Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger (CCCH type) protein - putative

Species:

Leishmania infantum

UniProt:

A4HWB3_LEIIN

TriTrypDb:

LINF_150006500

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWB3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.675
CLV_NRD_NRD_1	171	173	PF00675	0.671
CLV_NRD_NRD_1	294	296	PF00675	0.745
CLV_NRD_NRD_1	5	7	PF00675	0.511
CLV_NRD_NRD_1	691	693	PF00675	0.603
CLV_NRD_NRD_1	713	715	PF00675	0.633
CLV_NRD_NRD_1	764	766	PF00675	0.679
CLV_NRD_NRD_1	824	826	PF00675	0.579
CLV_PCSK_FUR_1	825	829	PF00082	0.669
CLV_PCSK_KEX2_1	115	117	PF00082	0.780
CLV_PCSK_KEX2_1	171	173	PF00082	0.670
CLV_PCSK_KEX2_1	294	296	PF00082	0.722
CLV_PCSK_KEX2_1	5	7	PF00082	0.511
CLV_PCSK_KEX2_1	690	692	PF00082	0.609
CLV_PCSK_KEX2_1	713	715	PF00082	0.637
CLV_PCSK_KEX2_1	763	765	PF00082	0.683
CLV_PCSK_KEX2_1	827	829	PF00082	0.667
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.779
CLV_PCSK_PC1ET2_1	690	692	PF00082	0.588
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.671
CLV_PCSK_SKI1_1	34	38	PF00082	0.420
CLV_PCSK_SKI1_1	828	832	PF00082	0.671
DEG_APCC_DBOX_1	827	835	PF00400	0.595
DEG_SCF_FBW7_1	446	453	PF00400	0.630
DEG_SCF_TRCP1_1	440	445	PF00400	0.706
DEG_SPOP_SBC_1	283	287	PF00917	0.689
DEG_SPOP_SBC_1	482	486	PF00917	0.583
DEG_SPOP_SBC_1	515	519	PF00917	0.646
DEG_SPOP_SBC_1	526	530	PF00917	0.565
DEG_SPOP_SBC_1	772	776	PF00917	0.619
DOC_CKS1_1	202	207	PF01111	0.625
DOC_CKS1_1	346	351	PF01111	0.657
DOC_CKS1_1	806	811	PF01111	0.614
DOC_PP2B_LxvP_1	175	178	PF13499	0.589
DOC_PP2B_LxvP_1	193	196	PF13499	0.800
DOC_PP2B_LxvP_1	272	275	PF13499	0.545
DOC_PP2B_LxvP_1	679	682	PF13499	0.664
DOC_PP4_FxxP_1	463	466	PF00568	0.605
DOC_USP7_MATH_1	104	108	PF00917	0.610
DOC_USP7_MATH_1	141	145	PF00917	0.727
DOC_USP7_MATH_1	185	189	PF00917	0.588
DOC_USP7_MATH_1	281	285	PF00917	0.690
DOC_USP7_MATH_1	304	308	PF00917	0.613
DOC_USP7_MATH_1	370	374	PF00917	0.610
DOC_USP7_MATH_1	375	379	PF00917	0.607
DOC_USP7_MATH_1	391	395	PF00917	0.578
DOC_USP7_MATH_1	423	427	PF00917	0.619
DOC_USP7_MATH_1	428	432	PF00917	0.591
DOC_USP7_MATH_1	436	440	PF00917	0.585
DOC_USP7_MATH_1	454	458	PF00917	0.528
DOC_USP7_MATH_1	482	486	PF00917	0.628
DOC_USP7_MATH_1	515	519	PF00917	0.633
DOC_USP7_MATH_1	521	525	PF00917	0.678
DOC_USP7_MATH_1	526	530	PF00917	0.733
DOC_USP7_MATH_1	658	662	PF00917	0.633
DOC_USP7_MATH_1	675	679	PF00917	0.551
DOC_USP7_MATH_1	682	686	PF00917	0.598
DOC_USP7_UBL2_3	115	119	PF12436	0.611
DOC_USP7_UBL2_3	719	723	PF12436	0.585
DOC_WW_Pin1_4	105	110	PF00397	0.665
DOC_WW_Pin1_4	201	206	PF00397	0.658
DOC_WW_Pin1_4	345	350	PF00397	0.580
DOC_WW_Pin1_4	363	368	PF00397	0.605
