Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF202) - putative

Species:

Leishmania infantum

UniProt:

A4HW46_LEIIN

TriTrypDb:

LINF_140016500

Length:

180

Annotations

Annotations by Jardim et al.

Acidocalcisome, vacuolar transporter chaperone

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HW46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	50	52	PF00082	0.416
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.416
CLV_PCSK_SKI1_1	41	45	PF00082	0.468
CLV_PCSK_SKI1_1	61	65	PF00082	0.282
CLV_PCSK_SKI1_1	68	72	PF00082	0.282
CLV_Separin_Metazoa	131	135	PF03568	0.616
DEG_APCC_DBOX_1	67	75	PF00400	0.482
DEG_Nend_UBRbox_2	1	3	PF02207	0.714
DOC_MAPK_MEF2A_6	139	148	PF00069	0.482
DOC_MAPK_MEF2A_6	72	80	PF00069	0.335
DOC_USP7_UBL2_3	57	61	PF12436	0.573
LIG_14-3-3_CanoR_1	162	169	PF00244	0.410
LIG_14-3-3_CanoR_1	6	11	PF00244	0.701
LIG_14-3-3_CterR_2	177	180	PF00244	0.418
LIG_APCC_ABBA_1	117	122	PF00400	0.355
LIG_BRCT_BRCA1_1	108	112	PF00533	0.335
LIG_BRCT_BRCA1_1	174	178	PF00533	0.421
LIG_FHA_1	140	146	PF00498	0.482
LIG_FHA_1	163	169	PF00498	0.450
LIG_FHA_1	42	48	PF00498	0.673
LIG_IRF3_LxIS_1	70	77	PF10401	0.355
LIG_LIR_Gen_1	29	38	PF02991	0.643
LIG_LIR_Nem_3	109	115	PF02991	0.355
LIG_LIR_Nem_3	29	35	PF02991	0.632
LIG_SH2_STAP1	115	119	PF00017	0.355
LIG_SH2_STAP1	164	168	PF00017	0.419
LIG_SH2_STAT5	10	13	PF00017	0.665
LIG_SH2_STAT5	164	167	PF00017	0.454
LIG_SH3_3	101	107	PF00018	0.335
LIG_SUMO_SIM_anti_2	142	148	PF11976	0.335
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.335
LIG_SUMO_SIM_anti_2	84	89	PF11976	0.335
LIG_SUMO_SIM_par_1	144	150	PF11976	0.413
LIG_WRC_WIRS_1	169	174	PF05994	0.440
MOD_CK1_1	170	176	PF00069	0.435
MOD_CK2_1	168	174	PF00069	0.468
MOD_GlcNHglycan	149	152	PF01048	0.424
MOD_GlcNHglycan	174	177	PF01048	0.656
MOD_GSK3_1	135	142	PF00069	0.576
MOD_GSK3_1	164	171	PF00069	0.368
MOD_GSK3_1	172	179	PF00069	0.375
MOD_N-GLC_1	41	46	PF02516	0.461
MOD_NEK2_1	113	118	PF00069	0.328
MOD_NEK2_1	172	177	PF00069	0.426
MOD_NEK2_1	43	48	PF00069	0.674
MOD_NEK2_1	74	79	PF00069	0.324
MOD_NEK2_1	83	88	PF00069	0.328
MOD_NEK2_1	90	95	PF00069	0.282
MOD_NEK2_2	153	158	PF00069	0.402
MOD_PIKK_1	162	168	PF00454	0.427
MOD_PK_1	72	78	PF00069	0.335
MOD_Plk_1	66	72	PF00069	0.474
MOD_Plk_4	106	112	PF00069	0.335
MOD_Plk_4	113	119	PF00069	0.331
MOD_Plk_4	139	145	PF00069	0.480
MOD_Plk_4	153	159	PF00069	0.335
MOD_Plk_4	164	170	PF00069	0.390
MOD_Plk_4	59	65	PF00069	0.478
MOD_Plk_4	6	12	PF00069	0.674
MOD_Plk_4	83	89	PF00069	0.334
TRG_DiLeu_BaEn_1	99	104	PF01217	0.378
TRG_ENDOCYTIC_2	115	118	PF00928	0.378
TRG_ENDOCYTIC_2	32	35	PF00928	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA80	Leptomonas seymouri	92%	100%
A0A0S4IYL4	Bodo saltans	69%	96%
A0A1X0NNJ4	Trypanosomatidae	79%	100%
A0A3S7WT40	Leishmania donovani	100%	100%
A0A422MQN2	Trypanosoma rangeli	74%	100%
A4H7Q7	Leishmania braziliensis	94%	100%
C9ZSX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9APU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QFN1	Leishmania major	99%	100%