Serine/threonine-protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 1 catalitic subunit - putative

Species:

Leishmania infantum

UniProt:

A4HWC1_LEIIN

TriTrypDb:

LINF_150007300

Length:

374

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HWC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWC1

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004721	phosphoprotein phosphatase activity	3	11
GO:0004722	protein serine/threonine phosphatase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0017018	myosin phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.341
CLV_NRD_NRD_1	190	192	PF00675	0.246
CLV_NRD_NRD_1	271	273	PF00675	0.264
CLV_PCSK_KEX2_1	103	105	PF00082	0.261
CLV_PCSK_KEX2_1	189	191	PF00082	0.246
CLV_PCSK_KEX2_1	271	273	PF00082	0.264
CLV_PCSK_KEX2_1	313	315	PF00082	0.355
CLV_PCSK_KEX2_1	5	7	PF00082	0.532
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.389
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.246

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S7	Leptomonas seymouri	44%	100%
A0A0N0P7Y2	Leptomonas seymouri	35%	68%
A0A0N1HSR2	Leptomonas seymouri	85%	100%
A0A0N1I0V3	Leptomonas seymouri	43%	95%
A0A0N1IBK9	Leptomonas seymouri	39%	100%
A0A0N1ILH2	Leptomonas seymouri	29%	88%
A0A0N1P9X9	Leptomonas seymouri	37%	100%
A0A0N1PAV9	Leptomonas seymouri	45%	100%
A0A0N1PBN9	Leptomonas seymouri	36%	80%
A0A0N1PCC5	Leptomonas seymouri	38%	100%

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