Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWA8_LEIIN

TriTrypDb:

LINF_150006000

Length:

797

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HWA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.613
CLV_NRD_NRD_1	105	107	PF00675	0.745
CLV_NRD_NRD_1	231	233	PF00675	0.693
CLV_NRD_NRD_1	257	259	PF00675	0.439
CLV_NRD_NRD_1	387	389	PF00675	0.474
CLV_NRD_NRD_1	526	528	PF00675	0.366
CLV_NRD_NRD_1	759	761	PF00675	0.474
CLV_NRD_NRD_1	777	779	PF00675	0.542
CLV_PCSK_FUR_1	106	110	PF00082	0.534
CLV_PCSK_FUR_1	385	389	PF00082	0.544
CLV_PCSK_KEX2_1	105	107	PF00082	0.749
CLV_PCSK_KEX2_1	108	110	PF00082	0.702
CLV_PCSK_KEX2_1	257	259	PF00082	0.445
CLV_PCSK_KEX2_1	387	389	PF00082	0.448
CLV_PCSK_KEX2_1	526	528	PF00082	0.402
CLV_PCSK_KEX2_1	692	694	PF00082	0.687
CLV_PCSK_KEX2_1	759	761	PF00082	0.474
CLV_PCSK_KEX2_1	777	779	PF00082	0.542
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.633
CLV_PCSK_PC1ET2_1	692	694	PF00082	0.687
CLV_PCSK_SKI1_1	232	236	PF00082	0.748
CLV_PCSK_SKI1_1	388	392	PF00082	0.447
CLV_PCSK_SKI1_1	576	580	PF00082	0.526
CLV_PCSK_SKI1_1	616	620	PF00082	0.445
CLV_PCSK_SKI1_1	78	82	PF00082	0.547
CLV_Separin_Metazoa	774	778	PF03568	0.573
DEG_APCC_DBOX_1	306	314	PF00400	0.470
DEG_APCC_DBOX_1	615	623	PF00400	0.455
DEG_MDM2_SWIB_1	295	302	PF02201	0.510
DEG_Nend_UBRbox_1	1	4	PF02207	0.764
DEG_SCF_FBW7_1	555	562	PF00400	0.607
DEG_SCF_FBW7_1	577	583	PF00400	0.467
DOC_CKS1_1	380	385	PF01111	0.571
DOC_CKS1_1	577	582	PF01111	0.473
DOC_CYCLIN_RxL_1	613	623	PF00134	0.571
DOC_MAPK_HePTP_8	635	647	PF00069	0.556
DOC_MAPK_MEF2A_6	638	647	PF00069	0.529
DOC_PP1_RVXF_1	416	423	PF00149	0.463
DOC_PP1_RVXF_1	552	558	PF00149	0.543
DOC_PP2B_LxvP_1	511	514	PF13499	0.436
DOC_PP4_FxxP_1	393	396	PF00568	0.440
DOC_PP4_FxxP_1	735	738	PF00568	0.613
DOC_USP7_MATH_1	140	144	PF00917	0.547
DOC_USP7_MATH_1	224	228	PF00917	0.745
DOC_USP7_MATH_1	27	31	PF00917	0.610
DOC_USP7_MATH_1	326	330	PF00917	0.696
DOC_USP7_MATH_1	356	360	PF00917	0.698
DOC_USP7_MATH_1	364	368	PF00917	0.677
DOC_USP7_MATH_1	547	551	PF00917	0.487
DOC_USP7_MATH_1	580	584	PF00917	0.519
DOC_USP7_MATH_1	596	600	PF00917	0.330
DOC_USP7_MATH_1	705	709	PF00917	0.602
DOC_USP7_MATH_1	782	786	PF00917	0.595
DOC_USP7_MATH_1	88	92	PF00917	0.741
DOC_USP7_UBL2_3	686	690	PF12436	0.716
DOC_WW_Pin1_4	359	364	PF00397	0.732
DOC_WW_Pin1_4	379	384	PF00397	0.523
DOC_WW_Pin1_4	426	431	PF00397	0.455
DOC_WW_Pin1_4	450	455	PF00397	0.425
DOC_WW_Pin1_4	543	548	PF00397	0.492
DOC_WW_Pin1_4	555	560	PF00397	0.469
