LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
sodium/hydrogen exchanger - putative
Species:
Leishmania infantum
UniProt:
A4HW40_LEIIN
TriTrypDb:
LINF_140015900
Length:
646

Annotations

LeishMANIAdb annotations

Homologous to animal Na+ / H+ exchangers.. Interestingly most heavily expanded in Strigomonas species and the non-parazitic Bodo saltans

Annotations by Jardim et al.

Transporters, sodium/hydrogen exchanger, putative (FTP) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0016020 membrane 2 18
GO:0110165 cellular anatomical entity 1 18

Expansion

Sequence features

A4HW40
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW40

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 14
GO:0005451 obsolete monoatomic cation:proton antiporter activity 5 14
GO:0008324 monoatomic cation transmembrane transporter activity 4 14
GO:0015075 monoatomic ion transmembrane transporter activity 3 14
GO:0015078 proton transmembrane transporter activity 5 14
GO:0015291 secondary active transmembrane transporter activity 4 14
GO:0015297 antiporter activity 5 14
GO:0015298 obsolete solute:monoatomic cation antiporter activity 5 14
GO:0015299 obsolete solute:proton antiporter activity 6 14
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 14
GO:0022804 active transmembrane transporter activity 3 14
GO:0022853 active monoatomic ion transmembrane transporter activity 4 14
GO:0022857 transmembrane transporter activity 2 14
GO:0022890 inorganic cation transmembrane transporter activity 4 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 638 640 PF00675 0.457
CLV_NRD_NRD_1 73 75 PF00675 0.332
CLV_PCSK_FUR_1 557 561 PF00082 0.444
CLV_PCSK_KEX2_1 559 561 PF00082 0.484
CLV_PCSK_KEX2_1 637 639 PF00082 0.548
CLV_PCSK_KEX2_1 73 75 PF00082 0.349
CLV_PCSK_PC1ET2_1 559 561 PF00082 0.500
CLV_PCSK_SKI1_1 154 158 PF00082 0.527
CLV_PCSK_SKI1_1 162 166 PF00082 0.511
CLV_PCSK_SKI1_1 430 434 PF00082 0.513
CLV_PCSK_SKI1_1 435 439 PF00082 0.490
CLV_PCSK_SKI1_1 544 548 PF00082 0.390
DOC_CDC14_PxL_1 131 139 PF14671 0.345
DOC_MAPK_DCC_7 130 140 PF00069 0.473
DOC_MAPK_gen_1 468 475 PF00069 0.520
DOC_MAPK_HePTP_8 82 94 PF00069 0.385
DOC_MAPK_MEF2A_6 170 177 PF00069 0.309
DOC_MAPK_MEF2A_6 292 299 PF00069 0.283
DOC_MAPK_MEF2A_6 468 475 PF00069 0.508
DOC_MAPK_MEF2A_6 63 70 PF00069 0.527
DOC_MAPK_MEF2A_6 78 86 PF00069 0.340
DOC_PP1_RVXF_1 83 89 PF00149 0.419
DOC_PP2B_LxvP_1 132 135 PF13499 0.316
DOC_SPAK_OSR1_1 452 456 PF12202 0.432
DOC_USP7_MATH_1 483 487 PF00917 0.338
DOC_USP7_MATH_1 553 557 PF00917 0.725
DOC_USP7_MATH_1 561 565 PF00917 0.731
DOC_USP7_MATH_1 605 609 PF00917 0.790
DOC_USP7_UBL2_3 183 187 PF12436 0.525
DOC_USP7_UBL2_3 426 430 PF12436 0.339
DOC_USP7_UBL2_3 544 548 PF12436 0.632
DOC_USP7_UBL2_3 555 559 PF12436 0.675
DOC_WW_Pin1_4 236 241 PF00397 0.316
DOC_WW_Pin1_4 607 612 PF00397 0.744
LIG_14-3-3_CanoR_1 452 458 PF00244 0.325
LIG_BRCT_BRCA1_1 38 42 PF00533 0.565
LIG_deltaCOP1_diTrp_1 53 62 PF00928 0.586
LIG_EH1_1 318 326 PF00400 0.385
LIG_eIF4E_1 110 116 PF01652 0.308
LIG_FHA_1 155 161 PF00498 0.234
LIG_FHA_1 172 178 PF00498 0.369
LIG_FHA_1 194 200 PF00498 0.501
LIG_FHA_1 278 284 PF00498 0.283
LIG_FHA_1 454 460 PF00498 0.336
LIG_FHA_1 570 576 PF00498 0.734
LIG_FHA_1 620 626 PF00498 0.694
LIG_FHA_2 510 516 PF00498 0.315
LIG_FHA_2 581 587 PF00498 0.746
LIG_GBD_Chelix_1 119 127 PF00786 0.410
LIG_GBD_Chelix_1 490 498 PF00786 0.428
LIG_LIR_Apic_2 39 44 PF02991 0.521
LIG_LIR_Gen_1 29 36 PF02991 0.525
LIG_LIR_Gen_1 347 358 PF02991 0.319
LIG_LIR_Gen_1 405 414 PF02991 0.450
LIG_LIR_Gen_1 524 535 PF02991 0.372
LIG_LIR_Gen_1 640 646 PF02991 0.649
LIG_LIR_Nem_3 29 34 PF02991 0.520
LIG_LIR_Nem_3 347 353 PF02991 0.339
LIG_LIR_Nem_3 356 361 PF02991 0.326
LIG_LIR_Nem_3 405 409 PF02991 0.459
LIG_LIR_Nem_3 410 414 PF02991 0.322
LIG_LIR_Nem_3 524 530 PF02991 0.372
LIG_LIR_Nem_3 640 645 PF02991 0.645
LIG_PDZ_Class_1 641 646 PF00595 0.648
LIG_Pex14_1 278 282 PF04695 0.316
LIG_Pex14_2 433 437 PF04695 0.244
LIG_Pex14_2 453 457 PF04695 0.105
LIG_PTB_Apo_2 213 220 PF02174 0.353
LIG_PTB_Apo_2 331 338 PF02174 0.457
LIG_PTB_Apo_2 431 438 PF02174 0.264
LIG_PTB_Phospho_1 331 337 PF10480 0.465
LIG_REV1ctd_RIR_1 360 370 PF16727 0.428
LIG_SH2_CRK 31 35 PF00017 0.535
LIG_SH2_CRK 358 362 PF00017 0.423
LIG_SH2_CRK 642 646 PF00017 0.648
LIG_SH2_NCK_1 358 362 PF00017 0.428
LIG_SH2_NCK_1 642 646 PF00017 0.648
LIG_SH2_STAP1 289 293 PF00017 0.280
LIG_SH2_STAP1 358 362 PF00017 0.361
LIG_SH2_STAP1 642 646 PF00017 0.648
LIG_SH2_STAT5 110 113 PF00017 0.241
LIG_SH2_STAT5 155 158 PF00017 0.242
LIG_SH2_STAT5 17 20 PF00017 0.588
LIG_SH2_STAT5 249 252 PF00017 0.482
LIG_SH2_STAT5 320 323 PF00017 0.294
LIG_SH2_STAT5 337 340 PF00017 0.411
LIG_SH2_STAT5 36 39 PF00017 0.394
LIG_SH2_STAT5 402 405 PF00017 0.463
LIG_SH2_STAT5 477 480 PF00017 0.482
LIG_SH2_STAT5 527 530 PF00017 0.327
LIG_SH3_3 108 114 PF00018 0.263
LIG_SH3_3 239 245 PF00018 0.297
LIG_SH3_3 295 301 PF00018 0.264
LIG_SH3_3 411 417 PF00018 0.367
LIG_SUMO_SIM_anti_2 113 119 PF11976 0.369
LIG_SUMO_SIM_par_1 115 121 PF11976 0.383
LIG_TRFH_1 31 35 PF08558 0.440
LIG_UBA3_1 283 292 PF00899 0.369
LIG_UBA3_1 419 426 PF00899 0.354
LIG_UBA3_1 498 506 PF00899 0.449
MOD_CDC14_SPxK_1 610 613 PF00782 0.616
MOD_CDK_SPxK_1 607 613 PF00069 0.618
MOD_CK1_1 236 242 PF00069 0.337
MOD_CK1_1 509 515 PF00069 0.399
MOD_CK1_1 562 568 PF00069 0.698
MOD_CK1_1 606 612 PF00069 0.668
MOD_CK2_1 42 48 PF00069 0.446
MOD_CK2_1 509 515 PF00069 0.378
MOD_CK2_1 580 586 PF00069 0.747
MOD_Cter_Amidation 71 74 PF01082 0.484
MOD_GlcNHglycan 120 123 PF01048 0.327
MOD_GlcNHglycan 266 269 PF01048 0.329
MOD_GlcNHglycan 380 383 PF01048 0.376
MOD_GlcNHglycan 462 465 PF01048 0.369
MOD_GlcNHglycan 481 484 PF01048 0.313
MOD_GlcNHglycan 523 526 PF01048 0.400
MOD_GlcNHglycan 561 564 PF01048 0.706
MOD_GlcNHglycan 566 569 PF01048 0.702
MOD_GlcNHglycan 598 601 PF01048 0.760
MOD_GSK3_1 260 267 PF00069 0.314
MOD_GSK3_1 479 486 PF00069 0.304
MOD_GSK3_1 549 556 PF00069 0.610
MOD_GSK3_1 559 566 PF00069 0.644
MOD_GSK3_1 603 610 PF00069 0.763
MOD_N-GLC_1 433 438 PF02516 0.390
MOD_N-GLC_1 586 591 PF02516 0.759
MOD_N-GLC_2 343 345 PF02516 0.444
MOD_NEK2_1 165 170 PF00069 0.422
MOD_NEK2_1 198 203 PF00069 0.374
MOD_NEK2_1 233 238 PF00069 0.322
MOD_NEK2_1 264 269 PF00069 0.295
MOD_NEK2_1 380 385 PF00069 0.316
MOD_NEK2_1 419 424 PF00069 0.356
MOD_NEK2_1 433 438 PF00069 0.279
MOD_NEK2_1 445 450 PF00069 0.270
MOD_NEK2_1 453 458 PF00069 0.161
MOD_NEK2_1 580 585 PF00069 0.698
MOD_PK_1 603 609 PF00069 0.629
MOD_PK_1 73 79 PF00069 0.515
MOD_PKA_1 559 565 PF00069 0.677
MOD_PKA_1 73 79 PF00069 0.515
MOD_PKA_2 451 457 PF00069 0.444
MOD_PKA_2 559 565 PF00069 0.683
MOD_PKA_2 628 634 PF00069 0.610
MOD_PKA_2 73 79 PF00069 0.480
MOD_Plk_1 19 25 PF00069 0.540
MOD_Plk_1 433 439 PF00069 0.406
MOD_Plk_1 506 512 PF00069 0.292
MOD_Plk_1 580 586 PF00069 0.737
MOD_Plk_4 171 177 PF00069 0.322
MOD_Plk_4 209 215 PF00069 0.421
MOD_Plk_4 233 239 PF00069 0.343
MOD_Plk_4 244 250 PF00069 0.317
MOD_Plk_4 260 266 PF00069 0.200
MOD_Plk_4 29 35 PF00069 0.425
MOD_Plk_4 402 408 PF00069 0.345
MOD_Plk_4 433 439 PF00069 0.354
MOD_Plk_4 453 459 PF00069 0.285
MOD_ProDKin_1 236 242 PF00069 0.316
MOD_ProDKin_1 607 613 PF00069 0.719
MOD_SUMO_for_1 325 328 PF00179 0.340
TRG_ENDOCYTIC_2 31 34 PF00928 0.423
TRG_ENDOCYTIC_2 358 361 PF00928 0.378
TRG_ENDOCYTIC_2 527 530 PF00928 0.317
TRG_ENDOCYTIC_2 642 645 PF00928 0.578
TRG_ER_diArg_1 637 639 PF00400 0.603
TRG_ER_diArg_1 73 75 PF00400 0.450
TRG_Pf-PMV_PEXEL_1 102 106 PF00026 0.481

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7H5 Leptomonas seymouri 32% 71%
A0A0N1I1I3 Leptomonas seymouri 80% 79%
A0A0S4IUH4 Bodo saltans 41% 93%
A0A0S4IYS7 Bodo saltans 47% 100%
A0A0S4J2L9 Bodo saltans 51% 100%
A0A1X0NSQ8 Trypanosomatidae 66% 90%
A0A3Q8I9W9 Leishmania donovani 100% 100%
A0A3R7NWD7 Trypanosoma rangeli 28% 86%
A0A422N0A8 Trypanosoma rangeli 59% 96%
C9ZP87 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
D0A5M2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 81%
E9AI47 Leishmania braziliensis 86% 100%
E9APU3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 99%
Q4QFN7 Leishmania major 95% 100%
Q5BKR2 Mus musculus 25% 100%
Q5R6B8 Pongo abelii 23% 100%
Q86UD5 Homo sapiens 23% 100%
V5BES3 Trypanosoma cruzi 63% 96%
V5BN48 Trypanosoma cruzi 28% 81%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS