Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW50_LEIIN

TriTrypDb:

LINF_140017000

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HW50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.520
CLV_NRD_NRD_1	138	140	PF00675	0.478
CLV_NRD_NRD_1	181	183	PF00675	0.469
CLV_NRD_NRD_1	260	262	PF00675	0.564
CLV_NRD_NRD_1	3	5	PF00675	0.709
CLV_NRD_NRD_1	304	306	PF00675	0.581
CLV_PCSK_KEX2_1	118	120	PF00082	0.741
CLV_PCSK_KEX2_1	138	140	PF00082	0.531
CLV_PCSK_KEX2_1	260	262	PF00082	0.486
CLV_PCSK_KEX2_1	3	5	PF00082	0.709
CLV_PCSK_KEX2_1	304	306	PF00082	0.581
CLV_PCSK_KEX2_1	327	329	PF00082	0.552
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.741
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.552
CLV_PCSK_SKI1_1	10	14	PF00082	0.590
CLV_PCSK_SKI1_1	118	122	PF00082	0.532
CLV_PCSK_SKI1_1	138	142	PF00082	0.531
CLV_PCSK_SKI1_1	306	310	PF00082	0.647
CLV_PCSK_SKI1_1	324	328	PF00082	0.376
CLV_PCSK_SKI1_1	339	343	PF00082	0.474
CLV_PCSK_SKI1_1	91	95	PF00082	0.668
CLV_Separin_Metazoa	232	236	PF03568	0.719
DEG_APCC_DBOX_1	181	189	PF00400	0.607
DEG_Nend_UBRbox_3	1	3	PF02207	0.590
DEG_SCF_FBW7_2	129	136	PF00400	0.668
DEG_SPOP_SBC_1	171	175	PF00917	0.704
DEG_SPOP_SBC_1	273	277	PF00917	0.601
DOC_CKS1_1	130	135	PF01111	0.565
DOC_CYCLIN_RxL_1	180	189	PF00134	0.609
DOC_MAPK_DCC_7	80	89	PF00069	0.740
DOC_MAPK_FxFP_2	29	32	PF00069	0.564
DOC_MAPK_FxFP_2	342	345	PF00069	0.527
DOC_MAPK_HePTP_8	77	89	PF00069	0.657
DOC_MAPK_MEF2A_6	80	89	PF00069	0.740
DOC_PP1_RVXF_1	337	343	PF00149	0.485
DOC_PP2B_LxvP_1	150	153	PF13499	0.730
DOC_PP2B_LxvP_1	155	158	PF13499	0.695
DOC_PP4_FxxP_1	130	133	PF00568	0.669
DOC_PP4_FxxP_1	29	32	PF00568	0.564
DOC_PP4_FxxP_1	342	345	PF00568	0.527
DOC_USP7_MATH_1	171	175	PF00917	0.702
DOC_USP7_MATH_1	196	200	PF00917	0.648
DOC_USP7_MATH_1	268	272	PF00917	0.752
DOC_USP7_MATH_1	331	335	PF00917	0.569
DOC_USP7_MATH_1	76	80	PF00917	0.633
DOC_USP7_MATH_1	95	99	PF00917	0.642
DOC_WW_Pin1_4	12	17	PF00397	0.661
DOC_WW_Pin1_4	129	134	PF00397	0.570
DOC_WW_Pin1_4	160	165	PF00397	0.725
DOC_WW_Pin1_4	167	172	PF00397	0.693
DOC_WW_Pin1_4	310	315	PF00397	0.652
LIG_14-3-3_CanoR_1	10	15	PF00244	0.581
LIG_14-3-3_CanoR_1	154	158	PF00244	0.730
LIG_14-3-3_CanoR_1	217	223	PF00244	0.618
LIG_14-3-3_CanoR_1	50	57	PF00244	0.682
LIG_14-3-3_CanoR_1	80	88	PF00244	0.731
LIG_BIR_III_4	110	114	PF00653	0.583
LIG_deltaCOP1_diTrp_1	8	11	PF00928	0.648
LIG_FHA_1	147	153	PF00498	0.604
LIG_FHA_1	228	234	PF00498	0.678
LIG_FHA_2	219	225	PF00498	0.493
LIG_HP1_1	184	188	PF01393	0.594
LIG_IBAR_NPY_1	236	238	PF08397	0.727
LIG_LIR_Gen_1	212	220	PF02991	0.579
LIG_LIR_Gen_1	294	303	PF02991	0.564
LIG_LIR_Gen_1	319	330	PF02991	0.551
LIG_LIR_Gen_1	367	375	PF02991	0.581
LIG_LIR_Gen_1	8	19	PF02991	0.610
LIG_LIR_Nem_3	109	115	PF02991	0.762
LIG_LIR_Nem_3	132	137	PF02991	0.539
LIG_LIR_Nem_3	212	216	PF02991	0.482
LIG_LIR_Nem_3	294	299	PF02991	0.576
LIG_LIR_Nem_3	319	325	PF02991	0.553
LIG_LIR_Nem_3	367	371	PF02991	0.538
LIG_LIR_Nem_3	8	14	PF02991	0.635
LIG_MYND_1	16	20	PF01753	0.633
LIG_Pex14_1	391	395	PF04695	0.528
LIG_Pex14_2	130	134	PF04695	0.664
LIG_REV1ctd_RIR_1	369	376	PF16727	0.610
LIG_RPA_C_Fungi	300	312	PF08784	0.534
LIG_SH2_NCK_1	242	246	PF00017	0.606
LIG_SH2_SRC	242	245	PF00017	0.569
LIG_SH2_STAT5	215	218	PF00017	0.618
LIG_SH2_STAT5	296	299	PF00017	0.565
LIG_SH2_STAT5	336	339	PF00017	0.528
LIG_SH2_STAT5	368	371	PF00017	0.535
LIG_SH3_3	231	237	PF00018	0.725
LIG_SUMO_SIM_par_1	183	189	PF11976	0.500
LIG_TRAF2_1	102	105	PF00917	0.693
LIG_UBA3_1	298	306	PF00899	0.534
MOD_CDK_SPK_2	160	165	PF00069	0.725
MOD_CDK_SPxK_1	129	135	PF00069	0.570
MOD_CK1_1	170	176	PF00069	0.682
MOD_CK1_1	197	203	PF00069	0.563
MOD_CK1_1	271	277	PF00069	0.777
MOD_CK1_1	34	40	PF00069	0.604
MOD_CK1_1	79	85	PF00069	0.677
MOD_CK2_1	288	294	PF00069	0.614
MOD_CK2_1	99	105	PF00069	0.693
MOD_GlcNHglycan	124	127	PF01048	0.698
MOD_GlcNHglycan	188	191	PF01048	0.523
MOD_GlcNHglycan	270	273	PF01048	0.668
MOD_GlcNHglycan	276	279	PF01048	0.692
MOD_GlcNHglycan	59	62	PF01048	0.545
MOD_GlcNHglycan	96	100	PF01048	0.769
MOD_GSK3_1	156	163	PF00069	0.720
MOD_GSK3_1	167	174	PF00069	0.594
MOD_GSK3_1	196	203	PF00069	0.635
MOD_GSK3_1	268	275	PF00069	0.666
MOD_GSK3_1	284	291	PF00069	0.630
MOD_GSK3_1	31	38	PF00069	0.509
MOD_GSK3_1	312	319	PF00069	0.568
MOD_GSK3_1	357	364	PF00069	0.698
MOD_GSK3_1	91	98	PF00069	0.731
MOD_N-GLC_1	346	351	PF02516	0.501
MOD_N-GLC_2	73	75	PF02516	0.642
MOD_NEK2_1	251	256	PF00069	0.634
MOD_NEK2_1	57	62	PF00069	0.550
MOD_PIKK_1	361	367	PF00454	0.717
MOD_PKA_2	153	159	PF00069	0.672
MOD_PKA_2	43	49	PF00069	0.693
MOD_PKA_2	79	85	PF00069	0.737
MOD_Plk_1	294	300	PF00069	0.535
MOD_Plk_1	34	40	PF00069	0.588
MOD_Plk_1	357	363	PF00069	0.650
MOD_Plk_2-3	227	233	PF00069	0.621
MOD_Plk_4	218	224	PF00069	0.458
MOD_Plk_4	294	300	PF00069	0.471
MOD_Plk_4	346	352	PF00069	0.515
MOD_ProDKin_1	12	18	PF00069	0.654
MOD_ProDKin_1	129	135	PF00069	0.570
MOD_ProDKin_1	160	166	PF00069	0.727
MOD_ProDKin_1	167	173	PF00069	0.691
MOD_ProDKin_1	310	316	PF00069	0.646
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.583
TRG_ENDOCYTIC_2	296	299	PF00928	0.549
TRG_ENDOCYTIC_2	368	371	PF00928	0.466
TRG_ER_diArg_1	137	139	PF00400	0.526
TRG_ER_diArg_1	259	261	PF00400	0.481
TRG_ER_diArg_1	3	6	PF00400	0.712
TRG_ER_diArg_1	303	305	PF00400	0.589
TRG_ER_diArg_1	41	44	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	119	124	PF00026	0.725
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P428	Leptomonas seymouri	50%	100%
A0A3S7WT47	Leishmania donovani	99%	100%
A4H7R2	Leishmania braziliensis	71%	100%
E9APV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QFM7	Leishmania major	92%	100%