LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HWC7_LEIIN
TriTrypDb:
LINF_150007900
Length:
477

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005929 cilium 4 1
GO:0005930 axoneme 2 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

A4HWC7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWC7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 212 216 PF00656 0.491
CLV_C14_Caspase3-7 436 440 PF00656 0.643
CLV_C14_Caspase3-7 84 88 PF00656 0.481
CLV_NRD_NRD_1 115 117 PF00675 0.602
CLV_NRD_NRD_1 153 155 PF00675 0.517
CLV_NRD_NRD_1 201 203 PF00675 0.700
CLV_NRD_NRD_1 268 270 PF00675 0.575
CLV_PCSK_FUR_1 113 117 PF00082 0.486
CLV_PCSK_KEX2_1 115 117 PF00082 0.456
CLV_PCSK_KEX2_1 151 153 PF00082 0.531
CLV_PCSK_KEX2_1 268 270 PF00082 0.575
CLV_PCSK_PC1ET2_1 151 153 PF00082 0.540
CLV_PCSK_PC7_1 147 153 PF00082 0.599
CLV_PCSK_SKI1_1 205 209 PF00082 0.504
CLV_PCSK_SKI1_1 222 226 PF00082 0.424
CLV_PCSK_SKI1_1 268 272 PF00082 0.540
CLV_PCSK_SKI1_1 309 313 PF00082 0.612
CLV_PCSK_SKI1_1 31 35 PF00082 0.539
CLV_PCSK_SKI1_1 332 336 PF00082 0.475
CLV_PCSK_SKI1_1 340 344 PF00082 0.361
CLV_PCSK_SKI1_1 371 375 PF00082 0.440
DEG_Nend_UBRbox_2 1 3 PF02207 0.545
DEG_SPOP_SBC_1 405 409 PF00917 0.514
DOC_USP7_MATH_1 352 356 PF00917 0.548
DOC_USP7_MATH_1 405 409 PF00917 0.621
DOC_USP7_MATH_1 434 438 PF00917 0.712
DOC_WW_Pin1_4 280 285 PF00397 0.654
DOC_WW_Pin1_4 350 355 PF00397 0.547
DOC_WW_Pin1_4 406 411 PF00397 0.751
LIG_14-3-3_CanoR_1 103 111 PF00244 0.586
LIG_14-3-3_CanoR_1 116 122 PF00244 0.393
LIG_14-3-3_CanoR_1 123 129 PF00244 0.398
LIG_14-3-3_CanoR_1 268 278 PF00244 0.570
LIG_14-3-3_CanoR_1 362 366 PF00244 0.545
LIG_14-3-3_CanoR_1 59 69 PF00244 0.647
LIG_Actin_WH2_2 175 193 PF00022 0.536
LIG_BIR_III_2 429 433 PF00653 0.648
LIG_BRCT_BRCA1_1 63 67 PF00533 0.648
LIG_FHA_1 463 469 PF00498 0.507
LIG_FHA_2 1 7 PF00498 0.549
LIG_FHA_2 207 213 PF00498 0.442
LIG_FHA_2 269 275 PF00498 0.601
LIG_LIR_Gen_1 232 240 PF02991 0.431
LIG_LIR_LC3C_4 420 424 PF02991 0.655
LIG_LIR_Nem_3 2 7 PF02991 0.558
LIG_LIR_Nem_3 232 236 PF02991 0.468
LIG_LIR_Nem_3 28 33 PF02991 0.501
LIG_Pex14_1 117 121 PF04695 0.411
LIG_Pex14_2 236 240 PF04695 0.545
LIG_SH2_CRK 30 34 PF00017 0.542
LIG_SH2_CRK 472 476 PF00017 0.448
LIG_SH2_STAP1 21 25 PF00017 0.566
LIG_SH2_STAP1 233 237 PF00017 0.411
LIG_SH2_STAT5 21 24 PF00017 0.609
LIG_SH2_STAT5 470 473 PF00017 0.476
LIG_SH3_2 66 71 PF14604 0.495
LIG_SH3_3 193 199 PF00018 0.627
LIG_SH3_3 278 284 PF00018 0.609
LIG_SH3_3 410 416 PF00018 0.743
LIG_SH3_3 6 12 PF00018 0.645
LIG_SH3_3 63 69 PF00018 0.573
LIG_TRAF2_1 209 212 PF00917 0.589
LIG_TRAF2_1 90 93 PF00917 0.511
LIG_UBA3_1 454 462 PF00899 0.507
LIG_ULM_U2AF65_1 202 207 PF00076 0.534
LIG_WRC_WIRS_1 118 123 PF05994 0.432
MOD_CK1_1 19 25 PF00069 0.621
MOD_CK1_1 280 286 PF00069 0.610
MOD_CK1_1 325 331 PF00069 0.573
MOD_CK1_1 390 396 PF00069 0.589
MOD_CK1_1 70 76 PF00069 0.556
MOD_CK1_1 82 88 PF00069 0.554
MOD_CK2_1 124 130 PF00069 0.505
MOD_CK2_1 206 212 PF00069 0.455
MOD_CK2_1 235 241 PF00069 0.458
MOD_CK2_1 280 286 PF00069 0.604
MOD_GlcNHglycan 171 174 PF01048 0.561
MOD_GlcNHglycan 18 21 PF01048 0.602
MOD_GlcNHglycan 327 330 PF01048 0.505
MOD_GlcNHglycan 392 395 PF01048 0.699
MOD_GlcNHglycan 43 46 PF01048 0.659
MOD_GlcNHglycan 436 439 PF01048 0.632
MOD_GlcNHglycan 444 447 PF01048 0.617
MOD_GlcNHglycan 63 66 PF01048 0.533
MOD_GSK3_1 105 112 PF00069 0.521
MOD_GSK3_1 124 131 PF00069 0.560
MOD_GSK3_1 16 23 PF00069 0.674
MOD_GSK3_1 165 172 PF00069 0.629
MOD_GSK3_1 186 193 PF00069 0.602
MOD_GSK3_1 37 44 PF00069 0.641
MOD_GSK3_1 400 407 PF00069 0.640
MOD_GSK3_1 458 465 PF00069 0.496
MOD_N-GLC_1 169 174 PF02516 0.654
MOD_N-GLC_1 260 265 PF02516 0.474
MOD_N-GLC_1 60 65 PF02516 0.707
MOD_NEK2_1 190 195 PF00069 0.744
MOD_PIKK_1 105 111 PF00454 0.600
MOD_PIKK_1 14 20 PF00454 0.608
MOD_PIKK_1 462 468 PF00454 0.522
MOD_PKA_1 268 274 PF00069 0.509
MOD_PKA_2 102 108 PF00069 0.610
MOD_PKA_2 268 274 PF00069 0.580
MOD_PKA_2 361 367 PF00069 0.558
MOD_PKA_2 37 43 PF00069 0.649
MOD_Plk_1 260 266 PF00069 0.533
MOD_Plk_1 381 387 PF00069 0.596
MOD_Plk_4 277 283 PF00069 0.655
MOD_Plk_4 381 387 PF00069 0.594
MOD_ProDKin_1 280 286 PF00069 0.653
MOD_ProDKin_1 350 356 PF00069 0.546
MOD_ProDKin_1 406 412 PF00069 0.751
TRG_DiLeu_BaLyEn_6 329 334 PF01217 0.575
TRG_ENDOCYTIC_2 233 236 PF00928 0.415
TRG_ENDOCYTIC_2 30 33 PF00928 0.541
TRG_ENDOCYTIC_2 4 7 PF00928 0.536
TRG_ER_diArg_1 113 116 PF00400 0.545
TRG_ER_diArg_1 152 154 PF00400 0.575
TRG_ER_diArg_1 267 269 PF00400 0.581
TRG_ER_diArg_1 330 333 PF00400 0.510
TRG_NLS_MonoCore_2 201 206 PF00514 0.535
TRG_NLS_MonoExtN_4 199 206 PF00514 0.514
TRG_Pf-PMV_PEXEL_1 133 138 PF00026 0.593
TRG_Pf-PMV_PEXEL_1 222 226 PF00026 0.541
TRG_Pf-PMV_PEXEL_1 453 457 PF00026 0.516

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P362 Leptomonas seymouri 65% 100%
A0A0S4JPG7 Bodo saltans 36% 98%
A0A1X0NUB6 Trypanosomatidae 41% 100%
A0A3R7NLS4 Trypanosoma rangeli 41% 100%
A0A3S7WTC2 Leishmania donovani 100% 100%
A4H7Z9 Leishmania braziliensis 80% 100%
C9ZNW9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9AQ27 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QFF4 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS