DEK_C domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW70_LEIIN

TriTrypDb:

LINF_140018800

Length:

302

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HW70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW70

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	5
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003677	DNA binding	4	5
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	5
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.556
CLV_NRD_NRD_1	197	199	PF00675	0.470
CLV_NRD_NRD_1	60	62	PF00675	0.377
CLV_PCSK_KEX2_1	144	146	PF00082	0.601
CLV_PCSK_KEX2_1	197	199	PF00082	0.364
CLV_PCSK_KEX2_1	59	61	PF00082	0.367
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.601
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.526
CLV_PCSK_SKI1_1	197	201	PF00082	0.357
CLV_PCSK_SKI1_1	207	211	PF00082	0.379
CLV_PCSK_SKI1_1	246	250	PF00082	0.485
CLV_PCSK_SKI1_1	61	65	PF00082	0.447
CLV_PCSK_SKI1_1	81	85	PF00082	0.207
DEG_SPOP_SBC_1	266	270	PF00917	0.495
DOC_MAPK_MEF2A_6	95	103	PF00069	0.482
DOC_PP2B_LxvP_1	118	121	PF13499	0.457
DOC_SPAK_OSR1_1	126	130	PF12202	0.434
DOC_USP7_MATH_1	134	138	PF00917	0.710
DOC_USP7_MATH_1	166	170	PF00917	0.671
DOC_USP7_MATH_1	174	178	PF00917	0.569
DOC_USP7_MATH_1	184	188	PF00917	0.395
DOC_USP7_MATH_1	281	285	PF00917	0.685
DOC_USP7_MATH_1	63	67	PF00917	0.392
DOC_WW_Pin1_4	128	133	PF00397	0.552
DOC_WW_Pin1_4	138	143	PF00397	0.595
DOC_WW_Pin1_4	200	205	PF00397	0.445
DOC_WW_Pin1_4	268	273	PF00397	0.620
DOC_WW_Pin1_4	296	301	PF00397	0.573
LIG_14-3-3_CanoR_1	126	132	PF00244	0.556
LIG_14-3-3_CanoR_1	216	220	PF00244	0.432
LIG_Actin_WH2_2	75	93	PF00022	0.492
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_FHA_1	113	119	PF00498	0.391
LIG_FHA_2	201	207	PF00498	0.436
LIG_FHA_2	215	221	PF00498	0.326
LIG_FHA_2	271	277	PF00498	0.645
LIG_LIR_Nem_3	194	199	PF02991	0.451
LIG_LIR_Nem_3	66	70	PF02991	0.267
LIG_SH2_CRK	196	200	PF00017	0.371
LIG_SH3_1	145	151	PF00018	0.610
LIG_SH3_1	159	165	PF00018	0.590
LIG_SH3_3	126	132	PF00018	0.584
LIG_SH3_3	140	146	PF00018	0.722
LIG_SH3_3	159	165	PF00018	0.656
LIG_SH3_3	280	286	PF00018	0.589
LIG_SH3_3	294	300	PF00018	0.531
LIG_TRAF2_1	2	5	PF00917	0.605
LIG_TRAF2_1	218	221	PF00917	0.464
LIG_WRC_WIRS_1	64	69	PF05994	0.436
MOD_CDC14_SPxK_1	141	144	PF00782	0.672
MOD_CDK_SPxK_1	138	144	PF00069	0.647
MOD_CDK_SPxxK_3	138	145	PF00069	0.665
MOD_CDK_SPxxK_3	200	207	PF00069	0.482
MOD_CK1_1	177	183	PF00069	0.552
MOD_CK1_1	268	274	PF00069	0.632
MOD_CK2_1	103	109	PF00069	0.494
MOD_CK2_1	157	163	PF00069	0.591
MOD_CK2_1	214	220	PF00069	0.431
MOD_CK2_1	270	276	PF00069	0.653
MOD_CK2_1	281	287	PF00069	0.588
MOD_Cter_Amidation	57	60	PF01082	0.502
MOD_GlcNHglycan	168	171	PF01048	0.623
MOD_GlcNHglycan	177	180	PF01048	0.514
MOD_GlcNHglycan	182	185	PF01048	0.416
MOD_GlcNHglycan	273	276	PF01048	0.665
MOD_GlcNHglycan	283	286	PF01048	0.654
MOD_GSK3_1	134	141	PF00069	0.562
MOD_GSK3_1	180	187	PF00069	0.623
MOD_GSK3_1	235	242	PF00069	0.414
MOD_GSK3_1	24	31	PF00069	0.501
MOD_GSK3_1	261	268	PF00069	0.498
MOD_GSK3_1	271	278	PF00069	0.584
MOD_NEK2_1	127	132	PF00069	0.625
MOD_NEK2_1	267	272	PF00069	0.557
MOD_NEK2_1	289	294	PF00069	0.593
MOD_NEK2_2	63	68	PF00069	0.360
MOD_PKA_2	215	221	PF00069	0.453
MOD_ProDKin_1	128	134	PF00069	0.553
MOD_ProDKin_1	138	144	PF00069	0.597
MOD_ProDKin_1	200	206	PF00069	0.447
MOD_ProDKin_1	268	274	PF00069	0.624
MOD_ProDKin_1	296	302	PF00069	0.577
MOD_SUMO_rev_2	152	160	PF00179	0.602
TRG_DiLeu_BaEn_4	220	226	PF01217	0.535
TRG_ENDOCYTIC_2	196	199	PF00928	0.367
TRG_ER_diArg_1	196	198	PF00400	0.489
TRG_NLS_Bipartite_1	144	162	PF00514	0.680
TRG_NLS_MonoExtC_3	157	162	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C3	Leptomonas seymouri	60%	88%
A0A1X0NNS7	Trypanosomatidae	33%	73%
A0A3Q8IC32	Leishmania donovani	100%	100%
A0A422MT09	Trypanosoma rangeli	40%	81%
A4H7U4	Leishmania braziliensis	77%	95%
C9ZSU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	99%
E9APX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QFL0	Leishmania major	95%	100%
V5AW13	Trypanosoma cruzi	41%	83%