Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4HW67_LEIIN

TriTrypDb:

LINF_140018500

Length:

261

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW67

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.632
CLV_NRD_NRD_1	167	169	PF00675	0.317
CLV_NRD_NRD_1	257	259	PF00675	0.518
CLV_PCSK_KEX2_1	123	125	PF00082	0.638
CLV_PCSK_KEX2_1	167	169	PF00082	0.317
CLV_PCSK_KEX2_1	257	259	PF00082	0.511
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.638
CLV_PCSK_PC7_1	119	125	PF00082	0.629
CLV_PCSK_SKI1_1	252	256	PF00082	0.398
CLV_PCSK_SKI1_1	5	9	PF00082	0.332
DEG_COP1_1	130	140	PF00400	0.519
DEG_SCF_SKP2-CKS1_1	202	209	PF00560	0.294
DEG_SPOP_SBC_1	101	105	PF00917	0.651
DOC_ANK_TNKS_1	22	29	PF00023	0.551
DOC_PP1_RVXF_1	147	153	PF00149	0.422
DOC_USP7_MATH_1	108	112	PF00917	0.692
DOC_USP7_MATH_1	171	175	PF00917	0.266
DOC_WW_Pin1_4	203	208	PF00397	0.325
LIG_14-3-3_CanoR_1	69	73	PF00244	0.422
LIG_BRCT_BRCA1_1	184	188	PF00533	0.422
LIG_EH1_1	239	247	PF00400	0.368
LIG_FHA_1	198	204	PF00498	0.294
LIG_FHA_1	33	39	PF00498	0.450
LIG_FHA_1	69	75	PF00498	0.414
LIG_FHA_2	125	131	PF00498	0.594
LIG_FHA_2	13	19	PF00498	0.334
LIG_FHA_2	159	165	PF00498	0.294
LIG_FHA_2	178	184	PF00498	0.294
LIG_GBD_Chelix_1	8	16	PF00786	0.339
LIG_Integrin_isoDGR_2	114	116	PF01839	0.618
LIG_LIR_Gen_1	185	195	PF02991	0.391
LIG_LIR_Gen_1	215	221	PF02991	0.351
LIG_LIR_Nem_3	164	169	PF02991	0.366
LIG_LIR_Nem_3	185	191	PF02991	0.319
LIG_LIR_Nem_3	215	220	PF02991	0.351
LIG_MYND_1	2	6	PF01753	0.494
LIG_Pex14_2	152	156	PF04695	0.294
LIG_PTB_Apo_2	73	80	PF02174	0.441
LIG_SH2_STAT5	217	220	PF00017	0.422
LIG_SH3_3	141	147	PF00018	0.317
LIG_SUMO_SIM_par_1	199	206	PF11976	0.308
LIG_TRAF2_1	132	135	PF00917	0.619
LIG_TRAF2_1	97	100	PF00917	0.600
MOD_CDK_SPxK_1	203	209	PF00069	0.294
MOD_CK1_1	64	70	PF00069	0.409
MOD_CK1_1	81	87	PF00069	0.561
MOD_CK2_1	12	18	PF00069	0.328
MOD_CK2_1	124	130	PF00069	0.600
MOD_CK2_1	133	139	PF00069	0.551
MOD_Cter_Amidation	120	123	PF01082	0.581
MOD_GlcNHglycan	104	107	PF01048	0.765
MOD_GlcNHglycan	110	113	PF01048	0.681
MOD_GSK3_1	154	161	PF00069	0.284
MOD_GSK3_1	64	71	PF00069	0.378
MOD_N-GLC_1	81	86	PF02516	0.718
MOD_NEK2_1	12	17	PF00069	0.341
MOD_PIKK_1	182	188	PF00454	0.419
MOD_PKA_1	124	130	PF00069	0.596
MOD_PKA_2	12	18	PF00069	0.328
MOD_PKA_2	124	130	PF00069	0.596
MOD_PKA_2	68	74	PF00069	0.402
MOD_Plk_1	133	139	PF00069	0.538
MOD_Plk_1	158	164	PF00069	0.460
MOD_Plk_1	182	188	PF00069	0.405
MOD_Plk_1	32	38	PF00069	0.501
MOD_Plk_1	81	87	PF00069	0.656
MOD_Plk_2-3	133	139	PF00069	0.518
MOD_Plk_4	12	18	PF00069	0.330
MOD_Plk_4	197	203	PF00069	0.332
MOD_ProDKin_1	203	209	PF00069	0.325
MOD_SUMO_for_1	228	231	PF00179	0.337
MOD_SUMO_for_1	97	100	PF00179	0.527
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.441
TRG_ENDOCYTIC_2	217	220	PF00928	0.422
TRG_ER_diArg_1	124	126	PF00400	0.632
TRG_ER_diArg_1	166	168	PF00400	0.317
TRG_ER_diArg_1	256	258	PF00400	0.533
TRG_NLS_MonoCore_2	121	126	PF00514	0.528
TRG_NLS_MonoExtC_3	121	126	PF00514	0.586
TRG_NLS_MonoExtN_4	119	126	PF00514	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q2	Leptomonas seymouri	60%	94%
A0A0S4IS02	Bodo saltans	42%	100%
A0A1X0NNH3	Trypanosomatidae	40%	100%
A0A3R7R775	Trypanosoma rangeli	46%	100%
A0A3S7WT65	Leishmania donovani	100%	100%
A4H7U1	Leishmania braziliensis	72%	100%
C9ZSV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9APW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFL3	Leishmania major	91%	100%