Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW44_LEIIN

TriTrypDb:

LINF_140016300

Length:

314

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.732
CLV_NRD_NRD_1	20	22	PF00675	0.529
CLV_NRD_NRD_1	204	206	PF00675	0.614
CLV_NRD_NRD_1	207	209	PF00675	0.618
CLV_NRD_NRD_1	273	275	PF00675	0.722
CLV_NRD_NRD_1	293	295	PF00675	0.429
CLV_PCSK_KEX2_1	126	128	PF00082	0.632
CLV_PCSK_KEX2_1	20	22	PF00082	0.529
CLV_PCSK_KEX2_1	293	295	PF00082	0.562
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.593
CLV_PCSK_SKI1_1	105	109	PF00082	0.706
CLV_PCSK_SKI1_1	127	131	PF00082	0.579
DOC_CYCLIN_RxL_1	121	132	PF00134	0.568
DOC_MAPK_gen_1	215	224	PF00069	0.607
DOC_MAPK_gen_1	253	260	PF00069	0.639
DOC_MAPK_gen_1	274	281	PF00069	0.706
DOC_MAPK_JIP1_4	218	224	PF00069	0.666
DOC_USP7_MATH_1	306	310	PF00917	0.620
DOC_USP7_UBL2_3	122	126	PF12436	0.625
DOC_WW_Pin1_4	144	149	PF00397	0.796
LIG_14-3-3_CanoR_1	127	137	PF00244	0.635
LIG_14-3-3_CanoR_1	208	212	PF00244	0.661
LIG_14-3-3_CanoR_1	253	259	PF00244	0.602
LIG_APCC_ABBAyCdc20_2	126	132	PF00400	0.633
LIG_BRCT_BRCA1_1	40	44	PF00533	0.542
LIG_CtBP_PxDLS_1	278	284	PF00389	0.489
LIG_FHA_1	153	159	PF00498	0.629
LIG_FHA_1	185	191	PF00498	0.683
LIG_FHA_1	296	302	PF00498	0.636
LIG_FHA_2	118	124	PF00498	0.698
LIG_LIR_Apic_2	254	259	PF02991	0.559
LIG_LIR_Gen_1	24	30	PF02991	0.550
LIG_LIR_Gen_1	41	49	PF02991	0.507
LIG_LIR_Nem_3	210	214	PF02991	0.704
LIG_LIR_Nem_3	24	29	PF02991	0.547
LIG_LIR_Nem_3	41	47	PF02991	0.506
LIG_LYPXL_yS_3	133	136	PF13949	0.600
LIG_Pex14_1	26	30	PF04695	0.559
LIG_SH2_CRK	63	67	PF00017	0.659
LIG_SH2_SRC	55	58	PF00017	0.668
LIG_SH2_STAT5	161	164	PF00017	0.687
LIG_SH3_1	63	69	PF00018	0.664
LIG_SH3_2	103	108	PF14604	0.680
LIG_SH3_3	100	106	PF00018	0.677
LIG_SH3_3	131	137	PF00018	0.582
LIG_SH3_3	257	263	PF00018	0.653
LIG_SH3_3	63	69	PF00018	0.556
MOD_CDK_SPK_2	144	149	PF00069	0.645
MOD_CK1_1	147	153	PF00069	0.654
MOD_CK1_1	285	291	PF00069	0.598
MOD_CMANNOS	23	26	PF00535	0.525
MOD_GlcNHglycan	40	43	PF01048	0.617
MOD_GlcNHglycan	58	61	PF01048	0.490
MOD_GlcNHglycan	74	78	PF01048	0.732
MOD_GSK3_1	113	120	PF00069	0.601
MOD_GSK3_1	263	270	PF00069	0.585
MOD_GSK3_1	305	312	PF00069	0.574
MOD_N-GLC_1	295	300	PF02516	0.608
MOD_NEK2_1	152	157	PF00069	0.511
MOD_NEK2_1	297	302	PF00069	0.680
MOD_PIKK_1	295	301	PF00454	0.643
MOD_PKA_2	113	119	PF00069	0.741
MOD_PKA_2	207	213	PF00069	0.717
MOD_PKA_2	38	44	PF00069	0.546
MOD_PKA_2	86	92	PF00069	0.663
MOD_Plk_1	282	288	PF00069	0.669
MOD_ProDKin_1	144	150	PF00069	0.795
MOD_SUMO_rev_2	202	207	PF00179	0.704
TRG_ENDOCYTIC_2	133	136	PF00928	0.600
TRG_ENDOCYTIC_2	211	214	PF00928	0.651
TRG_ER_diArg_1	179	182	PF00400	0.547
TRG_ER_diArg_1	292	294	PF00400	0.671
TRG_NES_CRM1_1	90	102	PF08389	0.661
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.635
TRG_PTS1	311	314	PF00515	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIK5	Leptomonas seymouri	75%	100%
A0A0S4J633	Bodo saltans	40%	76%
A0A1X0NNI6	Trypanosomatidae	58%	96%
A0A3Q8ID70	Leishmania donovani	100%	100%
A0A422N494	Trypanosoma rangeli	59%	98%
A4H7Q5	Leishmania braziliensis	89%	100%
C9ZSX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	98%
E9APU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QFN3	Leishmania major	96%	100%
V5BJ00	Trypanosoma cruzi	60%	98%