LeishMANIAdb
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ADP/ATP translocase

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ADP/ATP translocase
Gene product:
ADP/ATP mitochondrial carrier-like protein
Species:
Leishmania infantum
UniProt:
A4HW41_LEIIN
TriTrypDb:
LINF_140016000
Length:
376

Annotations

Annotations by Jardim et al.

Transporters, ADP/ATP mitochondrial carrier-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005743 mitochondrial inner membrane 5 18
GO:0016020 membrane 2 18
GO:0019866 organelle inner membrane 4 18
GO:0031090 organelle membrane 3 18
GO:0031966 mitochondrial membrane 4 18
GO:0110165 cellular anatomical entity 1 18
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Phosphorylation

Amastigote: 227

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HW41
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW41

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 18
GO:0006811 monoatomic ion transport 4 18
GO:0006820 monoatomic anion transport 5 18
GO:0006862 nucleotide transport 6 18
GO:0009987 cellular process 1 18
GO:0015711 organic anion transport 5 18
GO:0015748 organophosphate ester transport 5 18
GO:0015865 purine nucleotide transport 7 18
GO:0015866 ADP transport 6 18
GO:0015867 ATP transport 6 18
GO:0015868 purine ribonucleotide transport 6 18
GO:0015931 nucleobase-containing compound transport 5 18
GO:0034220 monoatomic ion transmembrane transport 3 18
GO:0051179 localization 1 18
GO:0051234 establishment of localization 2 18
GO:0051503 adenine nucleotide transport 8 18
GO:0055085 transmembrane transport 2 18
GO:0071702 organic substance transport 4 18
GO:0071705 nitrogen compound transport 4 18
GO:0072530 purine-containing compound transmembrane transport 3 18
GO:0098656 monoatomic anion transmembrane transport 4 18
GO:0140021 mitochondrial ADP transmembrane transport 4 18
GO:1901264 carbohydrate derivative transport 5 18
GO:1901679 nucleotide transmembrane transport 3 18
GO:1990542 mitochondrial transmembrane transport 3 18
GO:1990544 mitochondrial ATP transmembrane transport 4 18
Molecular functions
Term Name Level Count
GO:0000295 adenine nucleotide transmembrane transporter activity 6 18
GO:0005215 transporter activity 1 18
GO:0005346 purine ribonucleotide transmembrane transporter activity 4 18
GO:0005347 ATP transmembrane transporter activity 5 18
GO:0005471 ATP:ADP antiporter activity 5 18
GO:0008509 monoatomic anion transmembrane transporter activity 4 18
GO:0008514 organic anion transmembrane transporter activity 5 18
GO:0015075 monoatomic ion transmembrane transporter activity 3 18
GO:0015215 nucleotide transmembrane transporter activity 4 18
GO:0015216 purine nucleotide transmembrane transporter activity 5 18
GO:0015217 ADP transmembrane transporter activity 5 18
GO:0015291 secondary active transmembrane transporter activity 4 18
GO:0015297 antiporter activity 5 18
GO:0015605 organophosphate ester transmembrane transporter activity 3 18
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 18
GO:0022804 active transmembrane transporter activity 3 18
GO:0022853 active monoatomic ion transmembrane transporter activity 4 18
GO:0022857 transmembrane transporter activity 2 18
GO:0140323 obsolete solute:monoatomic anion antiporter activity 6 18
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 18

