LeishMANIAdb
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Putative serine/threonine-protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine/threonine-protein kinase
Gene product:
serine/threonine-protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4HWB5_LEIIN
TriTrypDb:
LINF_150006700
Length:
745

Annotations

Annotations by Jardim et al.

Protein kinase, serine/threonine- kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HWB5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWB5

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009987 cellular process 1 6
GO:0016310 phosphorylation 5 6
GO:0019538 protein metabolic process 3 6
GO:0036211 protein modification process 4 6
GO:0043170 macromolecule metabolic process 3 6
GO:0043412 macromolecule modification 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0071704 organic substance metabolic process 2 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009891 positive regulation of biosynthetic process 5 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010557 positive regulation of macromolecule biosynthetic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018107 peptidyl-threonine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0018210 peptidyl-threonine modification 6 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0031328 positive regulation of cellular biosynthetic process 6 1
GO:0045893 positive regulation of DNA-templated transcription 7 1
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 6 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051254 positive regulation of RNA metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1902680 positive regulation of RNA biosynthetic process 7 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:1903508 positive regulation of nucleic acid-templated transcription 8 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 6
GO:0003824 catalytic activity 1 6
GO:0004672 protein kinase activity 3 6
GO:0004674 protein serine/threonine kinase activity 4 4
GO:0005488 binding 1 6
GO:0005524 ATP binding 5 6
GO:0016301 kinase activity 4 6
GO:0016740 transferase activity 2 6
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 6
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 6
GO:0017076 purine nucleotide binding 4 6
GO:0030554 adenyl nucleotide binding 5 6
GO:0032553 ribonucleotide binding 3 6
GO:0032555 purine ribonucleotide binding 4 6
GO:0032559 adenyl ribonucleotide binding 5 6
GO:0035639 purine ribonucleoside triphosphate binding 4 6
GO:0036094 small molecule binding 2 6
GO:0043167 ion binding 2 6
GO:0043168 anion binding 3 6
GO:0097159 organic cyclic compound binding 2 6
GO:0097367 carbohydrate derivative binding 2 6
GO:0140096 catalytic activity, acting on a protein 2 6
GO:1901265 nucleoside phosphate binding 3 6
GO:1901363 heterocyclic compound binding 2 6
GO:0003712 transcription coregulator activity 2 1
