
MOD_CDK_SPxxK_3 521 528 PF00069 0.346
MOD_CK1_1 172 178 PF00069 0.620
MOD_CK1_1 196 202 PF00069 0.543
MOD_CK1_1 258 264 PF00069 0.292
MOD_CK1_1 467 473 PF00069 0.328
MOD_CK1_1 501 507 PF00069 0.693
MOD_CK1_1 521 527 PF00069 0.257
MOD_CK1_1 625 631 PF00069 0.698
MOD_CK1_1 634 640 PF00069 0.599
MOD_CK1_1 655 661 PF00069 0.624
MOD_CK1_1 747 753 PF00069 0.714
MOD_CK2_1 212 218 PF00069 0.416
MOD_CK2_1 310 316 PF00069 0.285
MOD_CK2_1 530 536 PF00069 0.441
MOD_CK2_1 636 642 PF00069 0.577
MOD_CK2_1 684 690 PF00069 0.571
MOD_CK2_1 791 797 PF00069 0.557
MOD_CK2_1 97 103 PF00069 0.625
MOD_Cter_Amidation 608 611 PF01082 0.495
MOD_GlcNHglycan 195 198 PF01048 0.574
MOD_GlcNHglycan 351 354 PF01048 0.419
MOD_GlcNHglycan 432 437 PF01048 0.572
MOD_GlcNHglycan 54 57 PF01048 0.592
MOD_GlcNHglycan 552 555 PF01048 0.454
MOD_GlcNHglycan 568 571 PF01048 0.326
MOD_GlcNHglycan 576 579 PF01048 0.341
MOD_GlcNHglycan 601 604 PF01048 0.685
MOD_GlcNHglycan 607 610 PF01048 0.622
MOD_GlcNHglycan 624 627 PF01048 0.561
MOD_GlcNHglycan 638 641 PF01048 0.525
MOD_GlcNHglycan 741 744 PF01048 0.688
MOD_GlcNHglycan 749 752 PF01048 0.706
MOD_GlcNHglycan 94 97 PF01048 0.774
MOD_GSK3_1 105 112 PF00069 0.637
MOD_GSK3_1 127 134 PF00069 0.379
MOD_GSK3_1 139 146 PF00069 0.320
MOD_GSK3_1 187 194 PF00069 0.589
MOD_GSK3_1 290 297 PF00069 0.490
MOD_GSK3_1 337 344 PF00069 0.561
MOD_GSK3_1 428 435 PF00069 0.542
MOD_GSK3_1 494 501 PF00069 0.547
MOD_GSK3_1 52 59 PF00069 0.514
MOD_GSK3_1 601 608 PF00069 0.756
MOD_GSK3_1 622 629 PF00069 0.664
MOD_GSK3_1 651 658 PF00069 0.802
MOD_GSK3_1 734 741 PF00069 0.652
MOD_N-GLC_2 88 90 PF02516 0.552
MOD_NEK2_1 193 198 PF00069 0.542
MOD_NEK2_1 384 389 PF00069 0.505
MOD_NEK2_1 62 67 PF00069 0.722
MOD_NEK2_2 127 132 PF00069 0.398
MOD_NEK2_2 6 11 PF00069 0.716
MOD_PIKK_1 337 343 PF00454 0.447
MOD_PIKK_1 385 391 PF00454 0.393
MOD_PIKK_1 499 505 PF00454 0.644
MOD_PKA_1 620 626 PF00069 0.574
MOD_PKA_2 131 137 PF00069 0.354
MOD_PKA_2 191 197 PF00069 0.783
MOD_PKA_2 294 300 PF00069 0.511
MOD_PKA_2 499 505 PF00069 0.676
MOD_PKA_2 620 626 PF00069 0.605
MOD_PKB_1 618 626 PF00069 0.596
MOD_Plk_1 255 261 PF00069 0.294
MOD_Plk_1 361 367 PF00069 0.329
MOD_Plk_1 634 640 PF00069 0.530
MOD_Plk_1 706 712 PF00069 0.543
MOD_Plk_2-3 792 798 PF00069 0.547
MOD_Plk_4 139 145 PF00069 0.351
MOD_Plk_4 244 250 PF00069 0.282
MOD_Plk_4 255 261 PF00069 0.294
MOD_Plk_4 317 323 PF00069 0.372
MOD_Plk_4 361 367 PF00069 0.333
MOD_Plk_4 464 470 PF00069 0.383
MOD_Plk_4 530 536 PF00069 0.441
MOD_Plk_4 715 721 PF00069 0.525
MOD_ProDKin_1 12 18 PF00069 0.595
MOD_ProDKin_1 172 178 PF00069 0.588
MOD_ProDKin_1 43 49 PF00069 0.597
MOD_ProDKin_1 469 475 PF00069 0.365
MOD_ProDKin_1 521 527 PF00069 0.324
MOD_ProDKin_1 601 607 PF00069 0.559
MOD_ProDKin_1 653 659 PF00069 0.570
MOD_ProDKin_1 734 740 PF00069 0.525
MOD_ProDKin_1 777 783 PF00069 0.722
MOD_SUMO_rev_2 792 800 PF00179 0.592
TRG_DiLeu_BaEn_1 23 28 PF01217 0.579
TRG_DiLeu_BaLyEn_6 153 158 PF01217 0.351
TRG_DiLeu_BaLyEn_6 368 373 PF01217 0.466
TRG_DiLeu_BaLyEn_6 39 44 PF01217 0.540
TRG_DiLeu_BaLyEn_6 57 62 PF01217 0.534
TRG_ENDOCYTIC_2 205 208 PF00928 0.500
TRG_ENDOCYTIC_2 211 214 PF00928 0.394
TRG_ENDOCYTIC_2 476 479 PF00928 0.364
TRG_ER_diArg_1 10 13 PF00400 0.678
TRG_ER_diArg_1 116 118 PF00400 0.489
TRG_ER_diArg_1 131 133 PF00400 0.328
TRG_ER_diArg_1 305 307 PF00400 0.380
TRG_ER_diArg_1 331 334 PF00400 0.449
TRG_ER_diArg_1 357 360 PF00400 0.375
TRG_ER_diArg_1 454 456 PF00400 0.496
TRG_ER_diArg_1 610 612 PF00400 0.559
TRG_ER_diArg_1 618 621 PF00400 0.492
TRG_ER_diArg_1 727 729 PF00400 0.609
TRG_ER_diArg_1 730 732 PF00400 0.611
TRG_ER_diArg_1 765 768 PF00400 0.568
TRG_ER_diArg_1 770 773 PF00400 0.603
TRG_ER_diArg_1 79 81 PF00400 0.676
TRG_NLS_MonoCore_2 611 616 PF00514 0.546
TRG_NLS_MonoExtN_4 610 617 PF00514 0.630
TRG_Pf-PMV_PEXEL_1 229 233 PF00026 0.409
TRG_Pf-PMV_PEXEL_1 252 256 PF00026 0.332
TRG_Pf-PMV_PEXEL_1 60 64 PF00026 0.749

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HU74 Leptomonas seymouri 64% 100%
A0A1X0NU60 Trypanosomatidae 46% 100%
A0A3S7WTA7 Leishmania donovani 100% 100%
A0A422N3L6 Trypanosoma rangeli 51% 100%
A4H803 Leishmania braziliensis 80% 99%
C9ZNX5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AQ31 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QFF1 Leishmania major 95% 100%
V5BL46 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS