Putative phosphatidylserine synthase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylserine synthase - putative

Species:

Leishmania infantum

UniProt:

A4HW66_LEIIN

TriTrypDb:

LINF_140018400

Length:

531

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, phosphatidylserine synthase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HW66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW66

Function

Biological processes
Term	Name	Level	Count
GO:0006575	cellular modified amino acid metabolic process	3	12
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006658	phosphatidylserine metabolic process	4	12
GO:0006659	phosphatidylserine biosynthetic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0042398	cellular modified amino acid biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003882	CDP-diacylglycerol-serine O-phosphatidyltransferase activity	6	5
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	5
GO:0106245	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.463
CLV_NRD_NRD_1	188	190	PF00675	0.423
CLV_NRD_NRD_1	479	481	PF00675	0.348
CLV_PCSK_FUR_1	408	412	PF00082	0.294
CLV_PCSK_FUR_1	476	480	PF00082	0.395
CLV_PCSK_KEX2_1	15	17	PF00082	0.539
CLV_PCSK_KEX2_1	324	326	PF00082	0.283
CLV_PCSK_KEX2_1	36	38	PF00082	0.526
CLV_PCSK_KEX2_1	410	412	PF00082	0.270
CLV_PCSK_KEX2_1	478	480	PF00082	0.339
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.305
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.526
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.270
CLV_PCSK_SKI1_1	164	168	PF00082	0.297
CLV_PCSK_SKI1_1	250	254	PF00082	0.313
CLV_PCSK_SKI1_1	324	328	PF00082	0.263
CLV_PCSK_SKI1_1	370	374	PF00082	0.444
CLV_PCSK_SKI1_1	385	389	PF00082	0.297
CLV_PCSK_SKI1_1	513	517	PF00082	0.532
CLV_PCSK_SKI1_1	525	529	PF00082	0.505
CLV_PCSK_SKI1_1	79	83	PF00082	0.523
DEG_APCC_DBOX_1	384	392	PF00400	0.354
DEG_MDM2_SWIB_1	273	281	PF02201	0.244
DEG_SCF_FBW7_1	28	33	PF00400	0.622
DEG_SPOP_SBC_1	30	34	PF00917	0.663
DOC_CDC14_PxL_1	503	511	PF14671	0.432
DOC_CYCLIN_RxL_1	239	248	PF00134	0.354
DOC_CYCLIN_RxL_1	320	328	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.664
DOC_MAPK_gen_1	247	257	PF00069	0.443
DOC_MAPK_gen_1	478	487	PF00069	0.591
DOC_MAPK_MEF2A_6	164	171	PF00069	0.313
DOC_MAPK_MEF2A_6	250	259	PF00069	0.293
DOC_MAPK_MEF2A_6	480	489	PF00069	0.549
DOC_MAPK_MEF2A_6	55	63	PF00069	0.674
DOC_MAPK_NFAT4_5	164	172	PF00069	0.364
DOC_PP1_RVXF_1	87	94	PF00149	0.637
DOC_PP2B_LxvP_1	54	57	PF13499	0.602
DOC_PP4_FxxP_1	343	346	PF00568	0.456
DOC_USP7_MATH_1	31	35	PF00917	0.728
DOC_USP7_MATH_1	515	519	PF00917	0.391
DOC_USP7_MATH_1	67	71	PF00917	0.658
DOC_USP7_MATH_2	67	73	PF00917	0.667
DOC_USP7_UBL2_3	320	324	PF12436	0.516
DOC_WW_Pin1_4	26	31	PF00397	0.705
DOC_WW_Pin1_4	342	347	PF00397	0.499
DOC_WW_Pin1_4	82	87	PF00397	0.635
DOC_WW_Pin1_4	96	101	PF00397	0.548
LIG_14-3-3_CanoR_1	213	222	PF00244	0.238
LIG_14-3-3_CanoR_1	250	259	PF00244	0.297
LIG_14-3-3_CanoR_1	411	421	PF00244	0.470
LIG_AP2alpha_2	219	221	PF02296	0.321
LIG_APCC_ABBA_1	179	184	PF00400	0.417
LIG_BRCT_BRCA1_1	255	259	PF00533	0.297
LIG_deltaCOP1_diTrp_1	217	228	PF00928	0.332
LIG_EH1_1	238	246	PF00400	0.331
LIG_EH1_1	349	357	PF00400	0.384
LIG_EH1_1	366	374	PF00400	0.198
LIG_eIF4E_1	194	200	PF01652	0.328
LIG_eIF4E_1	239	245	PF01652	0.354
LIG_eIF4E_1	484	490	PF01652	0.363
LIG_FHA_1	100	106	PF00498	0.300
LIG_FHA_1	176	182	PF00498	0.417
LIG_FHA_1	351	357	PF00498	0.392
LIG_FHA_1	376	382	PF00498	0.274
LIG_FHA_1	392	398	PF00498	0.259
LIG_FHA_1	413	419	PF00498	0.321
LIG_FHA_1	425	431	PF00498	0.288
LIG_FHA_1	51	57	PF00498	0.689
LIG_FHA_2	214	220	PF00498	0.269
LIG_FHA_2	224	230	PF00498	0.244
LIG_FHA_2	45	51	PF00498	0.626
LIG_LIR_Gen_1	102	111	PF02991	0.390
LIG_LIR_Gen_1	178	185	PF02991	0.299
LIG_LIR_Gen_1	226	234	PF02991	0.302
LIG_LIR_Gen_1	256	266	PF02991	0.297
LIG_LIR_Gen_1	275	286	PF02991	0.113
LIG_LIR_Gen_1	399	409	PF02991	0.465
LIG_LIR_Gen_1	414	425	PF02991	0.211
LIG_LIR_Nem_3	102	107	PF02991	0.390
LIG_LIR_Nem_3	178	182	PF02991	0.328
LIG_LIR_Nem_3	218	224	PF02991	0.238
LIG_LIR_Nem_3	226	231	PF02991	0.158
LIG_LIR_Nem_3	248	252	PF02991	0.505
LIG_LIR_Nem_3	256	262	PF02991	0.297
LIG_LIR_Nem_3	263	269	PF02991	0.297
LIG_LIR_Nem_3	275	281	PF02991	0.113
LIG_LIR_Nem_3	334	338	PF02991	0.447
LIG_LIR_Nem_3	347	352	PF02991	0.437
LIG_LIR_Nem_3	414	420	PF02991	0.421
LIG_LIR_Nem_3	524	529	PF02991	0.367
LIG_LYPXL_yS_3	122	125	PF13949	0.355
LIG_NRBOX	356	362	PF00104	0.362
LIG_NRBOX	387	393	PF00104	0.417
LIG_Pex14_1	463	467	PF04695	0.297
LIG_Pex14_2	273	277	PF04695	0.244
LIG_PTB_Apo_2	485	492	PF02174	0.331
LIG_SH2_PTP2	526	529	PF00017	0.410
LIG_SH2_STAP1	195	199	PF00017	0.322
LIG_SH2_STAP1	492	496	PF00017	0.417
LIG_SH2_STAP1	523	527	PF00017	0.322
LIG_SH2_STAT5	173	176	PF00017	0.266
LIG_SH2_STAT5	239	242	PF00017	0.325
LIG_SH2_STAT5	439	442	PF00017	0.313
LIG_SH2_STAT5	467	470	PF00017	0.377
LIG_SH2_STAT5	484	487	PF00017	0.213
LIG_SH2_STAT5	526	529	PF00017	0.367
LIG_SH2_STAT5	98	101	PF00017	0.568
LIG_SH3_3	145	151	PF00018	0.417
LIG_SH3_3	25	31	PF00018	0.681
LIG_SH3_3	446	452	PF00018	0.322
LIG_SH3_3	80	86	PF00018	0.659
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.374
LIG_SUMO_SIM_anti_2	353	359	PF11976	0.418
LIG_SUMO_SIM_par_1	242	248	PF11976	0.297
LIG_SUMO_SIM_par_1	260	265	PF11976	0.297
LIG_SUMO_SIM_par_1	469	474	PF11976	0.530
LIG_TRAF2_1	215	218	PF00917	0.324
LIG_TYR_ITIM	465	470	PF00017	0.382
LIG_UBA3_1	181	190	PF00899	0.394
LIG_UBA3_1	299	306	PF00899	0.382
LIG_WRC_WIRS_1	176	181	PF05994	0.299
MOD_CDC14_SPxK_1	345	348	PF00782	0.505
MOD_CDK_SPxK_1	342	348	PF00069	0.505
MOD_CDK_SPxxK_3	82	89	PF00069	0.653
MOD_CK1_1	44	50	PF00069	0.746
MOD_CK1_1	70	76	PF00069	0.701
MOD_CK2_1	212	218	PF00069	0.281
MOD_CK2_1	29	35	PF00069	0.757
MOD_CK2_1	44	50	PF00069	0.629
MOD_DYRK1A_RPxSP_1	96	100	PF00069	0.603
MOD_GlcNHglycan	135	138	PF01048	0.338
MOD_GlcNHglycan	517	520	PF01048	0.597
MOD_GSK3_1	105	112	PF00069	0.392
MOD_GSK3_1	26	33	PF00069	0.724
MOD_GSK3_1	424	431	PF00069	0.384
MOD_GSK3_1	67	74	PF00069	0.666
MOD_N-GLC_1	271	276	PF02516	0.424
MOD_NEK2_1	223	228	PF00069	0.244
MOD_NEK2_1	233	238	PF00069	0.293
MOD_NEK2_1	350	355	PF00069	0.350
MOD_NEK2_1	391	396	PF00069	0.407
MOD_PKA_2	212	218	PF00069	0.269
MOD_Plk_1	195	201	PF00069	0.299
MOD_Plk_1	204	210	PF00069	0.282
MOD_Plk_1	262	268	PF00069	0.297
MOD_Plk_4	109	115	PF00069	0.278
MOD_Plk_4	150	156	PF00069	0.518
MOD_Plk_4	175	181	PF00069	0.347
MOD_Plk_4	195	201	PF00069	0.278
MOD_Plk_4	424	430	PF00069	0.313
MOD_Plk_4	99	105	PF00069	0.488
MOD_ProDKin_1	26	32	PF00069	0.707
MOD_ProDKin_1	342	348	PF00069	0.499
MOD_ProDKin_1	82	88	PF00069	0.629
MOD_ProDKin_1	96	102	PF00069	0.543
TRG_DiLeu_BaEn_2	523	529	PF01217	0.305
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.530
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.668
TRG_ENDOCYTIC_2	122	125	PF00928	0.316
TRG_ENDOCYTIC_2	173	176	PF00928	0.297
TRG_ENDOCYTIC_2	308	311	PF00928	0.463
TRG_ENDOCYTIC_2	401	404	PF00928	0.444
TRG_ENDOCYTIC_2	467	470	PF00928	0.377
TRG_ENDOCYTIC_2	484	487	PF00928	0.382
TRG_ENDOCYTIC_2	526	529	PF00928	0.375
TRG_ER_diArg_1	476	479	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIC0	Leptomonas seymouri	74%	100%
A0A0S4ILR0	Bodo saltans	48%	100%
A0A1X0NNG6	Trypanosomatidae	56%	100%
A0A3R7N202	Trypanosoma rangeli	53%	100%
A0A3S7WT59	Leishmania donovani	100%	100%
A4H7U0	Leishmania braziliensis	87%	100%
B2GV22	Rattus norvegicus	34%	100%
C9ZSV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E1BYA3	Gallus gallus	35%	100%
E7EY42	Danio rerio	35%	100%
E9APW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O08888	Cricetulus griseus	35%	100%
P48651	Homo sapiens	32%	100%
Q00576	Cricetulus griseus	32%	100%
Q08D11	Xenopus tropicalis	35%	100%
Q2KHY9	Bos taurus	32%	100%
Q4QFL4	Leishmania major	94%	100%
Q5PQL5	Rattus norvegicus	32%	100%
Q5ZM65	Gallus gallus	32%	100%
Q6I628	Oryza sativa subsp. japonica	35%	100%
Q803C9	Danio rerio	32%	100%
Q99LH2	Mus musculus	32%	100%
Q9VPD3	Drosophila melanogaster	32%	100%
Q9Z1X2	Mus musculus	35%	100%
V5DC50	Trypanosoma cruzi	57%	100%