Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWA4_LEIIN

TriTrypDb:

LINF_150005600

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.519
CLV_C14_Caspase3-7	93	97	PF00656	0.459
CLV_MEL_PAP_1	121	127	PF00089	0.506
CLV_NRD_NRD_1	183	185	PF00675	0.743
CLV_NRD_NRD_1	284	286	PF00675	0.547
CLV_NRD_NRD_1	34	36	PF00675	0.456
CLV_NRD_NRD_1	354	356	PF00675	0.526
CLV_NRD_NRD_1	426	428	PF00675	0.500
CLV_PCSK_FUR_1	181	185	PF00082	0.615
CLV_PCSK_KEX2_1	183	185	PF00082	0.725
CLV_PCSK_KEX2_1	284	286	PF00082	0.542
CLV_PCSK_KEX2_1	34	36	PF00082	0.456
CLV_PCSK_KEX2_1	354	356	PF00082	0.526
CLV_PCSK_KEX2_1	426	428	PF00082	0.482
CLV_PCSK_PC7_1	350	356	PF00082	0.496
DEG_APCC_DBOX_1	123	131	PF00400	0.514
DEG_APCC_DBOX_1	425	433	PF00400	0.360
DOC_CYCLIN_RxL_1	390	401	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.547
DOC_MAPK_gen_1	354	361	PF00069	0.546
DOC_USP7_MATH_1	165	169	PF00917	0.653
DOC_USP7_MATH_1	172	176	PF00917	0.739
DOC_USP7_MATH_1	190	194	PF00917	0.749
DOC_USP7_MATH_1	198	202	PF00917	0.791
DOC_USP7_MATH_1	2	6	PF00917	0.529
DOC_USP7_MATH_1	219	223	PF00917	0.692
DOC_USP7_MATH_1	237	241	PF00917	0.594
DOC_USP7_MATH_1	461	465	PF00917	0.736
DOC_WW_Pin1_4	144	149	PF00397	0.749
DOC_WW_Pin1_4	161	166	PF00397	0.715
DOC_WW_Pin1_4	168	173	PF00397	0.784
DOC_WW_Pin1_4	210	215	PF00397	0.643
DOC_WW_Pin1_4	449	454	PF00397	0.513
LIG_14-3-3_CanoR_1	124	128	PF00244	0.522
LIG_14-3-3_CanoR_1	157	166	PF00244	0.633
LIG_14-3-3_CanoR_1	224	233	PF00244	0.737
LIG_14-3-3_CanoR_1	236	242	PF00244	0.572
LIG_14-3-3_CanoR_1	34	42	PF00244	0.435
LIG_eIF4E_1	443	449	PF01652	0.440
LIG_EVH1_1	414	418	PF00568	0.516
LIG_FHA_1	14	20	PF00498	0.528
LIG_FHA_1	153	159	PF00498	0.583
LIG_FHA_1	215	221	PF00498	0.587
LIG_FHA_1	256	262	PF00498	0.555
LIG_FHA_1	59	65	PF00498	0.678
LIG_FHA_2	240	246	PF00498	0.502
LIG_FHA_2	27	33	PF00498	0.398
LIG_FHA_2	71	77	PF00498	0.517
LIG_FHA_2	91	97	PF00498	0.316
LIG_IBAR_NPY_1	264	266	PF08397	0.552
LIG_LIR_Gen_1	90	95	PF02991	0.504
LIG_LIR_Nem_3	419	425	PF02991	0.513
LIG_LIR_Nem_3	90	94	PF02991	0.502
LIG_RPA_C_Fungi	350	362	PF08784	0.612
LIG_SH2_NCK_1	443	447	PF00017	0.433
LIG_SH2_STAP1	102	106	PF00017	0.486
LIG_SH2_STAT5	44	47	PF00017	0.546
LIG_SH3_3	109	115	PF00018	0.506
LIG_SH3_3	142	148	PF00018	0.609
LIG_SH3_3	179	185	PF00018	0.760
LIG_SH3_3	213	219	PF00018	0.606
LIG_SH3_3	410	416	PF00018	0.602
LIG_SH3_3	450	456	PF00018	0.531
LIG_SH3_3	61	67	PF00018	0.624
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.449
LIG_SUMO_SIM_par_1	444	452	PF11976	0.481
LIG_TRAF2_1	385	388	PF00917	0.628
LIG_TRAF2_1	398	401	PF00917	0.486
LIG_TRAF2_1	83	86	PF00917	0.621
LIG_WRC_WIRS_1	88	93	PF05994	0.450
MOD_CK1_1	164	170	PF00069	0.779
MOD_CK1_1	193	199	PF00069	0.722
MOD_CK1_1	223	229	PF00069	0.650
MOD_CK1_1	244	250	PF00069	0.619
MOD_CK1_1	46	52	PF00069	0.497
MOD_CK2_1	123	129	PF00069	0.672
MOD_CK2_1	144	150	PF00069	0.747
MOD_CK2_1	239	245	PF00069	0.515
MOD_CK2_1	341	347	PF00069	0.479
MOD_CK2_1	461	467	PF00069	0.616
MOD_CK2_1	72	78	PF00069	0.429
MOD_GlcNHglycan	108	111	PF01048	0.522
MOD_GlcNHglycan	159	162	PF01048	0.664
MOD_GlcNHglycan	200	203	PF01048	0.699
MOD_GlcNHglycan	254	258	PF01048	0.551
MOD_GlcNHglycan	422	425	PF01048	0.498
MOD_GlcNHglycan	444	447	PF01048	0.499
MOD_GlcNHglycan	49	52	PF01048	0.467
MOD_GSK3_1	13	20	PF00069	0.452
MOD_GSK3_1	152	159	PF00069	0.689
MOD_GSK3_1	161	168	PF00069	0.628
MOD_GSK3_1	172	179	PF00069	0.772
MOD_GSK3_1	190	197	PF00069	0.690
MOD_GSK3_1	210	217	PF00069	0.756
MOD_GSK3_1	219	226	PF00069	0.595
MOD_GSK3_1	237	244	PF00069	0.681
MOD_GSK3_1	374	381	PF00069	0.529
MOD_GSK3_1	43	50	PF00069	0.465
MOD_GSK3_1	72	79	PF00069	0.672
MOD_NEK2_1	13	18	PF00069	0.423
MOD_NEK2_1	220	225	PF00069	0.590
MOD_PIKK_1	176	182	PF00454	0.617
MOD_PKA_1	34	40	PF00069	0.402
MOD_PKA_2	123	129	PF00069	0.586
MOD_PKA_2	156	162	PF00069	0.675
MOD_PKA_2	191	197	PF00069	0.726
MOD_PKA_2	208	214	PF00069	0.733
MOD_PKA_2	223	229	PF00069	0.717
MOD_PKA_2	34	40	PF00069	0.483
MOD_PKA_2	374	380	PF00069	0.592
MOD_Plk_1	244	250	PF00069	0.531
MOD_Plk_2-3	123	129	PF00069	0.621
MOD_Plk_2-3	98	104	PF00069	0.477
MOD_Plk_4	87	93	PF00069	0.487
MOD_ProDKin_1	144	150	PF00069	0.749
MOD_ProDKin_1	161	167	PF00069	0.716
MOD_ProDKin_1	168	174	PF00069	0.784
MOD_ProDKin_1	210	216	PF00069	0.643
MOD_ProDKin_1	449	455	PF00069	0.520
MOD_SUMO_for_1	7	10	PF00179	0.475
TRG_DiLeu_BaEn_3	86	92	PF01217	0.443
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.465
TRG_ER_diArg_1	181	184	PF00400	0.664
TRG_ER_diArg_1	284	286	PF00400	0.456
TRG_ER_diArg_1	33	35	PF00400	0.457
TRG_ER_diArg_1	425	427	PF00400	0.474
TRG_Pf-PMV_PEXEL_1	277	282	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C4	Leptomonas seymouri	40%	87%
A0A3Q8IIJ0	Leishmania donovani	100%	100%
A0A422NS55	Trypanosoma rangeli	31%	78%
A4H7X7	Leishmania braziliensis	64%	100%
C9ZNT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	87%
E9AQ04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QFH7	Leishmania major	89%	100%