Mannose-P-dolichol utilization defect 1 protein homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PQ loop repeat - putative

Species:

Leishmania infantum

UniProt:

A4HW51_LEIIN

TriTrypDb:

LINF_140017100

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HW51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	212	214	PF00675	0.318
CLV_NRD_NRD_1	97	99	PF00675	0.374
CLV_PCSK_FUR_1	213	217	PF00082	0.299
CLV_PCSK_KEX2_1	212	214	PF00082	0.358
CLV_PCSK_KEX2_1	215	217	PF00082	0.346
CLV_PCSK_KEX2_1	97	99	PF00082	0.316
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.424
CLV_PCSK_SKI1_1	169	173	PF00082	0.249
CLV_PCSK_SKI1_1	183	187	PF00082	0.411
CLV_PCSK_SKI1_1	212	216	PF00082	0.318
CLV_PCSK_SKI1_1	225	229	PF00082	0.412
DEG_APCC_DBOX_1	150	158	PF00400	0.469
DEG_SPOP_SBC_1	170	174	PF00917	0.279
DOC_MAPK_gen_1	147	156	PF00069	0.477
DOC_MAPK_gen_1	181	190	PF00069	0.278
DOC_MAPK_gen_1	94	103	PF00069	0.517
DOC_MAPK_MEF2A_6	181	190	PF00069	0.297
DOC_MAPK_RevD_3	199	213	PF00069	0.414
DOC_PP1_SILK_1	23	28	PF00149	0.391
DOC_PP2B_LxvP_1	26	29	PF13499	0.264
DOC_USP7_MATH_1	112	116	PF00917	0.500
LIG_14-3-3_CanoR_1	151	157	PF00244	0.531
LIG_14-3-3_CanoR_1	169	179	PF00244	0.137
LIG_14-3-3_CanoR_1	97	102	PF00244	0.569
LIG_BIR_II_1	1	5	PF00653	0.386
LIG_DLG_GKlike_1	97	105	PF00625	0.496
LIG_FHA_1	103	109	PF00498	0.510
LIG_FHA_1	156	162	PF00498	0.249
LIG_FHA_1	170	176	PF00498	0.249
LIG_FHA_1	77	83	PF00498	0.445
LIG_FHA_2	119	125	PF00498	0.561
LIG_GBD_Chelix_1	167	175	PF00786	0.389
LIG_LIR_Gen_1	155	163	PF02991	0.285
LIG_LIR_Gen_1	16	25	PF02991	0.403
LIG_LIR_Gen_1	74	85	PF02991	0.357
LIG_LIR_LC3C_4	79	84	PF02991	0.254
LIG_LIR_Nem_3	12	17	PF02991	0.354
LIG_LIR_Nem_3	155	159	PF02991	0.294
LIG_LIR_Nem_3	58	64	PF02991	0.315
LIG_LIR_Nem_3	74	80	PF02991	0.264
LIG_NRBOX	44	50	PF00104	0.192
LIG_NRBOX	81	87	PF00104	0.391
LIG_Pex14_2	132	136	PF04695	0.469
LIG_Pex14_2	156	160	PF04695	0.309
LIG_SH2_CRK	17	21	PF00017	0.249
LIG_SH2_GRB2like	143	146	PF00017	0.483
LIG_SH2_SRC	55	58	PF00017	0.384
LIG_SH2_STAP1	17	21	PF00017	0.309
LIG_SH2_STAT5	125	128	PF00017	0.528
LIG_SH2_STAT5	14	17	PF00017	0.304
LIG_SH2_STAT5	55	58	PF00017	0.355
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.462
LIG_SUMO_SIM_par_1	47	54	PF11976	0.272
LIG_TYR_ITIM	15	20	PF00017	0.267
LIG_TYR_ITIM	204	209	PF00017	0.349
LIG_UBA3_1	85	91	PF00899	0.407
LIG_ULM_U2AF65_1	215	220	PF00076	0.455
LIG_WRC_WIRS_1	156	161	PF05994	0.273
MOD_CK1_1	13	19	PF00069	0.224
MOD_CK1_1	155	161	PF00069	0.264
MOD_CK1_1	2	8	PF00069	0.339
MOD_CK1_1	44	50	PF00069	0.300
MOD_CK2_1	118	124	PF00069	0.521
MOD_GlcNHglycan	114	117	PF01048	0.291
MOD_GlcNHglycan	127	130	PF01048	0.241
MOD_GSK3_1	171	178	PF00069	0.325
MOD_GSK3_1	51	58	PF00069	0.331
MOD_GSK3_1	9	16	PF00069	0.309
MOD_GSK3_1	93	100	PF00069	0.559
MOD_LATS_1	221	227	PF00433	0.510
MOD_N-GLC_1	175	180	PF02516	0.419
MOD_NEK2_1	10	15	PF00069	0.176
MOD_NEK2_1	171	176	PF00069	0.255
MOD_NEK2_1	92	97	PF00069	0.495
MOD_PKA_1	97	103	PF00069	0.495
MOD_PKA_2	97	103	PF00069	0.513
MOD_Plk_1	175	181	PF00069	0.237
MOD_Plk_4	10	16	PF00069	0.223
MOD_Plk_4	152	158	PF00069	0.417
MOD_Plk_4	2	8	PF00069	0.335
MOD_Plk_4	21	27	PF00069	0.213
MOD_Plk_4	44	50	PF00069	0.343
MOD_Plk_4	51	57	PF00069	0.343
TRG_ENDOCYTIC_2	17	20	PF00928	0.267
TRG_ENDOCYTIC_2	206	209	PF00928	0.530
TRG_ER_diArg_1	146	149	PF00400	0.462
TRG_ER_diArg_1	212	214	PF00400	0.574
TRG_NLS_MonoExtN_4	212	219	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I8	Leptomonas seymouri	69%	100%
A0A0S4JQ57	Bodo saltans	53%	82%
A0A1X0NQ59	Trypanosomatidae	48%	91%
A0A3S7WT35	Leishmania donovani	100%	100%
A0A422MWP8	Trypanosoma rangeli	49%	94%
A4H7R3	Leishmania braziliensis	78%	100%
C9ZSW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	96%
E9APV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O75352	Homo sapiens	30%	93%
Q20157	Caenorhabditis elegans	31%	95%
Q4QFM6	Leishmania major	93%	100%
Q60441	Cricetulus griseus	30%	93%
Q8VY63	Arabidopsis thaliana	33%	98%
Q9LTI3	Arabidopsis thaliana	30%	96%
Q9R0Q9	Mus musculus	30%	93%
Q9VMW8	Drosophila melanogaster	28%	91%
V5BJ03	Trypanosoma cruzi	51%	91%