LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4HW88_LEIIN
TriTrypDb:
LINF_140020600
Length:
555

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HW88
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW88

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 26
GO:0006793 phosphorus metabolic process 3 26
GO:0006796 phosphate-containing compound metabolic process 4 26
GO:0006807 nitrogen compound metabolic process 2 26
GO:0008152 metabolic process 1 26
GO:0009987 cellular process 1 26
GO:0016310 phosphorylation 5 26
GO:0019538 protein metabolic process 3 26
GO:0036211 protein modification process 4 26
GO:0043170 macromolecule metabolic process 3 26
GO:0043412 macromolecule modification 4 26
GO:0044237 cellular metabolic process 2 26
GO:0044238 primary metabolic process 2 26
GO:0071704 organic substance metabolic process 2 26
GO:1901564 organonitrogen compound metabolic process 3 26
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 26
GO:0003824 catalytic activity 1 26
GO:0004672 protein kinase activity 3 26
GO:0005488 binding 1 26
GO:0005524 ATP binding 5 26
GO:0016301 kinase activity 4 26
GO:0016740 transferase activity 2 26
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 26
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 26
GO:0017076 purine nucleotide binding 4 26
GO:0030554 adenyl nucleotide binding 5 26
GO:0032553 ribonucleotide binding 3 26
GO:0032555 purine ribonucleotide binding 4 26
GO:0032559 adenyl ribonucleotide binding 5 26
GO:0035639 purine ribonucleoside triphosphate binding 4 26
GO:0036094 small molecule binding 2 26
GO:0043167 ion binding 2 26
GO:0043168 anion binding 3 26
GO:0097159 organic cyclic compound binding 2 26
GO:0097367 carbohydrate derivative binding 2 26
GO:0140096 catalytic activity, acting on a protein 2 26
GO:1901265 nucleoside phosphate binding 3 26
GO:1901363 heterocyclic compound binding 2 26
GO:0004674 protein serine/threonine kinase activity 4 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 365 369 PF00656 0.517
CLV_NRD_NRD_1 123 125 PF00675 0.226
CLV_NRD_NRD_1 494 496 PF00675 0.581
CLV_NRD_NRD_1 502 504 PF00675 0.609
CLV_NRD_NRD_1 72 74 PF00675 0.265
CLV_PCSK_KEX2_1 502 504 PF00082 0.601
CLV_PCSK_SKI1_1 105 109 PF00082 0.228
CLV_PCSK_SKI1_1 124 128 PF00082 0.269
CLV_PCSK_SKI1_1 129 133 PF00082 0.325
CLV_PCSK_SKI1_1 208 212 PF00082 0.326
CLV_PCSK_SKI1_1 542 546 PF00082 0.484
DEG_APCC_DBOX_1 104 112 PF00400 0.217
DEG_APCC_DBOX_1 247 255 PF00400 0.321
DEG_Nend_UBRbox_2 1 3 PF02207 0.443
DEG_SPOP_SBC_1 362 366 PF00917 0.508
DOC_ANK_TNKS_1 521 528 PF00023 0.480
DOC_CDC14_PxL_1 385 393 PF14671 0.578
DOC_CKS1_1 166 171 PF01111 0.320
DOC_CKS1_1 427 432 PF01111 0.540
DOC_CYCLIN_yCln2_LP_2 178 184 PF00134 0.269
DOC_CYCLIN_yCln2_LP_2 201 207 PF00134 0.213
DOC_CYCLIN_yCln2_LP_2 531 537 PF00134 0.516
DOC_MAPK_DCC_7 383 393 PF00069 0.503
DOC_MAPK_gen_1 129 138 PF00069 0.361
DOC_MAPK_gen_1 248 257 PF00069 0.357
DOC_MAPK_gen_1 73 80 PF00069 0.269
DOC_MAPK_gen_1 93 102 PF00069 0.265
DOC_MAPK_MEF2A_6 250 259 PF00069 0.369
DOC_MAPK_MEF2A_6 73 82 PF00069 0.351
DOC_MAPK_RevD_3 112 125 PF00069 0.269
DOC_PP2B_LxvP_1 255 258 PF13499 0.269
DOC_PP2B_LxvP_1 398 401 PF13499 0.524
DOC_PP2B_LxvP_1 531 534 PF13499 0.520
DOC_PP2B_LxvP_1 535 538 PF13499 0.492
DOC_PP4_FxxP_1 349 352 PF00568 0.505
DOC_PP4_FxxP_1 423 426 PF00568 0.530
DOC_PP4_FxxP_1 427 430 PF00568 0.532
DOC_PP4_FxxP_1 458 461 PF00568 0.519
DOC_PP4_FxxP_1 518 521 PF00568 0.568
DOC_USP7_MATH_1 297 301 PF00917 0.655
DOC_USP7_MATH_1 358 362 PF00917 0.492
DOC_USP7_MATH_1 417 421 PF00917 0.528
DOC_USP7_MATH_1 72 76 PF00917 0.269
DOC_USP7_UBL2_3 8 12 PF12436 0.298
DOC_WW_Pin1_4 165 170 PF00397 0.316
DOC_WW_Pin1_4 320 325 PF00397 0.517
DOC_WW_Pin1_4 341 346 PF00397 0.584
DOC_WW_Pin1_4 415 420 PF00397 0.725
DOC_WW_Pin1_4 422 427 PF00397 0.525
DOC_WW_Pin1_4 449 454 PF00397 0.684
DOC_WW_Pin1_4 480 485 PF00397 0.546
LIG_14-3-3_CanoR_1 317 324 PF00244 0.495
LIG_14-3-3_CanoR_1 424 430 PF00244 0.549
LIG_14-3-3_CanoR_1 45 50 PF00244 0.320
LIG_14-3-3_CanoR_1 53 59 PF00244 0.308
LIG_14-3-3_CanoR_1 73 81 PF00244 0.269
LIG_Actin_RPEL_3 236 255 PF02755 0.250
LIG_APCC_ABBA_1 218 223 PF00400 0.201
LIG_APCC_ABBAyCdc20_2 124 130 PF00400 0.313
LIG_BRCT_BRCA1_1 419 423 PF00533 0.638
LIG_eIF4E_1 171 177 PF01652 0.269
LIG_EVH1_1 535 539 PF00568 0.478
LIG_FHA_1 131 137 PF00498 0.312
LIG_FHA_1 15 21 PF00498 0.262
LIG_FHA_1 427 433 PF00498 0.551
LIG_FHA_2 316 322 PF00498 0.728
LIG_FHA_2 325 331 PF00498 0.491
LIG_LIR_Apic_2 168 174 PF02991 0.325
LIG_LIR_Apic_2 420 426 PF02991 0.509
LIG_LIR_Apic_2 469 475 PF02991 0.643
LIG_LIR_Apic_2 510 516 PF02991 0.582
LIG_LIR_Gen_1 2 10 PF02991 0.319
LIG_LIR_Nem_3 2 7 PF02991 0.319
LIG_LIR_Nem_3 26 32 PF02991 0.276
LIG_LYPXL_S_1 406 410 PF13949 0.490
LIG_LYPXL_yS_3 407 410 PF13949 0.491
LIG_MAD2 216 224 PF02301 0.320
LIG_MAD2 53 61 PF02301 0.269
LIG_MYND_1 380 384 PF01753 0.504
LIG_MYND_1 480 484 PF01753 0.467
LIG_MYND_1 512 516 PF01753 0.527
LIG_MYND_1 533 537 PF01753 0.506
LIG_NRP_CendR_1 552 555 PF00754 0.459
LIG_Pex14_2 423 427 PF04695 0.501
LIG_PTB_Apo_2 512 519 PF02174 0.581
LIG_SH2_CRK 222 226 PF00017 0.225
LIG_SH2_CRK 385 389 PF00017 0.566
LIG_SH2_CRK 4 8 PF00017 0.232
LIG_SH2_CRK 472 476 PF00017 0.515
LIG_SH2_GRB2like 385 388 PF00017 0.512
LIG_SH2_GRB2like 513 516 PF00017 0.531
LIG_SH2_NCK_1 159 163 PF00017 0.230
LIG_SH2_NCK_1 472 476 PF00017 0.515
LIG_SH2_SRC 513 516 PF00017 0.531
LIG_SH2_SRC 66 69 PF00017 0.269
LIG_SH2_SRC 84 87 PF00017 0.263
LIG_SH2_STAP1 229 233 PF00017 0.368
LIG_SH2_STAT3 120 123 PF00017 0.213
LIG_SH2_STAT3 399 402 PF00017 0.602
LIG_SH2_STAT3 476 479 PF00017 0.534
LIG_SH2_STAT5 120 123 PF00017 0.268
LIG_SH2_STAT5 171 174 PF00017 0.347
LIG_SH2_STAT5 278 281 PF00017 0.364
LIG_SH2_STAT5 30 33 PF00017 0.243
LIG_SH2_STAT5 4 7 PF00017 0.309
LIG_SH2_STAT5 476 479 PF00017 0.507
LIG_SH2_STAT5 488 491 PF00017 0.536
LIG_SH2_STAT5 513 516 PF00017 0.531
LIG_SH2_STAT5 66 69 PF00017 0.370
LIG_SH3_3 163 169 PF00018 0.354
LIG_SH3_3 239 245 PF00018 0.285
LIG_SH3_3 342 348 PF00018 0.551
LIG_SH3_3 374 380 PF00018 0.574
LIG_SH3_3 390 396 PF00018 0.573
LIG_SH3_3 398 404 PF00018 0.503
LIG_SH3_3 465 471 PF00018 0.503
LIG_SH3_3 474 480 PF00018 0.478
LIG_SH3_3 506 512 PF00018 0.608
LIG_SH3_3 527 533 PF00018 0.632
LIG_SH3_3 97 103 PF00018 0.301
LIG_SUMO_SIM_par_1 114 119 PF11976 0.213
LIG_TRAF2_1 312 315 PF00917 0.449
LIG_TRFH_1 170 174 PF08558 0.351
LIG_TYR_ITIM 194 199 PF00017 0.356
LIG_TYR_ITIM 220 225 PF00017 0.321
LIG_UBA3_1 198 202 PF00899 0.439
LIG_WRC_WIRS_1 67 72 PF05994 0.278
LIG_WW_2 533 536 PF00397 0.496
MOD_CDC14_SPxK_1 418 421 PF00782 0.666
MOD_CDK_SPxK_1 415 421 PF00069 0.667
MOD_CK1_1 300 306 PF00069 0.589
MOD_CK1_1 320 326 PF00069 0.564
MOD_CK1_1 350 356 PF00069 0.510
MOD_CK1_1 361 367 PF00069 0.486
MOD_CK1_1 425 431 PF00069 0.564
MOD_CK1_1 507 513 PF00069 0.688
MOD_CK2_1 315 321 PF00069 0.730
MOD_CK2_1 45 51 PF00069 0.283
MOD_DYRK1A_RPxSP_1 415 419 PF00069 0.504
MOD_GlcNHglycan 229 232 PF01048 0.354
MOD_GlcNHglycan 302 305 PF01048 0.486
MOD_GlcNHglycan 360 363 PF01048 0.531
MOD_GlcNHglycan 365 368 PF01048 0.520
MOD_GlcNHglycan 434 437 PF01048 0.576
MOD_GlcNHglycan 461 464 PF01048 0.531
MOD_GlcNHglycan 509 512 PF01048 0.747
MOD_GlcNHglycan 518 521 PF01048 0.484
MOD_GlcNHglycan 86 89 PF01048 0.250
MOD_GSK3_1 151 158 PF00069 0.270
MOD_GSK3_1 161 168 PF00069 0.379
MOD_GSK3_1 293 300 PF00069 0.597
MOD_GSK3_1 316 323 PF00069 0.535
MOD_GSK3_1 347 354 PF00069 0.537
MOD_GSK3_1 358 365 PF00069 0.499
MOD_GSK3_1 422 429 PF00069 0.623
MOD_N-GLC_1 334 339 PF02516 0.523
MOD_N-GLC_1 368 373 PF02516 0.511
MOD_N-GLC_2 77 79 PF02516 0.213
MOD_NEK2_1 432 437 PF00069 0.482
MOD_PIKK_1 130 136 PF00454 0.283
MOD_PKA_2 316 322 PF00069 0.512
MOD_PKA_2 375 381 PF00069 0.509
MOD_PKA_2 38 44 PF00069 0.301
MOD_PKA_2 459 465 PF00069 0.522
MOD_PKA_2 507 513 PF00069 0.518
MOD_PKA_2 72 78 PF00069 0.269
MOD_Plk_1 293 299 PF00069 0.404
MOD_Plk_1 35 41 PF00069 0.284
MOD_Plk_4 161 167 PF00069 0.293
MOD_Plk_4 224 230 PF00069 0.250
MOD_Plk_4 66 72 PF00069 0.273
MOD_ProDKin_1 165 171 PF00069 0.316
MOD_ProDKin_1 320 326 PF00069 0.520
MOD_ProDKin_1 341 347 PF00069 0.586
MOD_ProDKin_1 415 421 PF00069 0.726
MOD_ProDKin_1 422 428 PF00069 0.524
MOD_ProDKin_1 449 455 PF00069 0.680
MOD_ProDKin_1 480 486 PF00069 0.546
TRG_ENDOCYTIC_2 196 199 PF00928 0.352
TRG_ENDOCYTIC_2 222 225 PF00928 0.282
TRG_ENDOCYTIC_2 29 32 PF00928 0.276
TRG_ENDOCYTIC_2 385 388 PF00928 0.512
TRG_ENDOCYTIC_2 4 7 PF00928 0.247
TRG_ENDOCYTIC_2 407 410 PF00928 0.495
TRG_ER_diArg_1 501 503 PF00400 0.577
TRG_ER_diArg_1 552 555 PF00400 0.525
TRG_NES_CRM1_1 106 119 PF08389 0.345
TRG_NES_CRM1_1 209 223 PF08389 0.213
TRG_NES_CRM1_1 232 244 PF08389 0.226
TRG_Pf-PMV_PEXEL_1 239 244 PF00026 0.316

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9A0 Leptomonas seymouri 27% 85%
A0A0N1IHM7 Leptomonas seymouri 54% 94%
A0A0S4JIJ6 Bodo saltans 29% 98%
A0A3Q8IC87 Leishmania donovani 30% 100%
A0A3Q8IFK8 Leishmania donovani 37% 100%
A0A3Q8IIH5 Leishmania donovani 100% 100%
A0A3Q8INQ4 Leishmania donovani 29% 100%
A0A3S5H789 Leishmania donovani 23% 100%
A0A3S7X2W3 Leishmania donovani 27% 100%
A0A3S7X5M4 Leishmania donovani 27% 85%
A0A3S7X7Y2 Leishmania donovani 28% 100%
A4H7W1 Leishmania braziliensis 77% 100%
A4HAS1 Leishmania braziliensis 29% 100%
A4HH03 Leishmania braziliensis 31% 100%
A4HHN1 Leishmania braziliensis 27% 100%
A4HJT5 Leishmania braziliensis 37% 100%
A4HKG9 Leishmania braziliensis 27% 85%
A4HYX6 Leishmania infantum 23% 100%
A4HZV1 Leishmania infantum 30% 100%
A4I1T4 Leishmania infantum 29% 100%
A4I4U6 Leishmania infantum 28% 100%
A4I7A1 Leishmania infantum 37% 100%
A4I7Z6 Leishmania infantum 27% 85%
A4I9Y5 Leishmania infantum 28% 100%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9APY9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 85%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
P53351 Mus musculus 29% 81%
Q4Q2Z2 Leishmania major 28% 100%
Q4Q3K6 Leishmania major 26% 100%
Q4Q598 Leishmania major 27% 85%
Q4Q5T9 Leishmania major 40% 100%
Q4Q5W2 Leishmania major 38% 100%
Q4Q9K2 Leishmania major 29% 100%
Q4QBR6 Leishmania major 30% 100%
Q4QCR3 Leishmania major 23% 100%
Q4QFJ2 Leishmania major 92% 100%
Q6CSX2 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 27% 67%
Q9Y077 Leishmania major 27% 100%
V5B141 Trypanosoma cruzi 30% 100%
V5BAZ8 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS