5_nucleotid_C domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW71_LEIIN

TriTrypDb:

LINF_140018900

Length:

205

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.368
CLV_NRD_NRD_1	10	12	PF00675	0.542
CLV_PCSK_KEX2_1	10	12	PF00082	0.542
CLV_PCSK_PC7_1	6	12	PF00082	0.452
CLV_PCSK_SKI1_1	141	145	PF00082	0.674
CLV_PCSK_SKI1_1	198	202	PF00082	0.672
CLV_PCSK_SKI1_1	78	82	PF00082	0.595
DOC_CKS1_1	94	99	PF01111	0.396
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.435
DOC_MAPK_gen_1	10	17	PF00069	0.554
DOC_MAPK_MEF2A_6	10	19	PF00069	0.506
DOC_MAPK_MEF2A_6	83	91	PF00069	0.476
DOC_USP7_MATH_1	79	83	PF00917	0.587
DOC_USP7_UBL2_3	44	48	PF12436	0.435
DOC_WW_Pin1_4	65	70	PF00397	0.495
DOC_WW_Pin1_4	93	98	PF00397	0.462
LIG_14-3-3_CanoR_1	194	198	PF00244	0.417
LIG_14-3-3_CanoR_1	6	14	PF00244	0.644
LIG_APCC_ABBA_1	107	112	PF00400	0.408
LIG_FHA_1	132	138	PF00498	0.522
LIG_FHA_1	147	153	PF00498	0.373
LIG_FHA_1	154	160	PF00498	0.362
LIG_FHA_1	75	81	PF00498	0.475
LIG_FHA_2	37	43	PF00498	0.482
LIG_LIR_Gen_1	59	69	PF02991	0.443
LIG_LIR_Nem_3	103	108	PF02991	0.501
LIG_LIR_Nem_3	59	65	PF02991	0.456
LIG_LIR_Nem_3	95	101	PF02991	0.428
LIG_PDZ_Class_3	200	205	PF00595	0.481
LIG_Pex14_2	197	201	PF04695	0.465
LIG_SH2_CRK	105	109	PF00017	0.465
LIG_SH2_CRK	62	66	PF00017	0.450
LIG_SH2_CRK	98	102	PF00017	0.414
LIG_SH2_STAT5	147	150	PF00017	0.421
LIG_SH2_STAT5	180	183	PF00017	0.477
LIG_SH2_STAT5	75	78	PF00017	0.475
LIG_SH3_3	112	118	PF00018	0.401
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.365
MOD_CK1_1	63	69	PF00069	0.477
MOD_CK1_1	93	99	PF00069	0.441
MOD_GlcNHglycan	125	128	PF01048	0.635
MOD_GlcNHglycan	138	141	PF01048	0.588
MOD_GSK3_1	132	139	PF00069	0.487
MOD_GSK3_1	56	63	PF00069	0.477
MOD_GSK3_1	74	81	PF00069	0.464
MOD_N-GLC_1	129	134	PF02516	0.687
MOD_N-GLC_1	6	11	PF02516	0.532
MOD_NEK2_1	148	153	PF00069	0.484
MOD_NEK2_1	171	176	PF00069	0.432
MOD_NEK2_1	61	66	PF00069	0.531
MOD_NEK2_2	193	198	PF00069	0.471
MOD_PKA_2	193	199	PF00069	0.417
MOD_PKA_2	5	11	PF00069	0.657
MOD_Plk_1	49	55	PF00069	0.385
MOD_Plk_4	110	116	PF00069	0.425
MOD_Plk_4	148	154	PF00069	0.447
MOD_Plk_4	176	182	PF00069	0.497
MOD_ProDKin_1	65	71	PF00069	0.493
MOD_ProDKin_1	93	99	PF00069	0.456
MOD_SUMO_for_1	47	50	PF00179	0.434
TRG_DiLeu_BaEn_1	104	109	PF01217	0.471
TRG_ENDOCYTIC_2	105	108	PF00928	0.462
TRG_ENDOCYTIC_2	184	187	PF00928	0.483
TRG_ENDOCYTIC_2	62	65	PF00928	0.446
TRG_ENDOCYTIC_2	98	101	PF00928	0.413
TRG_ER_diArg_1	10	12	PF00400	0.742
TRG_NES_CRM1_1	166	178	PF08389	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ7	Leptomonas seymouri	43%	100%
A0A3S7WT67	Leishmania donovani	100%	100%
A4H7U5	Leishmania braziliensis	71%	100%
E9APX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QFK9	Leishmania major	92%	100%