Expression site-associated gene (ESAG-like) protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW99_LEIIN

TriTrypDb:

LINF_150005100

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HW99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.423
CLV_C14_Caspase3-7	530	534	PF00656	0.365
CLV_NRD_NRD_1	477	479	PF00675	0.637
CLV_NRD_NRD_1	545	547	PF00675	0.548
CLV_NRD_NRD_1	561	563	PF00675	0.484
CLV_NRD_NRD_1	578	580	PF00675	0.575
CLV_NRD_NRD_1	92	94	PF00675	0.586
CLV_PCSK_FUR_1	409	413	PF00082	0.565
CLV_PCSK_FUR_1	49	53	PF00082	0.358
CLV_PCSK_KEX2_1	411	413	PF00082	0.575
CLV_PCSK_KEX2_1	476	478	PF00082	0.616
CLV_PCSK_KEX2_1	51	53	PF00082	0.338
CLV_PCSK_KEX2_1	545	547	PF00082	0.665
CLV_PCSK_KEX2_1	560	562	PF00082	0.591
CLV_PCSK_KEX2_1	578	580	PF00082	0.510
CLV_PCSK_KEX2_1	92	94	PF00082	0.545
CLV_PCSK_KEX2_1	98	100	PF00082	0.561
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.565
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.279
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.604
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.572
CLV_PCSK_SKI1_1	401	405	PF00082	0.540
CLV_PCSK_SKI1_1	51	55	PF00082	0.383
CLV_PCSK_SKI1_1	546	550	PF00082	0.625
CLV_PCSK_SKI1_1	579	583	PF00082	0.696
CLV_PCSK_SKI1_1	595	599	PF00082	0.433
CLV_PCSK_SKI1_1	93	97	PF00082	0.575
CLV_Separin_Metazoa	36	40	PF03568	0.510
DEG_APCC_DBOX_1	33	41	PF00400	0.594
DEG_APCC_DBOX_1	477	485	PF00400	0.429
DOC_CKS1_1	357	362	PF01111	0.381
DOC_CKS1_1	512	517	PF01111	0.423
DOC_CYCLIN_RxL_1	49	57	PF00134	0.478
DOC_MAPK_DCC_7	265	275	PF00069	0.337
DOC_MAPK_gen_1	31	40	PF00069	0.585
DOC_MAPK_gen_1	448	458	PF00069	0.431
DOC_MAPK_gen_1	490	497	PF00069	0.405
DOC_MAPK_MEF2A_6	196	204	PF00069	0.317
DOC_MAPK_MEF2A_6	451	460	PF00069	0.424
DOC_PP1_RVXF_1	138	144	PF00149	0.368
DOC_PP1_RVXF_1	27	33	PF00149	0.512
DOC_PP4_FxxP_1	313	316	PF00568	0.349
DOC_PP4_FxxP_1	454	457	PF00568	0.325
DOC_PP4_FxxP_1	497	500	PF00568	0.394
DOC_PP4_FxxP_1	512	515	PF00568	0.343
DOC_PP4_FxxP_1	617	620	PF00568	0.352
DOC_USP7_MATH_1	320	324	PF00917	0.401
DOC_USP7_MATH_1	506	510	PF00917	0.418
DOC_USP7_MATH_1	556	560	PF00917	0.411
DOC_USP7_MATH_1	577	581	PF00917	0.394
DOC_WW_Pin1_4	223	228	PF00397	0.372
DOC_WW_Pin1_4	256	261	PF00397	0.381
DOC_WW_Pin1_4	312	317	PF00397	0.350
DOC_WW_Pin1_4	356	361	PF00397	0.473
DOC_WW_Pin1_4	511	516	PF00397	0.429
DOC_WW_Pin1_4	612	617	PF00397	0.371
LIG_14-3-3_CanoR_1	167	171	PF00244	0.381
LIG_14-3-3_CanoR_1	308	314	PF00244	0.465
LIG_14-3-3_CanoR_1	52	62	PF00244	0.456
LIG_14-3-3_CanoR_1	578	582	PF00244	0.469
LIG_14-3-3_CanoR_1	9	15	PF00244	0.589
LIG_Actin_WH2_2	385	403	PF00022	0.317
LIG_Actin_WH2_2	581	597	PF00022	0.270
LIG_AP2alpha_2	452	454	PF02296	0.270
LIG_BRCT_BRCA1_1	427	431	PF00533	0.323
LIG_BRCT_BRCA1_1	508	512	PF00533	0.376
LIG_Clathr_ClatBox_1	460	464	PF01394	0.317
LIG_deltaCOP1_diTrp_1	151	154	PF00928	0.314
LIG_deltaCOP1_diTrp_1	569	575	PF00928	0.305
LIG_eIF4E_1	298	304	PF01652	0.319
LIG_EVH1_2	271	275	PF00568	0.317
LIG_FHA_1	129	135	PF00498	0.371
LIG_FHA_1	298	304	PF00498	0.317
LIG_FHA_1	470	476	PF00498	0.385
LIG_FHA_1	512	518	PF00498	0.409
LIG_FHA_1	55	61	PF00498	0.375
LIG_FHA_2	209	215	PF00498	0.387
LIG_FHA_2	347	353	PF00498	0.426
LIG_FHA_2	357	363	PF00498	0.315
LIG_FHA_2	496	502	PF00498	0.411
LIG_FHA_2	528	534	PF00498	0.459
LIG_FHA_2	587	593	PF00498	0.346
LIG_LIR_Apic_2	280	286	PF02991	0.362
LIG_LIR_Apic_2	312	316	PF02991	0.344
LIG_LIR_Apic_2	452	457	PF02991	0.382
LIG_LIR_Apic_2	494	500	PF02991	0.384
LIG_LIR_Apic_2	509	515	PF02991	0.345
LIG_LIR_Apic_2	615	620	PF02991	0.330
LIG_LIR_Gen_1	151	162	PF02991	0.316
LIG_LIR_Gen_1	174	183	PF02991	0.383
LIG_LIR_Gen_1	288	299	PF02991	0.414
LIG_LIR_Gen_1	551	557	PF02991	0.315
LIG_LIR_Gen_1	56	66	PF02991	0.407
LIG_LIR_Nem_3	151	157	PF02991	0.321
LIG_LIR_Nem_3	174	180	PF02991	0.355
LIG_LIR_Nem_3	184	189	PF02991	0.335
LIG_LIR_Nem_3	288	294	PF02991	0.405
LIG_LIR_Nem_3	325	330	PF02991	0.437
LIG_LIR_Nem_3	551	555	PF02991	0.407
LIG_LIR_Nem_3	56	62	PF02991	0.407
LIG_LIR_Nem_3	569	574	PF02991	0.269
LIG_LIR_Nem_3	580	584	PF02991	0.410
LIG_PCNA_PIPBox_1	118	127	PF02747	0.348
LIG_Pex14_1	570	574	PF04695	0.316
LIG_Pex14_2	218	222	PF04695	0.427
LIG_Pex14_2	571	575	PF04695	0.345
LIG_SH2_CRK	283	287	PF00017	0.342
LIG_SH2_CRK	330	334	PF00017	0.387
LIG_SH2_GRB2like	379	382	PF00017	0.327
LIG_SH2_NCK_1	225	229	PF00017	0.362
LIG_SH2_SRC	379	382	PF00017	0.322
LIG_SH2_SRC	83	86	PF00017	0.398
LIG_SH2_STAP1	177	181	PF00017	0.323
LIG_SH2_STAP1	183	187	PF00017	0.280
LIG_SH2_STAP1	427	431	PF00017	0.307
LIG_SH2_STAT3	124	127	PF00017	0.346
LIG_SH2_STAT3	282	285	PF00017	0.323
LIG_SH2_STAT5	124	127	PF00017	0.404
LIG_SH2_STAT5	136	139	PF00017	0.350
LIG_SH2_STAT5	186	189	PF00017	0.370
LIG_SH2_STAT5	298	301	PF00017	0.321
LIG_SH2_STAT5	379	382	PF00017	0.328
LIG_SH2_STAT5	488	491	PF00017	0.442
LIG_SH2_STAT5	564	567	PF00017	0.396
LIG_SH2_STAT5	574	577	PF00017	0.305
LIG_SH2_STAT5	59	62	PF00017	0.377
LIG_SH2_STAT5	83	86	PF00017	0.514
LIG_SH3_3	265	271	PF00018	0.369
LIG_SH3_3	447	453	PF00018	0.315
LIG_SH3_3	70	76	PF00018	0.362
LIG_SUMO_SIM_anti_2	528	533	PF11976	0.364
LIG_SUMO_SIM_par_1	197	207	PF11976	0.362
LIG_SUMO_SIM_par_1	459	464	PF11976	0.294
LIG_SUMO_SIM_par_1	62	68	PF11976	0.388
LIG_WRC_WIRS_1	549	554	PF05994	0.316
LIG_WW_3	522	526	PF00397	0.332
MOD_CDK_SPxxK_3	356	363	PF00069	0.414
MOD_CK1_1	147	153	PF00069	0.331
MOD_CK1_1	175	181	PF00069	0.340
MOD_CK1_1	226	232	PF00069	0.342
MOD_CK1_1	312	318	PF00069	0.387
MOD_CK1_1	486	492	PF00069	0.394
MOD_CK1_1	535	541	PF00069	0.364
MOD_CK2_1	346	352	PF00069	0.424
MOD_CMANNOS	570	573	PF00535	0.531
MOD_Cter_Amidation	96	99	PF01082	0.560
MOD_GlcNHglycan	249	252	PF01048	0.531
MOD_GlcNHglycan	508	511	PF01048	0.694
MOD_GlcNHglycan	540	543	PF01048	0.592
MOD_GSK3_1	128	135	PF00069	0.356
MOD_GSK3_1	252	259	PF00069	0.427
MOD_GSK3_1	293	300	PF00069	0.286
MOD_GSK3_1	3	10	PF00069	0.557
MOD_GSK3_1	482	489	PF00069	0.451
MOD_GSK3_1	534	541	PF00069	0.393
MOD_GSK3_1	582	589	PF00069	0.354
MOD_GSK3_1	612	619	PF00069	0.344
MOD_N-GLC_1	128	133	PF02516	0.586
MOD_N-GLC_1	147	152	PF02516	0.519
MOD_N-GLC_1	347	352	PF02516	0.609
MOD_N-GLC_1	600	605	PF02516	0.575
MOD_NEK2_1	117	122	PF00069	0.335
MOD_NEK2_1	252	257	PF00069	0.355
MOD_NEK2_1	346	351	PF00069	0.404
MOD_NEK2_1	384	389	PF00069	0.332
MOD_NEK2_1	438	443	PF00069	0.355
MOD_NEK2_1	469	474	PF00069	0.362
MOD_NEK2_1	527	532	PF00069	0.502
MOD_NEK2_1	53	58	PF00069	0.351
MOD_NEK2_1	64	69	PF00069	0.370
MOD_NEK2_1	7	12	PF00069	0.609
MOD_NEK2_2	577	582	PF00069	0.338
MOD_OFUCOSY	155	161	PF10250	0.500
MOD_PIKK_1	123	129	PF00454	0.326
MOD_PIKK_1	8	14	PF00454	0.532
MOD_PKA_2	166	172	PF00069	0.404
MOD_PKA_2	320	326	PF00069	0.464
MOD_PKA_2	538	544	PF00069	0.384
MOD_PKA_2	577	583	PF00069	0.457
MOD_PKA_2	8	14	PF00069	0.611
MOD_Plk_1	150	156	PF00069	0.310
MOD_Plk_1	173	179	PF00069	0.371
MOD_Plk_1	347	353	PF00069	0.377
MOD_Plk_1	416	422	PF00069	0.314
MOD_Plk_1	527	533	PF00069	0.349
MOD_Plk_1	600	606	PF00069	0.400
MOD_Plk_4	132	138	PF00069	0.306
MOD_Plk_4	166	172	PF00069	0.427
MOD_Plk_4	3	9	PF00069	0.571
MOD_Plk_4	309	315	PF00069	0.359
MOD_Plk_4	416	422	PF00069	0.317
MOD_Plk_4	483	489	PF00069	0.396
MOD_Plk_4	527	533	PF00069	0.373
MOD_Plk_4	54	60	PF00069	0.514
MOD_Plk_4	548	554	PF00069	0.317
MOD_Plk_4	586	592	PF00069	0.321
MOD_ProDKin_1	223	229	PF00069	0.375
MOD_ProDKin_1	256	262	PF00069	0.381
MOD_ProDKin_1	312	318	PF00069	0.352
MOD_ProDKin_1	356	362	PF00069	0.470
MOD_ProDKin_1	511	517	PF00069	0.427
MOD_ProDKin_1	612	618	PF00069	0.355
MOD_SUMO_for_1	410	413	PF00179	0.388
TRG_DiLeu_BaEn_2	351	357	PF01217	0.400
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.359
TRG_ENDOCYTIC_2	177	180	PF00928	0.379
TRG_ENDOCYTIC_2	19	22	PF00928	0.554
TRG_ENDOCYTIC_2	330	333	PF00928	0.412
TRG_ENDOCYTIC_2	334	337	PF00928	0.300
TRG_ENDOCYTIC_2	427	430	PF00928	0.325
TRG_ENDOCYTIC_2	59	62	PF00928	0.377
TRG_ENDOCYTIC_2	85	88	PF00928	0.351
TRG_ER_diArg_1	29	32	PF00400	0.582
TRG_ER_diArg_1	475	478	PF00400	0.396
TRG_ER_diArg_1	544	546	PF00400	0.363
TRG_ER_diArg_1	561	563	PF00400	0.276
TRG_NLS_Bipartite_1	545	564	PF00514	0.292
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	33%	97%
A0A0N1PDD7	Leptomonas seymouri	25%	100%
A0A3Q8ID98	Leishmania donovani	100%	100%
A0A3Q8IM92	Leishmania donovani	33%	93%
A4H7X2	Leishmania braziliensis	78%	100%
A4HLI8	Leishmania braziliensis	33%	100%
A4HLJ0	Leishmania braziliensis	32%	100%
A4HLJ2	Leishmania braziliensis	30%	99%
A4I8Z8	Leishmania infantum	33%	93%
E9APZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B3W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q457	Leishmania major	34%	100%
Q4QFI2	Leishmania major	91%	100%