NPL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWC2_LEIIN

TriTrypDb:

LINF_150007400

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.757
CLV_NRD_NRD_1	77	79	PF00675	0.448
CLV_NRD_NRD_1	9	11	PF00675	0.665
CLV_PCSK_KEX2_1	181	183	PF00082	0.747
CLV_PCSK_KEX2_1	77	79	PF00082	0.364
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.747
CLV_PCSK_SKI1_1	114	118	PF00082	0.462
CLV_PCSK_SKI1_1	122	126	PF00082	0.463
CLV_PCSK_SKI1_1	41	45	PF00082	0.521
DEG_APCC_DBOX_1	9	17	PF00400	0.582
DEG_Nend_Nbox_1	1	3	PF02207	0.685
DEG_SCF_FBW7_1	153	159	PF00400	0.617
DOC_CKS1_1	153	158	PF01111	0.618
DOC_CYCLIN_RxL_1	119	130	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.552
DOC_MAPK_DCC_7	91	101	PF00069	0.594
DOC_MAPK_MEF2A_6	91	99	PF00069	0.554
DOC_PP1_RVXF_1	120	127	PF00149	0.441
DOC_PP2B_LxvP_1	49	52	PF13499	0.529
DOC_PP4_FxxP_1	107	110	PF00568	0.601
DOC_USP7_MATH_1	132	136	PF00917	0.483
DOC_USP7_MATH_1	167	171	PF00917	0.601
DOC_USP7_MATH_1	174	178	PF00917	0.529
DOC_USP7_MATH_1	206	210	PF00917	0.545
DOC_USP7_MATH_1	43	47	PF00917	0.455
DOC_USP7_MATH_1	72	76	PF00917	0.624
DOC_WD40_RPTOR_TOS_1	30	35	PF00400	0.497
DOC_WW_Pin1_4	152	157	PF00397	0.613
DOC_WW_Pin1_4	161	166	PF00397	0.590
LIG_14-3-3_CanoR_1	10	14	PF00244	0.658
LIG_14-3-3_CanoR_1	182	187	PF00244	0.763
LIG_Actin_WH2_2	25	43	PF00022	0.593
LIG_Actin_WH2_2	64	79	PF00022	0.527
LIG_BRCT_BRCA1_1	63	67	PF00533	0.498
LIG_LIR_Apic_2	104	110	PF02991	0.609
LIG_LIR_Apic_2	148	153	PF02991	0.624
LIG_LIR_Gen_1	12	20	PF02991	0.645
LIG_LIR_Gen_1	202	212	PF02991	0.540
LIG_LIR_Nem_3	12	17	PF02991	0.609
LIG_LIR_Nem_3	166	171	PF02991	0.611
LIG_LIR_Nem_3	202	208	PF02991	0.650
LIG_SH2_CRK	205	209	PF00017	0.606
LIG_SH2_NCK_1	205	209	PF00017	0.698
LIG_SH2_STAT5	150	153	PF00017	0.573
LIG_SH3_1	150	156	PF00018	0.604
LIG_SH3_3	150	156	PF00018	0.625
LIG_SH3_3	168	174	PF00018	0.351
LIG_SH3_3	49	55	PF00018	0.552
LIG_SH3_3	90	96	PF00018	0.521
LIG_SUMO_SIM_par_1	97	104	PF11976	0.547
LIG_TYR_ITIM	203	208	PF00017	0.594
MOD_CK1_1	12	18	PF00069	0.632
MOD_CK1_1	159	165	PF00069	0.577
MOD_CK2_1	12	18	PF00069	0.583
MOD_CK2_1	167	173	PF00069	0.631
MOD_GlcNHglycan	134	137	PF01048	0.472
MOD_GlcNHglycan	139	142	PF01048	0.352
MOD_GlcNHglycan	145	148	PF01048	0.460
MOD_GlcNHglycan	176	179	PF01048	0.735
MOD_GlcNHglycan	208	211	PF01048	0.635
MOD_GSK3_1	101	108	PF00069	0.566
MOD_GSK3_1	152	159	PF00069	0.618
MOD_GSK3_1	176	183	PF00069	0.745
MOD_GSK3_1	56	63	PF00069	0.541
MOD_GSK3_1	67	74	PF00069	0.440
MOD_N-GLC_1	191	196	PF02516	0.713
MOD_NEK2_1	67	72	PF00069	0.474
MOD_NEK2_1	9	14	PF00069	0.521
MOD_NEK2_2	167	172	PF00069	0.550
MOD_NEK2_2	72	77	PF00069	0.497
MOD_PIKK_1	182	188	PF00454	0.733
MOD_PKA_1	180	186	PF00069	0.696
MOD_PKA_2	127	133	PF00069	0.490
MOD_PKA_2	9	15	PF00069	0.585
MOD_PKB_1	180	188	PF00069	0.735
MOD_Plk_1	191	197	PF00069	0.705
MOD_Plk_1	60	66	PF00069	0.493
MOD_Plk_4	156	162	PF00069	0.613
MOD_Plk_4	191	197	PF00069	0.712
MOD_Plk_4	199	205	PF00069	0.593
MOD_Plk_4	61	67	PF00069	0.483
MOD_Plk_4	9	15	PF00069	0.559
MOD_ProDKin_1	152	158	PF00069	0.613
MOD_ProDKin_1	161	167	PF00069	0.581
MOD_SUMO_rev_2	87	93	PF00179	0.592
TRG_DiLeu_BaEn_1	199	204	PF01217	0.562
TRG_DiLeu_BaEn_4	18	24	PF01217	0.639
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.481
TRG_ENDOCYTIC_2	14	17	PF00928	0.667
TRG_ENDOCYTIC_2	205	208	PF00928	0.588
TRG_ER_diArg_1	120	123	PF00400	0.415
TRG_ER_diArg_1	76	78	PF00400	0.394
TRG_NLS_MonoExtC_3	179	184	PF00514	0.702
TRG_NLS_MonoExtN_4	180	185	PF00514	0.743
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF0	Leptomonas seymouri	47%	100%
A0A1X0NTQ5	Trypanosomatidae	25%	83%
A0A3Q8IA55	Leishmania donovani	100%	100%
A4H7Z4	Leishmania braziliensis	70%	100%
C9ZNV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	85%
E9AQ22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QFF9	Leishmania major	93%	100%
V5DCR1	Trypanosoma cruzi	28%	82%