Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4HW76_LEIIN

TriTrypDb:

LINF_140019400

Length:

799

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HW76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW76

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0106310	protein serine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.328
CLV_C14_Caspase3-7	735	739	PF00656	0.619
CLV_NRD_NRD_1	124	126	PF00675	0.591
CLV_NRD_NRD_1	305	307	PF00675	0.328
CLV_NRD_NRD_1	534	536	PF00675	0.654
CLV_NRD_NRD_1	546	548	PF00675	0.659
CLV_NRD_NRD_1	562	564	PF00675	0.643
CLV_NRD_NRD_1	608	610	PF00675	0.657
CLV_PCSK_FUR_1	539	543	PF00082	0.651
CLV_PCSK_KEX2_1	124	126	PF00082	0.591
CLV_PCSK_KEX2_1	235	237	PF00082	0.344
CLV_PCSK_KEX2_1	305	307	PF00082	0.328
CLV_PCSK_KEX2_1	538	540	PF00082	0.678
CLV_PCSK_KEX2_1	541	543	PF00082	0.657
CLV_PCSK_KEX2_1	546	548	PF00082	0.640
CLV_PCSK_KEX2_1	562	564	PF00082	0.643
CLV_PCSK_KEX2_1	607	609	PF00082	0.661
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.328
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.675
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.660
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.643
CLV_PCSK_PC7_1	542	548	PF00082	0.647
CLV_PCSK_SKI1_1	236	240	PF00082	0.378
CLV_PCSK_SKI1_1	311	315	PF00082	0.407
CLV_PCSK_SKI1_1	482	486	PF00082	0.630
CLV_PCSK_SKI1_1	661	665	PF00082	0.641
CLV_PCSK_SKI1_1	690	694	PF00082	0.607
CLV_PCSK_SKI1_1	716	720	PF00082	0.586
DOC_CKS1_1	463	468	PF01111	0.643
DOC_CKS1_1	472	477	PF01111	0.548
DOC_CKS1_1	504	509	PF01111	0.538
DOC_CYCLIN_yClb5_NLxxxL_5	496	505	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	473	479	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.627
DOC_MAPK_gen_1	311	320	PF00069	0.413
DOC_MAPK_gen_1	61	71	PF00069	0.546
DOC_MAPK_gen_1	714	721	PF00069	0.604
DOC_PP2B_LxvP_1	473	476	PF13499	0.523
DOC_PP4_FxxP_1	284	287	PF00568	0.326
DOC_PP4_FxxP_1	353	356	PF00568	0.344
DOC_PP4_FxxP_1	472	475	PF00568	0.518
DOC_USP7_MATH_1	118	122	PF00917	0.663
DOC_USP7_MATH_1	136	140	PF00917	0.574
DOC_USP7_MATH_1	142	146	PF00917	0.438
DOC_USP7_MATH_1	207	211	PF00917	0.590
DOC_USP7_MATH_1	217	221	PF00917	0.600
DOC_USP7_MATH_1	277	281	PF00917	0.332
DOC_USP7_MATH_1	461	465	PF00917	0.593
DOC_USP7_MATH_1	783	787	PF00917	0.570
DOC_WW_Pin1_4	114	119	PF00397	0.609
DOC_WW_Pin1_4	202	207	PF00397	0.605
DOC_WW_Pin1_4	44	49	PF00397	0.790
DOC_WW_Pin1_4	462	467	PF00397	0.644
DOC_WW_Pin1_4	471	476	PF00397	0.562
DOC_WW_Pin1_4	484	489	PF00397	0.700
DOC_WW_Pin1_4	491	496	PF00397	0.697
DOC_WW_Pin1_4	503	508	PF00397	0.652
DOC_WW_Pin1_4	569	574	PF00397	0.673
DOC_WW_Pin1_4	611	616	PF00397	0.615
DOC_WW_Pin1_4	637	642	PF00397	0.662
DOC_WW_Pin1_4	674	679	PF00397	0.608
DOC_WW_Pin1_4	85	90	PF00397	0.681
LIG_14-3-3_CanoR_1	124	129	PF00244	0.665
LIG_14-3-3_CanoR_1	335	343	PF00244	0.241
LIG_14-3-3_CanoR_1	482	487	PF00244	0.657
LIG_14-3-3_CanoR_1	593	598	PF00244	0.651
LIG_14-3-3_CanoR_1	625	635	PF00244	0.642
LIG_14-3-3_CanoR_1	64	71	PF00244	0.548
LIG_14-3-3_CanoR_1	687	693	PF00244	0.618
LIG_14-3-3_CanoR_1	7	11	PF00244	0.590
LIG_Actin_WH2_2	679	695	PF00022	0.631
LIG_APCC_ABBA_1	262	267	PF00400	0.344
LIG_APCC_ABBAyCdc20_2	125	131	PF00400	0.476
LIG_APCC_ABBAyCdc20_2	306	312	PF00400	0.344
LIG_BRCT_BRCA1_1	66	70	PF00533	0.518
LIG_deltaCOP1_diTrp_1	417	427	PF00928	0.344
LIG_FHA_1	259	265	PF00498	0.468
LIG_FHA_1	273	279	PF00498	0.204
LIG_FHA_1	342	348	PF00498	0.347
LIG_FHA_1	405	411	PF00498	0.381
LIG_FHA_1	500	506	PF00498	0.607
LIG_FHA_1	658	664	PF00498	0.590
LIG_FHA_2	108	114	PF00498	0.563
LIG_FHA_2	366	372	PF00498	0.412
LIG_FHA_2	439	445	PF00498	0.379
LIG_FHA_2	529	535	PF00498	0.640
LIG_FHA_2	707	713	PF00498	0.590
LIG_LIR_Apic_2	283	287	PF02991	0.302
LIG_LIR_Apic_2	350	356	PF02991	0.416
LIG_LIR_Apic_2	471	475	PF02991	0.542
LIG_LIR_Apic_2	506	512	PF02991	0.558
LIG_LIR_Apic_2	629	635	PF02991	0.557
LIG_LIR_Gen_1	449	458	PF02991	0.404
LIG_LIR_Nem_3	162	166	PF02991	0.508
LIG_LIR_Nem_3	280	284	PF02991	0.362
LIG_LIR_Nem_3	449	454	PF02991	0.406
LIG_Pex14_1	450	454	PF04695	0.381
LIG_SH2_CRK	163	167	PF00017	0.511
LIG_SH2_CRK	509	513	PF00017	0.582
LIG_SH2_CRK	632	636	PF00017	0.558
LIG_SH2_GRB2like	252	255	PF00017	0.328
LIG_SH2_SRC	129	132	PF00017	0.463
LIG_SH2_SRC	413	416	PF00017	0.344
LIG_SH2_STAP1	681	685	PF00017	0.577
LIG_SH2_STAT5	252	255	PF00017	0.412
LIG_SH2_STAT5	268	271	PF00017	0.392
LIG_SH2_STAT5	352	355	PF00017	0.384
LIG_SH2_STAT5	413	416	PF00017	0.344
LIG_SH3_3	135	141	PF00018	0.573
LIG_SH3_3	210	216	PF00018	0.606
LIG_SH3_3	355	361	PF00018	0.344
LIG_SH3_3	455	461	PF00018	0.467
LIG_SH3_3	472	478	PF00018	0.549
LIG_SH3_3	501	507	PF00018	0.567
LIG_SH3_3	660	666	PF00018	0.564
LIG_SH3_3	86	92	PF00018	0.644
LIG_SUMO_SIM_anti_2	237	242	PF11976	0.344
LIG_SUMO_SIM_anti_2	441	447	PF11976	0.328
LIG_TRAF2_1	283	286	PF00917	0.328
LIG_TRFH_1	484	488	PF08558	0.576
LIG_UBA3_1	177	181	PF00899	0.423
LIG_WRC_WIRS_1	281	286	PF05994	0.328
LIG_WRC_WIRS_1	469	474	PF05994	0.516
MOD_CDC14_SPxK_1	487	490	PF00782	0.571
MOD_CDK_SPxK_1	484	490	PF00069	0.575
MOD_CK1_1	13	19	PF00069	0.593
MOD_CK1_1	145	151	PF00069	0.564
