LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4HW49_LEIIN
TriTrypDb:
LINF_140016900 *
Length:
905

Annotations

Annotations by Jardim et al.

Protein kinase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HW49
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW49

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018107 peptidyl-threonine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0018210 peptidyl-threonine modification 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0004674 protein serine/threonine kinase activity 4 1
GO:0004713 protein tyrosine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 276 280 PF00656 0.753
CLV_C14_Caspase3-7 43 47 PF00656 0.641
CLV_NRD_NRD_1 10 12 PF00675 0.569
CLV_NRD_NRD_1 114 116 PF00675 0.572
CLV_NRD_NRD_1 199 201 PF00675 0.681
CLV_NRD_NRD_1 253 255 PF00675 0.637
CLV_NRD_NRD_1 412 414 PF00675 0.488
CLV_NRD_NRD_1 566 568 PF00675 0.457
CLV_NRD_NRD_1 656 658 PF00675 0.250
CLV_NRD_NRD_1 774 776 PF00675 0.289
CLV_NRD_NRD_1 836 838 PF00675 0.313
CLV_PCSK_FUR_1 421 425 PF00082 0.607
CLV_PCSK_FUR_1 654 658 PF00082 0.250
CLV_PCSK_KEX2_1 199 201 PF00082 0.683
CLV_PCSK_KEX2_1 253 255 PF00082 0.637
CLV_PCSK_KEX2_1 362 364 PF00082 0.621
CLV_PCSK_KEX2_1 412 414 PF00082 0.485
CLV_PCSK_KEX2_1 423 425 PF00082 0.478
CLV_PCSK_KEX2_1 565 567 PF00082 0.485
CLV_PCSK_KEX2_1 656 658 PF00082 0.250
CLV_PCSK_KEX2_1 774 776 PF00082 0.289
CLV_PCSK_KEX2_1 887 889 PF00082 0.289
CLV_PCSK_KEX2_1 9 11 PF00082 0.572
CLV_PCSK_PC1ET2_1 362 364 PF00082 0.602
CLV_PCSK_PC1ET2_1 423 425 PF00082 0.617
CLV_PCSK_PC1ET2_1 565 567 PF00082 0.485
CLV_PCSK_PC1ET2_1 887 889 PF00082 0.289
CLV_PCSK_PC7_1 561 567 PF00082 0.495
CLV_PCSK_SKI1_1 566 570 PF00082 0.521
CLV_PCSK_SKI1_1 583 587 PF00082 0.180
CLV_PCSK_SKI1_1 594 598 PF00082 0.319
CLV_PCSK_SKI1_1 656 660 PF00082 0.326
CLV_PCSK_SKI1_1 774 778 PF00082 0.271
CLV_Separin_Metazoa 628 632 PF03568 0.404
DEG_COP1_1 753 760 PF00400 0.271
DEG_Nend_Nbox_1 1 3 PF02207 0.477
DEG_SCF_FBW7_1 821 827 PF00400 0.404
DEG_SCF_TRCP1_1 366 371 PF00400 0.412
DEG_SPOP_SBC_1 849 853 PF00917 0.419
DOC_CDC14_PxL_1 649 657 PF14671 0.289
DOC_CKS1_1 821 826 PF01111 0.271
DOC_MAPK_gen_1 716 725 PF00069 0.271
DOC_MAPK_HePTP_8 713 725 PF00069 0.271
DOC_MAPK_MEF2A_6 716 725 PF00069 0.271
DOC_PP1_RVXF_1 397 404 PF00149 0.441
DOC_PP1_RVXF_1 693 700 PF00149 0.271
DOC_PP4_FxxP_1 317 320 PF00568 0.477
DOC_PP4_FxxP_1 650 653 PF00568 0.289
DOC_USP7_MATH_1 142 146 PF00917 0.617
DOC_USP7_MATH_1 190 194 PF00917 0.739
DOC_USP7_MATH_1 284 288 PF00917 0.794
DOC_USP7_MATH_1 47 51 PF00917 0.776
DOC_USP7_MATH_1 544 548 PF00917 0.677
DOC_USP7_MATH_1 557 561 PF00917 0.677
DOC_USP7_UBL2_3 116 120 PF12436 0.614
DOC_USP7_UBL2_3 548 552 PF12436 0.735
DOC_USP7_UBL2_3 559 563 PF12436 0.526
DOC_WW_Pin1_4 277 282 PF00397 0.669
DOC_WW_Pin1_4 386 391 PF00397 0.442
DOC_WW_Pin1_4 511 516 PF00397 0.671
DOC_WW_Pin1_4 767 772 PF00397 0.404
DOC_WW_Pin1_4 820 825 PF00397 0.271
DOC_WW_Pin1_4 95 100 PF00397 0.708
LIG_14-3-3_CanoR_1 104 112 PF00244 0.819
LIG_14-3-3_CanoR_1 136 144 PF00244 0.684
LIG_14-3-3_CanoR_1 18 22 PF00244 0.584
LIG_14-3-3_CanoR_1 424 430 PF00244 0.620
LIG_14-3-3_CanoR_1 594 599 PF00244 0.289
LIG_14-3-3_CanoR_1 781 790 PF00244 0.278
LIG_14-3-3_CanoR_1 850 855 PF00244 0.281
LIG_14-3-3_CanoR_1 888 895 PF00244 0.404
LIG_AP2alpha_2 439 441 PF02296 0.511
LIG_BRCT_BRCA1_1 700 704 PF00533 0.277
LIG_EH1_1 462 470 PF00400 0.346
LIG_FHA_1 10 16 PF00498 0.556
LIG_FHA_1 202 208 PF00498 0.678
LIG_FHA_1 224 230 PF00498 0.545
LIG_FHA_1 34 40 PF00498 0.586
LIG_FHA_1 429 435 PF00498 0.567
LIG_FHA_1 517 523 PF00498 0.502
LIG_FHA_1 625 631 PF00498 0.285
LIG_FHA_1 657 663 PF00498 0.326
LIG_FHA_1 71 77 PF00498 0.676
LIG_FHA_1 745 751 PF00498 0.307
LIG_FHA_1 85 91 PF00498 0.554
LIG_FHA_2 217 223 PF00498 0.680
LIG_FHA_2 359 365 PF00498 0.430
LIG_FHA_2 38 44 PF00498 0.644
LIG_FHA_2 441 447 PF00498 0.467
LIG_FHA_2 631 637 PF00498 0.404
LIG_FHA_2 754 760 PF00498 0.271
LIG_FHA_2 888 894 PF00498 0.319
LIG_LIR_Apic_2 647 653 PF02991 0.289
LIG_LIR_Apic_2 715 721 PF02991 0.271
LIG_LIR_Gen_1 20 28 PF02991 0.513
LIG_LIR_Gen_1 367 378 PF02991 0.640
LIG_LIR_Gen_1 388 397 PF02991 0.431
LIG_LIR_Gen_1 400 408 PF02991 0.461
LIG_LIR_Gen_1 853 864 PF02991 0.305
LIG_LIR_Gen_1 870 881 PF02991 0.198
LIG_LIR_Nem_3 20 24 PF02991 0.507
LIG_LIR_Nem_3 219 224 PF02991 0.576
LIG_LIR_Nem_3 367 373 PF02991 0.507
LIG_LIR_Nem_3 388 394 PF02991 0.454
LIG_LIR_Nem_3 400 406 PF02991 0.470
LIG_LIR_Nem_3 448 454 PF02991 0.463
LIG_LIR_Nem_3 636 640 PF02991 0.271
LIG_LIR_Nem_3 647 652 PF02991 0.271
LIG_LIR_Nem_3 816 822 PF02991 0.273
LIG_LIR_Nem_3 853 859 PF02991 0.286
LIG_LIR_Nem_3 870 876 PF02991 0.219
LIG_MAD2 763 771 PF02301 0.271
LIG_NRBOX 594 600 PF00104 0.404
LIG_PDZ_Class_2 900 905 PF00595 0.449
LIG_Pex14_2 441 445 PF04695 0.598
LIG_SH2_CRK 221 225 PF00017 0.582
LIG_SH2_CRK 571 575 PF00017 0.404
LIG_SH2_CRK 822 826 PF00017 0.271
LIG_SH2_CRK 856 860 PF00017 0.271
LIG_SH2_GRB2like 786 789 PF00017 0.404
LIG_SH2_NCK_1 370 374 PF00017 0.631
LIG_SH2_NCK_1 463 467 PF00017 0.468
LIG_SH2_NCK_1 54 58 PF00017 0.611
LIG_SH2_NCK_1 822 826 PF00017 0.267
LIG_SH2_SRC 463 466 PF00017 0.327
LIG_SH2_SRC 635 638 PF00017 0.271
LIG_SH2_SRC 668 671 PF00017 0.271
LIG_SH2_SRC 794 797 PF00017 0.404
LIG_SH2_STAP1 21 25 PF00017 0.537
LIG_SH2_STAP1 391 395 PF00017 0.554
LIG_SH2_STAP1 499 503 PF00017 0.731
LIG_SH2_STAP1 689 693 PF00017 0.438
LIG_SH2_STAT3 481 484 PF00017 0.495
LIG_SH2_STAT5 370 373 PF00017 0.546
LIG_SH2_STAT5 649 652 PF00017 0.271
LIG_SH2_STAT5 668 671 PF00017 0.271
LIG_SH2_STAT5 712 715 PF00017 0.271
LIG_SH2_STAT5 766 769 PF00017 0.319
LIG_SH2_STAT5 786 789 PF00017 0.150
LIG_SH2_STAT5 819 822 PF00017 0.274
LIG_SH3_1 278 284 PF00018 0.667
LIG_SH3_1 449 455 PF00018 0.456
LIG_SH3_3 138 144 PF00018 0.556
LIG_SH3_3 278 284 PF00018 0.667
LIG_SH3_3 317 323 PF00018 0.458
LIG_SH3_3 384 390 PF00018 0.444
LIG_SH3_3 449 455 PF00018 0.456
LIG_SH3_3 842 848 PF00018 0.422
LIG_SUMO_SIM_anti_2 621 628 PF11976 0.424
LIG_SUMO_SIM_par_1 392 398 PF11976 0.392
LIG_TRAF2_1 408 411 PF00917 0.471
LIG_TYR_ITIM 569 574 PF00017 0.419
LIG_TYR_ITSM 217 224 PF00017 0.689
LIG_UBA3_1 465 471 PF00899 0.377
LIG_UBA3_1 595 603 PF00899 0.261
LIG_WRC_WIRS_1 429 434 PF05994 0.451
LIG_WW_3 847 851 PF00397 0.335
MOD_CDK_SPxxK_3 767 774 PF00069 0.404
MOD_CK1_1 268 274 PF00069 0.734
MOD_CK1_1 374 380 PF00069 0.580
MOD_CK1_1 41 47 PF00069 0.764
MOD_CK1_1 553 559 PF00069 0.661
MOD_CK1_1 836 842 PF00069 0.380
MOD_CK1_1 98 104 PF00069 0.721
MOD_CK2_1 10 16 PF00069 0.599
MOD_CK2_1 270 276 PF00069 0.657
MOD_CK2_1 37 43 PF00069 0.742
MOD_CK2_1 386 392 PF00069 0.486
MOD_CK2_1 440 446 PF00069 0.460
MOD_CK2_1 586 592 PF00069 0.271
MOD_CK2_1 74 80 PF00069 0.620
MOD_CK2_1 753 759 PF00069 0.271
MOD_CK2_1 887 893 PF00069 0.380
MOD_GlcNHglycan 259 262 PF01048 0.801
MOD_GlcNHglycan 272 275 PF01048 0.554
MOD_GlcNHglycan 366 369 PF01048 0.669
MOD_GlcNHglycan 372 376 PF01048 0.529
MOD_GlcNHglycan 509 512 PF01048 0.713
MOD_GlcNHglycan 544 547 PF01048 0.722
MOD_GlcNHglycan 82 85 PF01048 0.571
MOD_GlcNHglycan 890 893 PF01048 0.335
MOD_GSK3_1 265 272 PF00069 0.619
MOD_GSK3_1 296 303 PF00069 0.692
MOD_GSK3_1 33 40 PF00069 0.622
MOD_GSK3_1 364 371 PF00069 0.489
MOD_GSK3_1 381 388 PF00069 0.449
MOD_GSK3_1 507 514 PF00069 0.708
MOD_GSK3_1 531 538 PF00069 0.718
MOD_GSK3_1 540 547 PF00069 0.770
MOD_GSK3_1 553 560 PF00069 0.609
MOD_GSK3_1 664 671 PF00069 0.404
MOD_GSK3_1 699 706 PF00069 0.271
MOD_GSK3_1 70 77 PF00069 0.671
MOD_GSK3_1 708 715 PF00069 0.271
MOD_GSK3_1 80 87 PF00069 0.584
MOD_GSK3_1 820 827 PF00069 0.397
MOD_GSK3_1 829 836 PF00069 0.404
MOD_GSK3_1 850 857 PF00069 0.439
MOD_LATS_1 885 891 PF00433 0.404
MOD_N-GLC_1 268 273 PF02516 0.738
MOD_N-GLC_1 284 289 PF02516 0.756
MOD_N-GLC_1 300 305 PF02516 0.782
MOD_N-GLC_1 368 373 PF02516 0.433
MOD_N-GLC_1 37 42 PF02516 0.695
MOD_N-GLC_1 579 584 PF02516 0.282
MOD_NEK2_1 2 7 PF00069 0.565
MOD_NEK2_1 380 385 PF00069 0.509
MOD_NEK2_1 630 635 PF00069 0.414
MOD_NEK2_1 648 653 PF00069 0.185
MOD_NEK2_1 685 690 PF00069 0.315
MOD_NEK2_1 699 704 PF00069 0.330
MOD_PIKK_1 104 110 PF00454 0.757
MOD_PIKK_1 135 141 PF00454 0.651
MOD_PIKK_1 142 148 PF00454 0.628
MOD_PIKK_1 190 196 PF00454 0.662
MOD_PIKK_1 223 229 PF00454 0.571
MOD_PIKK_1 259 265 PF00454 0.545
MOD_PIKK_1 74 80 PF00454 0.620
MOD_PK_1 11 17 PF00069 0.617
MOD_PKA_1 656 662 PF00069 0.384
MOD_PKA_1 887 893 PF00069 0.404
MOD_PKA_1 9 15 PF00069 0.563
MOD_PKA_2 135 141 PF00069 0.643
MOD_PKA_2 17 23 PF00069 0.526
MOD_PKA_2 252 258 PF00069 0.546
MOD_PKA_2 265 271 PF00069 0.599
MOD_PKA_2 535 541 PF00069 0.729
MOD_PKA_2 630 636 PF00069 0.404
MOD_PKA_2 656 662 PF00069 0.384
MOD_PKA_2 780 786 PF00069 0.271
MOD_PKA_2 836 842 PF00069 0.399
MOD_PKA_2 849 855 PF00069 0.225
MOD_PKA_2 887 893 PF00069 0.404
MOD_PKA_2 9 15 PF00069 0.563
MOD_PKB_1 654 662 PF00069 0.404
MOD_PKB_1 9 17 PF00069 0.620
MOD_Plk_1 37 43 PF00069 0.675
MOD_Plk_1 380 386 PF00069 0.590
MOD_Plk_1 586 592 PF00069 0.315
MOD_Plk_2-3 165 171 PF00069 0.735
MOD_Plk_2-3 491 497 PF00069 0.680
MOD_Plk_4 454 460 PF00069 0.391
MOD_Plk_4 594 600 PF00069 0.308
MOD_Plk_4 630 636 PF00069 0.384
MOD_Plk_4 664 670 PF00069 0.413
MOD_Plk_4 708 714 PF00069 0.271
MOD_Plk_4 854 860 PF00069 0.294
MOD_ProDKin_1 277 283 PF00069 0.671
MOD_ProDKin_1 386 392 PF00069 0.444
MOD_ProDKin_1 511 517 PF00069 0.671
MOD_ProDKin_1 767 773 PF00069 0.404
MOD_ProDKin_1 820 826 PF00069 0.271
MOD_ProDKin_1 95 101 PF00069 0.709
MOD_SUMO_for_1 679 682 PF00179 0.271
MOD_SUMO_rev_2 270 280 PF00179 0.758
MOD_SUMO_rev_2 41 47 PF00179 0.730
MOD_SUMO_rev_2 446 451 PF00179 0.432
MOD_SUMO_rev_2 643 648 PF00179 0.292
TRG_DiLeu_BaEn_1 621 626 PF01217 0.271
TRG_DiLeu_BaEn_2 681 687 PF01217 0.271
TRG_DiLeu_BaEn_3 871 877 PF01217 0.292
TRG_DiLeu_BaEn_4 816 822 PF01217 0.404
TRG_DiLeu_BaLyEn_6 591 596 PF01217 0.271
TRG_DiLeu_BaLyEn_6 609 614 PF01217 0.271
TRG_ENDOCYTIC_2 21 24 PF00928 0.499
TRG_ENDOCYTIC_2 221 224 PF00928 0.582
TRG_ENDOCYTIC_2 238 241 PF00928 0.528
TRG_ENDOCYTIC_2 370 373 PF00928 0.622
TRG_ENDOCYTIC_2 391 394 PF00928 0.563
TRG_ENDOCYTIC_2 463 466 PF00928 0.327
TRG_ENDOCYTIC_2 571 574 PF00928 0.327
TRG_ENDOCYTIC_2 649 652 PF00928 0.271
TRG_ENDOCYTIC_2 822 825 PF00928 0.285
TRG_ENDOCYTIC_2 856 859 PF00928 0.271
TRG_ER_diArg_1 412 415 PF00400 0.507
TRG_ER_diArg_1 566 568 PF00400 0.450
TRG_ER_diArg_1 653 656 PF00400 0.272
TRG_ER_diArg_1 773 775 PF00400 0.289
TRG_ER_diArg_1 9 11 PF00400 0.574
TRG_NES_CRM1_1 664 678 PF08389 0.271
TRG_NES_CRM1_1 872 884 PF08389 0.404
TRG_NLS_MonoExtN_4 112 119 PF00514 0.568
TRG_NLS_MonoExtN_4 563 569 PF00514 0.446
TRG_Pf-PMV_PEXEL_1 334 339 PF00026 0.483
TRG_Pf-PMV_PEXEL_1 417 422 PF00026 0.478
TRG_Pf-PMV_PEXEL_1 435 439 PF00026 0.427
TRG_Pf-PMV_PEXEL_1 656 661 PF00026 0.285
TRG_Pf-PMV_PEXEL_1 775 779 PF00026 0.289

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4G9 Leptomonas seymouri 73% 88%
A0A1X0NNI0 Trypanosomatidae 53% 100%
A0A3Q8IIF0 Leishmania donovani 100% 87%
A0A422MWR8 Trypanosoma rangeli 47% 100%
A4H7R1 Leishmania braziliensis 81% 100%
C9ZSX0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9APV3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QFM8 Leishmania major 94% 100%
V5AZ01 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS