Protein-tyrosine sulfotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW45_LEIIN

TriTrypDb:

LINF_140016400

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW45

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.447
CLV_NRD_NRD_1	163	165	PF00675	0.400
CLV_NRD_NRD_1	167	169	PF00675	0.377
CLV_NRD_NRD_1	234	236	PF00675	0.391
CLV_NRD_NRD_1	243	245	PF00675	0.358
CLV_NRD_NRD_1	366	368	PF00675	0.516
CLV_NRD_NRD_1	399	401	PF00675	0.420
CLV_NRD_NRD_1	449	451	PF00675	0.554
CLV_NRD_NRD_1	501	503	PF00675	0.672
CLV_PCSK_FUR_1	397	401	PF00082	0.441
CLV_PCSK_KEX2_1	163	165	PF00082	0.400
CLV_PCSK_KEX2_1	234	236	PF00082	0.355
CLV_PCSK_KEX2_1	366	368	PF00082	0.466
CLV_PCSK_KEX2_1	377	379	PF00082	0.424
CLV_PCSK_KEX2_1	399	401	PF00082	0.439
CLV_PCSK_KEX2_1	501	503	PF00082	0.672
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.480
CLV_PCSK_SKI1_1	164	168	PF00082	0.370
CLV_PCSK_SKI1_1	272	276	PF00082	0.447
CLV_PCSK_SKI1_1	374	378	PF00082	0.459
CLV_PCSK_SKI1_1	382	386	PF00082	0.419
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DOC_AGCK_PIF_1	171	176	PF00069	0.447
DOC_CKS1_1	144	149	PF01111	0.447
DOC_CKS1_1	200	205	PF01111	0.447
DOC_CYCLIN_yCln2_LP_2	282	288	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	462	468	PF00134	0.691
DOC_MAPK_gen_1	450	456	PF00069	0.574
DOC_PP2B_LxvP_1	462	465	PF13499	0.593
DOC_PP4_FxxP_1	144	147	PF00568	0.408
DOC_PP4_FxxP_1	249	252	PF00568	0.480
DOC_USP7_MATH_1	32	36	PF00917	0.527
DOC_USP7_MATH_1	333	337	PF00917	0.498
DOC_USP7_MATH_1	475	479	PF00917	0.720
DOC_USP7_MATH_1	52	56	PF00917	0.269
DOC_WD40_RPTOR_TOS_1	391	396	PF00400	0.472
DOC_WW_Pin1_4	143	148	PF00397	0.384
DOC_WW_Pin1_4	151	156	PF00397	0.319
DOC_WW_Pin1_4	199	204	PF00397	0.408
DOC_WW_Pin1_4	281	286	PF00397	0.346
DOC_WW_Pin1_4	287	292	PF00397	0.350
DOC_WW_Pin1_4	457	462	PF00397	0.700
LIG_14-3-3_CanoR_1	172	177	PF00244	0.424
LIG_14-3-3_CanoR_1	308	317	PF00244	0.355
LIG_APCC_ABBA_1	227	232	PF00400	0.447
LIG_BRCT_BRCA1_1	140	144	PF00533	0.335
LIG_BRCT_BRCA1_1	34	38	PF00533	0.507
LIG_Clathr_ClatBox_1	158	162	PF01394	0.378
LIG_DCNL_PONY_1	1	4	PF03556	0.672
LIG_FHA_1	195	201	PF00498	0.355
LIG_FHA_1	269	275	PF00498	0.434
LIG_FHA_1	383	389	PF00498	0.420
LIG_FHA_1	406	412	PF00498	0.481
LIG_FHA_1	89	95	PF00498	0.473
LIG_FHA_2	453	459	PF00498	0.593
LIG_HP1_1	120	124	PF01393	0.378
LIG_LIR_Apic_2	141	147	PF02991	0.408
LIG_LIR_Apic_2	175	179	PF02991	0.447
LIG_LIR_Gen_1	180	189	PF02991	0.378
LIG_LIR_Gen_1	284	294	PF02991	0.395
LIG_LIR_Gen_1	35	45	PF02991	0.430
LIG_LIR_Gen_1	408	417	PF02991	0.501
LIG_LIR_Nem_3	180	184	PF02991	0.428
LIG_LIR_Nem_3	205	211	PF02991	0.325
LIG_LIR_Nem_3	254	260	PF02991	0.411
LIG_LIR_Nem_3	284	289	PF02991	0.395
LIG_LIR_Nem_3	35	41	PF02991	0.432
LIG_LIR_Nem_3	358	363	PF02991	0.465
LIG_LIR_Nem_3	387	393	PF02991	0.439
LIG_LIR_Nem_3	408	413	PF02991	0.477
LIG_LIR_Nem_3	434	439	PF02991	0.414
LIG_LIR_Nem_3	458	462	PF02991	0.554
LIG_NRP_CendR_1	502	505	PF00754	0.713
LIG_Pex14_2	167	171	PF04695	0.355
LIG_Pex14_2	448	452	PF04695	0.582
LIG_PTB_Apo_2	322	329	PF02174	0.335
LIG_PTB_Phospho_1	322	328	PF10480	0.335
LIG_Rb_LxCxE_1	215	232	PF01857	0.447
LIG_SH2_CRK	459	463	PF00017	0.563
LIG_SH2_PTP2	410	413	PF00017	0.568
LIG_SH2_SRC	176	179	PF00017	0.447
LIG_SH2_STAP1	355	359	PF00017	0.411
LIG_SH2_STAT3	439	442	PF00017	0.395
LIG_SH2_STAT5	176	179	PF00017	0.447
LIG_SH2_STAT5	217	220	PF00017	0.335
LIG_SH2_STAT5	230	233	PF00017	0.335
LIG_SH2_STAT5	328	331	PF00017	0.439
LIG_SH2_STAT5	390	393	PF00017	0.443
LIG_SH2_STAT5	410	413	PF00017	0.271
LIG_SH2_STAT5	424	427	PF00017	0.350
LIG_SH2_STAT5	439	442	PF00017	0.395
LIG_SH2_STAT5	459	462	PF00017	0.388
LIG_SH3_3	114	120	PF00018	0.496
LIG_SH3_3	181	187	PF00018	0.447
LIG_SH3_3	410	416	PF00018	0.530
LIG_SH3_3	48	54	PF00018	0.553
LIG_Sin3_3	38	45	PF02671	0.538
LIG_SUMO_SIM_par_1	156	162	PF11976	0.378
LIG_TRAF2_1	31	34	PF00917	0.488
LIG_TRAF2_1	99	102	PF00917	0.432
LIG_TYR_ITIM	388	393	PF00017	0.445
LIG_TYR_ITSM	406	413	PF00017	0.513
LIG_UBA3_1	1	5	PF00899	0.661
MOD_CDK_SPK_2	143	148	PF00069	0.447
MOD_CK1_1	316	322	PF00069	0.339
MOD_CK1_1	405	411	PF00069	0.577
MOD_CK1_1	88	94	PF00069	0.533
MOD_CK2_1	337	343	PF00069	0.524
MOD_CK2_1	452	458	PF00069	0.623
MOD_GlcNHglycan	140	143	PF01048	0.335
MOD_GlcNHglycan	318	321	PF01048	0.403
MOD_GlcNHglycan	350	353	PF01048	0.368
MOD_GlcNHglycan	404	407	PF01048	0.564
MOD_GlcNHglycan	482	485	PF01048	0.692
MOD_GSK3_1	149	156	PF00069	0.335
MOD_GSK3_1	247	254	PF00069	0.408
MOD_GSK3_1	333	340	PF00069	0.531
MOD_GSK3_1	378	385	PF00069	0.481
MOD_GSK3_1	405	412	PF00069	0.511
MOD_GSK3_1	476	483	PF00069	0.678
MOD_GSK3_1	76	83	PF00069	0.550
MOD_NEK2_1	138	143	PF00069	0.335
MOD_NEK2_1	26	31	PF00069	0.539
MOD_NEK2_1	323	328	PF00069	0.336
MOD_NEK2_1	452	457	PF00069	0.643
MOD_NEK2_1	85	90	PF00069	0.452
MOD_NEK2_2	293	298	PF00069	0.404
MOD_PIKK_1	308	314	PF00454	0.355
MOD_PIKK_1	333	339	PF00454	0.459
MOD_PIKK_1	80	86	PF00454	0.521
MOD_PKA_2	88	94	PF00069	0.483
MOD_Plk_1	194	200	PF00069	0.349
MOD_Plk_2-3	389	395	PF00069	0.480
MOD_Plk_4	153	159	PF00069	0.334
MOD_Plk_4	293	299	PF00069	0.404
MOD_Plk_4	323	329	PF00069	0.331
MOD_ProDKin_1	143	149	PF00069	0.384
MOD_ProDKin_1	151	157	PF00069	0.319
MOD_ProDKin_1	199	205	PF00069	0.408
MOD_ProDKin_1	281	287	PF00069	0.346
MOD_ProDKin_1	457	463	PF00069	0.695
MOD_SUMO_rev_2	445	452	PF00179	0.542
TRG_DiLeu_BaEn_4	101	107	PF01217	0.460
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.579
TRG_ENDOCYTIC_2	230	233	PF00928	0.347
TRG_ENDOCYTIC_2	283	286	PF00928	0.447
TRG_ENDOCYTIC_2	360	363	PF00928	0.497
TRG_ENDOCYTIC_2	390	393	PF00928	0.428
TRG_ENDOCYTIC_2	398	401	PF00928	0.419
TRG_ENDOCYTIC_2	410	413	PF00928	0.271
TRG_ENDOCYTIC_2	424	427	PF00928	0.310
TRG_ENDOCYTIC_2	459	462	PF00928	0.550
TRG_ER_diArg_1	233	235	PF00400	0.408
TRG_ER_diArg_1	366	368	PF00400	0.516
TRG_ER_diArg_1	398	400	PF00400	0.426
TRG_ER_diArg_1	86	89	PF00400	0.430
TRG_NLS_MonoExtC_3	167	172	PF00514	0.402
TRG_NLS_MonoExtN_4	168	173	PF00514	0.402
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU64	Leptomonas seymouri	84%	100%
A0A0S4J6G2	Bodo saltans	50%	100%
A0A1X0NNJ1	Trypanosomatidae	62%	100%
A0A3S7WT30	Leishmania donovani	100%	100%
A4H7Q6	Leishmania braziliensis	92%	100%
C9ZSX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9APU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QFN2	Leishmania major	98%	100%
V5BNF0	Trypanosoma cruzi	60%	100%