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 372 376 PF00656 0.407
CLV_NRD_NRD_1 103 105 PF00675 0.326
CLV_NRD_NRD_1 178 180 PF00675 0.298
CLV_NRD_NRD_1 248 250 PF00675 0.237
CLV_NRD_NRD_1 312 314 PF00675 0.190
CLV_NRD_NRD_1 325 327 PF00675 0.177
CLV_PCSK_KEX2_1 248 250 PF00082 0.248
CLV_PCSK_KEX2_1 312 314 PF00082 0.192
CLV_PCSK_KEX2_1 325 327 PF00082 0.181
CLV_PCSK_PC7_1 244 250 PF00082 0.220
CLV_PCSK_SKI1_1 313 317 PF00082 0.268
CLV_PCSK_SKI1_1 364 368 PF00082 0.507
CLV_PCSK_SKI1_1 54 58 PF00082 0.335
CLV_Separin_Metazoa 80 84 PF03568 0.493
DOC_CKS1_1 171 176 PF01111 0.318
DOC_CYCLIN_RxL_1 267 277 PF00134 0.388
DOC_CYCLIN_RxL_1 309 320 PF00134 0.478
DOC_CYCLIN_yCln2_LP_2 303 309 PF00134 0.360
DOC_MAPK_DCC_7 257 266 PF00069 0.498
DOC_MAPK_gen_1 351 358 PF00069 0.363
DOC_MAPK_MEF2A_6 351 358 PF00069 0.388
DOC_MAPK_RevD_3 297 313 PF00069 0.360
DOC_PP2B_LxvP_1 121 124 PF13499 0.289
DOC_USP7_MATH_1 163 167 PF00917 0.378
DOC_USP7_MATH_1 209 213 PF00917 0.363
DOC_USP7_MATH_2 306 312 PF00917 0.435
DOC_WW_Pin1_4 170 175 PF00397 0.318
DOC_WW_Pin1_4 224 229 PF00397 0.511
DOC_WW_Pin1_4 26 31 PF00397 0.690
DOC_WW_Pin1_4 4 9 PF00397 0.722
LIG_14-3-3_CanoR_1 353 359 PF00244 0.300
LIG_AP2alpha_1 127 131 PF02296 0.358
LIG_APCC_ABBA_1 367 372 PF00400 0.214
LIG_BH_BH3_1 288 304 PF00452 0.298
LIG_eIF4E_1 269 275 PF01652 0.334
LIG_FHA_1 131 137 PF00498 0.311
LIG_FHA_1 152 158 PF00498 0.324
LIG_FHA_1 196 202 PF00498 0.468
LIG_FHA_1 302 308 PF00498 0.376
LIG_FHA_1 363 369 PF00498 0.374
LIG_FHA_2 236 242 PF00498 0.461
LIG_FHA_2 315 321 PF00498 0.463
LIG_FHA_2 41 47 PF00498 0.558
LIG_FHA_2 73 79 PF00498 0.506
LIG_Integrin_isoDGR_2 215 217 PF01839 0.141
LIG_LIR_Gen_1 173 183 PF02991 0.491
LIG_LIR_Gen_1 365 374 PF02991 0.297
LIG_LIR_Nem_3 173 178 PF02991 0.491
LIG_LIR_Nem_3 268 272 PF02991 0.306
LIG_LIR_Nem_3 28 34 PF02991 0.718
LIG_LIR_Nem_3 324 330 PF02991 0.480
LIG_LIR_Nem_3 344 350 PF02991 0.423
LIG_LIR_Nem_3 365 370 PF02991 0.303
LIG_PCNA_TLS_4 105 113 PF02747 0.479
LIG_Pex14_1 252 256 PF04695 0.498
LIG_Pex14_2 127 131 PF04695 0.338
LIG_SH2_CRK 175 179 PF00017 0.498
LIG_SH2_CRK 269 273 PF00017 0.333
LIG_SH2_CRK 327 331 PF00017 0.461
LIG_SH2_NCK_1 236 240 PF00017 0.447
LIG_SH2_SRC 273 276 PF00017 0.388
LIG_SH2_STAP1 99 103 PF00017 0.484
LIG_SH2_STAT5 236 239 PF00017 0.431
LIG_SH2_STAT5 273 276 PF00017 0.301
LIG_SH3_3 168 174 PF00018 0.344
LIG_SH3_3 222 228 PF00018 0.420
LIG_SUMO_SIM_anti_2 69 75 PF11976 0.517
LIG_SUMO_SIM_par_1 118 125 PF11976 0.350
LIG_SUMO_SIM_par_1 153 161 PF11976 0.241
LIG_SUMO_SIM_par_1 262 268 PF11976 0.418
LIG_SUMO_SIM_par_1 304 311 PF11976 0.388
LIG_SUMO_SIM_par_1 354 360 PF11976 0.368
LIG_TRAF2_1 11 14 PF00917 0.656
LIG_TRAF2_1 228 231 PF00917 0.481
LIG_TYR_ITSM 171 178 PF00017 0.388
LIG_WRC_WIRS_1 128 133 PF05994 0.399
MOD_CK1_1 130 136 PF00069 0.304
MOD_CK1_1 357 363 PF00069 0.392
MOD_CK2_1 235 241 PF00069 0.433
MOD_CK2_1 72 78 PF00069 0.503
MOD_GlcNHglycan 124 127 PF01048 0.312
MOD_GlcNHglycan 165 168 PF01048 0.275
MOD_GlcNHglycan 211 214 PF01048 0.220
MOD_GlcNHglycan 347 350 PF01048 0.245
MOD_GlcNHglycan 372 375 PF01048 0.607
MOD_GSK3_1 158 165 PF00069 0.276
MOD_GSK3_1 17 24 PF00069 0.575
MOD_GSK3_1 235 242 PF00069 0.433
MOD_GSK3_1 274 281 PF00069 0.359
MOD_GSK3_1 341 348 PF00069 0.465
MOD_NEK2_1 127 132 PF00069 0.312
MOD_NEK2_1 152 157 PF00069 0.326
MOD_NEK2_1 162 167 PF00069 0.250
MOD_NEK2_1 274 279 PF00069 0.235
MOD_NEK2_1 314 319 PF00069 0.398
MOD_NEK2_1 354 359 PF00069 0.263
MOD_NEK2_1 40 45 PF00069 0.608
MOD_NEK2_1 60 65 PF00069 0.538
MOD_NEK2_1 72 77 PF00069 0.527
MOD_NEK2_2 362 367 PF00069 0.343
MOD_PIKK_1 17 23 PF00454 0.672
MOD_PIKK_1 301 307 PF00454 0.300
MOD_PKA_2 178 184 PF00069 0.498
MOD_PKA_2 234 240 PF00069 0.500
MOD_Plk_4 152 158 PF00069 0.378
MOD_Plk_4 178 184 PF00069 0.413
MOD_Plk_4 274 280 PF00069 0.215
MOD_ProDKin_1 170 176 PF00069 0.318
MOD_ProDKin_1 224 230 PF00069 0.511
MOD_ProDKin_1 26 32 PF00069 0.692
MOD_ProDKin_1 4 10 PF00069 0.717
TRG_DiLeu_BaLyEn_6 139 144 PF01217 0.445
TRG_ENDOCYTIC_2 175 178 PF00928 0.492
TRG_ENDOCYTIC_2 269 272 PF00928 0.268
TRG_ENDOCYTIC_2 327 330 PF00928 0.424
TRG_ENDOCYTIC_2 99 102 PF00928 0.487
TRG_ER_diArg_1 247 249 PF00400 0.449
TRG_ER_diArg_1 312 314 PF00400 0.385
TRG_ER_diArg_1 325 327 PF00400 0.395
TRG_NES_CRM1_1 305 320 PF08389 0.360

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD69 Leptomonas seymouri 68% 100%
A0A0S4J2G4 Bodo saltans 33% 100%
A0A1X0NP33 Trypanosomatidae 26% 100%
A0A1X0NQ13 Trypanosomatidae 43% 100%
A0A1X0P6F0 Trypanosomatidae 22% 100%
A0A1X0P6P9 Trypanosomatidae 22% 100%
A0A3R7K844 Trypanosoma rangeli 23% 100%
A0A3R7KEL4 Trypanosoma rangeli 27% 100%
A0A3R7NBU8 Trypanosoma rangeli 30% 100%
A0A3S7WT37 Leishmania donovani 100% 100%
A0A422N466 Trypanosoma rangeli 45% 100%
A4H7Q2 Leishmania braziliensis 84% 100%
C9ZSY0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
D0A0D8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
E9APU4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P04710 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P18238 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
P18239 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 100%
Q4QFN6 Leishmania major 94% 100%
Q5IS35 Macaca fascicularis 21% 100%
Q5NVC1 Pongo abelii 20% 100%
Q9HC21 Homo sapiens 20% 100%
V5BNE7 Trypanosoma cruzi 42% 100%
V5BWX9 Trypanosoma cruzi 23% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS