Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW42_LEIIN

TriTrypDb:

LINF_140016100

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005743	mitochondrial inner membrane	5	2
GO:0019866	organelle inner membrane	4	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2

Expansion

Sequence features

A4HW42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW42

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006820	monoatomic anion transport	5	2
GO:0006862	nucleotide transport	6	2
GO:0009987	cellular process	1	2
GO:0015711	organic anion transport	5	2
GO:0015748	organophosphate ester transport	5	2
GO:0015865	purine nucleotide transport	7	2
GO:0015866	ADP transport	6	2
GO:0015867	ATP transport	6	2
GO:0015868	purine ribonucleotide transport	6	2
GO:0015931	nucleobase-containing compound transport	5	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051503	adenine nucleotide transport	8	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072530	purine-containing compound transmembrane transport	3	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:0140021	mitochondrial ADP transmembrane transport	4	2
GO:1901264	carbohydrate derivative transport	5	2
GO:1901679	nucleotide transmembrane transport	3	2
GO:1990542	mitochondrial transmembrane transport	3	2
GO:1990544	mitochondrial ATP transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0000295	adenine nucleotide transmembrane transporter activity	6	2
GO:0005215	transporter activity	1	2
GO:0005346	purine ribonucleotide transmembrane transporter activity	4	2
GO:0005347	ATP transmembrane transporter activity	5	2
GO:0005471	ATP:ADP antiporter activity	5	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	2
GO:0008514	organic anion transmembrane transporter activity	5	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015215	nucleotide transmembrane transporter activity	4	2
GO:0015216	purine nucleotide transmembrane transporter activity	5	2
GO:0015217	ADP transmembrane transporter activity	5	2
GO:0015291	secondary active transmembrane transporter activity	4	2
GO:0015297	antiporter activity	5	2
GO:0015605	organophosphate ester transmembrane transporter activity	3	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:0022804	active transmembrane transporter activity	3	2
GO:0022853	active monoatomic ion transmembrane transporter activity	4	2
GO:0022857	transmembrane transporter activity	2	2
GO:0140323	obsolete solute:monoatomic anion antiporter activity	6	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.548
CLV_NRD_NRD_1	12	14	PF00675	0.576
CLV_NRD_NRD_1	238	240	PF00675	0.595
CLV_NRD_NRD_1	26	28	PF00675	0.362
CLV_NRD_NRD_1	373	375	PF00675	0.453
CLV_NRD_NRD_1	90	92	PF00675	0.430
CLV_PCSK_KEX2_1	11	13	PF00082	0.595
CLV_PCSK_KEX2_1	112	114	PF00082	0.527
CLV_PCSK_KEX2_1	237	239	PF00082	0.606
CLV_PCSK_KEX2_1	26	28	PF00082	0.356
CLV_PCSK_KEX2_1	373	375	PF00082	0.453
CLV_PCSK_SKI1_1	26	30	PF00082	0.501
CLV_PCSK_SKI1_1	260	264	PF00082	0.468
CLV_PCSK_SKI1_1	346	350	PF00082	0.439
CLV_PCSK_SKI1_1	74	78	PF00082	0.419
DEG_APCC_DBOX_1	345	353	PF00400	0.604
DEG_SPOP_SBC_1	43	47	PF00917	0.633
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.598
DOC_MAPK_gen_1	208	216	PF00069	0.645
DOC_MAPK_gen_1	344	352	PF00069	0.597
DOC_MAPK_MEF2A_6	319	327	PF00069	0.455
DOC_USP7_MATH_1	111	115	PF00917	0.604
DOC_USP7_MATH_1	160	164	PF00917	0.590
DOC_USP7_MATH_1	220	224	PF00917	0.602
DOC_USP7_MATH_1	296	300	PF00917	0.385
DOC_USP7_MATH_1	43	47	PF00917	0.725
DOC_USP7_MATH_1	67	71	PF00917	0.664
DOC_USP7_MATH_1	95	99	PF00917	0.733
DOC_WW_Pin1_4	106	111	PF00397	0.802
DOC_WW_Pin1_4	227	232	PF00397	0.682
DOC_WW_Pin1_4	365	370	PF00397	0.769
LIG_14-3-3_CanoR_1	103	111	PF00244	0.808
LIG_14-3-3_CanoR_1	112	120	PF00244	0.698
LIG_14-3-3_CanoR_1	208	218	PF00244	0.606
LIG_14-3-3_CanoR_1	242	250	PF00244	0.696
LIG_14-3-3_CanoR_1	26	33	PF00244	0.722
LIG_14-3-3_CanoR_1	274	279	PF00244	0.662
LIG_Actin_WH2_2	195	210	PF00022	0.497
LIG_BIR_II_1	1	5	PF00653	0.751
LIG_Clathr_ClatBox_1	77	81	PF01394	0.650
LIG_FHA_1	211	217	PF00498	0.555
LIG_FHA_1	405	411	PF00498	0.501
LIG_FHA_1	52	58	PF00498	0.676
LIG_FHA_2	47	53	PF00498	0.729
LIG_Integrin_RGD_1	13	15	PF01839	0.455
LIG_LIR_Nem_3	118	123	PF02991	0.656
LIG_LIR_Nem_3	143	147	PF02991	0.499
LIG_LIR_Nem_3	247	253	PF02991	0.677
LIG_NRBOX	322	328	PF00104	0.424
LIG_PCNA_yPIPBox_3	390	398	PF02747	0.608
LIG_PTAP_UEV_1	420	425	PF05743	0.487
LIG_SH2_GRB2like	378	381	PF00017	0.607
LIG_SH2_NCK_1	243	247	PF00017	0.652
LIG_SH2_SRC	378	381	PF00017	0.607
LIG_SH2_STAT5	243	246	PF00017	0.641
LIG_SH3_3	223	229	PF00018	0.763
LIG_SH3_3	281	287	PF00018	0.684
LIG_SH3_3	418	424	PF00018	0.538
LIG_WRC_WIRS_1	148	153	PF05994	0.492
LIG_WW_3	109	113	PF00397	0.640
MOD_CDC14_SPxK_1	109	112	PF00782	0.645
MOD_CDK_SPxK_1	106	112	PF00069	0.649
MOD_CDK_SPxxK_3	106	113	PF00069	0.771
MOD_CK1_1	115	121	PF00069	0.600
MOD_CK1_1	174	180	PF00069	0.423
MOD_CK1_1	201	207	PF00069	0.544
MOD_CK1_1	46	52	PF00069	0.736
MOD_CK1_1	63	69	PF00069	0.492
MOD_CK2_1	147	153	PF00069	0.433
MOD_CK2_1	242	248	PF00069	0.615
MOD_GlcNHglycan	1	4	PF01048	0.532
MOD_GlcNHglycan	117	120	PF01048	0.495
MOD_GlcNHglycan	244	247	PF01048	0.456
MOD_GlcNHglycan	306	309	PF01048	0.385
MOD_GlcNHglycan	356	359	PF01048	0.431
MOD_GlcNHglycan	426	429	PF01048	0.698
MOD_GlcNHglycan	54	57	PF01048	0.481
MOD_GSK3_1	102	109	PF00069	0.749
MOD_GSK3_1	111	118	PF00069	0.612
MOD_GSK3_1	167	174	PF00069	0.474
MOD_GSK3_1	190	197	PF00069	0.440
MOD_GSK3_1	270	277	PF00069	0.629
MOD_GSK3_1	304	311	PF00069	0.326
MOD_GSK3_1	42	49	PF00069	0.720
MOD_GSK3_1	63	70	PF00069	0.656
MOD_NEK2_1	190	195	PF00069	0.401
MOD_NEK2_1	198	203	PF00069	0.350
MOD_NEK2_1	219	224	PF00069	0.655
MOD_NEK2_1	28	33	PF00069	0.711
MOD_NEK2_1	280	285	PF00069	0.687
MOD_NEK2_1	297	302	PF00069	0.220
MOD_NEK2_1	405	410	PF00069	0.376
MOD_NEK2_1	413	418	PF00069	0.410
MOD_NEK2_1	60	65	PF00069	0.657
MOD_PIKK_1	171	177	PF00454	0.396
MOD_PKA_1	112	118	PF00069	0.611
MOD_PKA_1	26	32	PF00069	0.728
MOD_PKA_2	102	108	PF00069	0.727
MOD_PKA_2	111	117	PF00069	0.646
MOD_PKA_2	210	216	PF00069	0.648
MOD_PKA_2	241	247	PF00069	0.657
MOD_PKA_2	26	32	PF00069	0.728
MOD_Plk_1	220	226	PF00069	0.683
MOD_Plk_1	29	35	PF00069	0.660
MOD_Plk_4	147	153	PF00069	0.433
MOD_Plk_4	167	173	PF00069	0.292
MOD_Plk_4	198	204	PF00069	0.432
MOD_Plk_4	308	314	PF00069	0.375
MOD_Plk_4	406	412	PF00069	0.501
MOD_Plk_4	67	73	PF00069	0.619
MOD_ProDKin_1	106	112	PF00069	0.802
MOD_ProDKin_1	227	233	PF00069	0.685
MOD_ProDKin_1	365	371	PF00069	0.764
TRG_DiLeu_BaEn_4	23	29	PF01217	0.709
TRG_DiLeu_BaLyEn_6	409	414	PF01217	0.557
TRG_ER_diArg_1	10	13	PF00400	0.796
TRG_ER_diArg_1	111	113	PF00400	0.637
TRG_ER_diArg_1	237	239	PF00400	0.714
TRG_ER_diArg_1	26	28	PF00400	0.544
TRG_ER_diArg_1	343	346	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NP33	Trypanosomatidae	24%	100%
A0A3Q8I9V0	Leishmania donovani	98%	99%
A4H7Q3	Leishmania braziliensis	71%	100%
C9ZSY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9APU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QFN5	Leishmania major	89%	100%