DOC_WW_Pin1_4	424	429	PF00397	0.646
DOC_WW_Pin1_4	442	447	PF00397	0.517
DOC_WW_Pin1_4	469	474	PF00397	0.570
DOC_WW_Pin1_4	608	613	PF00397	0.618
DOC_WW_Pin1_4	626	631	PF00397	0.597
DOC_WW_Pin1_4	72	77	PF00397	0.626
DOC_WW_Pin1_4	757	762	PF00397	0.611
DOC_WW_Pin1_4	805	810	PF00397	0.591
LIG_14-3-3_CanoR_1	319	327	PF00244	0.606
LIG_14-3-3_CanoR_1	429	436	PF00244	0.649
LIG_14-3-3_CanoR_1	589	599	PF00244	0.501
LIG_14-3-3_CanoR_1	825	831	PF00244	0.594
LIG_BIR_III_2	303	307	PF00653	0.640
LIG_BRCT_BRCA1_1	187	191	PF00533	0.564
LIG_BRCT_BRCA1_1	210	214	PF00533	0.611
LIG_BRCT_BRCA1_1	77	81	PF00533	0.649
LIG_deltaCOP1_diTrp_1	580	590	PF00928	0.460
LIG_EVH1_1	175	179	PF00568	0.659
LIG_EVH1_1	272	276	PF00568	0.604
LIG_EVH1_2	464	468	PF00568	0.634
LIG_FHA_1	106	112	PF00498	0.565
LIG_FHA_1	188	194	PF00498	0.691
LIG_FHA_1	294	300	PF00498	0.538
LIG_FHA_1	316	322	PF00498	0.634
LIG_FHA_1	49	55	PF00498	0.684
LIG_FHA_1	515	521	PF00498	0.637
LIG_FHA_1	555	561	PF00498	0.438
LIG_FHA_1	582	588	PF00498	0.450
LIG_FHA_1	635	641	PF00498	0.762
LIG_FHA_1	644	650	PF00498	0.622
LIG_FHA_1	774	780	PF00498	0.630
LIG_FHA_2	339	345	PF00498	0.631
LIG_FHA_2	591	597	PF00498	0.480
LIG_FHA_2	640	646	PF00498	0.620
LIG_FHA_2	833	839	PF00498	0.569
LIG_Integrin_RGD_1	157	159	PF01839	0.711
LIG_LIR_Gen_1	415	424	PF02991	0.624
LIG_LIR_Gen_1	538	548	PF02991	0.530
LIG_LIR_Gen_1	553	563	PF02991	0.455
LIG_LIR_Gen_1	744	749	PF02991	0.423
LIG_LIR_Nem_3	211	217	PF02991	0.598
LIG_LIR_Nem_3	260	266	PF02991	0.670
LIG_LIR_Nem_3	415	419	PF02991	0.616
LIG_LIR_Nem_3	538	544	PF02991	0.536
LIG_LIR_Nem_3	553	558	PF02991	0.462
LIG_LIR_Nem_3	744	748	PF02991	0.415
LIG_LYPXL_yS_3	263	266	PF13949	0.627
LIG_PDZ_Class_2	838	843	PF00595	0.552
LIG_PROFILIN_1	273	279	PF00235	0.541
LIG_Rb_LxCxE_1	732	753	PF01857	0.446
LIG_REV1ctd_RIR_1	20	28	PF16727	0.512
LIG_SH2_CRK	541	545	PF00017	0.502
LIG_SH2_CRK	555	559	PF00017	0.463
LIG_SH2_NCK_1	555	559	PF00017	0.463
LIG_SH2_SRC	232	235	PF00017	0.647
LIG_SH2_SRC	747	750	PF00017	0.468
LIG_SH2_STAT3	647	650	PF00017	0.596
LIG_SH2_STAT5	232	235	PF00017	0.600
LIG_SH2_STAT5	351	354	PF00017	0.736
LIG_SH2_STAT5	555	558	PF00017	0.459
LIG_SH2_STAT5	738	741	PF00017	0.433
LIG_SH2_STAT5	747	750	PF00017	0.440
LIG_SH3_2	708	713	PF14604	0.570
LIG_SH3_3	173	179	PF00018	0.621
LIG_SH3_3	193	199	PF00018	0.587
LIG_SH3_3	200	206	PF00018	0.564
LIG_SH3_3	224	230	PF00018	0.544
LIG_SH3_3	270	276	PF00018	0.575
LIG_SH3_3	343	349	PF00018	0.581
LIG_SH3_3	376	382	PF00018	0.662
LIG_SH3_3	387	393	PF00018	0.557
LIG_SH3_3	705	711	PF00018	0.563
LIG_SH3_3	743	749	PF00018	0.440
LIG_SH3_3	776	782	PF00018	0.601
LIG_SUMO_SIM_par_1	284	293	PF11976	0.550
LIG_SUMO_SIM_par_1	474	479	PF11976	0.543
LIG_SUMO_SIM_par_1	661	667	PF11976	0.638
LIG_TRAF2_1	530	533	PF00917	0.640
LIG_TRAF2_1	835	838	PF00917	0.606
LIG_WRC_WIRS_1	19	24	PF05994	0.432
LIG_WW_2	178	181	PF00397	0.557
LIG_WW_2	198	201	PF00397	0.599
MOD_CDK_SPK_2	424	429	PF00069	0.600
MOD_CDK_SPxK_1	757	763	PF00069	0.671
MOD_CDK_SPxxK_3	757	764	PF00069	0.672
MOD_CK1_1	105	111	PF00069	0.695
MOD_CK1_1	122	128	PF00069	0.582
MOD_CK1_1	129	135	PF00069	0.605
MOD_CK1_1	18	24	PF00069	0.429
MOD_CK1_1	262	268	PF00069	0.669
MOD_CK1_1	284	290	PF00069	0.599
MOD_CK1_1	323	329	PF00069	0.644
MOD_CK1_1	431	437	PF00069	0.620
MOD_CK1_1	438	444	PF00069	0.638
MOD_CK1_1	484	490	PF00069	0.596
MOD_CK1_1	495	501	PF00069	0.639
MOD_CK1_1	519	525	PF00069	0.649
MOD_CK1_1	553	559	PF00069	0.476
MOD_CK1_1	568	574	PF00069	0.541
MOD_CK1_1	651	657	PF00069	0.726
MOD_CK1_1	684	690	PF00069	0.723
MOD_CK1_1	75	81	PF00069	0.660
MOD_CK1_1	750	756	PF00069	0.641
MOD_CK1_1	802	808	PF00069	0.709
MOD_CK2_1	362	368	PF00069	0.760
MOD_CK2_1	526	532	PF00069	0.680
MOD_CK2_1	567	573	PF00069	0.546
MOD_CK2_1	590	596	PF00069	0.464
MOD_CK2_1	639	645	PF00069	0.695
MOD_CK2_1	682	688	PF00069	0.639
MOD_CK2_1	826	832	PF00069	0.668
MOD_Cter_Amidation	761	764	PF01082	0.678
MOD_Cter_Amidation	823	826	PF01082	0.576
MOD_GlcNHglycan	103	107	PF01048	0.587
MOD_GlcNHglycan	126	129	PF01048	0.632
MOD_GlcNHglycan	131	134	PF01048	0.631
MOD_GlcNHglycan	143	146	PF01048	0.657
MOD_GlcNHglycan	147	150	PF01048	0.794
MOD_GlcNHglycan	151	154	PF01048	0.585
MOD_GlcNHglycan	210	213	PF01048	0.645
MOD_GlcNHglycan	241	244	PF01048	0.645
MOD_GlcNHglycan	286	289	PF01048	0.683
MOD_GlcNHglycan	338	341	PF01048	0.614
MOD_GlcNHglycan	393	396	PF01048	0.581
MOD_GlcNHglycan	440	443	PF01048	0.745
MOD_GlcNHglycan	456	459	PF01048	0.536
MOD_GlcNHglycan	490	493	PF01048	0.637
MOD_GlcNHglycan	523	526	PF01048	0.647
MOD_GlcNHglycan	537	540	PF01048	0.731
MOD_GlcNHglycan	545	548	PF01048	0.523
MOD_GlcNHglycan	567	570	PF01048	0.541
MOD_GlcNHglycan	684	687	PF01048	0.610
MOD_GlcNHglycan	731	734	PF01048	0.461
MOD_GlcNHglycan	749	752	PF01048	0.513
MOD_GlcNHglycan	86	89	PF01048	0.587
MOD_GSK3_1	10	17	PF00069	0.448
MOD_GSK3_1	115	122	PF00069	0.673
MOD_GSK3_1	123	130	PF00069	0.584
MOD_GSK3_1	141	148	PF00069	0.568
MOD_GSK3_1	18	25	PF00069	0.428
MOD_GSK3_1	187	194	PF00069	0.624
MOD_GSK3_1	204	211	PF00069	0.601
MOD_GSK3_1	258	265	PF00069	0.664
MOD_GSK3_1	279	286	PF00069	0.710
MOD_GSK3_1	323	330	PF00069	0.641
MOD_GSK3_1	400	407	PF00069	0.631
MOD_GSK3_1	408	415	PF00069	0.543
MOD_GSK3_1	424	431	PF00069	0.623
MOD_GSK3_1	438	445	PF00069	0.590
MOD_GSK3_1	446	453	PF00069	0.778
MOD_GSK3_1	484	491	PF00069	0.627
MOD_GSK3_1	515	522	PF00069	0.658
MOD_GSK3_1	550	557	PF00069	0.469
MOD_GSK3_1	618	625	PF00069	0.606
MOD_GSK3_1	626	633	PF00069	0.578
MOD_GSK3_1	639	646	PF00069	0.731
MOD_GSK3_1	66	73	PF00069	0.626
MOD_GSK3_1	771	778	PF00069	0.590
MOD_GSK3_1	80	87	PF00069	0.772
MOD_N-GLC_1	336	341	PF02516	0.673
MOD_N-GLC_1	363	368	PF02516	0.658
MOD_N-GLC_1	526	531	PF02516	0.565
MOD_N-GLC_1	675	680	PF02516	0.627
MOD_NEK2_1	123	128	PF00069	0.658
MOD_NEK2_1	191	196	PF00069	0.714
MOD_NEK2_1	257	262	PF00069	0.669
MOD_NEK2_1	290	295	PF00069	0.575
MOD_NEK2_1	327	332	PF00069	0.607
MOD_NEK2_1	362	367	PF00069	0.630
MOD_NEK2_1	483	488	PF00069	0.631
MOD_NEK2_1	501	506	PF00069	0.514
MOD_NEK2_1	516	521	PF00069	0.525
MOD_NEK2_1	581	586	PF00069	0.453
MOD_NEK2_1	634	639	PF00069	0.493
MOD_NEK2_1	649	654	PF00069	0.468
MOD_NEK2_1	722	727	PF00069	0.532
MOD_NEK2_2	789	794	PF00069	0.543
MOD_PIKK_1	370	376	PF00454	0.634
MOD_PIKK_1	706	712	PF00454	0.693
MOD_PIKK_1	799	805	PF00454	0.618
MOD_PK_1	826	832	PF00069	0.592
MOD_PKA_1	115	121	PF00069	0.639
MOD_PKA_1	826	832	PF00069	0.592
MOD_PKA_2	115	121	PF00069	0.644
MOD_PKA_2	293	299	PF00069	0.538
MOD_PKA_2	428	434	PF00069	0.656
MOD_PKA_2	495	501	PF00069	0.572
MOD_PKB_1	313	321	PF00069	0.632
MOD_Plk_1	675	681	PF00069	0.628
MOD_Plk_2-3	832	838	PF00069	0.576
MOD_Plk_4	18	24	PF00069	0.431
MOD_Plk_4	401	407	PF00069	0.572
MOD_Plk_4	501	507	PF00069	0.650
MOD_Plk_4	66	72	PF00069	0.634
MOD_Plk_4	741	747	PF00069	0.485
MOD_ProDKin_1	105	111	PF00069	0.665
MOD_ProDKin_1	201	207	PF00069	0.662
MOD_ProDKin_1	345	351	PF00069	0.582
MOD_ProDKin_1	363	369	PF00069	0.606
MOD_ProDKin_1	424	430	PF00069	0.647
MOD_ProDKin_1	442	448	PF00069	0.516
MOD_ProDKin_1	469	475	PF00069	0.568
MOD_ProDKin_1	608	614	PF00069	0.617
MOD_ProDKin_1	626	632	PF00069	0.594
MOD_ProDKin_1	72	78	PF00069	0.626
MOD_ProDKin_1	757	763	PF00069	0.614
MOD_ProDKin_1	805	811	PF00069	0.592
MOD_SUMO_rev_2	41	51	PF00179	0.610
MOD_SUMO_rev_2	784	789	PF00179	0.606
TRG_DiLeu_BaEn_2	740	746	PF01217	0.448
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.621
TRG_ENDOCYTIC_2	219	222	PF00928	0.614
TRG_ENDOCYTIC_2	263	266	PF00928	0.675
TRG_ENDOCYTIC_2	353	356	PF00928	0.588
TRG_ENDOCYTIC_2	541	544	PF00928	0.511
TRG_ENDOCYTIC_2	555	558	PF00928	0.459
TRG_ER_diArg_1	691	693	PF00400	0.676
TRG_ER_diArg_1	763	765	PF00400	0.635
TRG_NLS_MonoCore_2	824	829	PF00514	0.616
TRG_NLS_MonoExtC_3	114	119	PF00514	0.625
TRG_NLS_MonoExtN_4	115	120	PF00514	0.586
TRG_NLS_MonoExtN_4	823	830	PF00514	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y8	Leptomonas seymouri	41%	100%
A0A3Q8I906	Leishmania donovani	99%	100%
A4H7Y5	Leishmania braziliensis	61%	95%
E9AQ13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QFG8	Leishmania major	90%	99%