Uncharacterized protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW91_LEIIN

TriTrypDb:

LINF_140020900

Length:

1006

Annotations

Annotations by Jardim et al.

Structural Proteins, cytoskeleton associated , putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0030863	cortical cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 910
Promastigote: 905
Promastigote/Amastigote: 601, 607, 908, 930

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HW91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.445
CLV_NRD_NRD_1	325	327	PF00675	0.449
CLV_NRD_NRD_1	39	41	PF00675	0.513
CLV_NRD_NRD_1	422	424	PF00675	0.315
CLV_NRD_NRD_1	537	539	PF00675	0.525
CLV_NRD_NRD_1	540	542	PF00675	0.486
CLV_NRD_NRD_1	60	62	PF00675	0.608
CLV_NRD_NRD_1	65	67	PF00675	0.580
CLV_NRD_NRD_1	710	712	PF00675	0.566
CLV_NRD_NRD_1	730	732	PF00675	0.584
CLV_NRD_NRD_1	754	756	PF00675	0.585
CLV_NRD_NRD_1	802	804	PF00675	0.597
CLV_NRD_NRD_1	850	852	PF00675	0.569
CLV_NRD_NRD_1	91	93	PF00675	0.560
CLV_NRD_NRD_1	927	929	PF00675	0.646
CLV_NRD_NRD_1	988	990	PF00675	0.785
CLV_NRD_NRD_1	994	996	PF00675	0.569
CLV_PCSK_FUR_1	538	542	PF00082	0.447
CLV_PCSK_FUR_1	924	928	PF00082	0.667
CLV_PCSK_KEX2_1	38	40	PF00082	0.462
CLV_PCSK_KEX2_1	422	424	PF00082	0.315
CLV_PCSK_KEX2_1	524	526	PF00082	0.462
CLV_PCSK_KEX2_1	539	541	PF00082	0.441
CLV_PCSK_KEX2_1	60	62	PF00082	0.595
CLV_PCSK_KEX2_1	65	67	PF00082	0.592
CLV_PCSK_KEX2_1	710	712	PF00082	0.566
CLV_PCSK_KEX2_1	730	732	PF00082	0.584
CLV_PCSK_KEX2_1	754	756	PF00082	0.585
CLV_PCSK_KEX2_1	802	804	PF00082	0.603
CLV_PCSK_KEX2_1	850	852	PF00082	0.594
CLV_PCSK_KEX2_1	91	93	PF00082	0.560
CLV_PCSK_KEX2_1	926	928	PF00082	0.655
CLV_PCSK_KEX2_1	988	990	PF00082	0.785
CLV_PCSK_KEX2_1	994	996	PF00082	0.569
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.462
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.441
CLV_PCSK_PC7_1	61	67	PF00082	0.614
CLV_PCSK_SKI1_1	31	35	PF00082	0.645
CLV_PCSK_SKI1_1	711	715	PF00082	0.566
CLV_PCSK_SKI1_1	91	95	PF00082	0.513
DEG_APCC_DBOX_1	37	45	PF00400	0.460
DEG_Nend_Nbox_1	1	3	PF02207	0.502
DOC_CYCLIN_yCln2_LP_2	709	715	PF00134	0.628
DOC_CYCLIN_yCln2_LP_2	729	735	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	753	759	PF00134	0.580
DOC_CYCLIN_yCln2_LP_2	777	783	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	801	807	PF00134	0.590
DOC_CYCLIN_yCln2_LP_2	825	831	PF00134	0.584
DOC_CYCLIN_yCln2_LP_2	849	855	PF00134	0.568
DOC_MAPK_DCC_7	94	104	PF00069	0.485
DOC_MAPK_FxFP_2	150	153	PF00069	0.340
DOC_MAPK_gen_1	135	144	PF00069	0.298
DOC_MAPK_gen_1	326	333	PF00069	0.461
DOC_MAPK_gen_1	38	46	PF00069	0.508
DOC_MAPK_gen_1	94	104	PF00069	0.567
DOC_MAPK_MEF2A_6	326	335	PF00069	0.458
DOC_MAPK_MEF2A_6	38	46	PF00069	0.508
DOC_MAPK_MEF2A_6	95	104	PF00069	0.578
DOC_MAPK_NFAT4_5	39	47	PF00069	0.515
DOC_PP2B_LxvP_1	245	248	PF13499	0.495
DOC_PP2B_LxvP_1	526	529	PF13499	0.497
DOC_PP4_FxxP_1	150	153	PF00568	0.340
DOC_USP7_MATH_1	12	16	PF00917	0.536
DOC_USP7_MATH_1	203	207	PF00917	0.433
DOC_USP7_MATH_1	296	300	PF00917	0.510
DOC_USP7_MATH_1	398	402	PF00917	0.511
DOC_USP7_MATH_1	53	57	PF00917	0.520
DOC_USP7_MATH_1	713	717	PF00917	0.682
DOC_USP7_MATH_1	719	723	PF00917	0.606
DOC_USP7_MATH_1	733	737	PF00917	0.631
DOC_USP7_MATH_1	743	747	PF00917	0.635
DOC_USP7_MATH_1	757	761	PF00917	0.699
DOC_USP7_MATH_1	767	771	PF00917	0.676
DOC_USP7_MATH_1	781	785	PF00917	0.546
DOC_USP7_MATH_1	791	795	PF00917	0.579
DOC_USP7_MATH_1	805	809	PF00917	0.553
DOC_USP7_MATH_1	815	819	PF00917	0.538
DOC_USP7_MATH_1	829	833	PF00917	0.531
DOC_USP7_MATH_1	902	906	PF00917	0.584
DOC_USP7_MATH_1	935	939	PF00917	0.526
DOC_USP7_MATH_1	977	981	PF00917	0.424
DOC_USP7_MATH_1	993	997	PF00917	0.657
DOC_USP7_UBL2_3	94	98	PF12436	0.500
DOC_USP7_UBL2_3	963	967	PF12436	0.496
DOC_WW_Pin1_4	298	303	PF00397	0.542
DOC_WW_Pin1_4	618	623	PF00397	0.662
DOC_WW_Pin1_4	905	910	PF00397	0.557
DOC_WW_Pin1_4	930	935	PF00397	0.609
DOC_WW_Pin1_4	989	994	PF00397	0.644
DOC_WW_Pin1_4	999	1004	PF00397	0.668
LIG_14-3-3_CanoR_1	119	123	PF00244	0.340
LIG_14-3-3_CanoR_1	486	491	PF00244	0.290
LIG_14-3-3_CanoR_1	988	993	PF00244	0.632
LIG_14-3-3_CanoR_1	994	1003	PF00244	0.535
LIG_Actin_WH2_2	215	231	PF00022	0.375
LIG_APCC_ABBA_1	44	49	PF00400	0.524
LIG_BIR_III_2	168	172	PF00653	0.340
LIG_BRCT_BRCA1_1	408	412	PF00533	0.290
LIG_Clathr_ClatBox_1	41	45	PF01394	0.518
LIG_deltaCOP1_diTrp_1	377	388	PF00928	0.482
LIG_FHA_1	131	137	PF00498	0.340
LIG_FHA_1	242	248	PF00498	0.503
LIG_FHA_1	250	256	PF00498	0.394
LIG_FHA_1	268	274	PF00498	0.299
LIG_FHA_1	996	1002	PF00498	0.652
LIG_FHA_2	143	149	PF00498	0.275
LIG_FHA_2	712	718	PF00498	0.565
LIG_FHA_2	84	90	PF00498	0.571
LIG_G3BP_FGDF_1	889	894	PF02136	0.552
LIG_LIR_Apic_2	147	153	PF02991	0.340
LIG_LIR_Apic_2	307	313	PF02991	0.584
LIG_LIR_Apic_2	7	12	PF02991	0.541
LIG_LIR_Apic_2	930	934	PF02991	0.581
LIG_LIR_Apic_2	938	944	PF02991	0.552
LIG_LIR_Gen_1	145	154	PF02991	0.275
LIG_LIR_Gen_1	357	362	PF02991	0.479
LIG_LIR_Gen_1	409	420	PF02991	0.338
LIG_LIR_Gen_1	430	440	PF02991	0.336
LIG_LIR_Gen_1	464	472	PF02991	0.340
LIG_LIR_LC3C_4	162	166	PF02991	0.340
LIG_LIR_Nem_3	145	149	PF02991	0.319
LIG_LIR_Nem_3	151	155	PF02991	0.308
LIG_LIR_Nem_3	307	312	PF02991	0.476
LIG_LIR_Nem_3	357	361	PF02991	0.484
LIG_LIR_Nem_3	378	384	PF02991	0.471
LIG_LIR_Nem_3	408	414	PF02991	0.340
LIG_LIR_Nem_3	430	435	PF02991	0.336
LIG_LIR_Nem_3	464	470	PF02991	0.340
LIG_LIR_Nem_3	522	526	PF02991	0.461
LIG_LIR_Nem_3	890	894	PF02991	0.567
LIG_MLH1_MIPbox_1	408	412	PF16413	0.290
LIG_MYND_1	298	302	PF01753	0.490
LIG_Pex14_1	146	150	PF04695	0.340
LIG_SH2_CRK	523	527	PF00017	0.506
LIG_SH2_CRK	64	68	PF00017	0.621
LIG_SH2_GRB2like	154	157	PF00017	0.340
LIG_SH2_PTP2	432	435	PF00017	0.340
LIG_SH2_SRC	154	157	PF00017	0.290
LIG_SH2_SRC	311	314	PF00017	0.444
LIG_SH2_STAT5	154	157	PF00017	0.290
LIG_SH2_STAT5	227	230	PF00017	0.450
LIG_SH2_STAT5	269	272	PF00017	0.403
LIG_SH2_STAT5	311	314	PF00017	0.477
LIG_SH2_STAT5	432	435	PF00017	0.415
LIG_SH2_STAT5	647	650	PF00017	0.843
LIG_SH2_STAT5	9	12	PF00017	0.538
LIG_SH3_1	310	316	PF00018	0.451
LIG_SH3_1	941	947	PF00018	0.644
LIG_SH3_3	178	184	PF00018	0.326
LIG_SH3_3	197	203	PF00018	0.373
LIG_SH3_3	310	316	PF00018	0.451
LIG_SH3_3	330	336	PF00018	0.348
LIG_SH3_3	442	448	PF00018	0.446
LIG_SH3_3	696	702	PF00018	0.615
LIG_SH3_3	75	81	PF00018	0.622
LIG_SH3_3	856	862	PF00018	0.590
LIG_SH3_3	941	947	PF00018	0.648
LIG_SH3_4	291	298	PF00018	0.456
LIG_SUMO_SIM_anti_2	117	124	PF11976	0.335
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.340
LIG_SUMO_SIM_anti_2	339	352	PF11976	0.605
LIG_SUMO_SIM_anti_2	496	505	PF11976	0.340
LIG_SUMO_SIM_par_1	162	168	PF11976	0.340
LIG_SUMO_SIM_par_1	367	373	PF11976	0.488
LIG_TRAF2_1	145	148	PF00917	0.340
LIG_TRAF2_1	18	21	PF00917	0.432
LIG_TRAF2_1	213	216	PF00917	0.430
LIG_TRAF2_1	342	345	PF00917	0.545
LIG_TRAF2_1	531	534	PF00917	0.474
LIG_TRAF2_1	542	545	PF00917	0.503
LIG_TRAF2_1	551	554	PF00917	0.563
LIG_TRAF2_1	607	610	PF00917	0.641
LIG_TRAF2_1	658	661	PF00917	0.607
LIG_TRAF2_1	666	669	PF00917	0.635
LIG_TRAF2_1	682	685	PF00917	0.606
LIG_TRAF2_1	695	698	PF00917	0.585
LIG_TRAF2_1	724	727	PF00917	0.608
LIG_TRAF2_1	735	738	PF00917	0.604
LIG_TRAF2_1	748	751	PF00917	0.569
LIG_TRAF2_1	759	762	PF00917	0.556
LIG_TRAF2_1	772	775	PF00917	0.541
LIG_TRAF2_1	783	786	PF00917	0.546
LIG_TRAF2_1	796	799	PF00917	0.538
LIG_TRAF2_1	807	810	PF00917	0.547
LIG_TRAF2_1	820	823	PF00917	0.558
LIG_TRAF2_1	831	834	PF00917	0.540
LIG_TRAF2_1	844	847	PF00917	0.556
LIG_TRAF2_1	855	858	PF00917	0.576
LIG_TRAF2_1	862	865	PF00917	0.543
LIG_TRAF2_1	867	870	PF00917	0.538
LIG_TRAF2_2	83	88	PF00917	0.493
MOD_CDK_SPK_2	989	994	PF00069	0.644
MOD_CDK_SPxK_1	989	995	PF00069	0.648
MOD_CDK_SPxxK_3	930	937	PF00069	0.605
MOD_CK1_1	15	21	PF00069	0.529
MOD_CK1_1	206	212	PF00069	0.447
MOD_CK1_1	434	440	PF00069	0.340
MOD_CK1_1	653	659	PF00069	0.570
MOD_CK1_1	905	911	PF00069	0.557
MOD_CK1_1	930	936	PF00069	0.721
MOD_CK2_1	142	148	PF00069	0.275
MOD_CK2_1	15	21	PF00069	0.519
MOD_CK2_1	210	216	PF00069	0.423
MOD_CK2_1	338	344	PF00069	0.693
MOD_CK2_1	598	604	PF00069	0.679
MOD_CK2_1	697	703	PF00069	0.624
MOD_CK2_1	711	717	PF00069	0.657
MOD_CK2_1	741	747	PF00069	0.613
MOD_CK2_1	765	771	PF00069	0.583
MOD_CK2_1	789	795	PF00069	0.591
MOD_CK2_1	813	819	PF00069	0.584
MOD_CK2_1	83	89	PF00069	0.512
MOD_CK2_1	837	843	PF00069	0.588
MOD_CK2_1	857	863	PF00069	0.670
MOD_CK2_1	977	983	PF00069	0.605
MOD_DYRK1A_RPxSP_1	989	993	PF00069	0.638
MOD_GlcNHglycan	112	115	PF01048	0.340
MOD_GlcNHglycan	436	439	PF01048	0.290
MOD_GlcNHglycan	55	58	PF01048	0.541
MOD_GlcNHglycan	904	907	PF01048	0.584
MOD_GlcNHglycan	938	941	PF01048	0.650
MOD_GlcNHglycan	947	950	PF01048	0.694
MOD_GSK3_1	206	213	PF00069	0.453
MOD_GSK3_1	218	225	PF00069	0.343
MOD_GSK3_1	406	413	PF00069	0.413
MOD_GSK3_1	713	720	PF00069	0.697
MOD_GSK3_1	733	740	PF00069	0.609
MOD_GSK3_1	757	764	PF00069	0.575
MOD_GSK3_1	781	788	PF00069	0.568
MOD_GSK3_1	805	812	PF00069	0.653
MOD_GSK3_1	829	836	PF00069	0.555
MOD_GSK3_1	983	990	PF00069	0.589
MOD_GSK3_1	995	1002	PF00069	0.654
MOD_N-GLC_1	282	287	PF02516	0.503
MOD_NEK2_1	102	107	PF00069	0.340
MOD_NEK2_1	249	254	PF00069	0.392
MOD_NEK2_1	370	375	PF00069	0.506
MOD_NEK2_1	410	415	PF00069	0.340
MOD_NEK2_1	567	572	PF00069	0.622
MOD_NEK2_1	73	78	PF00069	0.589
MOD_NEK2_1	959	964	PF00069	0.569
MOD_PIKK_1	314	320	PF00454	0.523
MOD_PIKK_1	447	453	PF00454	0.227
MOD_PIKK_1	624	630	PF00454	0.607
MOD_PIKK_1	653	659	PF00454	0.593
MOD_PIKK_1	857	863	PF00454	0.565
MOD_PK_1	486	492	PF00069	0.290
MOD_PK_1	598	604	PF00069	0.596
MOD_PKA_1	927	933	PF00069	0.658
MOD_PKA_1	988	994	PF00069	0.638
MOD_PKA_2	118	124	PF00069	0.340
MOD_PKA_2	277	283	PF00069	0.476
MOD_PKA_2	927	933	PF00069	0.820
MOD_PKA_2	987	993	PF00069	0.625
MOD_PKA_2	994	1000	PF00069	0.526
MOD_Plk_1	203	209	PF00069	0.402
MOD_Plk_1	983	989	PF00069	0.586
MOD_Plk_2-3	340	346	PF00069	0.566
MOD_Plk_2-3	441	447	PF00069	0.340
MOD_Plk_2-3	604	610	PF00069	0.588
MOD_Plk_2-3	650	656	PF00069	0.633
MOD_Plk_2-3	697	703	PF00069	0.605
MOD_Plk_2-3	717	723	PF00069	0.741
MOD_Plk_2-3	741	747	PF00069	0.584
MOD_Plk_2-3	765	771	PF00069	0.568
MOD_Plk_2-3	789	795	PF00069	0.566
MOD_Plk_2-3	813	819	PF00069	0.584
MOD_Plk_2-3	837	843	PF00069	0.579
MOD_Plk_4	218	224	PF00069	0.398
MOD_Plk_4	249	255	PF00069	0.444
MOD_Plk_4	284	290	PF00069	0.504
MOD_Plk_4	406	412	PF00069	0.400
MOD_Plk_4	927	933	PF00069	0.667
MOD_ProDKin_1	298	304	PF00069	0.539
MOD_ProDKin_1	618	624	PF00069	0.664
MOD_ProDKin_1	905	911	PF00069	0.557
MOD_ProDKin_1	930	936	PF00069	0.606
MOD_ProDKin_1	989	995	PF00069	0.648
MOD_ProDKin_1	999	1005	PF00069	0.667
MOD_SUMO_for_1	336	339	PF00179	0.633
MOD_SUMO_for_1	658	661	PF00179	0.565
MOD_SUMO_rev_2	29	36	PF00179	0.491
MOD_SUMO_rev_2	604	613	PF00179	0.669
TRG_DiLeu_BaEn_1	22	27	PF01217	0.513
TRG_DiLeu_BaEn_1	344	349	PF01217	0.649
TRG_DiLeu_BaEn_1	37	42	PF01217	0.386
TRG_DiLeu_BaEn_1	483	488	PF01217	0.340
TRG_DiLeu_BaEn_3	498	504	PF01217	0.227
TRG_DiLeu_LyEn_5	22	27	PF01217	0.513
TRG_ENDOCYTIC_2	2	5	PF00928	0.567
TRG_ENDOCYTIC_2	309	312	PF00928	0.576
TRG_ENDOCYTIC_2	432	435	PF00928	0.340
TRG_ENDOCYTIC_2	523	526	PF00928	0.457
TRG_ENDOCYTIC_2	64	67	PF00928	0.622
TRG_ER_diArg_1	38	40	PF00400	0.573
TRG_ER_diArg_1	421	423	PF00400	0.315
TRG_ER_diArg_1	50	53	PF00400	0.450
TRG_ER_diArg_1	537	540	PF00400	0.495
TRG_ER_diArg_1	59	61	PF00400	0.505
TRG_ER_diArg_1	64	66	PF00400	0.487
TRG_ER_diArg_1	709	711	PF00400	0.572
TRG_ER_diArg_1	729	731	PF00400	0.590
TRG_ER_diArg_1	753	755	PF00400	0.586
TRG_ER_diArg_1	801	803	PF00400	0.595
TRG_ER_diArg_1	849	851	PF00400	0.566
TRG_ER_diArg_1	90	92	PF00400	0.680
TRG_ER_diArg_1	924	927	PF00400	0.653
TRG_ER_diArg_1	987	989	PF00400	0.767
TRG_ER_diArg_1	993	995	PF00400	0.730
TRG_NES_CRM1_1	346	359	PF08389	0.496
TRG_NES_CRM1_1	408	424	PF08389	0.315
TRG_NLS_Bipartite_1	524	543	PF00514	0.490
TRG_NLS_MonoCore_2	537	542	PF00514	0.451
TRG_NLS_MonoExtC_3	538	544	PF00514	0.447
TRG_NLS_MonoExtN_4	538	543	PF00514	0.444
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6T3	Leishmania donovani	98%	100%
A4H7W4	Leishmania braziliensis	70%	100%
E9APZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QFI9	Leishmania major	90%	100%