Lysine decarboxylase family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Possible lysine decarboxylase - putative

Species:

Leishmania infantum

UniProt:

A4HWA1_LEIIN

TriTrypDb:

LINF_150005300

Length:

332

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWA1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.579
CLV_NRD_NRD_1	231	233	PF00675	0.346
CLV_PCSK_KEX2_1	170	172	PF00082	0.666
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.666
CLV_PCSK_SKI1_1	75	79	PF00082	0.512
DOC_CYCLIN_RxL_1	217	225	PF00134	0.597
DOC_MAPK_DCC_7	263	273	PF00069	0.566
DOC_MAPK_gen_1	170	177	PF00069	0.624
DOC_MAPK_gen_1	263	273	PF00069	0.579
DOC_MAPK_MEF2A_6	266	275	PF00069	0.556
DOC_MIT_MIM_1	166	175	PF04212	0.655
DOC_PP1_RVXF_1	218	225	PF00149	0.597
DOC_PP4_FxxP_1	52	55	PF00568	0.506
DOC_USP7_UBL2_3	263	267	PF12436	0.614
DOC_WW_Pin1_4	154	159	PF00397	0.680
DOC_WW_Pin1_4	23	28	PF00397	0.532
DOC_WW_Pin1_4	325	330	PF00397	0.584
DOC_WW_Pin1_4	8	13	PF00397	0.668
LIG_14-3-3_CanoR_1	111	121	PF00244	0.528
LIG_14-3-3_CanoR_1	5	13	PF00244	0.746
LIG_14-3-3_CanoR_1	65	69	PF00244	0.434
LIG_14-3-3_CanoR_1	75	82	PF00244	0.473
LIG_Actin_WH2_2	249	265	PF00022	0.555
LIG_BIR_II_1	1	5	PF00653	0.762
LIG_BRCT_BRCA1_1	206	210	PF00533	0.555
LIG_BRCT_BRCA1_1	302	306	PF00533	0.579
LIG_deltaCOP1_diTrp_1	279	287	PF00928	0.631
LIG_FHA_1	217	223	PF00498	0.579
LIG_FHA_1	24	30	PF00498	0.617
LIG_FHA_1	263	269	PF00498	0.555
LIG_FHA_1	64	70	PF00498	0.457
LIG_FHA_2	155	161	PF00498	0.605
LIG_FHA_2	250	256	PF00498	0.546
LIG_HP1_1	272	276	PF01393	0.566
LIG_LIR_Apic_2	51	55	PF02991	0.501
LIG_LIR_Gen_1	225	234	PF02991	0.556
LIG_LIR_Gen_1	254	262	PF02991	0.546
LIG_LIR_Gen_1	279	289	PF02991	0.633
LIG_LIR_Gen_1	319	329	PF02991	0.603
LIG_LIR_LC3C_4	174	177	PF02991	0.508
LIG_LIR_Nem_3	146	150	PF02991	0.519
LIG_LIR_Nem_3	152	156	PF02991	0.542
LIG_LIR_Nem_3	225	229	PF02991	0.544
LIG_LIR_Nem_3	254	260	PF02991	0.555
LIG_LIR_Nem_3	279	284	PF02991	0.552
LIG_LIR_Nem_3	292	296	PF02991	0.529
LIG_LIR_Nem_3	319	324	PF02991	0.596
LIG_MAD2	47	55	PF02301	0.504
LIG_Pex14_2	226	230	PF04695	0.548
LIG_PTB_Apo_2	31	38	PF02174	0.500
LIG_REV1ctd_RIR_1	227	237	PF16727	0.546
LIG_SH2_CRK	293	297	PF00017	0.620
LIG_SH2_CRK	321	325	PF00017	0.575
LIG_SH2_STAP1	238	242	PF00017	0.546
LIG_SH2_STAP1	82	86	PF00017	0.578
LIG_SH2_STAT5	13	16	PF00017	0.566
LIG_SH2_STAT5	149	152	PF00017	0.528
LIG_SH2_STAT5	153	156	PF00017	0.542
LIG_SH2_STAT5	228	231	PF00017	0.577
LIG_SH3_1	266	272	PF00018	0.555
LIG_SH3_3	241	247	PF00018	0.579
LIG_SH3_3	266	272	PF00018	0.538
LIG_TRAF2_1	297	300	PF00917	0.581
LIG_TRAF2_1	309	312	PF00917	0.416
LIG_TRFH_1	154	158	PF08558	0.698
LIG_UBA3_1	256	263	PF00899	0.562
LIG_WRC_WIRS_1	144	149	PF05994	0.524
MOD_CDK_SPxxK_3	23	30	PF00069	0.591
MOD_CK1_1	7	13	PF00069	0.699
MOD_CK1_1	73	79	PF00069	0.568
MOD_CK2_1	133	139	PF00069	0.579
MOD_CK2_1	249	255	PF00069	0.546
MOD_CK2_1	294	300	PF00069	0.546
MOD_CK2_1	306	312	PF00069	0.416
MOD_GlcNHglycan	18	23	PF01048	0.625
MOD_GlcNHglycan	308	311	PF01048	0.452
MOD_GlcNHglycan	329	332	PF01048	0.569
MOD_GlcNHglycan	41	44	PF01048	0.593
MOD_GlcNHglycan	72	75	PF01048	0.469
MOD_GSK3_1	258	265	PF00069	0.555
MOD_GSK3_1	300	307	PF00069	0.637
MOD_GSK3_1	323	330	PF00069	0.557
MOD_GSK3_1	4	11	PF00069	0.776
MOD_GSK3_1	94	101	PF00069	0.636
MOD_NEK2_1	112	117	PF00069	0.534
MOD_NEK2_1	175	180	PF00069	0.463
MOD_NEK2_1	204	209	PF00069	0.555
MOD_NEK2_1	236	241	PF00069	0.563
MOD_NEK2_1	262	267	PF00069	0.555
MOD_NEK2_1	280	285	PF00069	0.559
MOD_NEK2_1	37	42	PF00069	0.577
MOD_NEK2_1	63	68	PF00069	0.514
MOD_NEK2_1	70	75	PF00069	0.464
MOD_PIKK_1	112	118	PF00454	0.537
MOD_PIKK_1	133	139	PF00454	0.621
MOD_PIKK_1	294	300	PF00454	0.594
MOD_PIKK_1	75	81	PF00454	0.638
MOD_PKA_2	4	10	PF00069	0.727
MOD_PKA_2	64	70	PF00069	0.428
MOD_Plk_1	82	88	PF00069	0.567
MOD_Plk_4	280	286	PF00069	0.543
MOD_Plk_4	300	306	PF00069	0.637
MOD_Plk_4	64	70	PF00069	0.428
MOD_ProDKin_1	154	160	PF00069	0.676
MOD_ProDKin_1	23	29	PF00069	0.525
MOD_ProDKin_1	325	331	PF00069	0.599
MOD_ProDKin_1	8	14	PF00069	0.659
TRG_DiLeu_BaEn_1	255	260	PF01217	0.547
TRG_DiLeu_BaEn_1	300	305	PF01217	0.637
TRG_ENDOCYTIC_2	153	156	PF00928	0.631
TRG_ENDOCYTIC_2	293	296	PF00928	0.620
TRG_ENDOCYTIC_2	32	35	PF00928	0.672
TRG_ENDOCYTIC_2	321	324	PF00928	0.571
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M2	Leptomonas seymouri	73%	100%
A0A0S4J0W4	Bodo saltans	42%	100%
A0A0S4KLV2	Bodo saltans	57%	98%
A0A1X0NU32	Trypanosomatidae	60%	100%
A0A3Q8IC52	Leishmania donovani	100%	100%
A0A422MT26	Trypanosoma rangeli	59%	100%
A4H7X4	Leishmania braziliensis	80%	100%
C9ZNT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AQ01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QFI0	Leishmania major	97%	100%
V5AWJ3	Trypanosoma cruzi	60%	88%