Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW69_LEIIN

TriTrypDb:

LINF_140018700

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.579
CLV_C14_Caspase3-7	512	516	PF00656	0.692
CLV_NRD_NRD_1	34	36	PF00675	0.486
CLV_NRD_NRD_1	566	568	PF00675	0.553
CLV_PCSK_KEX2_1	34	36	PF00082	0.474
CLV_PCSK_KEX2_1	566	568	PF00082	0.553
CLV_PCSK_SKI1_1	152	156	PF00082	0.510
CLV_PCSK_SKI1_1	240	244	PF00082	0.544
CLV_PCSK_SKI1_1	34	38	PF00082	0.516
CLV_PCSK_SKI1_1	387	391	PF00082	0.601
CLV_PCSK_SKI1_1	414	418	PF00082	0.481
DEG_Nend_UBRbox_1	1	4	PF02207	0.578
DEG_SCF_FBW7_1	311	318	PF00400	0.708
DEG_SPOP_SBC_1	425	429	PF00917	0.598
DOC_CKS1_1	299	304	PF01111	0.609
DOC_CKS1_1	312	317	PF01111	0.648
DOC_CYCLIN_RxL_1	237	244	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	467	473	PF00134	0.607
DOC_PP2B_LxvP_1	196	199	PF13499	0.499
DOC_PP4_FxxP_1	421	424	PF00568	0.744
DOC_USP7_MATH_1	128	132	PF00917	0.558
DOC_USP7_MATH_1	154	158	PF00917	0.627
DOC_USP7_MATH_1	191	195	PF00917	0.604
DOC_USP7_MATH_1	238	242	PF00917	0.564
DOC_USP7_MATH_1	335	339	PF00917	0.657
DOC_USP7_MATH_1	424	428	PF00917	0.601
DOC_USP7_MATH_1	430	434	PF00917	0.681
DOC_USP7_MATH_1	446	450	PF00917	0.537
DOC_USP7_MATH_1	47	51	PF00917	0.661
DOC_USP7_MATH_1	534	538	PF00917	0.701
DOC_WW_Pin1_4	111	116	PF00397	0.544
DOC_WW_Pin1_4	298	303	PF00397	0.700
DOC_WW_Pin1_4	307	312	PF00397	0.697
DOC_WW_Pin1_4	391	396	PF00397	0.682
DOC_WW_Pin1_4	420	425	PF00397	0.733
DOC_WW_Pin1_4	428	433	PF00397	0.537
DOC_WW_Pin1_4	484	489	PF00397	0.760
LIG_14-3-3_CanoR_1	207	213	PF00244	0.504
LIG_14-3-3_CanoR_1	319	325	PF00244	0.606
LIG_14-3-3_CanoR_1	387	395	PF00244	0.472
LIG_14-3-3_CanoR_1	435	443	PF00244	0.598
LIG_14-3-3_CanoR_1	7	16	PF00244	0.463
LIG_14-3-3_CanoR_1	78	88	PF00244	0.490
LIG_BRCT_BRCA1_1	130	134	PF00533	0.518
LIG_BRCT_BRCA1_1	156	160	PF00533	0.486
LIG_BRCT_BRCA1_1	186	190	PF00533	0.710
LIG_BRCT_BRCA1_1	286	290	PF00533	0.569
LIG_FAT_LD_1	25	33	PF03623	0.574
LIG_FHA_1	274	280	PF00498	0.485
LIG_FHA_1	293	299	PF00498	0.439
LIG_FHA_1	40	46	PF00498	0.460
LIG_FHA_1	405	411	PF00498	0.629
LIG_FHA_1	415	421	PF00498	0.437
LIG_FHA_1	540	546	PF00498	0.538
LIG_FHA_2	78	84	PF00498	0.516
LIG_GBD_Chelix_1	377	385	PF00786	0.475
LIG_LIR_Apic_2	418	424	PF02991	0.580
LIG_LIR_Gen_1	144	155	PF02991	0.523
LIG_LIR_Gen_1	559	568	PF02991	0.408
LIG_LIR_Nem_3	144	150	PF02991	0.530
LIG_LIR_Nem_3	352	357	PF02991	0.543
LIG_LIR_Nem_3	559	565	PF02991	0.411
LIG_NRBOX	238	244	PF00104	0.612
LIG_Pex14_1	206	210	PF04695	0.468
LIG_Pex14_2	134	138	PF04695	0.571
LIG_PTAP_UEV_1	302	307	PF05743	0.725
LIG_SH2_CRK	210	214	PF00017	0.571
LIG_SH2_STAP1	135	139	PF00017	0.443
LIG_SH2_STAP1	543	547	PF00017	0.448
LIG_SH2_STAT5	203	206	PF00017	0.461
LIG_SH2_STAT5	359	362	PF00017	0.583
LIG_SH2_STAT5	368	371	PF00017	0.436
LIG_SH3_3	155	161	PF00018	0.637
LIG_SH3_3	300	306	PF00018	0.690
LIG_SH3_3	35	41	PF00018	0.591
LIG_SH3_3	89	95	PF00018	0.560
LIG_TRAF2_1	503	506	PF00917	0.730
MOD_CDK_SPxxK_3	428	435	PF00069	0.606
MOD_CK1_1	122	128	PF00069	0.598
MOD_CK1_1	211	217	PF00069	0.499
MOD_CK1_1	304	310	PF00069	0.753
MOD_CK1_1	317	323	PF00069	0.633
MOD_CK1_1	367	373	PF00069	0.390
MOD_CK1_1	391	397	PF00069	0.526
MOD_CK1_1	433	439	PF00069	0.756
MOD_CK1_1	48	54	PF00069	0.634
MOD_CK1_1	523	529	PF00069	0.731
MOD_CK1_1	537	543	PF00069	0.425
MOD_CK1_1	79	85	PF00069	0.522
MOD_CK2_1	499	505	PF00069	0.719
MOD_CK2_1	77	83	PF00069	0.479
MOD_CMANNOS	66	69	PF00535	0.674
MOD_GlcNHglycan	121	124	PF01048	0.644
MOD_GlcNHglycan	167	170	PF01048	0.726
MOD_GlcNHglycan	193	196	PF01048	0.484
MOD_GlcNHglycan	20	24	PF01048	0.527
MOD_GlcNHglycan	235	238	PF01048	0.494
MOD_GlcNHglycan	252	256	PF01048	0.624
MOD_GlcNHglycan	303	306	PF01048	0.709
MOD_GlcNHglycan	337	340	PF01048	0.789
MOD_GlcNHglycan	390	393	PF01048	0.577
MOD_GlcNHglycan	428	431	PF01048	0.764
MOD_GlcNHglycan	432	435	PF01048	0.795
MOD_GlcNHglycan	47	50	PF01048	0.676
MOD_GlcNHglycan	494	497	PF01048	0.727
MOD_GlcNHglycan	559	562	PF01048	0.312
MOD_GlcNHglycan	58	61	PF01048	0.543
MOD_GSK3_1	111	118	PF00069	0.780
MOD_GSK3_1	161	168	PF00069	0.651
MOD_GSK3_1	208	215	PF00069	0.468
MOD_GSK3_1	269	276	PF00069	0.392
MOD_GSK3_1	297	304	PF00069	0.670
MOD_GSK3_1	307	314	PF00069	0.718
MOD_GSK3_1	318	325	PF00069	0.625
MOD_GSK3_1	335	342	PF00069	0.553
MOD_GSK3_1	364	371	PF00069	0.472
MOD_GSK3_1	420	427	PF00069	0.602
MOD_GSK3_1	48	55	PF00069	0.732
MOD_GSK3_1	487	494	PF00069	0.649
MOD_GSK3_1	515	522	PF00069	0.781
MOD_GSK3_1	557	564	PF00069	0.472
MOD_NEK2_1	110	115	PF00069	0.781
MOD_NEK2_1	212	217	PF00069	0.482
MOD_NEK2_1	232	237	PF00069	0.356
MOD_NEK2_1	344	349	PF00069	0.749
MOD_NEK2_1	369	374	PF00069	0.527
MOD_NEK2_1	388	393	PF00069	0.317
MOD_NEK2_2	128	133	PF00069	0.588
MOD_NEK2_2	340	345	PF00069	0.626
MOD_NEK2_2	561	566	PF00069	0.311
MOD_PIKK_1	48	54	PF00454	0.513
MOD_PIKK_1	521	527	PF00454	0.693
MOD_PIKK_1	534	540	PF00454	0.448
MOD_PKA_2	110	116	PF00069	0.742
MOD_PKA_2	318	324	PF00069	0.609
MOD_PKA_2	77	83	PF00069	0.562
MOD_Plk_1	184	190	PF00069	0.615
MOD_Plk_4	115	121	PF00069	0.574
MOD_Plk_4	154	160	PF00069	0.579
MOD_Plk_4	185	191	PF00069	0.620
MOD_Plk_4	208	214	PF00069	0.546
MOD_Plk_4	284	290	PF00069	0.603
MOD_Plk_4	364	370	PF00069	0.502
MOD_Plk_4	446	452	PF00069	0.577
MOD_ProDKin_1	111	117	PF00069	0.542
MOD_ProDKin_1	298	304	PF00069	0.712
MOD_ProDKin_1	307	313	PF00069	0.698
MOD_ProDKin_1	391	397	PF00069	0.686
MOD_ProDKin_1	420	426	PF00069	0.745
MOD_ProDKin_1	428	434	PF00069	0.537
MOD_ProDKin_1	484	490	PF00069	0.757
MOD_SUMO_rev_2	506	516	PF00179	0.590
TRG_DiLeu_BaEn_1	551	556	PF01217	0.440
TRG_DiLeu_BaEn_1	83	88	PF01217	0.505
TRG_ENDOCYTIC_2	135	138	PF00928	0.389
TRG_ENDOCYTIC_2	210	213	PF00928	0.567
TRG_ENDOCYTIC_2	354	357	PF00928	0.635
TRG_ER_diArg_1	1	4	PF00400	0.529
TRG_ER_diArg_1	34	36	PF00400	0.474
TRG_ER_diArg_1	565	567	PF00400	0.518
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAA7	Leptomonas seymouri	27%	98%
A0A3S7WTC0	Leishmania donovani	99%	100%
A4H7U3	Leishmania braziliensis	63%	99%
E9APX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QFL1	Leishmania major	84%	100%