Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW75_LEIIN

TriTrypDb:

LINF_140019300

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.586
CLV_C14_Caspase3-7	501	505	PF00656	0.544
CLV_C14_Caspase3-7	637	641	PF00656	0.603
CLV_NRD_NRD_1	131	133	PF00675	0.594
CLV_NRD_NRD_1	148	150	PF00675	0.349
CLV_NRD_NRD_1	191	193	PF00675	0.553
CLV_NRD_NRD_1	261	263	PF00675	0.541
CLV_NRD_NRD_1	336	338	PF00675	0.584
CLV_NRD_NRD_1	36	38	PF00675	0.447
CLV_NRD_NRD_1	377	379	PF00675	0.411
CLV_NRD_NRD_1	410	412	PF00675	0.517
CLV_NRD_NRD_1	454	456	PF00675	0.684
CLV_NRD_NRD_1	475	477	PF00675	0.813
CLV_NRD_NRD_1	494	496	PF00675	0.431
CLV_NRD_NRD_1	52	54	PF00675	0.465
CLV_NRD_NRD_1	599	601	PF00675	0.748
CLV_NRD_NRD_1	61	63	PF00675	0.469
CLV_NRD_NRD_1	648	650	PF00675	0.737
CLV_NRD_NRD_1	699	701	PF00675	0.571
CLV_NRD_NRD_1	779	781	PF00675	0.601
CLV_PCSK_FUR_1	34	38	PF00082	0.455
CLV_PCSK_FUR_1	452	456	PF00082	0.679
CLV_PCSK_FUR_1	475	479	PF00082	0.694
CLV_PCSK_KEX2_1	131	133	PF00082	0.594
CLV_PCSK_KEX2_1	147	149	PF00082	0.360
CLV_PCSK_KEX2_1	191	193	PF00082	0.553
CLV_PCSK_KEX2_1	261	263	PF00082	0.541
CLV_PCSK_KEX2_1	275	277	PF00082	0.419
CLV_PCSK_KEX2_1	336	338	PF00082	0.584
CLV_PCSK_KEX2_1	36	38	PF00082	0.456
CLV_PCSK_KEX2_1	377	379	PF00082	0.411
CLV_PCSK_KEX2_1	451	453	PF00082	0.674
CLV_PCSK_KEX2_1	454	456	PF00082	0.658
CLV_PCSK_KEX2_1	475	477	PF00082	0.643
CLV_PCSK_KEX2_1	494	496	PF00082	0.514
CLV_PCSK_KEX2_1	51	53	PF00082	0.514
CLV_PCSK_KEX2_1	599	601	PF00082	0.748
CLV_PCSK_KEX2_1	61	63	PF00082	0.463
CLV_PCSK_KEX2_1	699	701	PF00082	0.575
CLV_PCSK_KEX2_1	778	780	PF00082	0.609
CLV_PCSK_KEX2_1	90	92	PF00082	0.602
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.563
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.647
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.639
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.524
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.748
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.602
CLV_PCSK_PC7_1	775	781	PF00082	0.660
CLV_PCSK_SKI1_1	112	116	PF00082	0.662
CLV_PCSK_SKI1_1	148	152	PF00082	0.592
CLV_PCSK_SKI1_1	213	217	PF00082	0.488
CLV_PCSK_SKI1_1	27	31	PF00082	0.456
CLV_PCSK_SKI1_1	276	280	PF00082	0.446
CLV_PCSK_SKI1_1	400	404	PF00082	0.488
CLV_PCSK_SKI1_1	411	415	PF00082	0.475
CLV_PCSK_SKI1_1	497	501	PF00082	0.596
DEG_APCC_DBOX_1	147	155	PF00400	0.577
DEG_APCC_DBOX_1	496	504	PF00400	0.511
DEG_SCF_FBW7_2	519	526	PF00400	0.553
DEG_SPOP_SBC_1	742	746	PF00917	0.681
DOC_ANK_TNKS_1	477	484	PF00023	0.692
DOC_ANK_TNKS_1	728	735	PF00023	0.735
DOC_CKS1_1	614	619	PF01111	0.724
DOC_CYCLIN_RxL_1	146	157	PF00134	0.520
DOC_CYCLIN_RxL_1	21	33	PF00134	0.457
DOC_CYCLIN_RxL_1	210	217	PF00134	0.594
DOC_MAPK_gen_1	147	154	PF00069	0.518
DOC_MAPK_gen_1	336	343	PF00069	0.569
DOC_MAPK_gen_1	34	43	PF00069	0.444
DOC_MAPK_gen_1	366	373	PF00069	0.594
DOC_MAPK_gen_1	411	417	PF00069	0.533
DOC_MAPK_gen_1	51	60	PF00069	0.465
DOC_PP1_RVXF_1	147	154	PF00149	0.505
DOC_USP7_MATH_1	16	20	PF00917	0.467
DOC_USP7_MATH_1	274	278	PF00917	0.609
DOC_USP7_MATH_1	286	290	PF00917	0.437
DOC_USP7_MATH_1	312	316	PF00917	0.542
DOC_USP7_MATH_1	438	442	PF00917	0.614
DOC_USP7_MATH_1	622	626	PF00917	0.777
DOC_USP7_MATH_1	629	633	PF00917	0.695
DOC_USP7_MATH_1	718	722	PF00917	0.609
DOC_USP7_MATH_1	742	746	PF00917	0.629
DOC_USP7_MATH_1	768	772	PF00917	0.711
DOC_USP7_UBL2_3	51	55	PF12436	0.522
DOC_WW_Pin1_4	519	524	PF00397	0.635
DOC_WW_Pin1_4	549	554	PF00397	0.696
DOC_WW_Pin1_4	613	618	PF00397	0.699
DOC_WW_Pin1_4	625	630	PF00397	0.553
DOC_WW_Pin1_4	666	671	PF00397	0.625
DOC_WW_Pin1_4	724	729	PF00397	0.606
LIG_14-3-3_CanoR_1	159	164	PF00244	0.523
LIG_14-3-3_CanoR_1	170	179	PF00244	0.425
LIG_14-3-3_CanoR_1	213	219	PF00244	0.533
LIG_14-3-3_CanoR_1	256	264	PF00244	0.528
LIG_14-3-3_CanoR_1	411	416	PF00244	0.448
LIG_14-3-3_CanoR_1	467	474	PF00244	0.614
LIG_14-3-3_CanoR_1	494	503	PF00244	0.524
LIG_14-3-3_CanoR_1	564	568	PF00244	0.602
LIG_14-3-3_CanoR_1	6	12	PF00244	0.444
LIG_14-3-3_CanoR_1	605	613	PF00244	0.623
LIG_14-3-3_CanoR_1	739	747	PF00244	0.660
LIG_Actin_WH2_2	338	356	PF00022	0.563
LIG_AP2alpha_1	796	800	PF02296	0.503
LIG_APCC_ABBA_1	225	230	PF00400	0.508
LIG_BIR_II_1	1	5	PF00653	0.492
LIG_BRCT_BRCA1_1	743	747	PF00533	0.630
LIG_eIF4E_1	339	345	PF01652	0.555
LIG_FHA_1	156	162	PF00498	0.542
LIG_FHA_1	170	176	PF00498	0.364
LIG_FHA_1	329	335	PF00498	0.661
LIG_FHA_1	412	418	PF00498	0.444
LIG_FHA_1	560	566	PF00498	0.648
LIG_FHA_1	6	12	PF00498	0.466
LIG_FHA_1	629	635	PF00498	0.582
LIG_FHA_2	261	267	PF00498	0.584
LIG_FHA_2	288	294	PF00498	0.584
LIG_FHA_2	367	373	PF00498	0.551
LIG_FHA_2	656	662	PF00498	0.541
LIG_LIR_Gen_1	19	30	PF02991	0.465
LIG_LIR_Gen_1	752	761	PF02991	0.726
LIG_LIR_Gen_1	793	801	PF02991	0.515
LIG_LIR_Nem_3	19	25	PF02991	0.467
LIG_LIR_Nem_3	420	425	PF02991	0.453
LIG_LIR_Nem_3	640	646	PF02991	0.735
LIG_LIR_Nem_3	752	758	PF02991	0.784
LIG_NRBOX	139	145	PF00104	0.492
LIG_NRBOX	340	346	PF00104	0.487
LIG_Pex14_1	422	426	PF04695	0.572
LIG_Pex14_2	747	751	PF04695	0.710
LIG_Pex14_2	796	800	PF04695	0.503
LIG_RPA_C_Fungi	386	398	PF08784	0.493
LIG_RPA_C_Fungi	432	444	PF08784	0.604
LIG_SH2_CRK	426	430	PF00017	0.561
LIG_SH2_NCK_1	339	343	PF00017	0.559
LIG_SH2_SRC	228	231	PF00017	0.517
LIG_SH2_STAP1	228	232	PF00017	0.698
LIG_SH2_STAP1	339	343	PF00017	0.559
