Putative ribonucleoprotein p18, mitochondrial

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribonucleoprotein p18 - mitochondrial precursor - putative

Species:

Leishmania infantum

UniProt:

A4HWC9_LEIIN

TriTrypDb:

LINF_150008100

Length:

187

Annotations

Annotations by Jardim et al.

Nucleic acid binding, ribonucleo p18, mitochondrial

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	13
GO:1990904	ribonucleoprotein complex	2	13

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HWC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.544
CLV_PCSK_KEX2_1	147	149	PF00082	0.536
CLV_PCSK_KEX2_1	2	4	PF00082	0.544
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.536
DEG_Nend_UBRbox_1	1	4	PF02207	0.557
DOC_USP7_MATH_1	159	163	PF00917	0.501
DOC_USP7_MATH_2	89	95	PF00917	0.432
DOC_USP7_UBL2_3	165	169	PF12436	0.527
LIG_14-3-3_CanoR_1	2	9	PF00244	0.557
LIG_BRCT_BRCA1_1	128	132	PF00533	0.366
LIG_deltaCOP1_diTrp_1	116	121	PF00928	0.384
LIG_EH1_1	135	143	PF00400	0.488
LIG_eIF4E_1	136	142	PF01652	0.488
LIG_FHA_1	118	124	PF00498	0.410
LIG_LIR_Gen_1	116	127	PF02991	0.355
LIG_LIR_Gen_1	93	103	PF02991	0.371
LIG_LIR_Nem_3	116	122	PF02991	0.367
LIG_LIR_Nem_3	143	149	PF02991	0.524
LIG_SH2_NCK_1	50	54	PF00017	0.350
LIG_SH2_NCK_1	80	84	PF00017	0.455
LIG_SH2_SRC	50	53	PF00017	0.345
LIG_SH2_STAT5	136	139	PF00017	0.357
LIG_TRAF2_1	114	117	PF00917	0.422
LIG_UBA3_1	102	111	PF00899	0.435
LIG_UBA3_1	181	185	PF00899	0.562
MOD_GlcNHglycan	128	131	PF01048	0.388
MOD_GlcNHglycan	18	21	PF01048	0.530
MOD_GSK3_1	68	75	PF00069	0.431
MOD_N-GLC_1	159	164	PF02516	0.497
MOD_N-GLC_1	72	77	PF02516	0.426
MOD_N-GLC_1	91	96	PF02516	0.414
MOD_NEK2_1	8	13	PF00069	0.589
MOD_PIKK_1	3	9	PF00454	0.542
MOD_PKA_1	2	8	PF00069	0.542
MOD_PKA_2	2	8	PF00069	0.542
MOD_Plk_1	115	121	PF00069	0.402
MOD_Plk_1	72	78	PF00069	0.423
MOD_Plk_4	177	183	PF00069	0.614
MOD_SUMO_rev_2	143	149	PF00179	0.421
MOD_SUMO_rev_2	180	186	PF00179	0.633
MOD_SUMO_rev_2	87	96	PF00179	0.444
TRG_ENDOCYTIC_2	26	29	PF00928	0.422
TRG_ER_diArg_1	1	3	PF00400	0.544
TRG_NLS_MonoExtN_4	43	49	PF00514	0.339
TRG_Pf-PMV_PEXEL_1	2	7	PF00026	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K0	Leptomonas seymouri	86%	100%
A0A0S4JL15	Bodo saltans	69%	100%
A0A1X0NTQ1	Trypanosomatidae	77%	99%
A0A3R7KKM2	Trypanosoma rangeli	75%	98%
A0A3R7LMR0	Trypanosoma rangeli	56%	76%
A0A3S7WTC4	Leishmania donovani	100%	100%
A0A422NS95	Trypanosoma rangeli	78%	100%
A4H801	Leishmania braziliensis	89%	100%
A4HWD0	Leishmania infantum	99%	100%
C9ZNX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	99%
E9AQ29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P0DPG4	Trypanosoma brucei brucei	73%	99%
Q25423	Leishmania tarentolae	94%	100%
Q4QFF2	Leishmania major	99%	100%