Tub family protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tub family protein-like protein

Species:

Leishmania infantum

UniProt:

A4HW61_LEIIN

TriTrypDb:

LINF_140017800

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.563
CLV_C14_Caspase3-7	370	374	PF00656	0.377
CLV_NRD_NRD_1	159	161	PF00675	0.667
CLV_NRD_NRD_1	191	193	PF00675	0.363
CLV_NRD_NRD_1	200	202	PF00675	0.497
CLV_NRD_NRD_1	287	289	PF00675	0.339
CLV_NRD_NRD_1	304	306	PF00675	0.235
CLV_NRD_NRD_1	424	426	PF00675	0.453
CLV_NRD_NRD_1	511	513	PF00675	0.455
CLV_NRD_NRD_1	79	81	PF00675	0.563
CLV_PCSK_FUR_1	200	204	PF00082	0.358
CLV_PCSK_KEX2_1	191	193	PF00082	0.363
CLV_PCSK_KEX2_1	200	202	PF00082	0.497
CLV_PCSK_KEX2_1	287	289	PF00082	0.341
CLV_PCSK_KEX2_1	424	426	PF00082	0.322
CLV_PCSK_KEX2_1	81	83	PF00082	0.619
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.358
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.619
CLV_PCSK_SKI1_1	174	178	PF00082	0.481
CLV_PCSK_SKI1_1	191	195	PF00082	0.306
CLV_PCSK_SKI1_1	236	240	PF00082	0.389
CLV_PCSK_SKI1_1	306	310	PF00082	0.453
CLV_PCSK_SKI1_1	416	420	PF00082	0.310
CLV_PCSK_SKI1_1	487	491	PF00082	0.335
DEG_APCC_DBOX_1	492	500	PF00400	0.335
DEG_Nend_UBRbox_2	1	3	PF02207	0.607
DEG_SCF_FBW7_1	8	14	PF00400	0.599
DEG_SPOP_SBC_1	400	404	PF00917	0.278
DOC_CKS1_1	8	13	PF01111	0.577
DOC_CYCLIN_yCln2_LP_2	327	333	PF00134	0.453
DOC_MAPK_FxFP_2	492	495	PF00069	0.335
DOC_MAPK_gen_1	200	208	PF00069	0.335
DOC_MAPK_gen_1	287	297	PF00069	0.483
DOC_MAPK_gen_1	302	311	PF00069	0.251
DOC_MAPK_gen_1	350	360	PF00069	0.278
DOC_MAPK_MEF2A_6	305	313	PF00069	0.335
DOC_MAPK_MEF2A_6	425	434	PF00069	0.335
DOC_PP1_RVXF_1	448	454	PF00149	0.335
DOC_PP2B_PxIxI_1	429	435	PF00149	0.335
DOC_PP4_FxxP_1	492	495	PF00568	0.335
DOC_USP7_MATH_1	12	16	PF00917	0.655
DOC_USP7_MATH_1	131	135	PF00917	0.571
DOC_USP7_MATH_1	146	150	PF00917	0.611
DOC_USP7_MATH_1	365	369	PF00917	0.310
DOC_USP7_MATH_1	399	403	PF00917	0.369
DOC_USP7_MATH_1	47	51	PF00917	0.560
DOC_USP7_MATH_1	72	76	PF00917	0.616
DOC_USP7_UBL2_3	302	306	PF12436	0.335
DOC_USP7_UBL2_3	459	463	PF12436	0.453
DOC_WW_Pin1_4	132	137	PF00397	0.529
DOC_WW_Pin1_4	380	385	PF00397	0.389
DOC_WW_Pin1_4	40	45	PF00397	0.598
DOC_WW_Pin1_4	426	431	PF00397	0.332
DOC_WW_Pin1_4	54	59	PF00397	0.638
DOC_WW_Pin1_4	7	12	PF00397	0.572
DOC_WW_Pin1_4	74	79	PF00397	0.651
LIG_14-3-3_CanoR_1	13	17	PF00244	0.580
LIG_14-3-3_CanoR_1	215	220	PF00244	0.485
LIG_14-3-3_CanoR_1	321	327	PF00244	0.389
LIG_14-3-3_CanoR_1	353	360	PF00244	0.325
LIG_Actin_RPEL_3	193	212	PF02755	0.335
LIG_APCC_ABBA_1	294	299	PF00400	0.335
LIG_BRCT_BRCA1_1	217	221	PF00533	0.344
LIG_BRCT_BRCA1_1	263	267	PF00533	0.392
LIG_FHA_1	323	329	PF00498	0.335
LIG_FHA_2	157	163	PF00498	0.525
LIG_FHA_2	240	246	PF00498	0.389
LIG_LIR_Apic_2	183	189	PF02991	0.422
LIG_LIR_Apic_2	334	340	PF02991	0.334
LIG_LIR_Apic_2	491	495	PF02991	0.335
LIG_LIR_Gen_1	218	223	PF02991	0.344
LIG_LIR_Gen_1	322	331	PF02991	0.313
LIG_LIR_Gen_1	373	384	PF02991	0.476
LIG_LIR_Gen_1	462	473	PF02991	0.319
LIG_LIR_Nem_3	2	6	PF02991	0.554
LIG_LIR_Nem_3	218	222	PF02991	0.344
LIG_LIR_Nem_3	322	327	PF02991	0.334
LIG_LIR_Nem_3	383	389	PF02991	0.321
LIG_LIR_Nem_3	439	445	PF02991	0.453
LIG_LIR_Nem_3	462	468	PF02991	0.325
LIG_LIR_Nem_3	99	104	PF02991	0.565
LIG_NRBOX	308	314	PF00104	0.453
LIG_Pex14_2	488	492	PF04695	0.335
LIG_SH2_CRK	101	105	PF00017	0.566
LIG_SH2_CRK	187	191	PF00017	0.399
LIG_SH2_NCK_1	101	105	PF00017	0.566
LIG_SH2_PTP2	337	340	PF00017	0.335
LIG_SH2_SRC	6	9	PF00017	0.600
LIG_SH2_STAT5	197	200	PF00017	0.335
LIG_SH2_STAT5	337	340	PF00017	0.335
LIG_SH3_1	424	430	PF00018	0.335
LIG_SH3_2	55	60	PF14604	0.630
LIG_SH3_2	8	13	PF14604	0.577
LIG_SH3_3	14	20	PF00018	0.563
LIG_SH3_3	175	181	PF00018	0.487
LIG_SH3_3	323	329	PF00018	0.335
LIG_SH3_3	41	47	PF00018	0.622
LIG_SH3_3	424	430	PF00018	0.335
LIG_SH3_3	467	473	PF00018	0.313
LIG_SH3_3	5	11	PF00018	0.684
LIG_SH3_3	52	58	PF00018	0.625
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.453
LIG_SUMO_SIM_par_1	431	437	PF11976	0.453
LIG_SUMO_SIM_par_1	466	472	PF11976	0.313
LIG_TRAF2_1	94	97	PF00917	0.566
LIG_TYR_ITIM	185	190	PF00017	0.363
LIG_TYR_ITSM	97	104	PF00017	0.566
LIG_UBA3_1	432	438	PF00899	0.313
LIG_WRC_WIRS_1	235	240	PF05994	0.278
LIG_WW_2	46	49	PF00397	0.571
LIG_WW_3	10	14	PF00397	0.580
LIG_WW_3	18	22	PF00397	0.584
MOD_CDC14_SPxK_1	57	60	PF00782	0.563
MOD_CDK_SPxK_1	54	60	PF00069	0.561
MOD_CDK_SPxK_1	7	13	PF00069	0.576
MOD_CDK_SPxK_1	74	80	PF00069	0.520
MOD_CDK_SPxxK_3	74	81	PF00069	0.616
MOD_CK1_1	103	109	PF00069	0.559
MOD_CK1_1	134	140	PF00069	0.710
MOD_CK1_1	168	174	PF00069	0.758
MOD_CK1_1	237	243	PF00069	0.453
MOD_CK1_1	298	304	PF00069	0.335
MOD_CK1_1	322	328	PF00069	0.342
MOD_CK1_1	377	383	PF00069	0.389
MOD_CK1_1	403	409	PF00069	0.374
MOD_CK2_1	156	162	PF00069	0.465
MOD_CK2_1	239	245	PF00069	0.389
MOD_CK2_1	399	405	PF00069	0.389
MOD_CK2_1	63	69	PF00069	0.593
MOD_GlcNHglycan	148	151	PF01048	0.556
MOD_GlcNHglycan	165	168	PF01048	0.629
MOD_GlcNHglycan	21	24	PF01048	0.595
MOD_GlcNHglycan	248	251	PF01048	0.482
MOD_GlcNHglycan	334	337	PF01048	0.348
MOD_GlcNHglycan	391	394	PF01048	0.325
MOD_GlcNHglycan	65	68	PF01048	0.601
MOD_GSK3_1	161	168	PF00069	0.572
MOD_GSK3_1	261	268	PF00069	0.326
MOD_GSK3_1	316	323	PF00069	0.335
MOD_GSK3_1	380	387	PF00069	0.376
MOD_GSK3_1	399	406	PF00069	0.370
MOD_GSK3_1	454	461	PF00069	0.389
MOD_GSK3_1	503	510	PF00069	0.335
MOD_GSK3_1	7	14	PF00069	0.598
MOD_GSK3_1	96	103	PF00069	0.577
MOD_N-GLC_1	106	111	PF02516	0.536
MOD_N-GLC_1	319	324	PF02516	0.358
MOD_N-GLC_1	365	370	PF02516	0.389
MOD_N-GLC_1	384	389	PF02516	0.278
MOD_N-GLC_2	128	130	PF02516	0.508
MOD_NEK2_1	172	177	PF00069	0.551
MOD_NEK2_1	29	34	PF00069	0.598
MOD_NEK2_1	316	321	PF00069	0.325
MOD_PIKK_1	12	18	PF00454	0.582
MOD_PIKK_1	48	54	PF00454	0.692
MOD_PKA_1	80	86	PF00069	0.570
MOD_PKA_2	12	18	PF00069	0.577
MOD_PKA_2	320	326	PF00069	0.389
MOD_PKA_2	352	358	PF00069	0.485
MOD_PKA_2	455	461	PF00069	0.348
MOD_Plk_1	319	325	PF00069	0.389
MOD_Plk_1	384	390	PF00069	0.278
MOD_Plk_4	165	171	PF00069	0.566
MOD_Plk_4	207	213	PF00069	0.337
MOD_Plk_4	261	267	PF00069	0.278
MOD_Plk_4	504	510	PF00069	0.335
MOD_ProDKin_1	132	138	PF00069	0.529
MOD_ProDKin_1	380	386	PF00069	0.389
MOD_ProDKin_1	40	46	PF00069	0.597
MOD_ProDKin_1	426	432	PF00069	0.332
MOD_ProDKin_1	54	60	PF00069	0.639
MOD_ProDKin_1	7	13	PF00069	0.576
MOD_ProDKin_1	74	80	PF00069	0.651
MOD_SUMO_rev_2	75	83	PF00179	0.615
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.467
TRG_ENDOCYTIC_2	101	104	PF00928	0.566
TRG_ENDOCYTIC_2	187	190	PF00928	0.383
TRG_ENDOCYTIC_2	376	379	PF00928	0.421
TRG_ER_diArg_1	190	192	PF00400	0.489
TRG_ER_diArg_1	200	203	PF00400	0.267
TRG_ER_diArg_1	423	425	PF00400	0.453
TRG_NLS_Bipartite_1	191	206	PF00514	0.326
TRG_NLS_MonoCore_2	200	205	PF00514	0.358
TRG_NLS_MonoExtN_4	200	206	PF00514	0.453
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC07	Leptomonas seymouri	60%	100%
A0A3Q8I9W0	Leishmania donovani	100%	100%
A4H7R8	Leishmania braziliensis	73%	99%
E9APW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QFL9	Leishmania major	94%	100%