GO:0003713 transcription coactivator activity 3 1
GO:0140110 transcription regulator activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 296 300 PF00656 0.706
CLV_C14_Caspase3-7 344 348 PF00656 0.585
CLV_C14_Caspase3-7 43 47 PF00656 0.765
CLV_C14_Caspase3-7 664 668 PF00656 0.320
CLV_NRD_NRD_1 330 332 PF00675 0.622
CLV_NRD_NRD_1 394 396 PF00675 0.495
CLV_NRD_NRD_1 464 466 PF00675 0.495
CLV_NRD_NRD_1 615 617 PF00675 0.495
CLV_NRD_NRD_1 632 634 PF00675 0.214
CLV_PCSK_FUR_1 630 634 PF00082 0.495
CLV_PCSK_KEX2_1 330 332 PF00082 0.622
CLV_PCSK_KEX2_1 383 385 PF00082 0.495
CLV_PCSK_KEX2_1 394 396 PF00082 0.313
CLV_PCSK_KEX2_1 519 521 PF00082 0.495
CLV_PCSK_KEX2_1 615 617 PF00082 0.495
CLV_PCSK_KEX2_1 632 634 PF00082 0.214
CLV_PCSK_PC1ET2_1 383 385 PF00082 0.495
CLV_PCSK_PC1ET2_1 519 521 PF00082 0.495
CLV_PCSK_SKI1_1 425 429 PF00082 0.495
CLV_PCSK_SKI1_1 666 670 PF00082 0.401
CLV_PCSK_SKI1_1 728 732 PF00082 0.627
DEG_APCC_DBOX_1 118 126 PF00400 0.518
DEG_APCC_DBOX_1 546 554 PF00400 0.495
DEG_APCC_DBOX_1 614 622 PF00400 0.495
DEG_SPOP_SBC_1 211 215 PF00917 0.708
DEG_SPOP_SBC_1 266 270 PF00917 0.709
DEG_SPOP_SBC_1 99 103 PF00917 0.644
DOC_ANK_TNKS_1 127 134 PF00023 0.708
DOC_CKS1_1 541 546 PF01111 0.495
DOC_CKS1_1 634 639 PF01111 0.495
DOC_MAPK_gen_1 452 461 PF00069 0.495
DOC_MAPK_gen_1 528 538 PF00069 0.495
DOC_MAPK_HePTP_8 525 537 PF00069 0.495
DOC_MAPK_MEF2A_6 254 263 PF00069 0.689
DOC_MAPK_MEF2A_6 306 315 PF00069 0.630
DOC_MAPK_MEF2A_6 400 409 PF00069 0.495
DOC_MAPK_MEF2A_6 455 463 PF00069 0.495
DOC_MAPK_MEF2A_6 528 537 PF00069 0.495
DOC_PP1_RVXF_1 505 512 PF00149 0.495
DOC_PP2B_LxvP_1 200 203 PF13499 0.526
DOC_PP2B_LxvP_1 351 354 PF13499 0.560
DOC_PP4_FxxP_1 673 676 PF00568 0.601
DOC_USP7_MATH_1 100 104 PF00917 0.689
DOC_USP7_MATH_1 156 160 PF00917 0.685
DOC_USP7_MATH_1 168 172 PF00917 0.561
DOC_USP7_MATH_1 2 6 PF00917 0.753
DOC_USP7_MATH_1 221 225 PF00917 0.642
DOC_USP7_MATH_1 244 248 PF00917 0.720
DOC_USP7_MATH_1 266 270 PF00917 0.663
DOC_USP7_MATH_1 293 297 PF00917 0.628
DOC_USP7_MATH_2 659 665 PF00917 0.320
DOC_WW_Pin1_4 10 15 PF00397 0.671
DOC_WW_Pin1_4 105 110 PF00397 0.694
DOC_WW_Pin1_4 123 128 PF00397 0.578
DOC_WW_Pin1_4 331 336 PF00397 0.650
DOC_WW_Pin1_4 529 534 PF00397 0.495
DOC_WW_Pin1_4 540 545 PF00397 0.313
DOC_WW_Pin1_4 588 593 PF00397 0.495
DOC_WW_Pin1_4 633 638 PF00397 0.495
DOC_WW_Pin1_4 715 720 PF00397 0.598
LIG_14-3-3_CanoR_1 117 123 PF00244 0.681
LIG_14-3-3_CanoR_1 394 400 PF00244 0.495
LIG_14-3-3_CanoR_1 547 551 PF00244 0.495
LIG_14-3-3_CanoR_1 615 619 PF00244 0.495
LIG_14-3-3_CanoR_1 662 669 PF00244 0.320
LIG_14-3-3_CanoR_1 735 743 PF00244 0.715
LIG_APCC_ABBA_1 535 540 PF00400 0.495
LIG_BIR_II_1 1 5 PF00653 0.696
LIG_Clathr_ClatBox_1 475 479 PF01394 0.495
LIG_EH1_1 420 428 PF00400 0.495
LIG_FHA_1 470 476 PF00498 0.359
LIG_FHA_1 677 683 PF00498 0.637
LIG_FHA_1 725 731 PF00498 0.640
LIG_FHA_1 89 95 PF00498 0.691
LIG_FHA_2 127 133 PF00498 0.784
LIG_FHA_2 41 47 PF00498 0.699
LIG_FHA_2 541 547 PF00498 0.495
LIG_FHA_2 729 735 PF00498 0.728
LIG_Integrin_isoDGR_2 235 237 PF01839 0.748
LIG_LIR_Apic_2 302 307 PF02991 0.671
LIG_LIR_Apic_2 527 533 PF02991 0.495
LIG_LIR_Apic_2 540 544 PF02991 0.280
LIG_LIR_Gen_1 347 358 PF02991 0.548
LIG_LIR_Gen_1 646 655 PF02991 0.496
LIG_LIR_Nem_3 317 322 PF02991 0.562
LIG_LIR_Nem_3 347 353 PF02991 0.554
LIG_LIR_Nem_3 356 362 PF02991 0.389
LIG_LIR_Nem_3 372 376 PF02991 0.230
LIG_LIR_Nem_3 444 448 PF02991 0.495
LIG_LIR_Nem_3 454 459 PF02991 0.329
LIG_LIR_Nem_3 641 647 PF02991 0.430
LIG_LIR_Nem_3 652 657 PF02991 0.402
LIG_MYND_1 672 676 PF01753 0.495
LIG_NRBOX 406 412 PF00104 0.495
LIG_PCNA_yPIPBox_3 412 423 PF02747 0.495
LIG_Pex14_2 650 654 PF04695 0.495
LIG_PTB_Apo_2 320 327 PF02174 0.597
LIG_PTB_Phospho_1 320 326 PF10480 0.602
LIG_RPA_C_Fungi 320 332 PF08784 0.569
LIG_SH2_CRK 304 308 PF00017 0.665
LIG_SH2_CRK 319 323 PF00017 0.342
LIG_SH2_CRK 448 452 PF00017 0.495
LIG_SH2_CRK 541 545 PF00017 0.495
LIG_SH2_NCK_1 304 308 PF00017 0.587
LIG_SH2_NCK_1 75 79 PF00017 0.694
LIG_SH2_STAP1 36 40 PF00017 0.698
LIG_SH2_STAP1 678 682 PF00017 0.638
LIG_SH2_STAT3 326 329 PF00017 0.609
LIG_SH2_STAT3 362 365 PF00017 0.529
LIG_SH2_STAT5 326 329 PF00017 0.609
LIG_SH2_STAT5 350 353 PF00017 0.544
LIG_SH2_STAT5 362 365 PF00017 0.331
LIG_SH2_STAT5 516 519 PF00017 0.464
LIG_SH2_STAT5 52 55 PF00017 0.690
LIG_SH2_STAT5 524 527 PF00017 0.394
LIG_SH2_STAT5 678 681 PF00017 0.636
LIG_SH3_1 713 719 PF00018 0.600
LIG_SH3_2 697 702 PF14604 0.722
LIG_SH3_3 150 156 PF00018 0.748
LIG_SH3_3 236 242 PF00018 0.658
LIG_SH3_3 253 259 PF00018 0.604
LIG_SH3_3 687 693 PF00018 0.684
LIG_SH3_3 694 700 PF00018 0.727
LIG_SH3_3 713 719 PF00018 0.496
LIG_SH3_4 713 720 PF00018 0.735
LIG_SUMO_SIM_anti_2 406 411 PF11976 0.495
LIG_SUMO_SIM_anti_2 460 465 PF11976 0.495
LIG_SUMO_SIM_par_1 435 441 PF11976 0.495
LIG_UBA3_1 315 320 PF00899 0.601
LIG_UBA3_1 475 482 PF00899 0.354
LIG_WRC_WIRS_1 442 447 PF05994 0.495
MOD_CDC14_SPxK_1 13 16 PF00782 0.661
MOD_CDK_SPK_2 123 128 PF00069 0.693
MOD_CDK_SPK_2 588 593 PF00069 0.495
MOD_CDK_SPK_2 715 720 PF00069 0.596
MOD_CDK_SPxK_1 10 16 PF00069 0.672
MOD_CDK_SPxxK_3 331 338 PF00069 0.655
MOD_CDK_SPxxK_3 540 547 PF00069 0.495
MOD_CK1_1 103 109 PF00069 0.673
MOD_CK1_1 111 117 PF00069 0.644
MOD_CK1_1 123 129 PF00069 0.480
MOD_CK1_1 191 197 PF00069 0.762
MOD_CK1_1 212 218 PF00069 0.703
MOD_CK1_1 224 230 PF00069 0.571
MOD_CK1_1 264 270 PF00069 0.719
MOD_CK1_1 372 378 PF00069 0.495
MOD_CK1_1 398 404 PF00069 0.495
MOD_CK1_1 5 11 PF00069 0.761
MOD_CK1_1 709 715 PF00069 0.809
MOD_CK1_1 736 742 PF00069 0.716
MOD_CK1_1 76 82 PF00069 0.727
MOD_CK1_1 88 94 PF00069 0.592
MOD_CK2_1 126 132 PF00069 0.704
MOD_CK2_1 237 243 PF00069 0.690
MOD_CK2_1 728 734 PF00069 0.804
MOD_Cter_Amidation 630 633 PF01082 0.495
MOD_GlcNHglycan 110 113 PF01048 0.767
MOD_GlcNHglycan 170 173 PF01048 0.752
MOD_GlcNHglycan 191 194 PF01048 0.732
MOD_GlcNHglycan 223 226 PF01048 0.602
MOD_GlcNHglycan 269 272 PF01048 0.771
MOD_GlcNHglycan 280 283 PF01048 0.599
MOD_GlcNHglycan 340 343 PF01048 0.612
MOD_GlcNHglycan 503 506 PF01048 0.378
MOD_GlcNHglycan 512 515 PF01048 0.288
MOD_GlcNHglycan 603 606 PF01048 0.495
MOD_GlcNHglycan 694 697 PF01048 0.608
MOD_GlcNHglycan 738 741 PF01048 0.722
MOD_GlcNHglycan 77 81 PF01048 0.774
MOD_GSK3_1 1 8 PF00069 0.757
MOD_GSK3_1 107 114 PF00069 0.622
MOD_GSK3_1 188 195 PF00069 0.757
MOD_GSK3_1 224 231 PF00069 0.707
MOD_GSK3_1 245 252 PF00069 0.750
MOD_GSK3_1 261 268 PF00069 0.581
MOD_GSK3_1 390 397 PF00069 0.495
MOD_GSK3_1 40 47 PF00069 0.761
MOD_GSK3_1 510 517 PF00069 0.444
MOD_GSK3_1 724 731 PF00069 0.691
MOD_GSK3_1 98 105 PF00069 0.683
MOD_N-GLC_1 501 506 PF02516 0.495
MOD_N-GLC_1 600 605 PF02516 0.495
MOD_N-GLC_1 722 727 PF02516 0.575
MOD_N-GLC_2 163 165 PF02516 0.660
MOD_NEK2_1 1 6 PF00069 0.756
MOD_NEK2_1 120 125 PF00069 0.715
MOD_NEK2_1 157 162 PF00069 0.651
MOD_NEK2_1 390 395 PF00069 0.495
MOD_NEK2_1 471 476 PF00069 0.495
MOD_PIKK_1 398 404 PF00454 0.495
MOD_PIKK_1 40 46 PF00454 0.760
MOD_PIKK_1 703 709 PF00454 0.795
MOD_PKA_1 394 400 PF00069 0.495
MOD_PKA_2 118 124 PF00069 0.737
MOD_PKA_2 394 400 PF00069 0.495
MOD_PKA_2 546 552 PF00069 0.495
MOD_PKA_2 614 620 PF00069 0.495
MOD_PKA_2 661 667 PF00069 0.320
MOD_PKA_2 736 742 PF00069 0.722
MOD_PKA_2 88 94 PF00069 0.690
MOD_Plk_1 576 582 PF00069 0.495
MOD_Plk_2-3 614 620 PF00069 0.495
MOD_Plk_4 372 378 PF00069 0.495
MOD_Plk_4 471 477 PF00069 0.495
MOD_Plk_4 617 623 PF00069 0.495
MOD_ProDKin_1 10 16 PF00069 0.672
MOD_ProDKin_1 105 111 PF00069 0.694
MOD_ProDKin_1 123 129 PF00069 0.579
MOD_ProDKin_1 331 337 PF00069 0.654
MOD_ProDKin_1 529 535 PF00069 0.495
MOD_ProDKin_1 540 546 PF00069 0.313
MOD_ProDKin_1 588 594 PF00069 0.495
MOD_ProDKin_1 633 639 PF00069 0.495
MOD_ProDKin_1 715 721 PF00069 0.600
MOD_SUMO_for_1 403 406 PF00179 0.495
MOD_SUMO_for_1 491 494 PF00179 0.495
MOD_SUMO_for_1 574 577 PF00179 0.495
TRG_DiLeu_BaEn_1 406 411 PF01217 0.495
TRG_DiLeu_BaEn_2 533 539 PF01217 0.495
TRG_DiLeu_BaEn_2 645 651 PF01217 0.311
TRG_DiLeu_BaLyEn_6 422 427 PF01217 0.495
TRG_DiLeu_BaLyEn_6 504 509 PF01217 0.495
TRG_ENDOCYTIC_2 319 322 PF00928 0.600
TRG_ENDOCYTIC_2 350 353 PF00928 0.544
TRG_ENDOCYTIC_2 448 451 PF00928 0.495
TRG_ENDOCYTIC_2 644 647 PF00928 0.495
TRG_ER_diArg_1 117 120 PF00400 0.772
TRG_ER_diArg_1 330 332 PF00400 0.622
TRG_ER_diArg_1 629 632 PF00400 0.495
TRG_Pf-PMV_PEXEL_1 361 365 PF00026 0.528
TRG_Pf-PMV_PEXEL_1 653 658 PF00026 0.417

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WTA3 Leishmania donovani 99% 100%
A4H7Y7 Leishmania braziliensis 76% 100%
E9AQ15 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9AVG0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
Q4QC19 Leishmania major 31% 100%
Q4QFG6 Leishmania major 94% 100%
Q5U4C9 Mus musculus 36% 100%
Q92630 Homo sapiens 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS