LeishMANIAdb
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Poly(A) polymerase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Poly(A) polymerase
Gene product:
poly(A) polymerase - putative
Species:
Leishmania infantum
UniProt:
A4HW64_LEIIN
TriTrypDb:
LINF_140018200 *
Length:
709

Annotations

Annotations by Jardim et al.

RNA Processing, poly(A) polymerase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 14
GO:0005737 cytoplasm 2 14
GO:0043226 organelle 2 14
GO:0043227 membrane-bounded organelle 3 14
GO:0043229 intracellular organelle 3 14
GO:0043231 intracellular membrane-bounded organelle 4 14
GO:0110165 cellular anatomical entity 1 14
GO:0005654 nucleoplasm 2 1
GO:0005730 nucleolus 5 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Expansion

Sequence features

A4HW64
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW64

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 14
GO:0006396 RNA processing 6 14
GO:0006397 mRNA processing 7 14
GO:0006725 cellular aromatic compound metabolic process 3 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0008152 metabolic process 1 14
GO:0009987 cellular process 1 14
GO:0016070 RNA metabolic process 5 14
GO:0016071 mRNA metabolic process 6 14
GO:0031123 RNA 3'-end processing 7 14
GO:0034641 cellular nitrogen compound metabolic process 3 14
GO:0043170 macromolecule metabolic process 3 14
GO:0043631 RNA polyadenylation 6 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0046483 heterocycle metabolic process 3 14
GO:0071076 RNA 3' uridylation 8 14
GO:0071704 organic substance metabolic process 2 14
GO:0090304 nucleic acid metabolic process 4 14
GO:1901360 organic cyclic compound metabolic process 3 14
GO:0006378 mRNA polyadenylation 7 2
GO:0031124 mRNA 3'-end processing 8 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 14
GO:0003676 nucleic acid binding 3 14
GO:0003723 RNA binding 4 14
GO:0003824 catalytic activity 1 14
GO:0004652 obsolete polynucleotide adenylyltransferase activity 6 14
GO:0005488 binding 1 14
GO:0005524 ATP binding 5 14
GO:0016740 transferase activity 2 14
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 14
GO:0016779 nucleotidyltransferase activity 4 14
GO:0017076 purine nucleotide binding 4 14
GO:0030554 adenyl nucleotide binding 5 14
GO:0032553 ribonucleotide binding 3 14
GO:0032555 purine ribonucleotide binding 4 14
GO:0032559 adenyl ribonucleotide binding 5 14
GO:0035639 purine ribonucleoside triphosphate binding 4 14
GO:0036094 small molecule binding 2 14
GO:0043167 ion binding 2 14
GO:0043168 anion binding 3 14
GO:0043169 cation binding 3 14
GO:0046872 metal ion binding 4 14
GO:0050265 RNA uridylyltransferase activity 4 14
GO:0070566 adenylyltransferase activity 5 14
GO:0070569 uridylyltransferase activity 5 14
GO:0097159 organic cyclic compound binding 2 14
GO:0097367 carbohydrate derivative binding 2 14
GO:0140098 catalytic activity, acting on RNA 3 14
GO:0140640 catalytic activity, acting on a nucleic acid 2 14
GO:1901265 nucleoside phosphate binding 3 14
GO:1901363 heterocyclic compound binding 2 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 302 306 PF00656 0.314
CLV_C14_Caspase3-7 388 392 PF00656 0.293
CLV_C14_Caspase3-7 625 629 PF00656 0.793
CLV_C14_Caspase3-7 649 653 PF00656 0.753
CLV_NRD_NRD_1 434 436 PF00675 0.365
CLV_NRD_NRD_1 50 52 PF00675 0.335
CLV_NRD_NRD_1 655 657 PF00675 0.657
CLV_PCSK_KEX2_1 434 436 PF00082 0.339
CLV_PCSK_KEX2_1 49 51 PF00082 0.336
CLV_PCSK_KEX2_1 598 600 PF00082 0.630
CLV_PCSK_KEX2_1 657 659 PF00082 0.740
CLV_PCSK_PC1ET2_1 598 600 PF00082 0.630
CLV_PCSK_PC1ET2_1 657 659 PF00082 0.740
CLV_PCSK_SKI1_1 204 208 PF00082 0.320
CLV_PCSK_SKI1_1 212 216 PF00082 0.326
CLV_PCSK_SKI1_1 51 55 PF00082 0.326
CLV_PCSK_SKI1_1 9 13 PF00082 0.488
DEG_APCC_DBOX_1 207 215 PF00400 0.307
DEG_APCC_DBOX_1 50 58 PF00400 0.303
DEG_SPOP_SBC_1 604 608 PF00917 0.757
DOC_CKS1_1 312 317 PF01111 0.298
DOC_MAPK_DCC_7 140 149 PF00069 0.314
DOC_MAPK_FxFP_2 228 231 PF00069 0.314
DOC_MAPK_gen_1 300 309 PF00069 0.314
DOC_MAPK_HePTP_8 53 65 PF00069 0.436
DOC_MAPK_MEF2A_6 140 149 PF00069 0.317
DOC_MAPK_MEF2A_6 378 387 PF00069 0.358
DOC_MAPK_MEF2A_6 56 65 PF00069 0.436
DOC_PP1_RVXF_1 405 411 PF00149 0.321
DOC_PP2B_LxvP_1 108 111 PF13499 0.457
DOC_PP2B_PxIxI_1 544 550 PF00149 0.314
DOC_PP4_FxxP_1 228 231 PF00568 0.314
DOC_PP4_FxxP_1 436 439 PF00568 0.407
DOC_PP4_FxxP_1 73 76 PF00568 0.314
DOC_USP7_MATH_1 299 303 PF00917 0.314
DOC_USP7_MATH_1 456 460 PF00917 0.453
DOC_USP7_MATH_1 487 491 PF00917 0.334
DOC_USP7_MATH_1 584 588 PF00917 0.676
DOC_USP7_MATH_1 627 631 PF00917 0.818
DOC_USP7_MATH_1 647 651 PF00917 0.600
DOC_USP7_MATH_1 675 679 PF00917 0.753
DOC_USP7_MATH_1 681 685 PF00917 0.741
DOC_USP7_MATH_1 688 692 PF00917 0.684
DOC_USP7_MATH_1 89 93 PF00917 0.471
DOC_USP7_MATH_2 299 305 PF00917 0.314
DOC_USP7_UBL2_3 215 219 PF12436 0.298
DOC_WW_Pin1_4 311 316 PF00397 0.298
LIG_14-3-3_CanoR_1 126 131 PF00244 0.313
LIG_14-3-3_CanoR_1 208 212 PF00244 0.427
LIG_14-3-3_CanoR_1 258 264 PF00244 0.381
LIG_14-3-3_CanoR_1 288 297 PF00244 0.436
LIG_14-3-3_CanoR_1 417 422 PF00244 0.358
LIG_14-3-3_CanoR_1 49 54 PF00244 0.345
LIG_14-3-3_CanoR_1 525 531 PF00244 0.421
LIG_14-3-3_CanoR_1 66 70 PF00244 0.298
LIG_BIR_II_1 1 5 PF00653 0.563
LIG_BRCT_BRCA1_1 224 228 PF00533 0.314
LIG_EH1_1 194 202 PF00400 0.334
LIG_FHA_1 171 177 PF00498 0.330
LIG_FHA_1 238 244 PF00498 0.436
LIG_FHA_1 312 318 PF00498 0.309
LIG_FHA_2 272 278 PF00498 0.405
LIG_FHA_2 3 9 PF00498 0.583
LIG_FHA_2 37 43 PF00498 0.405
LIG_FHA_2 418 424 PF00498 0.436
LIG_FHA_2 546 552 PF00498 0.300
LIG_LIR_Apic_2 225 231 PF02991 0.314
LIG_LIR_Apic_2 265 269 PF02991 0.335
LIG_LIR_Apic_2 71 76 PF02991 0.314
LIG_LIR_Gen_1 117 127 PF02991 0.486
LIG_LIR_Gen_1 526 534 PF02991 0.391
LIG_LIR_Nem_3 117 123 PF02991 0.486
LIG_LIR_Nem_3 157 163 PF02991 0.321
LIG_LIR_Nem_3 257 263 PF02991 0.436
LIG_LIR_Nem_3 393 398 PF02991 0.330
LIG_LIR_Nem_3 422 427 PF02991 0.358
LIG_LIR_Nem_3 526 530 PF02991 0.391
LIG_MYND_1 311 315 PF01753 0.354
LIG_PDZ_Class_2 704 709 PF00595 0.518
LIG_Pex14_2 213 217 PF04695 0.298
LIG_Pex14_2 375 379 PF04695 0.366
LIG_PTB_Apo_2 318 325 PF02174 0.298
LIG_PTB_Phospho_1 318 324 PF10480 0.334
LIG_REV1ctd_RIR_1 257 265 PF16727 0.293
LIG_REV1ctd_RIR_1 373 382 PF16727 0.436
LIG_RPA_C_Fungi 580 592 PF08784 0.558
LIG_SH2_CRK 424 428 PF00017 0.436
LIG_SH2_GRB2like 224 227 PF00017 0.314
LIG_SH2_SRC 398 401 PF00017 0.349
LIG_SH2_STAP1 224 228 PF00017 0.321
LIG_SH2_STAT3 247 250 PF00017 0.436
LIG_SH2_STAT3 700 703 PF00017 0.583
LIG_SH2_STAT5 282 285 PF00017 0.314
LIG_SH2_STAT5 382 385 PF00017 0.289
LIG_SH2_STAT5 503 506 PF00017 0.302
LIG_SH2_STAT5 700 703 PF00017 0.583
LIG_SH3_3 309 315 PF00018 0.338
LIG_SH3_3 366 372 PF00018 0.489
LIG_SH3_3 490 496 PF00018 0.385
LIG_SUMO_SIM_par_1 545 551 PF11976 0.285
LIG_TRAF2_1 43 46 PF00917 0.384
LIG_TRAF2_1 572 575 PF00917 0.581
LIG_UBA3_1 197 204 PF00899 0.314
LIG_WRC_WIRS_1 524 529 PF05994 0.391
LIG_WRC_WIRS_1 555 560 PF05994 0.436
MOD_CK1_1 112 118 PF00069 0.419
MOD_CK1_1 159 165 PF00069 0.298
MOD_CK1_1 184 190 PF00069 0.292
MOD_CK1_1 222 228 PF00069 0.366
MOD_CK1_1 450 456 PF00069 0.352
MOD_CK1_1 459 465 PF00069 0.313
MOD_CK1_1 468 474 PF00069 0.186
MOD_CK1_1 491 497 PF00069 0.428
MOD_CK1_1 587 593 PF00069 0.698
MOD_CK1_1 603 609 PF00069 0.672
MOD_CK1_1 610 616 PF00069 0.748
MOD_CK1_1 617 623 PF00069 0.726
MOD_CK1_1 650 656 PF00069 0.641
MOD_CK2_1 271 277 PF00069 0.334
MOD_CK2_1 29 35 PF00069 0.385
MOD_CK2_1 349 355 PF00069 0.455
MOD_CK2_1 36 42 PF00069 0.436
MOD_CK2_1 387 393 PF00069 0.285
MOD_CK2_1 49 55 PF00069 0.153
MOD_CK2_1 574 580 PF00069 0.723
MOD_CK2_1 627 633 PF00069 0.765
MOD_GlcNHglycan 17 20 PF01048 0.451
MOD_GlcNHglycan 231 234 PF01048 0.298
MOD_GlcNHglycan 351 354 PF01048 0.509
MOD_GlcNHglycan 470 473 PF01048 0.376
MOD_GlcNHglycan 489 493 PF01048 0.324
MOD_GlcNHglycan 514 517 PF01048 0.391
MOD_GlcNHglycan 577 580 PF01048 0.592
MOD_GlcNHglycan 602 605 PF01048 0.769
MOD_GlcNHglycan 616 619 PF01048 0.677
MOD_GlcNHglycan 624 627 PF01048 0.664
MOD_GlcNHglycan 628 632 PF01048 0.631
MOD_GlcNHglycan 644 647 PF01048 0.594
MOD_GlcNHglycan 683 686 PF01048 0.714
MOD_GlcNHglycan 690 693 PF01048 0.627
MOD_GlcNHglycan 99 102 PF01048 0.324
MOD_GSK3_1 413 420 PF00069 0.366
MOD_GSK3_1 443 450 PF00069 0.399
MOD_GSK3_1 477 484 PF00069 0.411
MOD_GSK3_1 487 494 PF00069 0.435
MOD_GSK3_1 508 515 PF00069 0.414
MOD_GSK3_1 599 606 PF00069 0.653
MOD_GSK3_1 607 614 PF00069 0.680
MOD_GSK3_1 616 623 PF00069 0.799
MOD_GSK3_1 642 649 PF00069 0.629
MOD_GSK3_1 677 684 PF00069 0.674
MOD_LATS_1 654 660 PF00433 0.548
MOD_N-GLC_1 324 329 PF02516 0.298
MOD_N-GLC_1 412 417 PF02516 0.436
MOD_N-GLC_1 585 590 PF02516 0.759
MOD_N-GLC_2 321 323 PF02516 0.298
MOD_NEK2_1 1 6 PF00069 0.654
MOD_NEK2_1 119 124 PF00069 0.324
MOD_NEK2_1 207 212 PF00069 0.441
MOD_NEK2_1 259 264 PF00069 0.457
MOD_NEK2_1 283 288 PF00069 0.298
MOD_NEK2_1 349 354 PF00069 0.513
MOD_NEK2_1 481 486 PF00069 0.437
MOD_NEK2_2 319 324 PF00069 0.366
MOD_NEK2_2 523 528 PF00069 0.366
MOD_PK_1 219 225 PF00069 0.366
MOD_PK_1 49 55 PF00069 0.334
MOD_PKA_1 49 55 PF00069 0.363
MOD_PKA_1 656 662 PF00069 0.620
MOD_PKA_2 112 118 PF00069 0.298
MOD_PKA_2 139 145 PF00069 0.369
MOD_PKA_2 207 213 PF00069 0.316
MOD_PKA_2 299 305 PF00069 0.316
MOD_PKA_2 446 452 PF00069 0.363
MOD_PKA_2 462 468 PF00069 0.349
MOD_PKA_2 49 55 PF00069 0.344
MOD_PKA_2 575 581 PF00069 0.592
MOD_PKA_2 584 590 PF00069 0.540
MOD_PKA_2 65 71 PF00069 0.298
MOD_PKB_1 445 453 PF00069 0.436
MOD_Plk_1 156 162 PF00069 0.298
MOD_Plk_1 181 187 PF00069 0.292
MOD_Plk_1 29 35 PF00069 0.432
MOD_Plk_1 324 330 PF00069 0.314
MOD_Plk_1 566 572 PF00069 0.624
MOD_Plk_1 675 681 PF00069 0.774
MOD_Plk_2-3 170 176 PF00069 0.298
MOD_Plk_4 181 187 PF00069 0.326
MOD_Plk_4 262 268 PF00069 0.352
MOD_Plk_4 477 483 PF00069 0.228
MOD_Plk_4 494 500 PF00069 0.456
MOD_Plk_4 526 532 PF00069 0.370
MOD_Plk_4 554 560 PF00069 0.414
MOD_Plk_4 65 71 PF00069 0.298
MOD_ProDKin_1 311 317 PF00069 0.298
MOD_SUMO_for_1 127 130 PF00179 0.436
MOD_SUMO_for_1 673 676 PF00179 0.769
MOD_SUMO_rev_2 298 304 PF00179 0.316
MOD_SUMO_rev_2 352 358 PF00179 0.414
TRG_ENDOCYTIC_2 382 385 PF00928 0.315
TRG_ENDOCYTIC_2 424 427 PF00928 0.417
TRG_ER_diArg_1 287 290 PF00400 0.366
TRG_ER_diArg_1 405 408 PF00400 0.436
TRG_ER_diArg_1 433 435 PF00400 0.336
TRG_ER_diArg_1 444 447 PF00400 0.262
TRG_ER_diArg_1 49 51 PF00400 0.343
TRG_NLS_MonoExtC_3 655 660 PF00514 0.722
TRG_Pf-PMV_PEXEL_1 332 336 PF00026 0.298
TRG_Pf-PMV_PEXEL_1 532 536 PF00026 0.314
TRG_Pf-PMV_PEXEL_1 636 640 PF00026 0.651

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2K1 Leptomonas seymouri 72% 96%
A0A0S4JIG5 Bodo saltans 47% 100%
A0A1X0NP17 Trypanosomatidae 60% 100%
A0A3Q8ID77 Leishmania donovani 100% 100%
A0A3R7KE83 Trypanosoma rangeli 63% 100%
A4H7T8 Leishmania braziliensis 86% 100%
A4I4T6 Leishmania infantum 27% 100%
C9ZSW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9AEC2 Leishmania major 26% 100%
E9APW5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QFL6 Leishmania major 94% 99%
V5BKK6 Trypanosoma cruzi 59% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS