Putative glutathione-S-transferase/glutaredoxin

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutathione-S-transferase/glutaredoxin - putative

Species:

Leishmania infantum

UniProt:

A4HW95_LEIIN

TriTrypDb:

LINF_140021300

Length:

311

Annotations

Annotations by Jardim et al.

Redox homeostasis, glutathione-S-transferase/glutaredoxin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 16
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	9
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	9

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HW95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW95

Function

Biological processes
Term	Name	Level	Count
GO:0001516	prostaglandin biosynthetic process	8	4
GO:0006082	organic acid metabolic process	3	4
GO:0006629	lipid metabolic process	3	4
GO:0006631	fatty acid metabolic process	4	4
GO:0006633	fatty acid biosynthetic process	5	4
GO:0006636	unsaturated fatty acid biosynthetic process	6	4
GO:0006690	icosanoid metabolic process	6	4
GO:0006692	prostanoid metabolic process	6	4
GO:0006693	prostaglandin metabolic process	7	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0009058	biosynthetic process	2	4
GO:0009987	cellular process	1	4
GO:0016053	organic acid biosynthetic process	4	4
GO:0019752	carboxylic acid metabolic process	5	4
GO:0032787	monocarboxylic acid metabolic process	6	4
GO:0033559	unsaturated fatty acid metabolic process	5	4
GO:0043436	oxoacid metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0044281	small molecule metabolic process	2	4
GO:0044283	small molecule biosynthetic process	3	4
GO:0046394	carboxylic acid biosynthetic process	5	4
GO:0046456	icosanoid biosynthetic process	6	4
GO:0046457	prostanoid biosynthetic process	7	4
GO:0071704	organic substance metabolic process	2	4
GO:0072330	monocarboxylic acid biosynthetic process	6	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0015035	protein-disulfide reductase activity	3	16
GO:0015036	disulfide oxidoreductase activity	4	16
GO:0016491	oxidoreductase activity	2	16
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	16
GO:0016740	transferase activity	2	13
GO:0016853	isomerase activity	2	12
GO:0016860	intramolecular oxidoreductase activity	3	12
GO:0050220	prostaglandin-E synthase activity	4	12
GO:0097573	obsolete glutathione oxidoreductase activity	4	16
GO:0140096	catalytic activity, acting on a protein	2	16
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	5
GO:0019153	protein-disulfide reductase (glutathione) activity	4	5
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0036134	12-hydroxyheptadecatrienoic acid synthase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.277
CLV_NRD_NRD_1	265	267	PF00675	0.443
CLV_NRD_NRD_1	32	34	PF00675	0.454
CLV_NRD_NRD_1	8	10	PF00675	0.290
CLV_PCSK_KEX2_1	32	34	PF00082	0.467
CLV_PCSK_SKI1_1	169	173	PF00082	0.417
CLV_PCSK_SKI1_1	200	204	PF00082	0.413
CLV_PCSK_SKI1_1	222	226	PF00082	0.479
CLV_PCSK_SKI1_1	38	42	PF00082	0.512
CLV_PCSK_SKI1_1	85	89	PF00082	0.359
CLV_PCSK_SKI1_1	9	13	PF00082	0.196
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DOC_CDC14_PxL_1	113	121	PF14671	0.189
DOC_MAPK_gen_1	114	121	PF00069	0.153
DOC_MAPK_gen_1	266	273	PF00069	0.343
DOC_MAPK_MEF2A_6	114	121	PF00069	0.173
DOC_MAPK_MEF2A_6	65	72	PF00069	0.216
DOC_USP7_MATH_1	163	167	PF00917	0.315
DOC_USP7_UBL2_3	200	204	PF12436	0.214
LIG_14-3-3_CanoR_1	164	168	PF00244	0.193
LIG_14-3-3_CanoR_1	169	174	PF00244	0.170
LIG_14-3-3_CanoR_1	245	252	PF00244	0.337
LIG_14-3-3_CanoR_1	38	45	PF00244	0.259
LIG_14-3-3_CanoR_1	74	79	PF00244	0.179
LIG_APCC_ABBAyCdc20_2	236	242	PF00400	0.236
LIG_Clathr_ClatBox_1	270	274	PF01394	0.291
LIG_deltaCOP1_diTrp_1	157	162	PF00928	0.309
LIG_EH1_1	211	219	PF00400	0.184
LIG_FHA_1	273	279	PF00498	0.222
LIG_FHA_2	138	144	PF00498	0.302
LIG_FHA_2	50	56	PF00498	0.319
LIG_GBD_Chelix_1	137	145	PF00786	0.465
LIG_LIR_Gen_1	43	51	PF02991	0.278
LIG_LIR_Gen_1	89	98	PF02991	0.199
LIG_LIR_Nem_3	110	116	PF02991	0.195
LIG_LIR_Nem_3	274	279	PF02991	0.227
LIG_LIR_Nem_3	55	61	PF02991	0.307
LIG_LIR_Nem_3	89	93	PF02991	0.216
LIG_PTB_Apo_2	196	203	PF02174	0.246
LIG_SH2_CRK	113	117	PF00017	0.145
LIG_SH2_CRK	276	280	PF00017	0.227
LIG_SH2_CRK	90	94	PF00017	0.174
LIG_SH2_GRB2like	197	200	PF00017	0.274
LIG_SH2_NCK_1	90	94	PF00017	0.185
LIG_SH2_SRC	188	191	PF00017	0.274
LIG_SH2_STAP1	197	201	PF00017	0.254
LIG_SH2_STAT5	130	133	PF00017	0.254
LIG_SH2_STAT5	188	191	PF00017	0.247
LIG_SH2_STAT5	212	215	PF00017	0.221
LIG_SH2_STAT5	75	78	PF00017	0.226
LIG_SH3_3	215	221	PF00018	0.244
LIG_SUMO_SIM_par_1	269	275	PF11976	0.292
LIG_TYR_ITIM	88	93	PF00017	0.170
MOD_CK1_1	191	197	PF00069	0.278
MOD_CK2_1	137	143	PF00069	0.293
MOD_CMANNOS	159	162	PF00535	0.390
MOD_Cter_Amidation	264	267	PF01082	0.514
MOD_GSK3_1	158	165	PF00069	0.290
MOD_GSK3_1	184	191	PF00069	0.276
MOD_N-GLC_1	175	180	PF02516	0.421
MOD_N-GLC_1	36	41	PF02516	0.473
MOD_NEK2_1	108	113	PF00069	0.294
MOD_NEK2_1	12	17	PF00069	0.204
MOD_NEK2_1	131	136	PF00069	0.297
MOD_NEK2_1	175	180	PF00069	0.234
MOD_NEK2_1	216	221	PF00069	0.239
MOD_NEK2_2	80	85	PF00069	0.286
MOD_PIKK_1	292	298	PF00454	0.316
MOD_PKA_2	163	169	PF00069	0.195
MOD_PKA_2	244	250	PF00069	0.261
MOD_PKA_2	3	9	PF00069	0.646
MOD_PKA_2	73	79	PF00069	0.171
MOD_Plk_1	126	132	PF00069	0.147
MOD_Plk_1	175	181	PF00069	0.245
MOD_Plk_1	36	42	PF00069	0.360
MOD_Plk_4	108	114	PF00069	0.271
MOD_Plk_4	163	169	PF00069	0.214
MOD_Plk_4	184	190	PF00069	0.322
MOD_SUMO_for_1	104	107	PF00179	0.156
MOD_SUMO_for_1	151	154	PF00179	0.345
MOD_SUMO_rev_2	249	256	PF00179	0.352
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.309
TRG_ENDOCYTIC_2	113	116	PF00928	0.215
TRG_ENDOCYTIC_2	186	189	PF00928	0.238
TRG_ENDOCYTIC_2	276	279	PF00928	0.221
TRG_ENDOCYTIC_2	288	291	PF00928	0.239
TRG_ENDOCYTIC_2	90	93	PF00928	0.186
TRG_ER_diArg_1	32	35	PF00400	0.266
TRG_NLS_MonoCore_2	256	261	PF00514	0.262
TRG_NLS_MonoExtN_4	254	261	PF00514	0.367
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS46	Leptomonas seymouri	74%	100%
A0A0N1ILY8	Leptomonas seymouri	22%	80%
A0A0S4IXT4	Bodo saltans	57%	95%
A0A0S4JV60	Bodo saltans	30%	93%
A0A1X0NND6	Trypanosomatidae	57%	99%
A0A1X0NTT0	Trypanosomatidae	30%	93%
A0A3S7WT83	Leishmania donovani	100%	100%
A0A3S7WZV5	Leishmania donovani	25%	78%
A0A422MZ79	Trypanosoma rangeli	26%	92%
A0A422N3R5	Trypanosoma rangeli	56%	100%
A4H7W8	Leishmania braziliensis	88%	100%
A4HF09	Leishmania braziliensis	27%	100%
A4I288	Leishmania infantum	25%	78%
C9ZRQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	91%
C9ZSR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9APZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AYD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q940	Leishmania major	24%	100%
Q4QFI5	Leishmania major	97%	100%
Q66LN0	Bos taurus	26%	84%
Q7ZUC7	Danio rerio	26%	82%
Q8BWM0	Mus musculus	26%	81%
Q9H7Z7	Homo sapiens	27%	82%
Q9N0A4	Macaca fascicularis	26%	82%
V5AYZ4	Trypanosoma cruzi	29%	92%
V5DC17	Trypanosoma cruzi	57%	92%