Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW89_LEIIN

TriTrypDb:

LINF_140020700

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.598
CLV_NRD_NRD_1	118	120	PF00675	0.338
CLV_NRD_NRD_1	348	350	PF00675	0.364
CLV_NRD_NRD_1	427	429	PF00675	0.367
CLV_NRD_NRD_1	473	475	PF00675	0.342
CLV_NRD_NRD_1	525	527	PF00675	0.342
CLV_NRD_NRD_1	564	566	PF00675	0.398
CLV_NRD_NRD_1	60	62	PF00675	0.404
CLV_NRD_NRD_1	665	667	PF00675	0.592
CLV_PCSK_FUR_1	58	62	PF00082	0.446
CLV_PCSK_KEX2_1	348	350	PF00082	0.364
CLV_PCSK_KEX2_1	427	429	PF00082	0.378
CLV_PCSK_KEX2_1	473	475	PF00082	0.342
CLV_PCSK_KEX2_1	525	527	PF00082	0.351
CLV_PCSK_KEX2_1	58	60	PF00082	0.385
CLV_PCSK_KEX2_1	665	667	PF00082	0.551
CLV_PCSK_SKI1_1	181	185	PF00082	0.340
CLV_PCSK_SKI1_1	250	254	PF00082	0.346
CLV_PCSK_SKI1_1	325	329	PF00082	0.401
CLV_PCSK_SKI1_1	451	455	PF00082	0.363
CLV_PCSK_SKI1_1	525	529	PF00082	0.346
CLV_PCSK_SKI1_1	635	639	PF00082	0.500
CLV_PCSK_SKI1_1	665	669	PF00082	0.534
CLV_PCSK_SKI1_1	83	87	PF00082	0.387
CLV_Separin_Metazoa	20	24	PF03568	0.602
DEG_Nend_UBRbox_2	1	3	PF02207	0.689
DEG_ODPH_VHL_1	334	345	PF01847	0.552
DOC_CDC14_PxL_1	121	129	PF14671	0.587
DOC_CDC14_PxL_1	406	414	PF14671	0.441
DOC_CKS1_1	365	370	PF01111	0.308
DOC_CKS1_1	386	391	PF01111	0.372
DOC_CYCLIN_RxL_1	247	256	PF00134	0.546
DOC_CYCLIN_RxL_1	387	400	PF00134	0.312
DOC_MAPK_DCC_7	650	659	PF00069	0.357
DOC_MAPK_gen_1	178	186	PF00069	0.576
DOC_MAPK_gen_1	348	357	PF00069	0.545
DOC_MAPK_gen_1	565	572	PF00069	0.533
DOC_MAPK_MEF2A_6	178	186	PF00069	0.576
DOC_MAPK_MEF2A_6	23	31	PF00069	0.677
DOC_MAPK_MEF2A_6	239	248	PF00069	0.540
DOC_MAPK_MEF2A_6	325	334	PF00069	0.553
DOC_MAPK_MEF2A_6	350	359	PF00069	0.539
DOC_PP1_RVXF_1	632	639	PF00149	0.257
DOC_PP2B_LxvP_1	212	215	PF13499	0.625
DOC_PP2B_LxvP_1	502	505	PF13499	0.564
DOC_PP4_FxxP_1	36	39	PF00568	0.695
DOC_PP4_FxxP_1	582	585	PF00568	0.457
DOC_PP4_MxPP_1	194	197	PF00568	0.456
DOC_SPAK_OSR1_1	114	118	PF12202	0.586
DOC_USP7_MATH_1	171	175	PF00917	0.625
DOC_USP7_MATH_1	208	212	PF00917	0.620
DOC_USP7_MATH_1	22	26	PF00917	0.636
DOC_USP7_MATH_1	231	235	PF00917	0.555
DOC_USP7_MATH_1	416	420	PF00917	0.674
DOC_USP7_MATH_1	47	51	PF00917	0.645
DOC_USP7_MATH_1	511	515	PF00917	0.711
