Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWB6_LEIIN

TriTrypDb:

LINF_150006800

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.643
CLV_C14_Caspase3-7	547	551	PF00656	0.568
CLV_MEL_PAP_1	405	411	PF00089	0.562
CLV_NRD_NRD_1	275	277	PF00675	0.753
CLV_NRD_NRD_1	320	322	PF00675	0.657
CLV_NRD_NRD_1	367	369	PF00675	0.681
CLV_NRD_NRD_1	393	395	PF00675	0.706
CLV_NRD_NRD_1	476	478	PF00675	0.680
CLV_NRD_NRD_1	580	582	PF00675	0.644
CLV_PCSK_KEX2_1	275	277	PF00082	0.753
CLV_PCSK_KEX2_1	320	322	PF00082	0.656
CLV_PCSK_KEX2_1	367	369	PF00082	0.733
CLV_PCSK_KEX2_1	393	395	PF00082	0.600
CLV_PCSK_KEX2_1	476	478	PF00082	0.680
CLV_PCSK_KEX2_1	580	582	PF00082	0.683
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.577
CLV_PCSK_SKI1_1	404	408	PF00082	0.556
CLV_PCSK_SKI1_1	499	503	PF00082	0.589
DEG_Nend_UBRbox_2	1	3	PF02207	0.582
DEG_ODPH_VHL_1	233	246	PF01847	0.590
DEG_SCF_FBW7_1	196	203	PF00400	0.618
DEG_SCF_FBW7_1	84	90	PF00400	0.571
DEG_SCF_FBW7_2	33	38	PF00400	0.532
DEG_SPOP_SBC_1	466	470	PF00917	0.537
DOC_CKS1_1	289	294	PF01111	0.587
DOC_CKS1_1	84	89	PF01111	0.571
DOC_CYCLIN_RxL_1	401	411	PF00134	0.555
DOC_MAPK_gen_1	402	409	PF00069	0.535
DOC_MAPK_MEF2A_6	102	111	PF00069	0.595
DOC_MAPK_MEF2A_6	402	409	PF00069	0.627
DOC_MAPK_NFAT4_5	402	410	PF00069	0.564
DOC_PP2B_LxvP_1	519	522	PF13499	0.678
DOC_PP2B_LxvP_1	557	560	PF13499	0.601
DOC_USP7_MATH_1	101	105	PF00917	0.603
DOC_USP7_MATH_1	132	136	PF00917	0.583
DOC_USP7_MATH_1	142	146	PF00917	0.545
DOC_USP7_MATH_1	175	179	PF00917	0.677
DOC_USP7_MATH_1	21	25	PF00917	0.638
DOC_USP7_MATH_1	325	329	PF00917	0.595
DOC_USP7_MATH_1	345	349	PF00917	0.702
DOC_USP7_MATH_1	355	359	PF00917	0.610
DOC_USP7_MATH_1	456	460	PF00917	0.544
DOC_USP7_MATH_1	466	470	PF00917	0.602
DOC_USP7_MATH_1	529	533	PF00917	0.638
DOC_USP7_MATH_1	80	84	PF00917	0.689
DOC_USP7_MATH_1	87	91	PF00917	0.593
DOC_WW_Pin1_4	164	169	PF00397	0.668
DOC_WW_Pin1_4	196	201	PF00397	0.675
DOC_WW_Pin1_4	224	229	PF00397	0.685
DOC_WW_Pin1_4	236	241	PF00397	0.543
DOC_WW_Pin1_4	288	293	PF00397	0.678
DOC_WW_Pin1_4	31	36	PF00397	0.611
DOC_WW_Pin1_4	508	513	PF00397	0.567
DOC_WW_Pin1_4	522	527	PF00397	0.682
DOC_WW_Pin1_4	58	63	PF00397	0.671
DOC_WW_Pin1_4	83	88	PF00397	0.711
LIG_14-3-3_CanoR_1	138	146	PF00244	0.603
LIG_14-3-3_CanoR_1	171	175	PF00244	0.613
LIG_14-3-3_CanoR_1	333	337	PF00244	0.555
LIG_14-3-3_CanoR_1	455	465	PF00244	0.517
LIG_14-3-3_CanoR_1	530	535	PF00244	0.653
LIG_14-3-3_CanoR_1	562	567	PF00244	0.659
LIG_Actin_WH2_2	393	410	PF00022	0.574
LIG_BRCT_BRCA1_1	365	369	PF00533	0.575
LIG_BRCT_BRCA1_1	54	58	PF00533	0.602
LIG_CtBP_PxDLS_1	487	491	PF00389	0.489
LIG_FHA_1	154	160	PF00498	0.692
LIG_FHA_1	181	187	PF00498	0.525
LIG_FHA_1	201	207	PF00498	0.630
LIG_FHA_1	23	29	PF00498	0.777
LIG_FHA_1	280	286	PF00498	0.733
LIG_FHA_1	302	308	PF00498	0.615
LIG_FHA_1	325	331	PF00498	0.594
LIG_FHA_1	383	389	PF00498	0.616
LIG_FHA_1	92	98	PF00498	0.645
LIG_FHA_2	278	284	PF00498	0.718
LIG_FHA_2	289	295	PF00498	0.617
LIG_FHA_2	35	41	PF00498	0.581
LIG_GBD_Chelix_1	494	502	PF00786	0.491
LIG_HP1_1	242	246	PF01393	0.606
LIG_Integrin_RGD_1	450	452	PF01839	0.510
LIG_LIR_Gen_1	366	375	PF02991	0.568
LIG_LIR_Nem_3	237	241	PF02991	0.697
LIG_LIR_Nem_3	366	372	PF02991	0.682
LIG_MYND_3	70	74	PF01753	0.601
LIG_NRBOX	402	408	PF00104	0.682
LIG_NRBOX	493	499	PF00104	0.504
LIG_SH2_SRC	15	18	PF00017	0.579
LIG_SH2_STAT3	41	44	PF00017	0.609
LIG_SH2_STAT5	15	18	PF00017	0.540
LIG_SH2_STAT5	296	299	PF00017	0.631
LIG_SH2_STAT5	500	503	PF00017	0.526
LIG_SH3_1	553	559	PF00018	0.744
LIG_SH3_3	147	153	PF00018	0.684
LIG_SH3_3	199	205	PF00018	0.630
LIG_SH3_3	225	231	PF00018	0.660
LIG_SH3_3	286	292	PF00018	0.592
LIG_SH3_3	521	527	PF00018	0.760
LIG_SH3_3	553	559	PF00018	0.773
LIG_SH3_3	57	63	PF00018	0.643
LIG_SH3_3	65	71	PF00018	0.592
LIG_SH3_3	81	87	PF00018	0.611
LIG_SUMO_SIM_anti_2	120	126	PF11976	0.510
LIG_SUMO_SIM_par_1	241	247	PF11976	0.670
MOD_CDC14_SPxK_1	525	528	PF00782	0.661
MOD_CDK_SPxK_1	522	528	PF00069	0.670
MOD_CDK_SPxxK_3	164	171	PF00069	0.652
MOD_CDK_SPxxK_3	288	295	PF00069	0.653
MOD_CK1_1	204	210	PF00069	0.729
MOD_CK1_1	229	235	PF00069	0.654
MOD_CK1_1	250	256	PF00069	0.678
MOD_CK1_1	269	275	PF00069	0.705
MOD_CK1_1	277	283	PF00069	0.648
MOD_CK1_1	284	290	PF00069	0.604
MOD_CK1_1	301	307	PF00069	0.524
MOD_CK1_1	363	369	PF00069	0.744
MOD_CK1_1	469	475	PF00069	0.679
MOD_CK1_1	480	486	PF00069	0.573
MOD_CK1_1	533	539	PF00069	0.640
MOD_CK1_1	61	67	PF00069	0.677
MOD_CK1_1	83	89	PF00069	0.781
MOD_CK1_1	92	98	PF00069	0.635
MOD_CK2_1	175	181	PF00069	0.661
MOD_CK2_1	207	213	PF00069	0.694
MOD_CK2_1	345	351	PF00069	0.708
MOD_CK2_1	456	462	PF00069	0.537
MOD_GlcNHglycan	134	137	PF01048	0.650
MOD_GlcNHglycan	172	175	PF01048	0.643
MOD_GlcNHglycan	183	186	PF01048	0.541
MOD_GlcNHglycan	29	32	PF01048	0.580
MOD_GlcNHglycan	300	303	PF01048	0.626
MOD_GlcNHglycan	362	365	PF01048	0.658
MOD_GlcNHglycan	430	433	PF01048	0.556
MOD_GlcNHglycan	469	472	PF01048	0.598
MOD_GlcNHglycan	512	515	PF01048	0.629
MOD_GlcNHglycan	568	571	PF01048	0.709
MOD_GlcNHglycan	91	94	PF01048	0.655
MOD_GSK3_1	132	139	PF00069	0.608
MOD_GSK3_1	192	199	PF00069	0.717
MOD_GSK3_1	200	207	PF00069	0.634
MOD_GSK3_1	222	229	PF00069	0.707
MOD_GSK3_1	246	253	PF00069	0.589
MOD_GSK3_1	266	273	PF00069	0.731
MOD_GSK3_1	27	34	PF00069	0.664
MOD_GSK3_1	275	282	PF00069	0.640
MOD_GSK3_1	284	291	PF00069	0.542
MOD_GSK3_1	297	304	PF00069	0.539
MOD_GSK3_1	321	328	PF00069	0.640
MOD_GSK3_1	456	463	PF00069	0.607
MOD_GSK3_1	465	472	PF00069	0.603
MOD_GSK3_1	529	536	PF00069	0.646
MOD_GSK3_1	558	565	PF00069	0.799
MOD_GSK3_1	83	90	PF00069	0.709
MOD_GSK3_1	91	98	PF00069	0.580
MOD_NEK2_1	125	130	PF00069	0.526
MOD_NEK2_1	246	251	PF00069	0.658
MOD_NEK2_1	339	344	PF00069	0.548
MOD_NEK2_1	426	431	PF00069	0.657
MOD_NEK2_1	465	470	PF00069	0.589
MOD_NEK2_1	91	96	PF00069	0.663
MOD_OFUCOSY	453	460	PF10250	0.547
MOD_PIKK_1	277	283	PF00454	0.729
MOD_PIKK_1	445	451	PF00454	0.514
MOD_PK_1	368	374	PF00069	0.660
MOD_PK_1	530	536	PF00069	0.565
MOD_PKA_1	275	281	PF00069	0.733
MOD_PKA_1	413	419	PF00069	0.562
MOD_PKA_2	101	107	PF00069	0.655
MOD_PKA_2	137	143	PF00069	0.534
MOD_PKA_2	170	176	PF00069	0.646
MOD_PKA_2	254	260	PF00069	0.647
MOD_PKA_2	274	280	PF00069	0.733
MOD_PKA_2	332	338	PF00069	0.566
MOD_PKA_2	407	413	PF00069	0.572
MOD_PKA_2	426	432	PF00069	0.546
MOD_PKA_2	529	535	PF00069	0.641
MOD_Plk_1	16	22	PF00069	0.577
MOD_Plk_1	246	252	PF00069	0.660
MOD_Plk_1	325	331	PF00069	0.568
MOD_Plk_1	461	467	PF00069	0.545
MOD_Plk_4	247	253	PF00069	0.624
MOD_Plk_4	325	331	PF00069	0.594
MOD_Plk_4	332	338	PF00069	0.507
MOD_Plk_4	493	499	PF00069	0.539
MOD_ProDKin_1	164	170	PF00069	0.668
MOD_ProDKin_1	196	202	PF00069	0.675
MOD_ProDKin_1	224	230	PF00069	0.684
MOD_ProDKin_1	236	242	PF00069	0.540
MOD_ProDKin_1	288	294	PF00069	0.680
MOD_ProDKin_1	31	37	PF00069	0.608
MOD_ProDKin_1	508	514	PF00069	0.574
MOD_ProDKin_1	522	528	PF00069	0.708
MOD_ProDKin_1	58	64	PF00069	0.671
MOD_ProDKin_1	83	89	PF00069	0.709
TRG_DiLeu_BaEn_4	398	404	PF01217	0.502
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.583
TRG_ER_diArg_1	320	322	PF00400	0.656
TRG_ER_diArg_1	367	369	PF00400	0.644
TRG_ER_diArg_1	402	405	PF00400	0.561
TRG_ER_diArg_1	434	437	PF00400	0.535
TRG_NES_CRM1_1	492	507	PF08389	0.500
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC62	Leishmania donovani	100%	100%
A4H7Y8	Leishmania braziliensis	64%	100%
E9AQ16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QFG5	Leishmania major	90%	100%