Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWB2_LEIIN

TriTrypDb:

LINF_150006400

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.793
CLV_C14_Caspase3-7	29	33	PF00656	0.604
CLV_NRD_NRD_1	81	83	PF00675	0.503
CLV_PCSK_FUR_1	79	83	PF00082	0.514
CLV_PCSK_KEX2_1	81	83	PF00082	0.498
CLV_PCSK_SKI1_1	155	159	PF00082	0.554
DEG_SPOP_SBC_1	130	134	PF00917	0.785
DEG_SPOP_SBC_1	173	177	PF00917	0.673
DOC_CKS1_1	156	161	PF01111	0.556
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.684
DOC_MAPK_DCC_7	155	165	PF00069	0.615
DOC_PP4_FxxP_1	141	144	PF00568	0.741
DOC_PP4_FxxP_1	96	99	PF00568	0.592
DOC_USP7_MATH_1	130	134	PF00917	0.649
DOC_USP7_MATH_1	136	140	PF00917	0.629
DOC_USP7_MATH_1	171	175	PF00917	0.707
DOC_WW_Pin1_4	155	160	PF00397	0.556
LIG_14-3-3_CanoR_1	65	69	PF00244	0.705
LIG_Actin_WH2_2	61	76	PF00022	0.744
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BIR_III_3	1	5	PF00653	0.678
LIG_FHA_1	112	118	PF00498	0.780
LIG_LIR_Apic_2	139	144	PF02991	0.649
LIG_LIR_Gen_1	143	154	PF02991	0.729
LIG_LIR_Gen_1	15	24	PF02991	0.613
LIG_LIR_Gen_1	26	35	PF02991	0.380
LIG_LIR_Nem_3	143	149	PF02991	0.736
LIG_LIR_Nem_3	15	20	PF02991	0.612
LIG_LIR_Nem_3	26	30	PF02991	0.367
LIG_SH2_PTP2	146	149	PF00017	0.729
LIG_SH2_STAT5	146	149	PF00017	0.729
LIG_SH2_STAT5	8	11	PF00017	0.545
LIG_SH2_STAT5	84	87	PF00017	0.543
LIG_SUMO_SIM_par_1	161	167	PF11976	0.626
LIG_TRFH_1	96	100	PF08558	0.598
LIG_WRC_WIRS_1	138	143	PF05994	0.748
LIG_WRC_WIRS_1	24	29	PF05994	0.692
MOD_CK1_1	134	140	PF00069	0.720
MOD_CK1_1	164	170	PF00069	0.618
MOD_CK1_1	172	178	PF00069	0.558
MOD_CK1_1	49	55	PF00069	0.639
MOD_CK2_1	117	123	PF00069	0.698
MOD_CK2_1	137	143	PF00069	0.667
MOD_CK2_1	23	29	PF00069	0.693
MOD_CK2_1	38	44	PF00069	0.538
MOD_CK2_1	52	58	PF00069	0.678
MOD_GlcNHglycan	119	122	PF01048	0.800
MOD_GlcNHglycan	171	174	PF01048	0.567
MOD_GSK3_1	130	137	PF00069	0.734
MOD_GSK3_1	169	176	PF00069	0.641
MOD_GSK3_1	34	41	PF00069	0.654
MOD_GSK3_1	45	52	PF00069	0.624
MOD_N-GLC_1	49	54	PF02516	0.691
MOD_NEK2_1	117	122	PF00069	0.689
MOD_NEK2_1	145	150	PF00069	0.615
MOD_NEK2_2	2	7	PF00069	0.669
MOD_PKA_2	64	70	PF00069	0.703
MOD_Plk_4	23	29	PF00069	0.596
MOD_ProDKin_1	155	161	PF00069	0.558
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.610
TRG_ENDOCYTIC_2	146	149	PF00928	0.729
TRG_ER_diArg_1	79	82	PF00400	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXC4	Leptomonas seymouri	41%	99%
A0A3Q8IDA8	Leishmania donovani	99%	100%
E9AQ12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QFG9	Leishmania major	87%	100%