DOC_WW_Pin1_4	568	573	PF00397	0.322
DOC_WW_Pin1_4	576	581	PF00397	0.425
DOC_WW_Pin1_4	675	680	PF00397	0.692
DOC_WW_Pin1_4	734	739	PF00397	0.624
DOC_WW_Pin1_4	90	95	PF00397	0.719
LIG_14-3-3_CanoR_1	167	175	PF00244	0.455
LIG_14-3-3_CanoR_1	323	331	PF00244	0.636
LIG_14-3-3_CanoR_1	616	622	PF00244	0.525
LIG_14-3-3_CanoR_1	78	83	PF00244	0.687
LIG_Actin_WH2_2	271	289	PF00022	0.465
LIG_Actin_WH2_2	310	325	PF00022	0.564
LIG_AP2alpha_2	159	161	PF02296	0.505
LIG_BRCT_BRCA1_1	533	537	PF00533	0.503
LIG_CaM_IQ_9	711	727	PF13499	0.519
LIG_CtBP_PxDLS_1	482	486	PF00389	0.521
LIG_deltaCOP1_diTrp_1	296	299	PF00928	0.439
LIG_deltaCOP1_diTrp_1	494	497	PF00928	0.561
LIG_FHA_1	188	194	PF00498	0.455
LIG_FHA_1	209	215	PF00498	0.700
LIG_FHA_1	395	401	PF00498	0.463
LIG_FHA_1	464	470	PF00498	0.437
LIG_FHA_1	486	492	PF00498	0.562
LIG_FHA_1	506	512	PF00498	0.390
LIG_FHA_1	544	550	PF00498	0.424
LIG_FHA_1	589	595	PF00498	0.453
LIG_FHA_1	613	619	PF00498	0.529
LIG_FHA_1	712	718	PF00498	0.647
LIG_FHA_1	763	769	PF00498	0.544
LIG_FHA_1	84	90	PF00498	0.783
LIG_FHA_2	112	118	PF00498	0.643
LIG_FHA_2	478	484	PF00498	0.458
LIG_FHA_2	502	508	PF00498	0.476
LIG_LIR_Gen_1	148	158	PF02991	0.574
LIG_LIR_Gen_1	266	275	PF02991	0.496
LIG_LIR_Gen_1	296	304	PF02991	0.419
LIG_LIR_Gen_1	374	383	PF02991	0.530
LIG_LIR_Gen_1	453	464	PF02991	0.412
LIG_LIR_Gen_1	531	540	PF02991	0.522
LIG_LIR_Gen_1	591	596	PF02991	0.393
LIG_LIR_Nem_3	113	119	PF02991	0.612
LIG_LIR_Nem_3	148	153	PF02991	0.529
LIG_LIR_Nem_3	159	164	PF02991	0.427
LIG_LIR_Nem_3	296	302	PF02991	0.421
LIG_LIR_Nem_3	374	379	PF02991	0.542
LIG_LIR_Nem_3	389	393	PF02991	0.411
LIG_LIR_Nem_3	429	435	PF02991	0.374
LIG_LIR_Nem_3	453	459	PF02991	0.396
LIG_LIR_Nem_3	531	536	PF02991	0.587
LIG_LIR_Nem_3	542	548	PF02991	0.392
LIG_LIR_Nem_3	644	649	PF02991	0.410
LIG_MAD2	418	426	PF02301	0.384
LIG_MYND_1	426	430	PF01753	0.523
LIG_NRBOX	617	623	PF00104	0.353
LIG_Pex14_2	295	299	PF04695	0.490
LIG_SH2_CRK	533	537	PF00017	0.569
LIG_SH2_NCK_1	116	120	PF00017	0.598
LIG_SH2_NCK_1	533	537	PF00017	0.503
LIG_SH2_PTP2	519	522	PF00017	0.467
LIG_SH2_SRC	116	119	PF00017	0.510
LIG_SH2_STAP1	533	537	PF00017	0.575
LIG_SH2_STAP1	551	555	PF00017	0.506
LIG_SH2_STAP1	62	66	PF00017	0.558
LIG_SH2_STAT3	435	438	PF00017	0.469
LIG_SH2_STAT5	309	312	PF00017	0.364
LIG_SH2_STAT5	398	401	PF00017	0.395
LIG_SH2_STAT5	456	459	PF00017	0.381
LIG_SH2_STAT5	519	522	PF00017	0.403
LIG_SH2_STAT5	569	572	PF00017	0.447
LIG_SH2_STAT5	65	68	PF00017	0.552
LIG_SH2_STAT5	786	789	PF00017	0.567
LIG_SH3_2	380	385	PF14604	0.571
LIG_SH3_2	405	410	PF14604	0.571
LIG_SH3_3	190	196	PF00018	0.515
LIG_SH3_3	209	215	PF00018	0.670
LIG_SH3_3	240	246	PF00018	0.596
LIG_SH3_3	377	383	PF00018	0.534
LIG_SH3_3	402	408	PF00018	0.501
LIG_SH3_3	560	566	PF00018	0.484
LIG_SH3_3	740	746	PF00018	0.561
LIG_Sin3_3	409	416	PF02671	0.568
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.658
LIG_SUMO_SIM_anti_2	617	623	PF11976	0.574
LIG_SUMO_SIM_par_1	250	256	PF11976	0.528
LIG_SUMO_SIM_par_1	300	305	PF11976	0.530
LIG_SUMO_SIM_par_1	309	314	PF11976	0.511
LIG_SUMO_SIM_par_1	617	623	PF11976	0.552
LIG_TRAF2_1	290	293	PF00917	0.510
LIG_TRFH_1	376	380	PF08558	0.391
LIG_TYR_ITSM	112	119	PF00017	0.630
LIG_WRC_WIRS_1	456	461	PF05994	0.502
LIG_WRC_WIRS_1	621	626	PF05994	0.462
MOD_CDK_SPxK_1	379	385	PF00069	0.573
MOD_CDK_SPxxK_3	90	97	PF00069	0.670
MOD_CK1_1	145	151	PF00069	0.610
MOD_CK1_1	187	193	PF00069	0.544
MOD_CK1_1	29	35	PF00069	0.677
MOD_CK1_1	324	330	PF00069	0.720
MOD_CK1_1	359	365	PF00069	0.704
MOD_CK1_1	441	447	PF00069	0.489
MOD_CK1_1	455	461	PF00069	0.304
MOD_CK1_1	503	509	PF00069	0.545
MOD_CK1_1	620	626	PF00069	0.505
MOD_CK1_1	660	666	PF00069	0.628
MOD_CK1_1	708	714	PF00069	0.491
MOD_CK2_1	38	44	PF00069	0.633
MOD_CK2_1	462	468	PF00069	0.522
MOD_CK2_1	477	483	PF00069	0.354
MOD_CK2_1	701	707	PF00069	0.631
MOD_Cter_Amidation	103	106	PF01082	0.763
MOD_GlcNHglycan	149	153	PF01048	0.463
MOD_GlcNHglycan	215	218	PF01048	0.677
MOD_GlcNHglycan	312	316	PF01048	0.435
MOD_GlcNHglycan	324	327	PF01048	0.687
MOD_GlcNHglycan	366	369	PF01048	0.770
MOD_GlcNHglycan	445	448	PF01048	0.477
MOD_GlcNHglycan	450	453	PF01048	0.520
MOD_GlcNHglycan	533	536	PF01048	0.593
MOD_GlcNHglycan	638	641	PF01048	0.441
MOD_GlcNHglycan	694	698	PF01048	0.680
MOD_GlcNHglycan	703	706	PF01048	0.603
MOD_GSK3_1	162	169	PF00069	0.447
MOD_GSK3_1	187	194	PF00069	0.547
MOD_GSK3_1	22	29	PF00069	0.707
MOD_GSK3_1	311	318	PF00069	0.522
MOD_GSK3_1	322	329	PF00069	0.665
MOD_GSK3_1	448	455	PF00069	0.399
MOD_GSK3_1	501	508	PF00069	0.437
MOD_GSK3_1	531	538	PF00069	0.503
MOD_GSK3_1	543	550	PF00069	0.404
MOD_GSK3_1	555	562	PF00069	0.621
MOD_GSK3_1	576	583	PF00069	0.502
MOD_GSK3_1	671	678	PF00069	0.671
MOD_GSK3_1	701	708	PF00069	0.556
MOD_GSK3_1	74	81	PF00069	0.589
MOD_LATS_1	498	504	PF00433	0.463
MOD_N-GLC_1	372	377	PF02516	0.593
MOD_NEK2_1	162	167	PF00069	0.529
MOD_NEK2_1	191	196	PF00069	0.613
MOD_NEK2_1	271	276	PF00069	0.526
MOD_NEK2_1	295	300	PF00069	0.545
MOD_NEK2_1	31	36	PF00069	0.607
MOD_NEK2_1	322	327	PF00069	0.551
MOD_NEK2_1	391	396	PF00069	0.426
MOD_NEK2_1	399	404	PF00069	0.376
MOD_NEK2_1	412	417	PF00069	0.437
MOD_NEK2_1	448	453	PF00069	0.515
MOD_NEK2_1	485	490	PF00069	0.561
MOD_NEK2_1	509	514	PF00069	0.470
MOD_NEK2_1	89	94	PF00069	0.749
MOD_NEK2_2	38	43	PF00069	0.656
MOD_NEK2_2	474	479	PF00069	0.444
MOD_OFUCOSY	593	598	PF10250	0.514
MOD_PIKK_1	168	174	PF00454	0.420
MOD_PIKK_1	356	362	PF00454	0.804
MOD_PIKK_1	483	489	PF00454	0.596
MOD_PIKK_1	580	586	PF00454	0.480
MOD_PIKK_1	657	663	PF00454	0.677
MOD_PIKK_1	705	711	PF00454	0.638
MOD_PKA_2	166	172	PF00069	0.453
MOD_PKA_2	224	230	PF00069	0.693
MOD_PKA_2	322	328	PF00069	0.626
MOD_PKA_2	74	80	PF00069	0.664
MOD_Plk_1	112	118	PF00069	0.593
MOD_Plk_1	148	154	PF00069	0.542
MOD_Plk_1	295	301	PF00069	0.522
MOD_Plk_1	372	378	PF00069	0.497
MOD_Plk_1	752	758	PF00069	0.586
MOD_Plk_4	31	37	PF00069	0.668
MOD_Plk_4	38	44	PF00069	0.575
MOD_Plk_4	394	400	PF00069	0.432
MOD_Plk_4	452	458	PF00069	0.529
MOD_Plk_4	617	623	PF00069	0.505
MOD_Plk_4	782	788	PF00069	0.553
MOD_ProDKin_1	359	365	PF00069	0.733
MOD_ProDKin_1	379	385	PF00069	0.526
MOD_ProDKin_1	426	432	PF00069	0.454
MOD_ProDKin_1	450	456	PF00069	0.424
MOD_ProDKin_1	543	549	PF00069	0.488
MOD_ProDKin_1	555	561	PF00069	0.478
MOD_ProDKin_1	568	574	PF00069	0.321
MOD_ProDKin_1	576	582	PF00069	0.426
MOD_ProDKin_1	675	681	PF00069	0.693
MOD_ProDKin_1	734	740	PF00069	0.621
MOD_ProDKin_1	90	96	PF00069	0.718
TRG_DiLeu_BaEn_1	374	379	PF01217	0.601
TRG_DiLeu_BaEn_2	730	736	PF01217	0.557
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.569
TRG_DiLeu_BaLyEn_6	573	578	PF01217	0.524
TRG_ENDOCYTIC_2	116	119	PF00928	0.588
TRG_ENDOCYTIC_2	182	185	PF00928	0.346
TRG_ENDOCYTIC_2	268	271	PF00928	0.417
TRG_ENDOCYTIC_2	456	459	PF00928	0.384
TRG_ENDOCYTIC_2	518	521	PF00928	0.376
TRG_ENDOCYTIC_2	533	536	PF00928	0.490
TRG_ER_diArg_1	385	388	PF00400	0.483
TRG_ER_diArg_1	424	427	PF00400	0.540
TRG_ER_diArg_1	526	529	PF00400	0.457
TRG_ER_diArg_1	758	760	PF00400	0.472
TRG_ER_diArg_1	776	778	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR8	Leptomonas seymouri	50%	98%
A0A0S4KHH2	Bodo saltans	29%	92%
A0A1X0NTL8	Trypanosomatidae	40%	100%
A0A3Q8IA12	Leishmania donovani	100%	100%
A0A422NS84	Trypanosoma rangeli	37%	100%
A4H7Y1	Leishmania braziliensis	74%	100%
C9ZNU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AQ08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QFH3	Leishmania major	93%	100%
V5AWK1	Trypanosoma cruzi	35%	96%