Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

ras-like small GTPases - putative

Species:

Leishmania infantum

UniProt:

A4HW63_LEIIN

TriTrypDb:

LINF_140018100

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW63

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0003924	GTPase activity	7	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.199
CLV_NRD_NRD_1	373	375	PF00675	0.456
CLV_NRD_NRD_1	400	402	PF00675	0.436
CLV_NRD_NRD_1	59	61	PF00675	0.199
CLV_NRD_NRD_1	91	93	PF00675	0.199
CLV_PCSK_KEX2_1	372	374	PF00082	0.465
CLV_PCSK_KEX2_1	59	61	PF00082	0.199
CLV_PCSK_KEX2_1	91	93	PF00082	0.199
CLV_PCSK_SKI1_1	109	113	PF00082	0.199
CLV_PCSK_SKI1_1	15	19	PF00082	0.300
CLV_PCSK_SKI1_1	23	27	PF00082	0.199
CLV_PCSK_SKI1_1	60	64	PF00082	0.199
CLV_PCSK_SKI1_1	68	72	PF00082	0.199
DEG_SCF_FBW7_2	301	308	PF00400	0.267
DEG_SPOP_SBC_1	323	327	PF00917	0.347
DOC_CYCLIN_RxL_1	65	73	PF00134	0.199
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.252
DOC_MAPK_gen_1	59	66	PF00069	0.199
DOC_MAPK_MEF2A_6	59	66	PF00069	0.199
DOC_PP2B_LxvP_1	174	177	PF13499	0.470
DOC_USP7_MATH_1	164	168	PF00917	0.354
DOC_USP7_MATH_1	202	206	PF00917	0.464
DOC_USP7_MATH_1	222	226	PF00917	0.476
DOC_USP7_MATH_1	273	277	PF00917	0.427
DOC_USP7_MATH_1	324	328	PF00917	0.347
DOC_USP7_MATH_1	375	379	PF00917	0.420
DOC_WW_Pin1_4	17	22	PF00397	0.266
DOC_WW_Pin1_4	217	222	PF00397	0.473
DOC_WW_Pin1_4	224	229	PF00397	0.482
DOC_WW_Pin1_4	255	260	PF00397	0.456
DOC_WW_Pin1_4	261	266	PF00397	0.441
DOC_WW_Pin1_4	269	274	PF00397	0.473
DOC_WW_Pin1_4	301	306	PF00397	0.274
LIG_14-3-3_CanoR_1	109	114	PF00244	0.199
LIG_14-3-3_CanoR_1	15	21	PF00244	0.290
LIG_14-3-3_CanoR_1	291	300	PF00244	0.295
LIG_14-3-3_CanoR_1	367	375	PF00244	0.470
LIG_14-3-3_CanoR_1	59	65	PF00244	0.199
LIG_BIR_II_1	1	5	PF00653	0.414
LIG_BIR_III_4	284	288	PF00653	0.317
LIG_FHA_1	324	330	PF00498	0.359
LIG_FHA_1	61	67	PF00498	0.199
LIG_FHA_2	326	332	PF00498	0.375
LIG_LIR_Gen_1	304	315	PF02991	0.253
LIG_LIR_Nem_3	304	310	PF02991	0.256
LIG_LIR_Nem_3	85	90	PF02991	0.199
LIG_MYND_1	299	303	PF01753	0.278
LIG_NRBOX	394	400	PF00104	0.401
LIG_SH2_SRC	105	108	PF00017	0.199
LIG_SH2_STAT5	143	146	PF00017	0.409
LIG_SH3_3	230	236	PF00018	0.487
LIG_SH3_3	260	266	PF00018	0.442
LIG_SH3_3	47	53	PF00018	0.199
LIG_Sin3_3	162	169	PF02671	0.379
LIG_SUMO_SIM_anti_2	313	320	PF11976	0.283
LIG_SUMO_SIM_par_1	275	281	PF11976	0.344
LIG_WRC_WIRS_1	7	12	PF05994	0.342
MOD_CDC14_SPxK_1	20	23	PF00782	0.245
MOD_CDK_SPxK_1	17	23	PF00069	0.261
MOD_CK1_1	145	151	PF00069	0.441
MOD_CK1_1	167	173	PF00069	0.431
MOD_CK1_1	272	278	PF00069	0.416
MOD_CK1_1	325	331	PF00069	0.365
MOD_CK1_1	347	353	PF00069	0.446
MOD_CK1_1	354	360	PF00069	0.438
MOD_CK1_1	8	14	PF00069	0.330
MOD_CK2_1	273	279	PF00069	0.397
MOD_CK2_1	325	331	PF00069	0.365
MOD_GlcNHglycan	124	127	PF01048	0.199
MOD_GlcNHglycan	148	151	PF01048	0.455
MOD_GlcNHglycan	166	169	PF01048	0.374
MOD_GlcNHglycan	174	177	PF01048	0.470
MOD_GlcNHglycan	191	194	PF01048	0.447
MOD_GlcNHglycan	331	335	PF01048	0.383
MOD_GlcNHglycan	342	345	PF01048	0.434
MOD_GlcNHglycan	356	359	PF01048	0.439
MOD_GlcNHglycan	36	39	PF01048	0.199
MOD_GlcNHglycan	363	366	PF01048	0.472
MOD_GlcNHglycan	80	84	PF01048	0.199
MOD_GSK3_1	105	112	PF00069	0.199
MOD_GSK3_1	141	148	PF00069	0.404
MOD_GSK3_1	224	231	PF00069	0.483
MOD_GSK3_1	255	262	PF00069	0.453
MOD_GSK3_1	269	276	PF00069	0.457
MOD_GSK3_1	319	326	PF00069	0.332
MOD_GSK3_1	330	337	PF00069	0.391
MOD_GSK3_1	340	347	PF00069	0.438
MOD_GSK3_1	357	364	PF00069	0.443
MOD_N-GLC_1	172	177	PF02516	0.468
MOD_N-GLC_1	386	391	PF02516	0.352
MOD_N-GLC_2	216	218	PF02516	0.476
MOD_NEK2_1	16	21	PF00069	0.284
MOD_NEK2_1	172	177	PF00069	0.468
MOD_NEK2_1	310	315	PF00069	0.247
MOD_NEK2_1	386	391	PF00069	0.352
MOD_NEK2_2	292	297	PF00069	0.306
MOD_PIKK_1	44	50	PF00454	0.199
MOD_PKA_1	109	115	PF00069	0.199
MOD_PKA_2	51	57	PF00069	0.199
MOD_Plk_1	278	284	PF00069	0.314
MOD_Plk_1	319	325	PF00069	0.328
MOD_Plk_1	386	392	PF00069	0.358
MOD_Plk_4	109	115	PF00069	0.199
MOD_Plk_4	184	190	PF00069	0.450
MOD_Plk_4	273	279	PF00069	0.397
MOD_Plk_4	310	316	PF00069	0.253
MOD_ProDKin_1	17	23	PF00069	0.261
MOD_ProDKin_1	217	223	PF00069	0.473
MOD_ProDKin_1	224	230	PF00069	0.483
MOD_ProDKin_1	255	261	PF00069	0.454
MOD_ProDKin_1	269	275	PF00069	0.467
MOD_ProDKin_1	301	307	PF00069	0.267
MOD_SUMO_for_1	178	181	PF00179	0.450
TRG_DiLeu_BaEn_2	88	94	PF01217	0.199
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.310
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.274
TRG_ENDOCYTIC_2	87	90	PF00928	0.199
TRG_ER_diArg_1	372	374	PF00400	0.465
TRG_ER_diArg_1	90	92	PF00400	0.199
TRG_NES_CRM1_1	308	320	PF08389	0.269
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	68	73	PF00026	0.199