Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW94_LEIIN

TriTrypDb:

LINF_140021200

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HW94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.482
CLV_C14_Caspase3-7	268	272	PF00656	0.435
CLV_C14_Caspase3-7	38	42	PF00656	0.554
CLV_C14_Caspase3-7	382	386	PF00656	0.573
CLV_C14_Caspase3-7	472	476	PF00656	0.473
CLV_NRD_NRD_1	133	135	PF00675	0.484
CLV_NRD_NRD_1	138	140	PF00675	0.457
CLV_NRD_NRD_1	159	161	PF00675	0.576
CLV_NRD_NRD_1	177	179	PF00675	0.322
CLV_NRD_NRD_1	277	279	PF00675	0.466
CLV_NRD_NRD_1	283	285	PF00675	0.440
CLV_NRD_NRD_1	294	296	PF00675	0.434
CLV_NRD_NRD_1	298	300	PF00675	0.447
CLV_NRD_NRD_1	349	351	PF00675	0.490
CLV_NRD_NRD_1	398	400	PF00675	0.479
CLV_NRD_NRD_1	418	420	PF00675	0.274
CLV_NRD_NRD_1	421	423	PF00675	0.480
CLV_NRD_NRD_1	430	432	PF00675	0.448
CLV_NRD_NRD_1	433	435	PF00675	0.443
CLV_NRD_NRD_1	447	449	PF00675	0.445
CLV_NRD_NRD_1	62	64	PF00675	0.498
CLV_NRD_NRD_1	95	97	PF00675	0.621
CLV_PCSK_FUR_1	286	290	PF00082	0.463
CLV_PCSK_FUR_1	431	435	PF00082	0.494
CLV_PCSK_KEX2_1	133	135	PF00082	0.468
CLV_PCSK_KEX2_1	138	140	PF00082	0.440
CLV_PCSK_KEX2_1	177	179	PF00082	0.540
CLV_PCSK_KEX2_1	20	22	PF00082	0.542
CLV_PCSK_KEX2_1	248	250	PF00082	0.475
CLV_PCSK_KEX2_1	276	278	PF00082	0.450
CLV_PCSK_KEX2_1	285	287	PF00082	0.423
CLV_PCSK_KEX2_1	288	290	PF00082	0.419
CLV_PCSK_KEX2_1	294	296	PF00082	0.375
CLV_PCSK_KEX2_1	348	350	PF00082	0.487
CLV_PCSK_KEX2_1	392	394	PF00082	0.515
CLV_PCSK_KEX2_1	430	432	PF00082	0.452
CLV_PCSK_KEX2_1	433	435	PF00082	0.448
CLV_PCSK_KEX2_1	62	64	PF00082	0.565
CLV_PCSK_KEX2_1	95	97	PF00082	0.621
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.594
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.534
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.455
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.415
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.410
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.568
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.532
CLV_PCSK_PC7_1	129	135	PF00082	0.493
CLV_PCSK_PC7_1	273	279	PF00082	0.459
CLV_PCSK_PC7_1	284	290	PF00082	0.443
CLV_PCSK_SKI1_1	248	252	PF00082	0.456
CLV_PCSK_SKI1_1	31	35	PF00082	0.516
CLV_PCSK_SKI1_1	317	321	PF00082	0.450
CLV_PCSK_SKI1_1	356	360	PF00082	0.523
CLV_PCSK_SKI1_1	366	370	PF00082	0.526
CLV_PCSK_SKI1_1	381	385	PF00082	0.537
CLV_PCSK_SKI1_1	66	70	PF00082	0.522
DEG_APCC_DBOX_1	231	239	PF00400	0.405
DEG_Nend_Nbox_1	1	3	PF02207	0.670
DOC_CKS1_1	98	103	PF01111	0.604
DOC_CYCLIN_RxL_1	60	72	PF00134	0.561
DOC_CYCLIN_yClb5_NLxxxL_5	52	59	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.664
DOC_MAPK_gen_1	216	224	PF00069	0.409
DOC_MAPK_gen_1	445	455	PF00069	0.583
DOC_MAPK_MEF2A_6	448	455	PF00069	0.585
DOC_MIT_MIM_1	228	238	PF04212	0.518
DOC_PP1_RVXF_1	315	321	PF00149	0.452
DOC_PP4_FxxP_1	146	149	PF00568	0.475
DOC_PP4_FxxP_1	43	46	PF00568	0.472
DOC_USP7_MATH_1	106	110	PF00917	0.571
DOC_USP7_MATH_1	115	119	PF00917	0.609
DOC_USP7_MATH_1	19	23	PF00917	0.644
DOC_USP7_MATH_1	371	375	PF00917	0.677
DOC_USP7_UBL2_3	344	348	PF12436	0.613
DOC_USP7_UBL2_3	392	396	PF12436	0.610
DOC_USP7_UBL2_3	445	449	PF12436	0.502
DOC_USP7_UBL2_3	60	64	PF12436	0.466
DOC_WW_Pin1_4	358	363	PF00397	0.643
DOC_WW_Pin1_4	97	102	PF00397	0.618
LIG_14-3-3_CanoR_1	108	114	PF00244	0.648
LIG_14-3-3_CanoR_1	21	29	PF00244	0.615
LIG_14-3-3_CanoR_1	349	358	PF00244	0.565
LIG_BRCT_BRCA1_1	151	155	PF00533	0.527
LIG_deltaCOP1_diTrp_1	305	314	PF00928	0.572
LIG_deltaCOP1_diTrp_1	462	473	PF00928	0.499
LIG_FHA_1	261	267	PF00498	0.495
LIG_FHA_1	54	60	PF00498	0.475
LIG_FHA_2	149	155	PF00498	0.473
LIG_FHA_2	223	229	PF00498	0.409
LIG_FHA_2	263	269	PF00498	0.485
LIG_FHA_2	329	335	PF00498	0.600
LIG_FHA_2	33	39	PF00498	0.551
LIG_FHA_2	42	48	PF00498	0.531
LIG_FHA_2	459	465	PF00498	0.507
LIG_FHA_2	74	80	PF00498	0.630
LIG_FHA_2	98	104	PF00498	0.571
LIG_Integrin_RGD_1	39	41	PF01839	0.524
LIG_LIR_Apic_2	144	149	PF02991	0.477
LIG_LIR_Apic_2	41	46	PF02991	0.475
LIG_LIR_Gen_1	154	162	PF02991	0.442
LIG_LIR_Gen_1	3	13	PF02991	0.674
LIG_LIR_Nem_3	152	158	PF02991	0.435
LIG_LIR_Nem_3	246	250	PF02991	0.448
LIG_LIR_Nem_3	3	9	PF02991	0.675
LIG_LIR_Nem_3	391	397	PF02991	0.500
LIG_PCNA_PIPBox_1	74	83	PF02747	0.514
LIG_Pex14_2	155	159	PF04695	0.433
LIG_SH2_CRK	219	223	PF00017	0.441
LIG_SH2_CRK	394	398	PF00017	0.592
LIG_SH2_CRK	421	425	PF00017	0.574
LIG_SH2_CRK	435	439	PF00017	0.419
LIG_SH2_CRK	6	10	PF00017	0.697
LIG_SH2_GRB2like	402	405	PF00017	0.444
LIG_SH2_NCK_1	256	260	PF00017	0.484
LIG_SH2_SRC	13	16	PF00017	0.638
LIG_SH2_STAP1	124	128	PF00017	0.488
LIG_SH2_STAP1	402	406	PF00017	0.444
LIG_SH2_STAP1	435	439	PF00017	0.613
LIG_SH2_STAP1	6	10	PF00017	0.522
LIG_SH2_STAT5	201	204	PF00017	0.412
LIG_SH3_1	95	101	PF00018	0.572
LIG_SH3_3	95	101	PF00018	0.649
LIG_SUMO_SIM_par_1	261	268	PF11976	0.477
LIG_TRAF2_1	167	170	PF00917	0.614
LIG_TRAF2_1	259	262	PF00917	0.472
LIG_TRFH_1	304	308	PF08558	0.489
LIG_TYR_ITIM	217	222	PF00017	0.416
LIG_UBA3_1	383	392	PF00899	0.533
LIG_WRC_WIRS_1	191	196	PF05994	0.531
MOD_CDK_SPxxK_3	358	365	PF00069	0.650
MOD_CK1_1	118	124	PF00069	0.540
MOD_CK1_1	164	170	PF00069	0.525
MOD_CK2_1	148	154	PF00069	0.464
MOD_CK2_1	164	170	PF00069	0.472
MOD_CK2_1	262	268	PF00069	0.460
MOD_CK2_1	32	38	PF00069	0.496
MOD_CK2_1	328	334	PF00069	0.599
MOD_CK2_1	349	355	PF00069	0.496
MOD_CK2_1	358	364	PF00069	0.504
MOD_CK2_1	383	389	PF00069	0.584
MOD_CK2_1	39	45	PF00069	0.481
MOD_CK2_1	434	440	PF00069	0.462
MOD_CK2_1	458	464	PF00069	0.495
MOD_CK2_1	97	103	PF00069	0.605
MOD_Cter_Amidation	274	277	PF01082	0.465
MOD_Cter_Amidation	417	420	PF01082	0.438
MOD_Cter_Amidation	93	96	PF01082	0.622
MOD_GlcNHglycan	163	166	PF01048	0.559
MOD_GlcNHglycan	22	25	PF01048	0.544
MOD_GlcNHglycan	369	372	PF01048	0.570
MOD_GlcNHglycan	455	458	PF01048	0.610
MOD_GSK3_1	118	125	PF00069	0.639
MOD_GSK3_1	186	193	PF00069	0.563
MOD_GSK3_1	218	225	PF00069	0.430
MOD_GSK3_1	354	361	PF00069	0.503
MOD_GSK3_1	367	374	PF00069	0.514
MOD_GSK3_1	477	484	PF00069	0.614
MOD_N-GLC_1	453	458	PF02516	0.516
MOD_N-GLC_1	53	58	PF02516	0.520
MOD_NEK2_1	367	372	PF00069	0.606
MOD_NEK2_1	58	63	PF00069	0.574
MOD_NEK2_2	124	129	PF00069	0.549
MOD_PIKK_1	312	318	PF00454	0.454
MOD_PK_1	4	10	PF00069	0.528
MOD_PKA_1	20	26	PF00069	0.620
MOD_PKA_1	349	355	PF00069	0.638
MOD_PKA_1	395	401	PF00069	0.483
MOD_PKA_2	107	113	PF00069	0.627
MOD_PKA_2	20	26	PF00069	0.601
MOD_PKA_2	349	355	PF00069	0.529
MOD_PKB_1	37	45	PF00069	0.554
MOD_Plk_1	115	121	PF00069	0.648
MOD_Plk_1	197	203	PF00069	0.411
MOD_Plk_1	260	266	PF00069	0.507
MOD_Plk_1	354	360	PF00069	0.524
MOD_Plk_1	469	475	PF00069	0.614
MOD_Plk_1	53	59	PF00069	0.516
MOD_Plk_2-3	262	268	PF00069	0.485
MOD_Plk_2-3	41	47	PF00069	0.600
MOD_Plk_4	190	196	PF00069	0.428
MOD_Plk_4	197	203	PF00069	0.369
MOD_Plk_4	4	10	PF00069	0.528
MOD_Plk_4	469	475	PF00069	0.610
MOD_ProDKin_1	358	364	PF00069	0.639
MOD_ProDKin_1	97	103	PF00069	0.609
MOD_SUMO_for_1	69	72	PF00179	0.601
MOD_SUMO_rev_2	241	250	PF00179	0.542
MOD_SUMO_rev_2	361	368	PF00179	0.500
TRG_DiLeu_BaEn_1	355	360	PF01217	0.546
TRG_DiLeu_BaEn_4	261	267	PF01217	0.488
TRG_ENDOCYTIC_2	13	16	PF00928	0.581
TRG_ENDOCYTIC_2	156	159	PF00928	0.528
TRG_ENDOCYTIC_2	219	222	PF00928	0.411
TRG_ENDOCYTIC_2	394	397	PF00928	0.593
TRG_ENDOCYTIC_2	421	424	PF00928	0.467
TRG_ENDOCYTIC_2	435	438	PF00928	0.459
TRG_ENDOCYTIC_2	6	9	PF00928	0.698
TRG_ER_diArg_1	132	134	PF00400	0.546
TRG_ER_diArg_1	177	179	PF00400	0.540
TRG_ER_diArg_1	231	234	PF00400	0.446
TRG_ER_diArg_1	277	279	PF00400	0.466
TRG_ER_diArg_1	293	295	PF00400	0.454
TRG_ER_diArg_1	430	433	PF00400	0.458
TRG_ER_diArg_1	95	97	PF00400	0.621
TRG_NLS_MonoExtC_3	283	288	PF00514	0.460
TRG_NLS_MonoExtC_3	347	353	PF00514	0.625
TRG_NLS_MonoExtC_3	418	423	PF00514	0.469
TRG_NLS_MonoExtN_4	245	252	PF00514	0.570
TRG_NLS_MonoExtN_4	273	280	PF00514	0.472
TRG_NLS_MonoExtN_4	284	289	PF00514	0.459
TRG_NLS_MonoExtN_4	346	352	PF00514	0.619
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P376	Leptomonas seymouri	81%	100%
A0A0S4IY81	Bodo saltans	46%	93%
A0A1X0NNC4	Trypanosomatidae	64%	100%
A0A3Q8I9Z9	Leishmania donovani	100%	100%
A0A3R7MCK7	Trypanosoma rangeli	61%	100%
A4H7W7	Leishmania braziliensis	87%	100%
C9ZSR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9APZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QFI6	Leishmania major	95%	100%
V5BKF3	Trypanosoma cruzi	62%	86%