Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWB8_LEIIN

TriTrypDb:

LINF_150007000

Length:

364

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HWB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.475
CLV_NRD_NRD_1	142	144	PF00675	0.309
CLV_NRD_NRD_1	192	194	PF00675	0.397
CLV_NRD_NRD_1	326	328	PF00675	0.587
CLV_NRD_NRD_1	35	37	PF00675	0.205
CLV_NRD_NRD_1	6	8	PF00675	0.217
CLV_PCSK_KEX2_1	126	128	PF00082	0.475
CLV_PCSK_KEX2_1	142	144	PF00082	0.309
CLV_PCSK_KEX2_1	191	193	PF00082	0.392
CLV_PCSK_KEX2_1	35	37	PF00082	0.205
CLV_PCSK_KEX2_1	6	8	PF00082	0.215
CLV_PCSK_PC7_1	2	8	PF00082	0.342
CLV_PCSK_SKI1_1	151	155	PF00082	0.421
CLV_PCSK_SKI1_1	163	167	PF00082	0.408
CLV_PCSK_SKI1_1	29	33	PF00082	0.513
CLV_PCSK_SKI1_1	312	316	PF00082	0.605
CLV_PCSK_SKI1_1	35	39	PF00082	0.196
DEG_Nend_UBRbox_1	1	4	PF02207	0.560
DEG_SCF_FBW7_1	202	207	PF00400	0.684
DEG_SCF_FBW7_1	98	104	PF00400	0.627
DOC_CKS1_1	212	217	PF01111	0.696
DOC_CKS1_1	98	103	PF01111	0.682
DOC_CYCLIN_RxL_1	33	42	PF00134	0.199
DOC_MAPK_gen_1	249	257	PF00069	0.480
DOC_MAPK_gen_1	269	278	PF00069	0.183
DOC_MAPK_JIP1_4	82	88	PF00069	0.674
DOC_MAPK_MEF2A_6	251	259	PF00069	0.560
DOC_MAPK_MEF2A_6	272	280	PF00069	0.234
DOC_MAPK_RevD_3	21	36	PF00069	0.366
DOC_PP1_RVXF_1	33	40	PF00149	0.199
DOC_USP7_MATH_1	105	109	PF00917	0.711
DOC_USP7_MATH_1	27	31	PF00917	0.331
DOC_WW_Pin1_4	118	123	PF00397	0.716
DOC_WW_Pin1_4	200	205	PF00397	0.789
DOC_WW_Pin1_4	211	216	PF00397	0.691
DOC_WW_Pin1_4	97	102	PF00397	0.689
LIG_14-3-3_CanoR_1	126	132	PF00244	0.612
LIG_14-3-3_CanoR_1	151	158	PF00244	0.590
LIG_14-3-3_CanoR_1	29	39	PF00244	0.305
LIG_14-3-3_CanoR_1	61	67	PF00244	0.558
LIG_BRCT_BRCA1_1	15	19	PF00533	0.205
LIG_BRCT_BRCA1_1	41	45	PF00533	0.205
LIG_EH1_1	273	281	PF00400	0.318
LIG_FHA_1	102	108	PF00498	0.626
LIG_FHA_1	271	277	PF00498	0.367
LIG_FHA_1	345	351	PF00498	0.387
LIG_FHA_2	113	119	PF00498	0.735
LIG_FHA_2	195	201	PF00498	0.700
LIG_FHA_2	98	104	PF00498	0.691
LIG_GBD_Chelix_1	63	71	PF00786	0.348
LIG_LIR_Gen_1	130	139	PF02991	0.570
LIG_LIR_Gen_1	16	27	PF02991	0.205
LIG_LIR_Nem_3	130	134	PF02991	0.580
LIG_LIR_Nem_3	16	22	PF02991	0.205
LIG_LIR_Nem_3	343	348	PF02991	0.384
LIG_LIR_Nem_3	42	48	PF02991	0.205
LIG_NRBOX	254	260	PF00104	0.357
LIG_NRBOX	62	68	PF00104	0.533
LIG_Pex14_2	291	295	PF04695	0.378
LIG_Pex14_2	41	45	PF04695	0.205
LIG_SH2_PTP2	265	268	PF00017	0.363
LIG_SH2_PTP2	282	285	PF00017	0.267
LIG_SH2_STAT5	138	141	PF00017	0.583
LIG_SH2_STAT5	146	149	PF00017	0.559
LIG_SH2_STAT5	265	268	PF00017	0.329
LIG_SH2_STAT5	282	285	PF00017	0.270
LIG_SH2_STAT5	331	334	PF00017	0.351
LIG_SH2_STAT5	51	54	PF00017	0.498
LIG_SH3_3	209	215	PF00018	0.703
LIG_SH3_3	219	225	PF00018	0.646
LIG_SH3_3	84	90	PF00018	0.683
LIG_SH3_3	95	101	PF00018	0.684
LIG_TRAF2_1	130	133	PF00917	0.579
LIG_TYR_ITIM	263	268	PF00017	0.363
LIG_TYR_ITIM	280	285	PF00017	0.299
LIG_UBA3_1	278	286	PF00899	0.411
LIG_UBA3_1	309	315	PF00899	0.512
LIG_WRC_WIRS_1	114	119	PF05994	0.609
MOD_CK1_1	121	127	PF00069	0.646
MOD_CK1_1	30	36	PF00069	0.355
MOD_CK1_1	69	75	PF00069	0.574
MOD_CK2_1	127	133	PF00069	0.503
MOD_GlcNHglycan	171	174	PF01048	0.468
MOD_GSK3_1	105	112	PF00069	0.679
MOD_GSK3_1	11	18	PF00069	0.230
MOD_GSK3_1	200	207	PF00069	0.649
MOD_GSK3_1	301	308	PF00069	0.620
MOD_GSK3_1	340	347	PF00069	0.446
MOD_GSK3_1	62	69	PF00069	0.436
MOD_GSK3_1	97	104	PF00069	0.588
MOD_N-GLC_1	112	117	PF02516	0.561
MOD_N-GLC_1	151	156	PF02516	0.494
MOD_NEK2_1	13	18	PF00069	0.209
MOD_NEK2_1	22	27	PF00069	0.353
MOD_NEK2_1	270	275	PF00069	0.318
MOD_NEK2_1	281	286	PF00069	0.332
MOD_NEK2_1	340	345	PF00069	0.429
MOD_NEK2_1	39	44	PF00069	0.205
MOD_NEK2_1	62	67	PF00069	0.430
MOD_PIKK_1	156	162	PF00454	0.479
MOD_PIKK_1	202	208	PF00454	0.595
MOD_PIKK_1	55	61	PF00454	0.353
MOD_PKA_2	81	87	PF00069	0.611
MOD_Plk_1	112	118	PF00069	0.553
MOD_Plk_1	154	160	PF00069	0.468
MOD_Plk_4	238	244	PF00069	0.386
MOD_Plk_4	305	311	PF00069	0.499
MOD_Plk_4	340	346	PF00069	0.439
MOD_Plk_4	62	68	PF00069	0.427
MOD_Plk_4	81	87	PF00069	0.555
MOD_ProDKin_1	118	124	PF00069	0.641
MOD_ProDKin_1	200	206	PF00069	0.755
MOD_ProDKin_1	211	217	PF00069	0.612
MOD_ProDKin_1	97	103	PF00069	0.614
MOD_SUMO_for_1	314	317	PF00179	0.492
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.205
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.367
TRG_ENDOCYTIC_2	265	268	PF00928	0.415
TRG_ENDOCYTIC_2	282	285	PF00928	0.300
TRG_ER_diArg_1	142	144	PF00400	0.381
TRG_ER_diArg_1	190	193	PF00400	0.458
TRG_ER_diArg_1	248	251	PF00400	0.391
TRG_ER_diArg_1	35	37	PF00400	0.205
TRG_ER_diArg_1	5	7	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	355	360	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDS0	Leptomonas seymouri	34%	100%
A0A3S5H6T8	Leishmania donovani	98%	100%
A4H7Z0	Leishmania braziliensis	67%	100%
E9AQ18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QFG3	Leishmania major	89%	100%