Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cold-shock' DNA-binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HW60_LEIIN

TriTrypDb:

LINF_140017700

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HW60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW60

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003677	DNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.668
CLV_NRD_NRD_1	154	156	PF00675	0.725
CLV_NRD_NRD_1	252	254	PF00675	0.528
CLV_NRD_NRD_1	336	338	PF00675	0.498
CLV_NRD_NRD_1	453	455	PF00675	0.694
CLV_NRD_NRD_1	460	462	PF00675	0.691
CLV_NRD_NRD_1	68	70	PF00675	0.471
CLV_PCSK_KEX2_1	154	156	PF00082	0.742
CLV_PCSK_KEX2_1	252	254	PF00082	0.528
CLV_PCSK_KEX2_1	336	338	PF00082	0.497
CLV_PCSK_KEX2_1	460	462	PF00082	0.762
CLV_PCSK_KEX2_1	68	70	PF00082	0.472
CLV_PCSK_SKI1_1	118	122	PF00082	0.441
CLV_PCSK_SKI1_1	124	128	PF00082	0.388
CLV_PCSK_SKI1_1	338	342	PF00082	0.487
CLV_PCSK_SKI1_1	366	370	PF00082	0.270
DEG_SCF_FBW7_1	289	295	PF00400	0.480
DOC_CKS1_1	289	294	PF01111	0.472
DOC_CYCLIN_RxL_1	337	349	PF00134	0.651
DOC_MAPK_DCC_7	221	230	PF00069	0.425
DOC_MAPK_gen_1	221	230	PF00069	0.368
DOC_MAPK_gen_1	417	425	PF00069	0.407
DOC_MAPK_gen_1	463	473	PF00069	0.550
DOC_PP1_RVXF_1	136	142	PF00149	0.522
DOC_PP1_RVXF_1	231	238	PF00149	0.498
DOC_PP1_RVXF_1	279	286	PF00149	0.384
DOC_PP4_FxxP_1	341	344	PF00568	0.506
DOC_PP4_FxxP_1	40	43	PF00568	0.589
DOC_USP7_MATH_1	196	200	PF00917	0.731
DOC_USP7_MATH_1	292	296	PF00917	0.576
DOC_USP7_MATH_1	6	10	PF00917	0.644
DOC_USP7_UBL2_3	413	417	PF12436	0.442
DOC_WW_Pin1_4	157	162	PF00397	0.693
DOC_WW_Pin1_4	16	21	PF00397	0.654
DOC_WW_Pin1_4	182	187	PF00397	0.693
DOC_WW_Pin1_4	223	228	PF00397	0.434
DOC_WW_Pin1_4	288	293	PF00397	0.460
DOC_WW_Pin1_4	303	308	PF00397	0.534
DOC_WW_Pin1_4	9	14	PF00397	0.687
LIG_14-3-3_CanoR_1	138	142	PF00244	0.456
LIG_14-3-3_CanoR_1	207	213	PF00244	0.525
LIG_14-3-3_CanoR_1	22	30	PF00244	0.716
LIG_14-3-3_CanoR_1	261	267	PF00244	0.443
LIG_14-3-3_CanoR_1	401	405	PF00244	0.578
LIG_14-3-3_CanoR_1	47	56	PF00244	0.577
LIG_Actin_WH2_2	262	280	PF00022	0.424
LIG_Actin_WH2_2	72	89	PF00022	0.553
LIG_BIR_III_2	349	353	PF00653	0.588
LIG_BIR_III_4	448	452	PF00653	0.538
LIG_BRCT_BRCA1_1	118	122	PF00533	0.389
LIG_BRCT_BRCA1_1	383	387	PF00533	0.442
LIG_FHA_1	401	407	PF00498	0.552
LIG_FHA_1	6	12	PF00498	0.653
LIG_FHA_2	132	138	PF00498	0.536
LIG_FHA_2	217	223	PF00498	0.466
LIG_FHA_2	462	468	PF00498	0.584
LIG_LIR_Apic_2	38	43	PF02991	0.559
LIG_LIR_Gen_1	140	148	PF02991	0.524
LIG_LIR_Gen_1	279	290	PF02991	0.389
LIG_LIR_Gen_1	470	476	PF02991	0.536
LIG_LIR_Gen_1	89	98	PF02991	0.558
LIG_LIR_Nem_3	140	144	PF02991	0.488
LIG_LIR_Nem_3	229	234	PF02991	0.377
LIG_LIR_Nem_3	279	285	PF02991	0.393
LIG_LIR_Nem_3	358	364	PF02991	0.457
LIG_LIR_Nem_3	371	376	PF02991	0.404
LIG_LIR_Nem_3	383	389	PF02991	0.450
LIG_LIR_Nem_3	470	476	PF02991	0.536
LIG_LIR_Nem_3	89	93	PF02991	0.555
LIG_MLH1_MIPbox_1	118	122	PF16413	0.389
LIG_MLH1_MIPbox_1	383	387	PF16413	0.442
LIG_PDZ_Class_3	471	476	PF00595	0.563
LIG_REV1ctd_RIR_1	118	128	PF16727	0.502
LIG_SH2_CRK	231	235	PF00017	0.478
LIG_SH2_CRK	421	425	PF00017	0.411
LIG_SH2_CRK	71	75	PF00017	0.347
LIG_SH2_PTP2	90	93	PF00017	0.627
LIG_SH2_STAP1	421	425	PF00017	0.411
LIG_SH2_STAT5	132	135	PF00017	0.400
LIG_SH2_STAT5	282	285	PF00017	0.411
LIG_SH2_STAT5	404	407	PF00017	0.536
LIG_SH2_STAT5	90	93	PF00017	0.683
LIG_SH3_1	221	227	PF00018	0.444
LIG_SH3_2	145	150	PF14604	0.492
LIG_SH3_3	141	147	PF00018	0.537
LIG_SH3_3	221	227	PF00018	0.449
LIG_SH3_3	257	263	PF00018	0.559
LIG_SH3_3	286	292	PF00018	0.457
LIG_SUMO_SIM_anti_2	318	325	PF11976	0.475
LIG_SUMO_SIM_par_1	343	349	PF11976	0.676
LIG_TRAF2_1	108	111	PF00917	0.605
LIG_TRFH_1	285	289	PF08558	0.528
LIG_TYR_ITSM	227	234	PF00017	0.460
LIG_WW_3	146	150	PF00397	0.428
MOD_CDK_SPK_2	9	14	PF00069	0.459
MOD_CDK_SPxK_1	16	22	PF00069	0.605
MOD_CK1_1	160	166	PF00069	0.624
MOD_CK1_1	182	188	PF00069	0.683
MOD_CK1_1	195	201	PF00069	0.654
MOD_CK1_1	226	232	PF00069	0.515
MOD_CK1_1	359	365	PF00069	0.306
MOD_CK1_1	381	387	PF00069	0.548
MOD_CK1_1	390	396	PF00069	0.559
MOD_CK1_1	9	15	PF00069	0.685
MOD_CK2_1	131	137	PF00069	0.531
MOD_CK2_1	216	222	PF00069	0.461
MOD_CK2_1	306	312	PF00069	0.741
MOD_CK2_1	329	335	PF00069	0.417
MOD_Cter_Amidation	415	418	PF01082	0.430
MOD_GlcNHglycan	124	127	PF01048	0.543
MOD_GlcNHglycan	191	197	PF01048	0.665
MOD_GlcNHglycan	278	281	PF01048	0.511
MOD_GlcNHglycan	294	297	PF01048	0.598
MOD_GlcNHglycan	308	311	PF01048	0.723
MOD_GlcNHglycan	331	334	PF01048	0.427
MOD_GlcNHglycan	361	364	PF01048	0.478
MOD_GlcNHglycan	37	40	PF01048	0.635
MOD_GlcNHglycan	378	383	PF01048	0.308
MOD_GlcNHglycan	442	445	PF01048	0.644
MOD_GlcNHglycan	8	11	PF01048	0.655
MOD_GlcNHglycan	81	84	PF01048	0.628
MOD_GSK3_1	1	8	PF00069	0.696
MOD_GSK3_1	116	123	PF00069	0.439
MOD_GSK3_1	175	182	PF00069	0.564
MOD_GSK3_1	191	198	PF00069	0.711
MOD_GSK3_1	272	279	PF00069	0.572
MOD_GSK3_1	288	295	PF00069	0.561
MOD_GSK3_1	387	394	PF00069	0.509
MOD_N-GLC_1	390	395	PF02516	0.262
MOD_NEK2_1	1	6	PF00069	0.666
MOD_NEK2_1	116	121	PF00069	0.520
MOD_NEK2_1	122	127	PF00069	0.459
MOD_NEK2_1	30	35	PF00069	0.658
MOD_NEK2_1	387	392	PF00069	0.473
MOD_NEK2_1	58	63	PF00069	0.471
MOD_NEK2_1	86	91	PF00069	0.604
MOD_NMyristoyl	1	7	PF02799	0.539
MOD_PIKK_1	198	204	PF00454	0.777
MOD_PKA_2	137	143	PF00069	0.452
MOD_PKA_2	21	27	PF00069	0.596
MOD_PKA_2	359	365	PF00069	0.306
MOD_PKA_2	400	406	PF00069	0.496
MOD_PKA_2	459	465	PF00069	0.756
MOD_Plk_1	179	185	PF00069	0.638
MOD_Plk_1	192	198	PF00069	0.599
MOD_Plk_4	116	122	PF00069	0.431
MOD_Plk_4	226	232	PF00069	0.466
MOD_Plk_4	381	387	PF00069	0.456
MOD_Plk_4	400	406	PF00069	0.473
MOD_Plk_4	86	92	PF00069	0.543
MOD_ProDKin_1	157	163	PF00069	0.691
MOD_ProDKin_1	16	22	PF00069	0.656
MOD_ProDKin_1	182	188	PF00069	0.695
MOD_ProDKin_1	223	229	PF00069	0.429
MOD_ProDKin_1	288	294	PF00069	0.474
MOD_ProDKin_1	303	309	PF00069	0.533
MOD_ProDKin_1	9	15	PF00069	0.688
MOD_SUMO_rev_2	211	219	PF00179	0.433
MOD_SUMO_rev_2	362	370	PF00179	0.529
TRG_DiLeu_BaEn_1	319	324	PF01217	0.478
TRG_ENDOCYTIC_2	231	234	PF00928	0.466
TRG_ENDOCYTIC_2	282	285	PF00928	0.411
TRG_ENDOCYTIC_2	421	424	PF00928	0.409
TRG_ENDOCYTIC_2	71	74	PF00928	0.341
TRG_ENDOCYTIC_2	90	93	PF00928	0.551
TRG_ER_diArg_1	154	156	PF00400	0.740
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L8	Leptomonas seymouri	51%	87%
A0A1X0NNT6	Trypanosomatidae	40%	100%
A0A3R7R786	Trypanosoma rangeli	37%	100%
A0A3S7WTB0	Leishmania donovani	100%	100%
A4H7R7	Leishmania braziliensis	73%	100%
C9ZSW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9APW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QFM0	Leishmania major	92%	100%
V5DC73	Trypanosoma cruzi	38%	100%