LIG_SH2_STAP1	426	430	PF00017	0.561
LIG_SH2_STAT5	518	521	PF00017	0.563
LIG_SH3_1	583	589	PF00018	0.684
LIG_SH3_3	550	556	PF00018	0.654
LIG_SH3_3	583	589	PF00018	0.700
LIG_SH3_3	671	677	PF00018	0.682
LIG_SH3_3	771	777	PF00018	0.737
LIG_SH3_CIN85_PxpxPR_1	670	675	PF14604	0.623
LIG_SUMO_SIM_par_1	343	349	PF11976	0.466
LIG_SUMO_SIM_par_1	413	418	PF11976	0.441
LIG_TRAF2_1	238	241	PF00917	0.517
LIG_TRAF2_1	263	266	PF00917	0.603
LIG_TRAF2_1	299	302	PF00917	0.577
LIG_TRAF2_1	308	311	PF00917	0.475
LIG_TRAF2_1	524	527	PF00917	0.663
LIG_TYR_ITIM	424	429	PF00017	0.566
LIG_WRC_WIRS_1	103	108	PF05994	0.610
LIG_WW_3	472	476	PF00397	0.679
MOD_CDK_SPK_2	670	675	PF00069	0.623
MOD_CDK_SPK_2	724	729	PF00069	0.606
MOD_CDK_SPxxK_3	668	675	PF00069	0.622
MOD_CK1_1	511	517	PF00069	0.659
MOD_CK1_1	557	563	PF00069	0.798
MOD_CK1_1	625	631	PF00069	0.635
MOD_CK1_1	638	644	PF00069	0.623
MOD_CK1_1	660	666	PF00069	0.665
MOD_CK1_1	741	747	PF00069	0.663
MOD_CK1_1	749	755	PF00069	0.580
MOD_CK2_1	17	23	PF00069	0.467
MOD_CK2_1	260	266	PF00069	0.607
MOD_CK2_1	287	293	PF00069	0.586
MOD_CK2_1	312	318	PF00069	0.526
MOD_CK2_1	366	372	PF00069	0.551
MOD_CK2_1	495	501	PF00069	0.487
MOD_Cter_Amidation	129	132	PF01082	0.595
MOD_Cter_Amidation	189	192	PF01082	0.509
MOD_GlcNHglycan	106	109	PF01048	0.471
MOD_GlcNHglycan	172	175	PF01048	0.477
MOD_GlcNHglycan	246	249	PF01048	0.503
MOD_GlcNHglycan	257	260	PF01048	0.538
MOD_GlcNHglycan	301	306	PF01048	0.592
MOD_GlcNHglycan	439	443	PF01048	0.621
MOD_GlcNHglycan	469	472	PF01048	0.735
MOD_GlcNHglycan	497	500	PF01048	0.517
MOD_GlcNHglycan	539	542	PF01048	0.732
MOD_GlcNHglycan	624	627	PF01048	0.774
MOD_GlcNHglycan	631	634	PF01048	0.689
MOD_GlcNHglycan	650	653	PF01048	0.466
MOD_GlcNHglycan	714	717	PF01048	0.597
MOD_GlcNHglycan	720	723	PF01048	0.599
MOD_GlcNHglycan	735	738	PF01048	0.528
MOD_GlcNHglycan	740	743	PF01048	0.609
MOD_GlcNHglycan	92	95	PF01048	0.558
MOD_GSK3_1	155	162	PF00069	0.561
MOD_GSK3_1	190	197	PF00069	0.609
MOD_GSK3_1	276	283	PF00069	0.511
MOD_GSK3_1	507	514	PF00069	0.591
MOD_GSK3_1	554	561	PF00069	0.661
MOD_GSK3_1	563	570	PF00069	0.587
MOD_GSK3_1	625	632	PF00069	0.630
MOD_GSK3_1	635	642	PF00069	0.579
MOD_GSK3_1	666	673	PF00069	0.602
MOD_GSK3_1	714	721	PF00069	0.599
MOD_GSK3_1	724	731	PF00069	0.607
MOD_GSK3_1	733	740	PF00069	0.472
MOD_GSK3_1	742	749	PF00069	0.691
MOD_LATS_1	168	174	PF00433	0.566
MOD_LATS_1	409	415	PF00433	0.534
MOD_NEK2_1	214	219	PF00069	0.541
MOD_NEK2_1	320	325	PF00069	0.618
MOD_NEK2_1	353	358	PF00069	0.588
MOD_NEK2_1	387	392	PF00069	0.545
MOD_NEK2_1	508	513	PF00069	0.581
MOD_NEK2_1	563	568	PF00069	0.644
MOD_NEK2_2	223	228	PF00069	0.553
MOD_NEK2_2	559	564	PF00069	0.741
MOD_PIKK_1	508	514	PF00454	0.577
MOD_PIKK_1	532	538	PF00454	0.685
MOD_PK_1	159	165	PF00069	0.504
MOD_PK_1	568	574	PF00069	0.723
MOD_PKA_1	131	137	PF00069	0.487
MOD_PKA_1	411	417	PF00069	0.479
MOD_PKA_1	90	96	PF00069	0.531
MOD_PKA_2	131	137	PF00069	0.567
MOD_PKA_2	169	175	PF00069	0.543
MOD_PKA_2	177	183	PF00069	0.507
MOD_PKA_2	190	196	PF00069	0.433
MOD_PKA_2	255	261	PF00069	0.528
MOD_PKA_2	353	359	PF00069	0.551
MOD_PKA_2	387	393	PF00069	0.587
MOD_PKA_2	5	11	PF00069	0.445
MOD_PKA_2	563	569	PF00069	0.614
MOD_PKA_2	604	610	PF00069	0.614
MOD_PKA_2	648	654	PF00069	0.701
MOD_PKA_2	712	718	PF00069	0.676
MOD_PKA_2	728	734	PF00069	0.546
MOD_PKA_2	738	744	PF00069	0.640
MOD_PKA_2	90	96	PF00069	0.503
MOD_Plk_1	286	292	PF00069	0.487
MOD_Plk_1	639	645	PF00069	0.613
MOD_Plk_2-3	287	293	PF00069	0.549
MOD_Plk_4	223	229	PF00069	0.525
MOD_ProDKin_1	519	525	PF00069	0.634
MOD_ProDKin_1	549	555	PF00069	0.694
MOD_ProDKin_1	613	619	PF00069	0.700
MOD_ProDKin_1	625	631	PF00069	0.551
MOD_ProDKin_1	666	672	PF00069	0.625
MOD_ProDKin_1	724	730	PF00069	0.607
MOD_SUMO_for_1	367	370	PF00179	0.532
MOD_SUMO_rev_2	268	277	PF00179	0.601
MOD_SUMO_rev_2	361	367	PF00179	0.426
MOD_SUMO_rev_2	405	414	PF00179	0.455
TRG_DiLeu_BaEn_4	241	247	PF01217	0.492
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.501
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.454
TRG_DiLeu_BaLyEn_6	779	784	PF01217	0.617
TRG_ENDOCYTIC_2	22	25	PF00928	0.466
TRG_ENDOCYTIC_2	426	429	PF00928	0.628
TRG_ER_diArg_1	131	133	PF00400	0.594
TRG_ER_diArg_1	146	149	PF00400	0.372
TRG_ER_diArg_1	260	262	PF00400	0.548
TRG_ER_diArg_1	336	338	PF00400	0.643
TRG_ER_diArg_1	34	37	PF00400	0.449
TRG_ER_diArg_1	376	378	PF00400	0.416
TRG_ER_diArg_1	43	46	PF00400	0.460
TRG_ER_diArg_1	452	455	PF00400	0.681
TRG_ER_diArg_1	474	476	PF00400	0.682
TRG_ER_diArg_1	494	497	PF00400	0.466
TRG_ER_diArg_1	60	62	PF00400	0.357
TRG_ER_diArg_1	646	649	PF00400	0.674
TRG_ER_diArg_1	698	700	PF00400	0.575
TRG_ER_diArg_1	777	780	PF00400	0.606
TRG_NLS_Bipartite_1	36	55	PF00514	0.506
TRG_NLS_MonoExtC_3	450	455	PF00514	0.646
TRG_NLS_MonoExtC_3	475	480	PF00514	0.756
TRG_NLS_MonoExtC_3	50	55	PF00514	0.520
TRG_NLS_MonoExtN_4	448	455	PF00514	0.612
TRG_NLS_MonoExtN_4	473	480	PF00514	0.631
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	276	281	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	423	428	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P321	Leptomonas seymouri	39%	100%
A0A3S5H6T0	Leishmania donovani	100%	100%
A4H7U9	Leishmania braziliensis	69%	100%
E9APX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFK5	Leishmania major	90%	100%