LeishMANIAdb
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Putative nonspecific lipid-transfer protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative nonspecific lipid-transfer protein
Gene product:
sterol carrier protein - putative
Species:
Leishmania infantum
UniProt:
A4HWC5_LEIIN
TriTrypDb:
LINF_150007700
Length:
405

Annotations

Annotations by Jardim et al.

Transferases, nonspecific lipid-transfer

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HWC5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWC5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0016740 transferase activity 2 11
GO:0016746 acyltransferase activity 3 11
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 100 102 PF00675 0.479
CLV_NRD_NRD_1 183 185 PF00675 0.488
CLV_NRD_NRD_1 209 211 PF00675 0.401
CLV_NRD_NRD_1 237 239 PF00675 0.516
CLV_NRD_NRD_1 323 325 PF00675 0.497
CLV_NRD_NRD_1 381 383 PF00675 0.540
CLV_PCSK_KEX2_1 100 102 PF00082 0.479
CLV_PCSK_KEX2_1 126 128 PF00082 0.505
CLV_PCSK_KEX2_1 155 157 PF00082 0.439
CLV_PCSK_KEX2_1 160 162 PF00082 0.369
CLV_PCSK_KEX2_1 18 20 PF00082 0.504
CLV_PCSK_KEX2_1 185 187 PF00082 0.499
CLV_PCSK_KEX2_1 209 211 PF00082 0.386
CLV_PCSK_KEX2_1 237 239 PF00082 0.527
CLV_PCSK_KEX2_1 323 325 PF00082 0.497
CLV_PCSK_KEX2_1 381 383 PF00082 0.395
CLV_PCSK_PC1ET2_1 126 128 PF00082 0.532
CLV_PCSK_PC1ET2_1 155 157 PF00082 0.439
CLV_PCSK_PC1ET2_1 160 162 PF00082 0.369
CLV_PCSK_PC1ET2_1 18 20 PF00082 0.500
CLV_PCSK_PC1ET2_1 185 187 PF00082 0.502
CLV_PCSK_PC7_1 156 162 PF00082 0.424
CLV_PCSK_SKI1_1 26 30 PF00082 0.309
CLV_PCSK_SKI1_1 381 385 PF00082 0.441
DEG_APCC_DBOX_1 160 168 PF00400 0.355
DEG_APCC_DBOX_1 185 193 PF00400 0.506
DEG_APCC_DBOX_1 2 10 PF00400 0.453
DEG_Nend_UBRbox_3 1 3 PF02207 0.534
DEG_SCF_FBW7_1 46 53 PF00400 0.446
DOC_CDC14_PxL_1 164 172 PF14671 0.345
DOC_CKS1_1 47 52 PF01111 0.442
DOC_CYCLIN_yCln2_LP_2 137 143 PF00134 0.322
DOC_CYCLIN_yCln2_LP_2 251 257 PF00134 0.495
DOC_MAPK_gen_1 100 111 PF00069 0.464
DOC_MAPK_gen_1 18 24 PF00069 0.428
DOC_MAPK_gen_1 209 217 PF00069 0.342
DOC_MAPK_gen_1 237 244 PF00069 0.503
DOC_MAPK_JIP1_4 238 244 PF00069 0.476
DOC_MAPK_MEF2A_6 100 109 PF00069 0.514
DOC_MAPK_MEF2A_6 210 219 PF00069 0.335
DOC_MAPK_MEF2A_6 26 33 PF00069 0.423
DOC_MAPK_NFAT4_5 26 34 PF00069 0.429
DOC_PP2B_LxvP_1 251 254 PF13499 0.419
DOC_PP4_FxxP_1 348 351 PF00568 0.334
DOC_USP7_MATH_1 125 129 PF00917 0.438
DOC_USP7_MATH_1 48 52 PF00917 0.314
DOC_USP7_MATH_1 88 92 PF00917 0.444
DOC_WW_Pin1_4 131 136 PF00397 0.508
DOC_WW_Pin1_4 376 381 PF00397 0.500
DOC_WW_Pin1_4 46 51 PF00397 0.360
DOC_WW_Pin1_4 84 89 PF00397 0.451
LIG_14-3-3_CanoR_1 184 190 PF00244 0.451
LIG_BRCT_BRCA1_1 120 124 PF00533 0.448
LIG_BRCT_BRCA1_1 261 265 PF00533 0.347
LIG_BRCT_BRCA1_1 53 57 PF00533 0.388
LIG_BRCT_BRCA1_2 120 126 PF00533 0.543
LIG_FHA_1 276 282 PF00498 0.479
LIG_FHA_1 47 53 PF00498 0.447
LIG_FHA_2 254 260 PF00498 0.571
LIG_LIR_Nem_3 285 291 PF02991 0.336
LIG_Pex14_2 148 152 PF04695 0.451
LIG_Pex14_2 348 352 PF04695 0.338
LIG_REV1ctd_RIR_1 96 102 PF16727 0.396
LIG_SH2_NCK_1 358 362 PF00017 0.456
LIG_SH2_SRC 141 144 PF00017 0.291
LIG_SH2_STAP1 146 150 PF00017 0.330
LIG_SH2_STAT5 141 144 PF00017 0.458
LIG_SH2_STAT5 240 243 PF00017 0.462
LIG_SH2_STAT5 62 65 PF00017 0.405
LIG_SH3_3 129 135 PF00018 0.452
LIG_SH3_3 137 143 PF00018 0.332
LIG_SH3_3 173 179 PF00018 0.434
LIG_SH3_3 247 253 PF00018 0.435
LIG_SUMO_SIM_anti_2 395 403 PF11976 0.351
LIG_TRAF2_1 188 191 PF00917 0.507
LIG_TRAF2_1 220 223 PF00917 0.394
LIG_TRAF2_1 256 259 PF00917 0.581
MOD_CDK_SPK_2 376 381 PF00069 0.532
MOD_CDK_SPxK_1 376 382 PF00069 0.528
MOD_CK1_1 128 134 PF00069 0.432
MOD_CK1_1 172 178 PF00069 0.468
MOD_CK1_1 51 57 PF00069 0.376
MOD_CK1_1 87 93 PF00069 0.439
MOD_CK2_1 185 191 PF00069 0.445
MOD_CK2_1 253 259 PF00069 0.522
MOD_Cter_Amidation 235 238 PF01082 0.534
MOD_GlcNHglycan 171 174 PF01048 0.459
MOD_GlcNHglycan 246 250 PF01048 0.430
MOD_GlcNHglycan 392 395 PF01048 0.337
MOD_GlcNHglycan 53 56 PF01048 0.433
MOD_GSK3_1 115 122 PF00069 0.460
MOD_GSK3_1 259 266 PF00069 0.550
MOD_GSK3_1 275 282 PF00069 0.332
MOD_GSK3_1 46 53 PF00069 0.439
MOD_GSK3_1 80 87 PF00069 0.424
MOD_N-GLC_1 128 133 PF02516 0.460
MOD_NEK2_1 392 397 PF00069 0.331
MOD_NEK2_1 67 72 PF00069 0.491
MOD_PKA_1 185 191 PF00069 0.514
MOD_PKA_2 185 191 PF00069 0.514
MOD_Plk_1 128 134 PF00069 0.432
MOD_ProDKin_1 131 137 PF00069 0.503
MOD_ProDKin_1 376 382 PF00069 0.496
MOD_ProDKin_1 46 52 PF00069 0.362
MOD_ProDKin_1 84 90 PF00069 0.451
MOD_SUMO_for_1 159 162 PF00179 0.393
TRG_ENDOCYTIC_2 292 295 PF00928 0.322
TRG_ER_diArg_1 184 187 PF00400 0.482
TRG_ER_diArg_1 237 239 PF00400 0.520
TRG_ER_diArg_1 3 6 PF00400 0.436
TRG_ER_diArg_1 322 324 PF00400 0.525
TRG_ER_diArg_1 380 382 PF00400 0.543
TRG_ER_diArg_1 99 101 PF00400 0.416

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUB7 Leptomonas seymouri 79% 100%
A0A0S4JDZ8 Bodo saltans 61% 100%
A0A3S5H6U0 Leishmania donovani 100% 100%
A0A422NT95 Trypanosoma rangeli 59% 100%
A4H7Z7 Leishmania braziliensis 93% 100%
C9ZUV7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 99%
E9AQ25 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O26884 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 26% 100%
O62742 Oryctolagus cuniculus 31% 74%
P07857 Bos taurus 28% 75%
P11915 Rattus norvegicus 29% 74%
P22307 Homo sapiens 28% 74%
P32020 Mus musculus 27% 74%
Q07598 Gallus gallus 25% 74%
Q4QFF6 Leishmania major 96% 100%
Q58944 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 24% 100%
V5BHW0 Trypanosoma cruzi 62% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS