A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 10 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 7 |
NetGPI | no | yes: 0, no: 7 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005882 | intermediate filament | 6 | 1 |
GO:0099080 | supramolecular complex | 2 | 1 |
GO:0099081 | supramolecular polymer | 3 | 1 |
GO:0099512 | supramolecular fiber | 4 | 1 |
GO:0099513 | polymeric cytoskeletal fiber | 5 | 1 |
GO:0110165 | cellular anatomical entity | 1 | 1 |
Related structures:
AlphaFold database: A4HW56
Term | Name | Level | Count |
---|---|---|---|
GO:0007017 | microtubule-based process | 2 | 4 |
GO:0007018 | microtubule-based movement | 3 | 4 |
GO:0009987 | cellular process | 1 | 4 |
Term | Name | Level | Count |
---|---|---|---|
GO:0003774 | cytoskeletal motor activity | 1 | 4 |
GO:0003777 | microtubule motor activity | 2 | 4 |
GO:0140657 | ATP-dependent activity | 1 | 4 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
LIG_FHA_1 | 218 | 224 | PF00498 | 0.413 |
LIG_FHA_1 | 260 | 266 | PF00498 | 0.419 |
LIG_FHA_1 | 652 | 658 | PF00498 | 0.411 |
LIG_FHA_1 | 694 | 700 | PF00498 | 0.402 |
LIG_FHA_1 | 771 | 777 | PF00498 | 0.416 |
LIG_FHA_1 | 813 | 819 | PF00498 | 0.462 |
MOD_CK2_1 | 120 | 126 | PF00069 | 0.522 |
MOD_CK2_1 | 127 | 133 | PF00069 | 0.516 |
MOD_CK2_1 | 15 | 21 | PF00069 | 0.496 |
MOD_CK2_1 | 155 | 161 | PF00069 | 0.464 |
MOD_CK2_1 | 162 | 168 | PF00069 | 0.438 |
MOD_CK2_1 | 190 | 196 | PF00069 | 0.480 |
MOD_CK2_1 | 22 | 28 | PF00069 | 0.473 |
MOD_CK2_1 | 232 | 238 | PF00069 | 0.489 |
MOD_CK2_1 | 274 | 280 | PF00069 | 0.495 |
MOD_CK2_1 | 281 | 287 | PF00069 | 0.455 |
MOD_CK2_1 | 309 | 315 | PF00069 | 0.471 |
MOD_CK2_1 | 316 | 322 | PF00069 | 0.448 |
MOD_CK2_1 | 344 | 350 | PF00069 | 0.507 |
MOD_CK2_1 | 379 | 385 | PF00069 | 0.497 |
MOD_CK2_1 | 386 | 392 | PF00069 | 0.461 |
MOD_CK2_1 | 414 | 420 | PF00069 | 0.478 |
MOD_CK2_1 | 421 | 427 | PF00069 | 0.471 |
MOD_CK2_1 | 449 | 455 | PF00069 | 0.514 |
MOD_CK2_1 | 456 | 462 | PF00069 | 0.534 |
MOD_CK2_1 | 484 | 490 | PF00069 | 0.542 |
MOD_CK2_1 | 50 | 56 | PF00069 | 0.467 |
MOD_CK2_1 | 519 | 525 | PF00069 | 0.628 |
MOD_CK2_1 | 554 | 560 | PF00069 | 0.593 |
MOD_CK2_1 | 57 | 63 | PF00069 | 0.417 |
MOD_CK2_1 | 589 | 595 | PF00069 | 0.532 |
MOD_CK2_1 | 596 | 602 | PF00069 | 0.538 |
MOD_CK2_1 | 624 | 630 | PF00069 | 0.480 |
MOD_CK2_1 | 631 | 637 | PF00069 | 0.548 |
MOD_CK2_1 | 666 | 672 | PF00069 | 0.511 |
MOD_CK2_1 | 673 | 679 | PF00069 | 0.525 |
MOD_CK2_1 | 708 | 714 | PF00069 | 0.537 |
MOD_CK2_1 | 743 | 749 | PF00069 | 0.504 |
MOD_CK2_1 | 750 | 756 | PF00069 | 0.539 |
MOD_CK2_1 | 785 | 791 | PF00069 | 0.489 |
MOD_CK2_1 | 792 | 798 | PF00069 | 0.483 |
MOD_CK2_1 | 827 | 833 | PF00069 | 0.522 |
MOD_CK2_1 | 834 | 840 | PF00069 | 0.594 |
MOD_CK2_1 | 85 | 91 | PF00069 | 0.573 |
MOD_GlcNHglycan | 536 | 540 | PF01048 | 0.454 |
MOD_N-GLC_1 | 292 | 297 | PF02516 | 0.425 |
MOD_N-GLC_1 | 327 | 332 | PF02516 | 0.432 |
MOD_N-GLC_1 | 432 | 437 | PF02516 | 0.421 |
MOD_N-GLC_1 | 845 | 850 | PF02516 | 0.467 |
MOD_NEK2_1 | 216 | 221 | PF00069 | 0.430 |
MOD_NEK2_1 | 650 | 655 | PF00069 | 0.418 |
MOD_NEK2_1 | 692 | 697 | PF00069 | 0.408 |
MOD_NEK2_1 | 769 | 774 | PF00069 | 0.418 |
MOD_PIKK_1 | 217 | 223 | PF00454 | 0.414 |
MOD_PIKK_1 | 259 | 265 | PF00454 | 0.417 |
MOD_PIKK_1 | 651 | 657 | PF00454 | 0.539 |
MOD_PIKK_1 | 693 | 699 | PF00454 | 0.529 |
MOD_PIKK_1 | 770 | 776 | PF00454 | 0.542 |
MOD_PIKK_1 | 812 | 818 | PF00454 | 0.432 |
MOD_PKB_1 | 272 | 280 | PF00069 | 0.468 |
MOD_Plk_1 | 292 | 298 | PF00069 | 0.454 |
MOD_Plk_1 | 327 | 333 | PF00069 | 0.427 |
MOD_Plk_1 | 432 | 438 | PF00069 | 0.435 |
MOD_Plk_1 | 845 | 851 | PF00069 | 0.465 |
MOD_Plk_2-3 | 127 | 133 | PF00069 | 0.531 |
MOD_Plk_2-3 | 162 | 168 | PF00069 | 0.520 |
MOD_Plk_2-3 | 22 | 28 | PF00069 | 0.555 |
MOD_Plk_2-3 | 281 | 287 | PF00069 | 0.629 |
MOD_Plk_2-3 | 316 | 322 | PF00069 | 0.530 |
MOD_Plk_2-3 | 386 | 392 | PF00069 | 0.543 |
MOD_Plk_2-3 | 421 | 427 | PF00069 | 0.524 |
MOD_Plk_2-3 | 456 | 462 | PF00069 | 0.528 |
MOD_Plk_2-3 | 57 | 63 | PF00069 | 0.525 |
MOD_Plk_2-3 | 596 | 602 | PF00069 | 0.529 |
MOD_Plk_2-3 | 631 | 637 | PF00069 | 0.532 |
MOD_Plk_2-3 | 673 | 679 | PF00069 | 0.519 |
MOD_Plk_2-3 | 750 | 756 | PF00069 | 0.523 |
MOD_Plk_2-3 | 792 | 798 | PF00069 | 0.486 |
MOD_Plk_2-3 | 834 | 840 | PF00069 | 0.512 |
MOD_SUMO_rev_2 | 123 | 130 | PF00179 | 0.572 |
MOD_SUMO_rev_2 | 158 | 165 | PF00179 | 0.519 |
MOD_SUMO_rev_2 | 18 | 25 | PF00179 | 0.651 |
MOD_SUMO_rev_2 | 193 | 200 | PF00179 | 0.569 |
MOD_SUMO_rev_2 | 235 | 242 | PF00179 | 0.562 |
MOD_SUMO_rev_2 | 277 | 284 | PF00179 | 0.559 |
MOD_SUMO_rev_2 | 312 | 319 | PF00179 | 0.528 |
MOD_SUMO_rev_2 | 347 | 354 | PF00179 | 0.603 |
MOD_SUMO_rev_2 | 382 | 389 | PF00179 | 0.582 |
MOD_SUMO_rev_2 | 417 | 424 | PF00179 | 0.555 |
MOD_SUMO_rev_2 | 452 | 459 | PF00179 | 0.544 |
MOD_SUMO_rev_2 | 487 | 494 | PF00179 | 0.508 |
MOD_SUMO_rev_2 | 522 | 529 | PF00179 | 0.641 |
MOD_SUMO_rev_2 | 53 | 60 | PF00179 | 0.479 |
MOD_SUMO_rev_2 | 557 | 564 | PF00179 | 0.501 |
MOD_SUMO_rev_2 | 592 | 599 | PF00179 | 0.516 |
MOD_SUMO_rev_2 | 627 | 634 | PF00179 | 0.563 |
MOD_SUMO_rev_2 | 669 | 676 | PF00179 | 0.543 |
MOD_SUMO_rev_2 | 711 | 718 | PF00179 | 0.528 |
MOD_SUMO_rev_2 | 746 | 753 | PF00179 | 0.542 |
MOD_SUMO_rev_2 | 788 | 795 | PF00179 | 0.494 |
MOD_SUMO_rev_2 | 830 | 837 | PF00179 | 0.513 |
MOD_SUMO_rev_2 | 88 | 95 | PF00179 | 0.524 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A4H7T4 | Leishmania braziliensis | 73% | 100% |
A4HAX0 | Leishmania braziliensis | 33% | 68% |
A4HBI8 | Leishmania braziliensis | 38% | 100% |
C9ZSW5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 25% | 100% |
D0A9G5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 29% | 71% |
E8NHK3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 80% | 91% |