MOD_CK1_1	270	276	PF00069	0.393
MOD_CK1_1	280	286	PF00069	0.382
MOD_CK1_1	336	342	PF00069	0.369
MOD_CK1_1	462	468	PF00069	0.687
MOD_CK1_1	471	477	PF00069	0.584
MOD_CK1_1	49	55	PF00069	0.642
MOD_CK1_1	521	527	PF00069	0.717
MOD_CK1_1	528	534	PF00069	0.673
MOD_CK1_1	554	560	PF00069	0.740
MOD_CK1_1	561	567	PF00069	0.827
MOD_CK1_1	568	574	PF00069	0.637
MOD_CK1_1	576	582	PF00069	0.631
MOD_CK1_1	585	591	PF00069	0.559
MOD_CK1_1	624	630	PF00069	0.705
MOD_CK1_1	695	701	PF00069	0.797
MOD_CK1_1	753	759	PF00069	0.560
MOD_CK2_1	280	286	PF00069	0.328
MOD_CK2_1	438	444	PF00069	0.359
MOD_CK2_1	528	534	PF00069	0.633
MOD_CK2_1	625	631	PF00069	0.683
MOD_CK2_1	694	700	PF00069	0.616
MOD_CK2_1	706	712	PF00069	0.523
MOD_Cter_Amidation	536	539	PF01082	0.650
MOD_GlcNHglycan	100	103	PF01048	0.690
MOD_GlcNHglycan	120	123	PF01048	0.704
MOD_GlcNHglycan	130	135	PF01048	0.641
MOD_GlcNHglycan	224	227	PF01048	0.488
MOD_GlcNHglycan	269	272	PF01048	0.389
MOD_GlcNHglycan	32	35	PF01048	0.741
MOD_GlcNHglycan	404	407	PF01048	0.397
MOD_GlcNHglycan	514	517	PF01048	0.668
MOD_GlcNHglycan	543	546	PF01048	0.657
MOD_GlcNHglycan	553	556	PF01048	0.692
MOD_GlcNHglycan	557	560	PF01048	0.712
MOD_GlcNHglycan	583	587	PF01048	0.599
MOD_GlcNHglycan	642	645	PF01048	0.696
MOD_GlcNHglycan	653	657	PF01048	0.808
MOD_GlcNHglycan	694	697	PF01048	0.619
MOD_GlcNHglycan	752	755	PF01048	0.631
MOD_GlcNHglycan	781	784	PF01048	0.543
MOD_GSK3_1	114	121	PF00069	0.784
MOD_GSK3_1	16	23	PF00069	0.606
MOD_GSK3_1	26	33	PF00069	0.754
MOD_GSK3_1	333	340	PF00069	0.371
MOD_GSK3_1	461	468	PF00069	0.554
MOD_GSK3_1	491	498	PF00069	0.743
MOD_GSK3_1	499	506	PF00069	0.507
MOD_GSK3_1	518	525	PF00069	0.582
MOD_GSK3_1	546	553	PF00069	0.630
MOD_GSK3_1	554	561	PF00069	0.727
MOD_GSK3_1	564	571	PF00069	0.588
MOD_GSK3_1	574	581	PF00069	0.647
MOD_GSK3_1	587	594	PF00069	0.546
MOD_GSK3_1	6	13	PF00069	0.612
MOD_GSK3_1	621	628	PF00069	0.652
MOD_GSK3_1	666	673	PF00069	0.629
MOD_GSK3_1	688	695	PF00069	0.668
MOD_GSK3_1	750	757	PF00069	0.750
MOD_GSK3_1	773	780	PF00069	0.628
MOD_GSK3_1	785	792	PF00069	0.705
MOD_LATS_1	548	554	PF00433	0.598
MOD_N-GLC_1	24	29	PF02516	0.569
MOD_N-GLC_1	499	504	PF02516	0.561
MOD_N-GLC_1	657	662	PF02516	0.615
MOD_N-GLC_1	670	675	PF02516	0.540
MOD_N-GLC_1	712	717	PF02516	0.709
MOD_NEK2_1	10	15	PF00069	0.574
MOD_NEK2_1	112	117	PF00069	0.522
MOD_NEK2_1	199	204	PF00069	0.598
MOD_NEK2_1	319	324	PF00069	0.377
MOD_NEK2_1	446	451	PF00069	0.333
MOD_NEK2_1	686	691	PF00069	0.603
MOD_NEK2_1	692	697	PF00069	0.577
MOD_NEK2_1	736	741	PF00069	0.730
MOD_NEK2_1	98	103	PF00069	0.805
MOD_NEK2_2	217	222	PF00069	0.557
MOD_NEK2_2	688	693	PF00069	0.601
MOD_NEK2_2	785	790	PF00069	0.554
MOD_PIKK_1	16	22	PF00454	0.590
MOD_PIKK_1	321	327	PF00454	0.367
MOD_PIKK_1	426	432	PF00454	0.328
MOD_PIKK_1	49	55	PF00454	0.570
MOD_PIKK_1	561	567	PF00454	0.644
MOD_PKA_1	124	130	PF00069	0.577
MOD_PKA_1	541	547	PF00069	0.651
MOD_PKA_2	124	130	PF00069	0.654
MOD_PKA_2	145	151	PF00069	0.446
MOD_PKA_2	438	444	PF00069	0.379
MOD_PKA_2	521	527	PF00069	0.630
MOD_PKA_2	529	535	PF00069	0.572
MOD_PKA_2	541	547	PF00069	0.672
MOD_PKA_2	549	555	PF00069	0.676
MOD_PKA_2	561	567	PF00069	0.568
MOD_PKA_2	6	12	PF00069	0.556
MOD_PKA_2	624	630	PF00069	0.638
MOD_PKA_2	686	692	PF00069	0.611
MOD_PKA_2	792	798	PF00069	0.586
MOD_PKB_1	580	588	PF00069	0.616
MOD_Plk_1	130	136	PF00069	0.524
MOD_Plk_1	236	242	PF00069	0.344
MOD_Plk_1	416	422	PF00069	0.326
MOD_Plk_1	499	505	PF00069	0.502
MOD_Plk_1	737	743	PF00069	0.581
MOD_Plk_1	77	83	PF00069	0.515
MOD_Plk_2-3	72	78	PF00069	0.508
MOD_Plk_4	10	16	PF00069	0.553
MOD_Plk_4	124	130	PF00069	0.499
MOD_Plk_4	236	242	PF00069	0.354
MOD_Plk_4	446	452	PF00069	0.333
MOD_Plk_4	468	474	PF00069	0.614
MOD_Plk_4	659	665	PF00069	0.561
MOD_Plk_4	761	767	PF00069	0.579
MOD_ProDKin_1	114	120	PF00069	0.610
MOD_ProDKin_1	202	208	PF00069	0.603
MOD_ProDKin_1	44	50	PF00069	0.790
MOD_ProDKin_1	462	468	PF00069	0.644
MOD_ProDKin_1	471	477	PF00069	0.560
MOD_ProDKin_1	484	490	PF00069	0.699
MOD_ProDKin_1	491	497	PF00069	0.698
MOD_ProDKin_1	503	509	PF00069	0.655
MOD_ProDKin_1	569	575	PF00069	0.673
MOD_ProDKin_1	611	617	PF00069	0.617
MOD_ProDKin_1	637	643	PF00069	0.664
MOD_ProDKin_1	674	680	PF00069	0.607
MOD_ProDKin_1	85	91	PF00069	0.678
MOD_SUMO_for_1	153	156	PF00179	0.443
MOD_SUMO_for_1	221	224	PF00179	0.544
MOD_SUMO_for_1	234	237	PF00179	0.237
MOD_SUMO_rev_2	653	660	PF00179	0.596
MOD_SUMO_rev_2	710	715	PF00179	0.601
TRG_DiLeu_BaEn_2	422	428	PF01217	0.344
TRG_ENDOCYTIC_2	163	166	PF00928	0.503
TRG_ENDOCYTIC_2	167	170	PF00928	0.453
TRG_ENDOCYTIC_2	281	284	PF00928	0.344
TRG_NLS_MonoExtN_4	604	611	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	311	316	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	734	738	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W1	Leptomonas seymouri	44%	71%
A0A3S7WT68	Leishmania donovani	99%	73%
A4H7V0	Leishmania braziliensis	76%	99%
E9ACA4	Leishmania major	25%	100%
E9AJJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ALU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9APX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QFK4	Leishmania major	90%	98%