DOC_USP7_MATH_1	529	533	PF00917	0.629
DOC_USP7_MATH_2	416	422	PF00917	0.598
DOC_WW_Pin1_4	364	369	PF00397	0.308
DOC_WW_Pin1_4	385	390	PF00397	0.376
DOC_WW_Pin1_4	412	417	PF00397	0.625
DOC_WW_Pin1_4	507	512	PF00397	0.694
LIG_14-3-3_CanoR_1	105	112	PF00244	0.600
LIG_14-3-3_CanoR_1	132	137	PF00244	0.551
LIG_14-3-3_CanoR_1	181	187	PF00244	0.517
LIG_14-3-3_CanoR_1	23	31	PF00244	0.659
LIG_14-3-3_CanoR_1	239	246	PF00244	0.585
LIG_14-3-3_CanoR_1	308	317	PF00244	0.559
LIG_14-3-3_CanoR_1	32	37	PF00244	0.658
LIG_14-3-3_CanoR_1	46	52	PF00244	0.647
LIG_14-3-3_CanoR_1	590	596	PF00244	0.305
LIG_14-3-3_CanoR_1	83	91	PF00244	0.645
LIG_14-3-3_CanoR_1	94	100	PF00244	0.568
LIG_Clathr_ClatBox_1	572	576	PF01394	0.400
LIG_Clathr_ClatBox_1	657	661	PF01394	0.299
LIG_eIF4E_1	353	359	PF01652	0.502
LIG_FHA_1	12	18	PF00498	0.759
LIG_FHA_1	155	161	PF00498	0.591
LIG_FHA_1	235	241	PF00498	0.594
LIG_FHA_1	312	318	PF00498	0.602
LIG_FHA_1	365	371	PF00498	0.291
LIG_FHA_1	424	430	PF00498	0.563
LIG_FHA_1	517	523	PF00498	0.597
LIG_FHA_1	627	633	PF00498	0.339
LIG_FHA_2	105	111	PF00498	0.572
LIG_FHA_2	452	458	PF00498	0.479
LIG_FHA_2	615	621	PF00498	0.334
LIG_FHA_2	650	656	PF00498	0.355
LIG_LIR_Apic_2	35	39	PF02991	0.667
LIG_LIR_Apic_2	581	585	PF02991	0.476
LIG_LIR_Gen_1	219	230	PF02991	0.575
LIG_LIR_Gen_1	531	542	PF02991	0.557
LIG_LIR_Gen_1	553	563	PF02991	0.494
LIG_LIR_Gen_1	598	609	PF02991	0.359
LIG_LIR_Gen_1	98	103	PF02991	0.594
LIG_LIR_LC3C_4	241	246	PF02991	0.505
LIG_LIR_Nem_3	198	203	PF02991	0.500
LIG_LIR_Nem_3	219	225	PF02991	0.511
LIG_LIR_Nem_3	30	36	PF02991	0.649
LIG_LIR_Nem_3	53	57	PF02991	0.634
LIG_LIR_Nem_3	531	537	PF02991	0.564
LIG_LIR_Nem_3	598	604	PF02991	0.369
LIG_LIR_Nem_3	98	102	PF02991	0.590
LIG_LYPXL_yS_3	409	412	PF13949	0.551
LIG_NRBOX	289	295	PF00104	0.553
LIG_NRBOX	369	375	PF00104	0.360
LIG_Pex14_1	595	599	PF04695	0.315
LIG_Pex14_2	222	226	PF04695	0.505
LIG_SH2_CRK	413	417	PF00017	0.634
LIG_SH2_CRK	534	538	PF00017	0.465
LIG_SH2_STAP1	326	330	PF00017	0.583
LIG_SH2_STAP1	599	603	PF00017	0.344
LIG_SH2_STAT5	16	19	PF00017	0.716
LIG_SH2_STAT5	285	288	PF00017	0.448
LIG_SH2_STAT5	534	537	PF00017	0.517
LIG_SH2_STAT5	55	58	PF00017	0.682
LIG_SH2_STAT5	599	602	PF00017	0.360
LIG_SH3_1	170	176	PF00018	0.593
LIG_SH3_2	173	178	PF14604	0.597
LIG_SH3_3	170	176	PF00018	0.615
LIG_SH3_3	502	508	PF00018	0.661
LIG_SUMO_SIM_anti_2	133	138	PF11976	0.549
LIG_SUMO_SIM_anti_2	369	375	PF11976	0.360
LIG_SUMO_SIM_anti_2	600	606	PF11976	0.327
LIG_SUMO_SIM_anti_2	655	661	PF11976	0.344
LIG_SUMO_SIM_anti_2	73	79	PF11976	0.554
LIG_SUMO_SIM_par_1	144	152	PF11976	0.541
LIG_SUMO_SIM_par_1	340	347	PF11976	0.555
LIG_SUMO_SIM_par_1	375	381	PF11976	0.375
LIG_SUMO_SIM_par_1	518	523	PF11976	0.580
LIG_SUMO_SIM_par_1	655	661	PF11976	0.311
LIG_TRAF2_1	437	440	PF00917	0.521
LIG_TRAF2_1	9	12	PF00917	0.691
LIG_UBA3_1	165	170	PF00899	0.533
LIG_WRC_WIRS_1	33	38	PF05994	0.663
LIG_WW_3	20	24	PF00397	0.602
MOD_CDK_SPxxK_3	385	392	PF00069	0.261
MOD_CK1_1	189	195	PF00069	0.575
MOD_CK1_1	234	240	PF00069	0.566
MOD_CK1_1	272	278	PF00069	0.627
MOD_CK1_1	311	317	PF00069	0.564
MOD_CK1_1	366	372	PF00069	0.284
MOD_CK1_1	466	472	PF00069	0.502
MOD_CK1_1	506	512	PF00069	0.736
MOD_CK1_1	73	79	PF00069	0.554
MOD_CK2_1	104	110	PF00069	0.610
MOD_CK2_1	412	418	PF00069	0.619
MOD_CK2_1	438	444	PF00069	0.517
MOD_CK2_1	451	457	PF00069	0.467
MOD_CK2_1	614	620	PF00069	0.344
MOD_CK2_1	639	645	PF00069	0.349
MOD_CK2_1	649	655	PF00069	0.322
MOD_DYRK1A_RPxSP_1	507	511	PF00069	0.618
MOD_GlcNHglycan	233	236	PF01048	0.356
MOD_GlcNHglycan	24	27	PF01048	0.434
MOD_GlcNHglycan	271	274	PF01048	0.313
MOD_GlcNHglycan	310	313	PF01048	0.397
MOD_GlcNHglycan	465	468	PF01048	0.378
MOD_GlcNHglycan	513	516	PF01048	0.459
MOD_GlcNHglycan	538	541	PF01048	0.258
MOD_GlcNHglycan	63	66	PF01048	0.398
MOD_GlcNHglycan	72	75	PF01048	0.447
MOD_GSK3_1	182	189	PF00069	0.537
MOD_GSK3_1	234	241	PF00069	0.592
MOD_GSK3_1	303	310	PF00069	0.694
MOD_GSK3_1	311	318	PF00069	0.580
MOD_GSK3_1	381	388	PF00069	0.256
MOD_GSK3_1	412	419	PF00069	0.621
MOD_GSK3_1	503	510	PF00069	0.597
MOD_GSK3_1	529	536	PF00069	0.569
MOD_N-GLC_1	130	135	PF02516	0.411
MOD_NEK2_1	154	159	PF00069	0.583
MOD_NEK2_1	186	191	PF00069	0.542
MOD_NEK2_1	240	245	PF00069	0.535
MOD_NEK2_1	252	257	PF00069	0.460
MOD_NEK2_1	358	363	PF00069	0.355
MOD_NEK2_1	463	468	PF00069	0.530
MOD_NEK2_1	559	564	PF00069	0.630
MOD_NEK2_1	591	596	PF00069	0.325
MOD_NEK2_1	607	612	PF00069	0.204
MOD_NEK2_1	626	631	PF00069	0.393
MOD_NEK2_1	70	75	PF00069	0.699
MOD_NEK2_1	85	90	PF00069	0.598
MOD_NEK2_2	47	52	PF00069	0.655
MOD_NEK2_2	529	534	PF00069	0.560
MOD_PIKK_1	189	195	PF00454	0.575
MOD_PIKK_1	378	384	PF00454	0.341
MOD_PIKK_1	416	422	PF00454	0.615
MOD_PIKK_1	626	632	PF00454	0.302
MOD_PK_1	132	138	PF00069	0.552
MOD_PKA_2	104	110	PF00069	0.581
MOD_PKA_2	22	28	PF00069	0.685
MOD_PKA_2	238	244	PF00069	0.597
MOD_PKA_2	307	313	PF00069	0.545
MOD_PKA_2	506	512	PF00069	0.671
MOD_PKB_1	59	67	PF00069	0.645
MOD_Plk_1	11	17	PF00069	0.696
MOD_Plk_1	130	136	PF00069	0.552
MOD_Plk_1	597	603	PF00069	0.345
MOD_Plk_4	132	138	PF00069	0.552
MOD_Plk_4	161	167	PF00069	0.525
MOD_Plk_4	195	201	PF00069	0.567
MOD_Plk_4	240	246	PF00069	0.523
MOD_Plk_4	366	372	PF00069	0.386
MOD_Plk_4	458	464	PF00069	0.518
MOD_Plk_4	529	535	PF00069	0.511
MOD_Plk_4	597	603	PF00069	0.391
MOD_Plk_4	73	79	PF00069	0.691
MOD_ProDKin_1	364	370	PF00069	0.308
MOD_ProDKin_1	385	391	PF00069	0.377
MOD_ProDKin_1	412	418	PF00069	0.634
MOD_ProDKin_1	507	513	PF00069	0.695
MOD_SUMO_rev_2	300	304	PF00179	0.592
TRG_DiLeu_BaEn_1	523	528	PF01217	0.576
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.284
TRG_DiLeu_BaLyEn_6	653	658	PF01217	0.319
TRG_DiLeu_BaLyEn_6	663	668	PF01217	0.258
TRG_DiLeu_LyEn_5	523	528	PF01217	0.561
TRG_ENDOCYTIC_2	33	36	PF00928	0.701
TRG_ENDOCYTIC_2	352	355	PF00928	0.503
TRG_ENDOCYTIC_2	409	412	PF00928	0.532
TRG_ENDOCYTIC_2	534	537	PF00928	0.483
TRG_ENDOCYTIC_2	599	602	PF00928	0.347
TRG_ENDOCYTIC_2	99	102	PF00928	0.596
TRG_ER_diArg_1	427	429	PF00400	0.500
TRG_ER_diArg_1	472	474	PF00400	0.541
TRG_ER_diArg_1	524	526	PF00400	0.545
TRG_ER_diArg_1	57	60	PF00400	0.595
TRG_ER_diArg_1	664	666	PF00400	0.387
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	665	670	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAI6	Leptomonas seymouri	63%	100%
A0A3R7NL73	Trypanosoma rangeli	31%	95%
A0A3S7WT73	Leishmania donovani	100%	100%
A4H7W2	Leishmania braziliensis	85%	100%
C9ZSS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9APZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QFJ1	Leishmania major	93%	100%
V5AW01	Trypanosoma cruzi	31%	95%