Ubiquitin-60S ribosomal protein L40

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin/ribosomal protein S27a - putative

Species:

Leishmania infantum

UniProt:

A4HW73_LEIIN

TriTrypDb:

LINF_140019100

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 50

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 40

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	16
GO:0032991	protein-containing complex	1	16
GO:0043226	organelle	2	16
GO:0043228	non-membrane-bounded organelle	3	16
GO:0043229	intracellular organelle	3	16
GO:0043232	intracellular non-membrane-bounded organelle	4	16
GO:0110165	cellular anatomical entity	1	16
GO:1990904	ribonucleoprotein complex	2	16
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HW73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW73

PDB structure(s): 6az1_f

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	16
GO:0006518	peptide metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009058	biosynthetic process	2	16
GO:0009059	macromolecule biosynthetic process	4	16
GO:0009987	cellular process	1	16
GO:0019538	protein metabolic process	3	16
GO:0034641	cellular nitrogen compound metabolic process	3	16
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	16
GO:0043043	peptide biosynthetic process	5	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043603	amide metabolic process	3	16
GO:0043604	amide biosynthetic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044260	obsolete cellular macromolecule metabolic process	3	16
GO:0044271	cellular nitrogen compound biosynthetic process	4	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:1901566	organonitrogen compound biosynthetic process	4	16
GO:1901576	organic substance biosynthetic process	3	16
GO:0006508	proteolysis	4	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0016567	protein ubiquitination	7	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043412	macromolecule modification	4	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044248	cellular catabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	16
GO:0005198	structural molecule activity	1	16
GO:0005488	binding	1	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0031386	protein tag	1	2
GO:0031625	ubiquitin protein ligase binding	5	2
GO:0044389	ubiquitin-like protein ligase binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	13	19	PF00089	0.326
CLV_PCSK_KEX2_1	77	79	PF00082	0.628
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.628
CLV_PCSK_SKI1_1	77	81	PF00082	0.514
CLV_PCSK_SKI1_1	96	100	PF00082	0.395
DEG_APCC_DBOX_1	88	96	PF00400	0.483
DEG_Nend_UBRbox_3	1	3	PF02207	0.385
DOC_MAPK_MEF2A_6	57	65	PF00069	0.535
DOC_PP4_FxxP_1	80	83	PF00568	0.518
DOC_USP7_MATH_1	9	13	PF00917	0.587
DOC_USP7_UBL2_3	148	152	PF12436	0.522
DOC_USP7_UBL2_3	71	75	PF12436	0.514
LIG_14-3-3_CanoR_1	16	23	PF00244	0.526
LIG_ActinCP_TwfCPI_2	80	89	PF01115	0.505
LIG_FHA_1	58	64	PF00498	0.510
LIG_FHA_2	102	108	PF00498	0.470
LIG_FHA_2	114	120	PF00498	0.470
LIG_SH2_STAT3	130	133	PF00017	0.526
LIG_SH2_STAT5	100	103	PF00017	0.470
LIG_SH2_STAT5	139	142	PF00017	0.462
LIG_SH3_3	60	66	PF00018	0.518
LIG_SH3_3	80	86	PF00018	0.513
LIG_SUMO_SIM_anti_2	58	65	PF11976	0.525
LIG_TRAF2_1	45	48	PF00917	0.515
LIG_TYR_ITIM	98	103	PF00017	0.470
MOD_CK1_1	56	62	PF00069	0.526
MOD_Cter_Amidation	71	74	PF01082	0.511
MOD_GlcNHglycan	17	20	PF01048	0.305
MOD_GSK3_1	15	22	PF00069	0.474
MOD_GSK3_1	53	60	PF00069	0.564
MOD_N-GLC_1	30	35	PF02516	0.356
MOD_PIKK_1	30	36	PF00454	0.579
MOD_PKA_1	84	90	PF00069	0.611
MOD_PKA_2	15	21	PF00069	0.526
MOD_Plk_1	19	25	PF00069	0.521
MOD_Plk_1	46	52	PF00069	0.487
MOD_Plk_1	57	63	PF00069	0.438
TRG_ENDOCYTIC_2	100	103	PF00928	0.470
TRG_NES_CRM1_1	93	107	PF08389	0.316
TRG_NLS_MonoCore_2	72	77	PF00514	0.520
TRG_NLS_MonoExtC_3	72	77	PF00514	0.520
TRG_NLS_MonoExtN_4	71	78	PF00514	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IIY9	Bodo saltans	56%	100%
A0A1X0P981	Trypanosomatidae	66%	100%
A0A3Q8IIG2	Leishmania donovani	100%	100%
A0A3S7XAC2	Leishmania donovani	99%	100%
A0A422P284	Trypanosoma rangeli	71%	100%
A4H7U7	Leishmania braziliensis	93%	100%
A4HNS0	Leishmania braziliensis	96%	100%
A4ICS4	Leishmania infantum	99%	100%
C9ZSU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
D0A2N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	89%
E9APX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9ASI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
P05759	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P0C016	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P0C8R3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P0CG86	Hordeum vulgare	45%	98%
P0CG87	Hordeum vulgare	45%	98%
P14797	Dictyostelium discoideum	42%	99%
P14799	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	44%	99%
P15357	Drosophila melanogaster	43%	97%
P27923	Zea mays	46%	98%
P29504	Manduca sexta	41%	98%
P31753	Asparagus officinalis	50%	100%
P37164	Caenorhabditis briggsae	37%	93%
P37165	Caenorhabditis elegans	35%	93%
P47905	Lupinus albus	44%	98%
P51431	Oryza sativa subsp. japonica	45%	98%
P59232	Arabidopsis thaliana	46%	97%
P59233	Arabidopsis thaliana	45%	97%
P59271	Arabidopsis thaliana	44%	97%
P59272	Daucus carota	43%	100%
P62978	Cavia porcellus	44%	97%
P62979	Homo sapiens	44%	97%
P62980	Solanum lycopersicum	44%	97%
P62981	Solanum tuberosum	44%	97%
P62982	Rattus norvegicus	44%	97%
P62983	Mus musculus	44%	97%
P62992	Bos taurus	44%	97%
P68200	Ictalurus punctatus	44%	97%
P68202	Plutella xylostella	41%	98%
P68203	Spodoptera frugiperda	41%	97%
P69061	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	40%	100%
P79781	Gallus gallus	44%	97%
Q4Q216	Leishmania major	97%	100%
Q4QFK7	Leishmania major	98%	100%
Q5A109	Candida albicans (strain SC5314 / ATCC MYA-2876)	45%	79%
Q9ARZ9	Oryza sativa subsp. japonica	45%	98%