DUF667 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWC0_LEIIN

TriTrypDb:

LINF_150007200

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWC0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.462
CLV_C14_Caspase3-7	316	320	PF00656	0.617
CLV_NRD_NRD_1	381	383	PF00675	0.577
CLV_NRD_NRD_1	405	407	PF00675	0.509
CLV_NRD_NRD_1	430	432	PF00675	0.486
CLV_NRD_NRD_1	437	439	PF00675	0.469
CLV_PCSK_FUR_1	434	438	PF00082	0.469
CLV_PCSK_KEX2_1	378	380	PF00082	0.579
CLV_PCSK_KEX2_1	430	432	PF00082	0.486
CLV_PCSK_KEX2_1	436	438	PF00082	0.468
CLV_PCSK_KEX2_1	94	96	PF00082	0.236
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.578
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.250
CLV_PCSK_SKI1_1	256	260	PF00082	0.556
CLV_PCSK_SKI1_1	37	41	PF00082	0.256
CLV_PCSK_SKI1_1	370	374	PF00082	0.489
DEG_SCF_FBW7_1	42	49	PF00400	0.462
DEG_SPOP_SBC_1	167	171	PF00917	0.462
DOC_MAPK_gen_1	127	135	PF00069	0.456
DOC_MAPK_gen_1	430	441	PF00069	0.470
DOC_MAPK_gen_1	55	65	PF00069	0.443
DOC_MAPK_gen_1	94	100	PF00069	0.436
DOC_MAPK_MEF2A_6	127	135	PF00069	0.456
DOC_MAPK_MEF2A_6	33	42	PF00069	0.531
DOC_PP2B_LxvP_1	123	126	PF13499	0.456
DOC_PP4_FxxP_1	145	148	PF00568	0.456
DOC_PP4_FxxP_1	187	190	PF00568	0.361
DOC_USP7_MATH_1	220	224	PF00917	0.485
DOC_USP7_MATH_1	268	272	PF00917	0.637
DOC_USP7_MATH_1	331	335	PF00917	0.622
DOC_USP7_MATH_1	341	345	PF00917	0.543
DOC_USP7_MATH_1	391	395	PF00917	0.574
DOC_USP7_MATH_1	59	63	PF00917	0.510
DOC_USP7_UBL2_3	33	37	PF12436	0.510
DOC_WW_Pin1_4	177	182	PF00397	0.375
DOC_WW_Pin1_4	200	205	PF00397	0.528
DOC_WW_Pin1_4	234	239	PF00397	0.577
DOC_WW_Pin1_4	240	245	PF00397	0.616
DOC_WW_Pin1_4	364	369	PF00397	0.491
DOC_WW_Pin1_4	42	47	PF00397	0.462
LIG_14-3-3_CanoR_1	322	330	PF00244	0.535
LIG_14-3-3_CanoR_1	58	64	PF00244	0.443
LIG_BIR_II_1	1	5	PF00653	0.529
LIG_BRCT_BRCA1_1	164	168	PF00533	0.486
LIG_Clathr_ClatBox_1	210	214	PF01394	0.556
LIG_Clathr_ClatBox_1	371	375	PF01394	0.486
LIG_EH1_1	134	142	PF00400	0.443
LIG_FHA_1	116	122	PF00498	0.456
LIG_FHA_1	159	165	PF00498	0.441
LIG_FHA_1	220	226	PF00498	0.553
LIG_FHA_1	245	251	PF00498	0.571
LIG_FHA_1	360	366	PF00498	0.528
LIG_FHA_1	94	100	PF00498	0.465
LIG_FHA_2	110	116	PF00498	0.486
LIG_FHA_2	149	155	PF00498	0.566
LIG_FHA_2	167	173	PF00498	0.400
LIG_LIR_Apic_2	143	148	PF02991	0.456
LIG_LIR_Apic_2	286	290	PF02991	0.493
LIG_LIR_Gen_1	294	299	PF02991	0.543
LIG_LIR_Gen_1	350	360	PF02991	0.567
LIG_LIR_LC3C_4	362	365	PF02991	0.564
LIG_LIR_Nem_3	117	123	PF02991	0.486
LIG_LIR_Nem_3	266	270	PF02991	0.565
LIG_LIR_Nem_3	294	298	PF02991	0.545
LIG_LIR_Nem_3	350	355	PF02991	0.572
LIG_LYPXL_yS_3	267	270	PF13949	0.567
LIG_NRBOX	206	212	PF00104	0.544
LIG_SH2_CRK	287	291	PF00017	0.517
LIG_SH2_NCK_1	287	291	PF00017	0.492
LIG_SH2_PTP2	192	195	PF00017	0.474
LIG_SH2_PTP2	295	298	PF00017	0.536
LIG_SH2_SRC	192	195	PF00017	0.447
LIG_SH2_STAT5	120	123	PF00017	0.563
LIG_SH2_STAT5	192	195	PF00017	0.474
LIG_SH2_STAT5	295	298	PF00017	0.536
LIG_SH2_STAT5	488	491	PF00017	0.515
LIG_SH2_STAT5	91	94	PF00017	0.474
LIG_SH3_1	378	384	PF00018	0.618
LIG_SH3_1	385	391	PF00018	0.600
LIG_SH3_3	18	24	PF00018	0.398
LIG_SH3_3	235	241	PF00018	0.593
LIG_SH3_3	247	253	PF00018	0.584
LIG_SH3_3	262	268	PF00018	0.498
LIG_SH3_3	362	368	PF00018	0.513
LIG_SH3_3	378	384	PF00018	0.577
LIG_SH3_3	385	391	PF00018	0.600
LIG_SH3_3	48	54	PF00018	0.486
LIG_SH3_3	488	494	PF00018	0.557
LIG_SUMO_SIM_anti_2	362	367	PF11976	0.545
LIG_SUMO_SIM_par_1	361	367	PF11976	0.596
LIG_UBA3_1	251	259	PF00899	0.552
LIG_WW_1	264	267	PF00397	0.515
LIG_WW_3	379	383	PF00397	0.593
MOD_CDC14_SPxK_1	367	370	PF00782	0.493
MOD_CDK_SPxK_1	364	370	PF00069	0.496
MOD_CK1_1	223	229	PF00069	0.537
MOD_CK1_1	237	243	PF00069	0.730
MOD_CK1_1	246	252	PF00069	0.508
MOD_CK1_1	272	278	PF00069	0.598
MOD_CK1_1	288	294	PF00069	0.455
MOD_CK1_1	311	317	PF00069	0.560
MOD_CK1_1	326	332	PF00069	0.551
MOD_CK1_1	416	422	PF00069	0.620
MOD_CK1_1	426	432	PF00069	0.463
MOD_CK1_1	89	95	PF00069	0.311
MOD_CK2_1	109	115	PF00069	0.267
MOD_CK2_1	167	173	PF00069	0.328
MOD_CK2_1	270	276	PF00069	0.583
MOD_CK2_1	347	353	PF00069	0.614
MOD_CK2_1	391	397	PF00069	0.577
MOD_CK2_1	513	519	PF00069	0.568
MOD_GlcNHglycan	272	275	PF01048	0.604
MOD_GlcNHglycan	287	290	PF01048	0.511
MOD_GlcNHglycan	349	352	PF01048	0.625
MOD_GlcNHglycan	418	421	PF01048	0.581
MOD_GSK3_1	154	161	PF00069	0.287
MOD_GSK3_1	162	169	PF00069	0.291
MOD_GSK3_1	196	203	PF00069	0.503
MOD_GSK3_1	219	226	PF00069	0.695
MOD_GSK3_1	236	243	PF00069	0.523
MOD_GSK3_1	268	275	PF00069	0.613
MOD_GSK3_1	309	316	PF00069	0.568
MOD_GSK3_1	42	49	PF00069	0.294
MOD_GSK3_1	89	96	PF00069	0.288
MOD_N-GLC_1	342	347	PF02516	0.589
MOD_N-GLC_1	426	431	PF02516	0.555
MOD_N-GLC_1	449	454	PF02516	0.478
MOD_N-GLC_1	76	81	PF02516	0.282
MOD_NEK2_1	158	163	PF00069	0.294
MOD_NEK2_1	258	263	PF00069	0.557
MOD_NEK2_1	65	70	PF00069	0.285
MOD_NEK2_2	59	64	PF00069	0.361
MOD_PIKK_1	288	294	PF00454	0.546
MOD_PIKK_1	323	329	PF00454	0.568
MOD_PIKK_1	44	50	PF00454	0.328
MOD_PIKK_1	463	469	PF00454	0.560
MOD_PIKK_1	86	92	PF00454	0.285
MOD_PK_1	25	31	PF00069	0.294
MOD_Plk_1	172	178	PF00069	0.423
MOD_Plk_1	223	229	PF00069	0.542
MOD_Plk_1	308	314	PF00069	0.552
MOD_Plk_4	140	146	PF00069	0.323
MOD_Plk_4	206	212	PF00069	0.544
MOD_Plk_4	246	252	PF00069	0.594
MOD_Plk_4	359	365	PF00069	0.565
MOD_Plk_4	510	516	PF00069	0.601
MOD_Plk_4	65	71	PF00069	0.285
MOD_ProDKin_1	177	183	PF00069	0.383
MOD_ProDKin_1	200	206	PF00069	0.529
MOD_ProDKin_1	234	240	PF00069	0.576
MOD_ProDKin_1	364	370	PF00069	0.491
MOD_ProDKin_1	42	48	PF00069	0.294
MOD_SUMO_for_1	306	309	PF00179	0.571
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.285
TRG_ENDOCYTIC_2	120	123	PF00928	0.328
TRG_ENDOCYTIC_2	267	270	PF00928	0.567
TRG_ENDOCYTIC_2	295	298	PF00928	0.560
TRG_ENDOCYTIC_2	488	491	PF00928	0.515
TRG_ER_diArg_1	434	437	PF00400	0.540
TRG_ER_diArg_1	438	441	PF00400	0.583
TRG_NLS_MonoCore_2	381	386	PF00514	0.604
TRG_NLS_MonoExtN_4	379	386	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P363	Leptomonas seymouri	50%	91%
A0A3Q8IIK6	Leishmania donovani	99%	100%
A4H7Z2	Leishmania braziliensis	74%	100%
E9AQ20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QFG1	Leishmania major	93%	100%