LeishMANIAdb
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Inositol-3-phosphate synthase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Inositol-3-phosphate synthase
Gene product:
inositol-3-phosphate synthase
Species:
Leishmania infantum
UniProt:
A4HW82_LEIIN
TriTrypDb:
LINF_140020000 *
Length:
417

Annotations

Annotations by Jardim et al.

Carbohydrate metabolism, inositol-3-phosphate synthase INO1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) yes yes: 1
Forrest at al. (procyclic) yes yes: 1
Silverman et al. no yes: 0
Pissara et al. no yes: 6
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HW82
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW82

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 11
GO:0006020 inositol metabolic process 4 11
GO:0006021 inositol biosynthetic process 5 11
GO:0006066 alcohol metabolic process 3 11
GO:0006629 lipid metabolic process 3 11
GO:0006644 phospholipid metabolic process 4 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0008152 metabolic process 1 11
GO:0008610 lipid biosynthetic process 4 11
GO:0008654 phospholipid biosynthetic process 5 11
GO:0009058 biosynthetic process 2 11
GO:0009987 cellular process 1 11
GO:0016051 carbohydrate biosynthetic process 4 11
GO:0019637 organophosphate metabolic process 3 11
GO:0019751 polyol metabolic process 4 11
GO:0034637 obsolete cellular carbohydrate biosynthetic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044255 cellular lipid metabolic process 3 11
GO:0044262 obsolete cellular carbohydrate metabolic process 3 11
GO:0044281 small molecule metabolic process 2 11
GO:0044283 small molecule biosynthetic process 3 11
GO:0046165 alcohol biosynthetic process 4 11
GO:0046173 polyol biosynthetic process 5 11
GO:0071704 organic substance metabolic process 2 11
GO:0090407 organophosphate biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
GO:1901615 organic hydroxy compound metabolic process 3 11
GO:1901617 organic hydroxy compound biosynthetic process 4 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004512 inositol-3-phosphate synthase activity 4 11
GO:0016853 isomerase activity 2 11
GO:0016872 intramolecular lyase activity 3 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 126 130 PF00656 0.486
CLV_NRD_NRD_1 266 268 PF00675 0.269
CLV_NRD_NRD_1 41 43 PF00675 0.267
CLV_NRD_NRD_1 58 60 PF00675 0.267
CLV_NRD_NRD_1 97 99 PF00675 0.269
CLV_PCSK_KEX2_1 143 145 PF00082 0.267
CLV_PCSK_KEX2_1 285 287 PF00082 0.254
CLV_PCSK_KEX2_1 41 43 PF00082 0.267
CLV_PCSK_PC1ET2_1 143 145 PF00082 0.267
CLV_PCSK_PC1ET2_1 285 287 PF00082 0.254
CLV_PCSK_SKI1_1 102 106 PF00082 0.267
CLV_PCSK_SKI1_1 184 188 PF00082 0.390
CLV_PCSK_SKI1_1 203 207 PF00082 0.199
CLV_PCSK_SKI1_1 243 247 PF00082 0.254
CLV_PCSK_SKI1_1 285 289 PF00082 0.335
DOC_CYCLIN_yCln2_LP_2 314 320 PF00134 0.454
DOC_CYCLIN_yCln2_LP_2 362 368 PF00134 0.510
DOC_MAPK_gen_1 201 209 PF00069 0.498
DOC_MAPK_gen_1 267 275 PF00069 0.469
DOC_MAPK_gen_1 41 48 PF00069 0.467
DOC_MAPK_MEF2A_6 3 12 PF00069 0.402
DOC_MAPK_MEF2A_6 41 50 PF00069 0.455
DOC_PP2B_LxvP_1 314 317 PF13499 0.485
DOC_PP2B_LxvP_1 340 343 PF13499 0.430
DOC_PP2B_LxvP_1 362 365 PF13499 0.454
DOC_USP7_UBL2_3 105 109 PF12436 0.430
DOC_USP7_UBL2_3 243 247 PF12436 0.454
DOC_WW_Pin1_4 17 22 PF00397 0.549
DOC_WW_Pin1_4 341 346 PF00397 0.430
DOC_WW_Pin1_4 368 373 PF00397 0.454
LIG_14-3-3_CanoR_1 123 131 PF00244 0.467
LIG_14-3-3_CanoR_1 331 340 PF00244 0.477
LIG_14-3-3_CanoR_1 379 388 PF00244 0.414
LIG_FHA_1 290 296 PF00498 0.467
LIG_FHA_1 300 306 PF00498 0.436
LIG_FHA_1 369 375 PF00498 0.456
LIG_FHA_2 306 312 PF00498 0.454
LIG_LIR_Gen_1 222 230 PF02991 0.454
LIG_LIR_Gen_1 290 297 PF02991 0.454
LIG_LIR_Gen_1 347 355 PF02991 0.472
LIG_LIR_Gen_1 52 63 PF02991 0.502
LIG_LIR_Gen_1 89 97 PF02991 0.500
LIG_LIR_Nem_3 222 226 PF02991 0.454
LIG_LIR_Nem_3 290 296 PF02991 0.454
LIG_LIR_Nem_3 6 12 PF02991 0.517
LIG_LIR_Nem_3 89 94 PF02991 0.535
LIG_NRBOX 357 363 PF00104 0.454
LIG_Pex14_2 68 72 PF04695 0.454
LIG_SH2_NCK_1 155 159 PF00017 0.454
LIG_SH2_STAP1 155 159 PF00017 0.467
LIG_SH2_STAP1 291 295 PF00017 0.458
LIG_SH2_STAT5 277 280 PF00017 0.481
LIG_SH2_STAT5 291 294 PF00017 0.496
LIG_SH2_STAT5 360 363 PF00017 0.481
LIG_SH3_3 257 263 PF00018 0.549
LIG_SH3_3 362 368 PF00018 0.454
LIG_SH3_3 5 11 PF00018 0.476
LIG_SUMO_SIM_anti_2 111 118 PF11976 0.454
LIG_SUMO_SIM_anti_2 321 327 PF11976 0.454
LIG_SUMO_SIM_anti_2 352 359 PF11976 0.454
LIG_SUMO_SIM_par_1 111 118 PF11976 0.454
LIG_SUMO_SIM_par_1 316 321 PF11976 0.454
LIG_SUMO_SIM_par_1 352 359 PF11976 0.454
LIG_TYR_ITIM 221 226 PF00017 0.414
LIG_UBA3_1 138 143 PF00899 0.414
LIG_UBA3_1 357 363 PF00899 0.454
MOD_CK1_1 197 203 PF00069 0.454
MOD_CK1_1 344 350 PF00069 0.459
MOD_CK1_1 356 362 PF00069 0.452
MOD_CK2_1 379 385 PF00069 0.427
MOD_GlcNHglycan 105 108 PF01048 0.326
MOD_GlcNHglycan 176 179 PF01048 0.357
MOD_GlcNHglycan 196 199 PF01048 0.234
MOD_GlcNHglycan 203 206 PF01048 0.260
MOD_GlcNHglycan 334 337 PF01048 0.348
MOD_GlcNHglycan 381 384 PF01048 0.214
MOD_GSK3_1 118 125 PF00069 0.483
MOD_GSK3_1 197 204 PF00069 0.456
MOD_GSK3_1 239 246 PF00069 0.476
MOD_GSK3_1 305 312 PF00069 0.454
MOD_GSK3_1 330 337 PF00069 0.556
MOD_N-GLC_1 144 149 PF02516 0.349
MOD_N-GLC_1 232 237 PF02516 0.310
MOD_N-GLC_2 307 309 PF02516 0.254
MOD_NEK2_1 254 259 PF00069 0.485
MOD_NEK2_2 291 296 PF00069 0.454
MOD_PKA_2 122 128 PF00069 0.467
MOD_PKA_2 330 336 PF00069 0.485
MOD_Plk_1 289 295 PF00069 0.454
MOD_Plk_1 309 315 PF00069 0.529
MOD_Plk_4 150 156 PF00069 0.492
MOD_Plk_4 162 168 PF00069 0.426
MOD_Plk_4 299 305 PF00069 0.454
MOD_Plk_4 309 315 PF00069 0.454
MOD_Plk_4 350 356 PF00069 0.462
MOD_ProDKin_1 17 23 PF00069 0.549
MOD_ProDKin_1 341 347 PF00069 0.430
MOD_ProDKin_1 368 374 PF00069 0.454
MOD_SUMO_for_1 215 218 PF00179 0.454
MOD_SUMO_rev_2 100 107 PF00179 0.606
MOD_SUMO_rev_2 181 189 PF00179 0.498
MOD_SUMO_rev_2 193 197 PF00179 0.424
TRG_DiLeu_BaEn_2 161 167 PF01217 0.549
TRG_DiLeu_BaEn_2 184 190 PF01217 0.469
TRG_DiLeu_BaLyEn_6 314 319 PF01217 0.454
TRG_ENDOCYTIC_2 223 226 PF00928 0.472
TRG_ENDOCYTIC_2 55 58 PF00928 0.502
TRG_ER_diArg_1 40 42 PF00400 0.467
TRG_Pf-PMV_PEXEL_1 286 290 PF00026 0.335

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I042 Leptomonas seymouri 83% 79%
A0A0S4JLI5 Bodo saltans 69% 81%
A0A1X0P7U4 Trypanosomatidae 74% 79%
A0A3R7LTQ6 Trypanosoma rangeli 69% 79%
A0A3S5H6T1 Leishmania donovani 100% 79%
A4H7V6 Leishmania braziliensis 86% 100%
E9APY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O64437 Oryza sativa subsp. japonica 60% 82%
O65195 Hordeum vulgare 60% 82%
O97477 Drosophila melanogaster 59% 74%
P11986 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 51% 78%
P42800 Candida albicans (strain SC5314 / ATCC MYA-2876) 52% 80%
P42801 Arabidopsis thaliana 58% 82%
P42802 Citrus paradisi 56% 82%
P42803 Spirodela polyrhiza 58% 82%
Q2NL29 Bos taurus 59% 75%
Q38862 Arabidopsis thaliana 58% 82%
Q40271 Mesembryanthemum crystallinum 59% 81%
Q41107 Phaseolus vulgaris 57% 82%
Q4QFJ8 Leishmania major 97% 100%
Q4R6E3 Macaca fascicularis 59% 75%
Q54N49 Dictyostelium discoideum 60% 82%
Q6AYK3 Rattus norvegicus 58% 75%
Q6DDT1 Xenopus laevis 58% 74%
Q6FQI1 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 52% 78%
Q7ZXY0 Xenopus laevis 57% 74%
Q8A7J8 Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) 32% 97%
Q8I3Y8 Plasmodium falciparum (isolate 3D7) 38% 69%
Q8S5N2 Oryza sativa subsp. japonica 59% 82%
Q96348 Brassica napus 58% 82%
Q9FPK7 Zea mays 59% 82%
Q9FYV1 Sesamum indicum 60% 82%
Q9JHU9 Mus musculus 60% 75%
Q9LW96 Nicotiana tabacum 59% 82%
Q9LX12 Arabidopsis thaliana 58% 82%
Q9NPH2 Homo sapiens 59% 75%
Q9S7U0 Triticum aestivum 59% 82%
Q9SSV4 Nicotiana paniculata 59% 82%
V5B836 Trypanosoma cruzi 73% 79%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS