Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosomal protein L16p/L10e - putative

Species:

Leishmania infantum

UniProt:

A4HW37_LEIIN

TriTrypDb:

LINF_140015600

Length:

168

Annotations

Annotations by Jardim et al.

Ribosomal Protein, Ribosomal L16p/L10e

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	10
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

A4HW37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW37

PDB structure(s): 7aih_H , 7ane_H

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	10
GO:0006518	peptide metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0019538	protein metabolic process	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	10
GO:0043043	peptide biosynthetic process	5	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0043604	amide biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0032543	mitochondrial translation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003735	structural constituent of ribosome	2	10
GO:0005198	structural molecule activity	1	10
GO:0005488	binding	1	10
GO:0019843	rRNA binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.242
CLV_NRD_NRD_1	29	31	PF00675	0.471
CLV_NRD_NRD_1	73	75	PF00675	0.242
CLV_PCSK_KEX2_1	131	133	PF00082	0.242
CLV_PCSK_KEX2_1	73	75	PF00082	0.242
CLV_PCSK_SKI1_1	46	50	PF00082	0.289
DEG_Nend_UBRbox_3	1	3	PF02207	0.670
DOC_CYCLIN_RxL_1	43	53	PF00134	0.354
DOC_USP7_MATH_1	104	108	PF00917	0.484
DOC_USP7_MATH_1	127	131	PF00917	0.455
DOC_USP7_MATH_1	144	148	PF00917	0.508
DOC_USP7_MATH_1	76	80	PF00917	0.520
DOC_WW_Pin1_4	94	99	PF00397	0.447
LIG_14-3-3_CanoR_1	7	12	PF00244	0.592
LIG_APCC_ABBA_1	82	87	PF00400	0.460
LIG_FHA_1	115	121	PF00498	0.442
LIG_FHA_1	151	157	PF00498	0.442
LIG_FHA_2	84	90	PF00498	0.442
LIG_LIR_Gen_1	86	94	PF02991	0.444
LIG_LIR_Nem_3	147	151	PF02991	0.514
LIG_LIR_Nem_3	162	167	PF02991	0.387
LIG_LIR_Nem_3	53	59	PF02991	0.442
LIG_LIR_Nem_3	86	91	PF02991	0.444
LIG_Pex14_2	112	116	PF04695	0.442
LIG_SH2_CRK	15	19	PF00017	0.455
LIG_SH2_PTP2	17	20	PF00017	0.428
LIG_SH2_SRC	17	20	PF00017	0.438
LIG_SH2_STAT5	17	20	PF00017	0.438
LIG_SUMO_SIM_anti_2	41	46	PF11976	0.465
LIG_SxIP_EBH_1	146	155	PF03271	0.514
MOD_CDK_SPxxK_3	94	101	PF00069	0.442
MOD_CK1_1	97	103	PF00069	0.442
MOD_CK2_1	59	65	PF00069	0.442
MOD_CK2_1	83	89	PF00069	0.442
MOD_GlcNHglycan	3	6	PF01048	0.630
MOD_GSK3_1	123	130	PF00069	0.484
MOD_GSK3_1	76	83	PF00069	0.520
MOD_NEK2_1	1	6	PF00069	0.634
MOD_NEK2_1	123	128	PF00069	0.473
MOD_NEK2_1	80	85	PF00069	0.460
MOD_PIKK_1	57	63	PF00454	0.442
MOD_PKA_2	6	12	PF00069	0.599
MOD_PKA_2	76	82	PF00069	0.520
MOD_Plk_1	123	129	PF00069	0.477
MOD_Plk_4	7	13	PF00069	0.548
MOD_ProDKin_1	94	100	PF00069	0.447
TRG_ENDOCYTIC_2	15	18	PF00928	0.464
TRG_ENDOCYTIC_2	164	167	PF00928	0.403
TRG_ENDOCYTIC_2	88	91	PF00928	0.442
TRG_ER_diArg_1	131	133	PF00400	0.442
TRG_ER_diArg_1	157	160	PF00400	0.494
TRG_ER_diArg_1	72	74	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.242
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P481	Leptomonas seymouri	92%	100%
A0A1X0NNV3	Trypanosomatidae	85%	100%
A0A3R7M6C9	Trypanosoma rangeli	82%	100%
A0A3S7WT29	Leishmania donovani	99%	100%
A1QZS1	Borrelia turicatae (strain 91E135)	29%	100%
A1VIQ7	Polaromonas naphthalenivorans (strain CJ2)	34%	100%
A4H7P8	Leishmania braziliensis	98%	100%
A5IM90	Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)	32%	100%
A7HBM5	Anaeromyxobacter sp. (strain Fw109-5)	30%	100%
A9BPS5	Delftia acidovorans (strain DSM 14801 / SPH-1)	32%	100%
B1LBN3	Thermotoga sp. (strain RQ2)	32%	100%
B1Y8I0	Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6)	31%	100%
B2S0I8	Borrelia hermsii (strain HS1 / DAH)	30%	100%
B4UBA6	Anaeromyxobacter sp. (strain K)	31%	100%
B5RM43	Borrelia duttonii (strain Ly)	29%	100%
B5RPI9	Borrelia recurrentis (strain A1)	30%	100%
B8GV51	Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)	31%	100%
B8J867	Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)	31%	100%
C9ZSY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
E9APU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
P38509	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	31%	100%
P46173	Buchnera aphidicola subsp. Acyrthosiphon kondoi	31%	100%
Q0SQF1	Clostridium perfringens (strain SM101 / Type A)	31%	100%
Q0TMQ3	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	31%	100%
Q12GW4	Polaromonas sp. (strain JS666 / ATCC BAA-500)	33%	100%
Q2IJ83	Anaeromyxobacter dehalogenans (strain 2CP-C)	31%	100%
Q4QFP0	Leishmania major	100%	100%
Q6F7R9	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	30%	100%
Q72I11	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	28%	100%
Q7VQE1	Blochmannia floridanus	32%	100%
Q890P5	Clostridium tetani (strain Massachusetts / E88)	31%	100%
Q8K957	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	32%	100%
Q8XHT0	Clostridium perfringens (strain 13 / Type A)	31%	100%
Q97EI5	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	31%	100%