Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW36_LEIIN

TriTrypDb:

LINF_140015500

Length:

878

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW36

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.623
CLV_C14_Caspase3-7	414	418	PF00656	0.590
CLV_C14_Caspase3-7	527	531	PF00656	0.621
CLV_NRD_NRD_1	286	288	PF00675	0.581
CLV_NRD_NRD_1	533	535	PF00675	0.655
CLV_NRD_NRD_1	540	542	PF00675	0.643
CLV_PCSK_FUR_1	284	288	PF00082	0.577
CLV_PCSK_FUR_1	538	542	PF00082	0.680
CLV_PCSK_KEX2_1	286	288	PF00082	0.581
CLV_PCSK_KEX2_1	537	539	PF00082	0.676
CLV_PCSK_KEX2_1	540	542	PF00082	0.655
CLV_PCSK_KEX2_1	95	97	PF00082	0.546
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.676
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.546
CLV_PCSK_SKI1_1	360	364	PF00082	0.610
CLV_PCSK_SKI1_1	96	100	PF00082	0.544
DEG_Nend_Nbox_1	1	3	PF02207	0.622
DEG_SCF_FBW7_1	485	491	PF00400	0.589
DEG_SCF_FBW7_1	64	71	PF00400	0.656
DEG_SCF_TRCP1_1	659	665	PF00400	0.579
DEG_SPOP_SBC_1	267	271	PF00917	0.621
DEG_SPOP_SBC_1	586	590	PF00917	0.580
DOC_CKS1_1	367	372	PF01111	0.644
DOC_CKS1_1	395	400	PF01111	0.617
DOC_CKS1_1	485	490	PF01111	0.591
DOC_CKS1_1	719	724	PF01111	0.592
DOC_CYCLIN_RxL_1	93	103	PF00134	0.569
DOC_MAPK_DCC_7	294	304	PF00069	0.578
DOC_MAPK_gen_1	95	101	PF00069	0.543
DOC_MAPK_MEF2A_6	465	472	PF00069	0.583
DOC_PP2B_LxvP_1	526	529	PF13499	0.650
DOC_PP2B_LxvP_1	560	563	PF13499	0.639
DOC_PP2B_LxvP_1	790	793	PF13499	0.613
DOC_PP2B_PxIxI_1	59	65	PF00149	0.629
DOC_PP4_FxxP_1	367	370	PF00568	0.583
DOC_PP4_FxxP_1	719	722	PF00568	0.593
DOC_PP4_MxPP_1	859	862	PF00568	0.607
DOC_USP7_MATH_1	106	110	PF00917	0.599
DOC_USP7_MATH_1	143	147	PF00917	0.659
DOC_USP7_MATH_1	266	270	PF00917	0.615
DOC_USP7_MATH_1	37	41	PF00917	0.732
DOC_USP7_MATH_1	380	384	PF00917	0.756
DOC_USP7_MATH_1	4	8	PF00917	0.603
DOC_USP7_MATH_1	466	470	PF00917	0.661
DOC_USP7_MATH_1	488	492	PF00917	0.631
DOC_USP7_MATH_1	553	557	PF00917	0.711
DOC_USP7_MATH_1	576	580	PF00917	0.713
DOC_USP7_MATH_1	587	591	PF00917	0.671
DOC_USP7_MATH_1	617	621	PF00917	0.633
DOC_USP7_MATH_1	629	633	PF00917	0.691
DOC_USP7_MATH_1	666	670	PF00917	0.664
DOC_USP7_MATH_1	783	787	PF00917	0.564
DOC_USP7_MATH_1	828	832	PF00917	0.625
DOC_USP7_MATH_1	833	837	PF00917	0.606
DOC_WW_Pin1_4	151	156	PF00397	0.728
DOC_WW_Pin1_4	202	207	PF00397	0.644
DOC_WW_Pin1_4	224	229	PF00397	0.614
DOC_WW_Pin1_4	234	239	PF00397	0.560
DOC_WW_Pin1_4	254	259	PF00397	0.509
DOC_WW_Pin1_4	294	299	PF00397	0.631
DOC_WW_Pin1_4	304	309	PF00397	0.577
DOC_WW_Pin1_4	33	38	PF00397	0.667
DOC_WW_Pin1_4	343	348	PF00397	0.672
DOC_WW_Pin1_4	352	357	PF00397	0.602
DOC_WW_Pin1_4	362	367	PF00397	0.521
DOC_WW_Pin1_4	394	399	PF00397	0.768
DOC_WW_Pin1_4	484	489	PF00397	0.612
DOC_WW_Pin1_4	64	69	PF00397	0.658
DOC_WW_Pin1_4	662	667	PF00397	0.636
DOC_WW_Pin1_4	668	673	PF00397	0.610
DOC_WW_Pin1_4	676	681	PF00397	0.532
DOC_WW_Pin1_4	718	723	PF00397	0.592
DOC_WW_Pin1_4	770	775	PF00397	0.627
DOC_WW_Pin1_4	844	849	PF00397	0.585
LIG_14-3-3_CanoR_1	23	30	PF00244	0.579
LIG_14-3-3_CanoR_1	349	356	PF00244	0.606
LIG_14-3-3_CanoR_1	96	102	PF00244	0.579
LIG_BIR_III_2	103	107	PF00653	0.574
LIG_BRCT_BRCA1_1	588	592	PF00533	0.718
LIG_Clathr_ClatBox_1	311	315	PF01394	0.578
LIG_deltaCOP1_diTrp_1	755	763	PF00928	0.486
LIG_EVH1_1	560	564	PF00568	0.632
LIG_FHA_1	129	135	PF00498	0.638
LIG_FHA_1	269	275	PF00498	0.628
LIG_FHA_1	37	43	PF00498	0.643
LIG_FHA_1	602	608	PF00498	0.508
LIG_FHA_1	68	74	PF00498	0.639
LIG_FHA_2	171	177	PF00498	0.542
LIG_FHA_2	197	203	PF00498	0.617
LIG_FHA_2	225	231	PF00498	0.607
LIG_FHA_2	286	292	PF00498	0.621
LIG_FHA_2	453	459	PF00498	0.595
LIG_FHA_2	485	491	PF00498	0.589
LIG_FHA_2	509	515	PF00498	0.624
LIG_FHA_2	525	531	PF00498	0.544
LIG_FHA_2	572	578	PF00498	0.603
LIG_FHA_2	88	94	PF00498	0.561
LIG_IBAR_NPY_1	59	61	PF08397	0.649
LIG_KLC1_Yacidic_2	197	202	PF13176	0.599
LIG_LIR_Apic_2	197	203	PF02991	0.623
LIG_LIR_Apic_2	365	370	PF02991	0.587
LIG_LIR_Apic_2	556	562	PF02991	0.660
LIG_LIR_Gen_1	175	186	PF02991	0.657
LIG_LIR_Gen_1	40	51	PF02991	0.611
LIG_LIR_Gen_1	593	603	PF02991	0.538
LIG_LIR_Gen_1	610	619	PF02991	0.539
LIG_LIR_Gen_1	756	767	PF02991	0.661
LIG_LIR_Nem_3	293	299	PF02991	0.776
LIG_LIR_Nem_3	40	46	PF02991	0.614
LIG_LIR_Nem_3	589	595	PF02991	0.738
LIG_LIR_Nem_3	610	616	PF02991	0.532
LIG_LIR_Nem_3	755	761	PF02991	0.672
LIG_MYND_1	186	190	PF01753	0.612
LIG_Pex14_1	232	236	PF04695	0.575
LIG_Pex14_1	757	761	PF04695	0.500
LIG_Pex14_2	759	763	PF04695	0.525
LIG_PROFILIN_1	561	567	PF00235	0.587
LIG_SH2_CRK	351	355	PF00017	0.612
LIG_SH2_CRK	43	47	PF00017	0.652
LIG_SH2_CRK	596	600	PF00017	0.531
LIG_SH2_CRK	603	607	PF00017	0.537
LIG_SH2_NCK_1	351	355	PF00017	0.586
LIG_SH2_PTP2	61	64	PF00017	0.660
LIG_SH2_PTP2	761	764	PF00017	0.511
LIG_SH2_SRC	200	203	PF00017	0.625
LIG_SH2_SRC	559	562	PF00017	0.653
LIG_SH2_STAP1	260	264	PF00017	0.594
LIG_SH2_STAP1	596	600	PF00017	0.531
LIG_SH2_STAP1	603	607	PF00017	0.537
LIG_SH2_STAT3	102	105	PF00017	0.570
LIG_SH2_STAT3	409	412	PF00017	0.615
LIG_SH2_STAT3	500	503	PF00017	0.654
LIG_SH2_STAT5	200	203	PF00017	0.625
LIG_SH2_STAT5	351	354	PF00017	0.589
LIG_SH2_STAT5	559	562	PF00017	0.653
LIG_SH2_STAT5	603	606	PF00017	0.652
LIG_SH2_STAT5	61	64	PF00017	0.828
LIG_SH2_STAT5	682	685	PF00017	0.654
LIG_SH2_STAT5	761	764	PF00017	0.537
LIG_SH2_STAT5	826	829	PF00017	0.545
LIG_SH3_1	200	206	PF00018	0.633
LIG_SH3_1	558	564	PF00018	0.646
LIG_SH3_3	200	206	PF00018	0.633
LIG_SH3_3	344	350	PF00018	0.659
LIG_SH3_3	353	359	PF00018	0.611
LIG_SH3_3	431	437	PF00018	0.814
LIG_SH3_3	482	488	PF00018	0.645
LIG_SH3_3	558	564	PF00018	0.688
LIG_SH3_3	567	573	PF00018	0.719
LIG_SH3_3	695	701	PF00018	0.624
LIG_SH3_3	842	848	PF00018	0.613
LIG_SH3_3	857	863	PF00018	0.569
LIG_TRAF2_2	654	659	PF00917	0.577
LIG_WRC_WIRS_1	98	103	PF05994	0.542
LIG_WW_1	370	373	PF00397	0.636
LIG_WW_1	867	870	PF00397	0.594
LIG_WW_3	369	373	PF00397	0.573
MOD_CDC14_SPxK_1	346	349	PF00782	0.670
MOD_CDC14_SPxK_1	355	358	PF00782	0.599
MOD_CDK_SPK_2	484	489	PF00069	0.591
MOD_CDK_SPxK_1	343	349	PF00069	0.673
MOD_CDK_SPxK_1	352	358	PF00069	0.602
MOD_CDK_SPxK_1	366	372	PF00069	0.525
MOD_CDK_SPxxK_3	394	401	PF00069	0.591
MOD_CK1_1	109	115	PF00069	0.704
MOD_CK1_1	146	152	PF00069	0.681
MOD_CK1_1	220	226	PF00069	0.635
MOD_CK1_1	237	243	PF00069	0.527
MOD_CK1_1	322	328	PF00069	0.619
MOD_CK1_1	383	389	PF00069	0.720
MOD_CK1_1	400	406	PF00069	0.622
MOD_CK1_1	438	444	PF00069	0.682
MOD_CK1_1	45	51	PF00069	0.742
MOD_CK1_1	5	11	PF00069	0.635
MOD_CK1_1	524	530	PF00069	0.629
MOD_CK1_1	673	679	PF00069	0.587
MOD_CK1_1	685	691	PF00069	0.590
MOD_CK1_1	786	792	PF00069	0.564
MOD_CK2_1	170	176	PF00069	0.544
MOD_CK2_1	196	202	PF00069	0.626
MOD_CK2_1	224	230	PF00069	0.612
MOD_CK2_1	322	328	PF00069	0.594
MOD_CK2_1	387	393	PF00069	0.638
MOD_CK2_1	438	444	PF00069	0.559
MOD_CK2_1	452	458	PF00069	0.576
MOD_CK2_1	484	490	PF00069	0.591
MOD_CK2_1	689	695	PF00069	0.664
MOD_CK2_1	87	93	PF00069	0.599
MOD_DYRK1A_RPxSP_1	844	848	PF00069	0.585
MOD_GlcNHglycan	131	134	PF01048	0.717
MOD_GlcNHglycan	167	170	PF01048	0.733
MOD_GlcNHglycan	20	23	PF01048	0.567
MOD_GlcNHglycan	239	242	PF01048	0.616
MOD_GlcNHglycan	26	29	PF01048	0.685
MOD_GlcNHglycan	4	7	PF01048	0.630
MOD_GlcNHglycan	421	424	PF01048	0.625
MOD_GlcNHglycan	446	449	PF01048	0.698
MOD_GlcNHglycan	481	484	PF01048	0.766
MOD_GlcNHglycan	494	497	PF01048	0.590
MOD_GlcNHglycan	577	581	PF01048	0.716
MOD_GlcNHglycan	589	592	PF01048	0.526
MOD_GlcNHglycan	631	634	PF01048	0.724
MOD_GlcNHglycan	650	653	PF01048	0.563
MOD_GlcNHglycan	659	662	PF01048	0.743
MOD_GlcNHglycan	685	688	PF01048	0.757
MOD_GlcNHglycan	689	692	PF01048	0.688
MOD_GlcNHglycan	745	748	PF01048	0.546
MOD_GlcNHglycan	796	799	PF01048	0.601
MOD_GlcNHglycan	82	85	PF01048	0.633
MOD_GlcNHglycan	830	833	PF01048	0.596
MOD_GlcNHglycan	835	838	PF01048	0.576
MOD_GSK3_1	146	153	PF00069	0.717
MOD_GSK3_1	220	227	PF00069	0.607
MOD_GSK3_1	266	273	PF00069	0.629
MOD_GSK3_1	290	297	PF00069	0.748
MOD_GSK3_1	298	305	PF00069	0.643
MOD_GSK3_1	320	327	PF00069	0.794
MOD_GSK3_1	33	40	PF00069	0.764
MOD_GSK3_1	362	369	PF00069	0.664
MOD_GSK3_1	383	390	PF00069	0.730
MOD_GSK3_1	393	400	PF00069	0.677
MOD_GSK3_1	407	414	PF00069	0.593
MOD_GSK3_1	45	52	PF00069	0.645
MOD_GSK3_1	475	482	PF00069	0.742
MOD_GSK3_1	484	491	PF00069	0.670
MOD_GSK3_1	5	12	PF00069	0.636
MOD_GSK3_1	64	71	PF00069	0.656
MOD_GSK3_1	657	664	PF00069	0.642
MOD_GSK3_1	666	673	PF00069	0.580
MOD_GSK3_1	683	690	PF00069	0.608
MOD_GSK3_1	766	773	PF00069	0.544
MOD_GSK3_1	788	795	PF00069	0.612
MOD_N-GLC_1	224	229	PF02516	0.575
MOD_N-GLC_1	49	54	PF02516	0.641
MOD_NEK2_1	107	112	PF00069	0.672
MOD_NEK2_1	2	7	PF00069	0.628
MOD_NEK2_1	326	331	PF00069	0.666
MOD_NEK2_1	381	386	PF00069	0.663
MOD_NEK2_1	407	412	PF00069	0.567
MOD_NEK2_1	42	47	PF00069	0.646
MOD_NEK2_1	683	688	PF00069	0.648
MOD_NEK2_1	9	14	PF00069	0.597
MOD_NEK2_2	553	558	PF00069	0.668
MOD_PIKK_1	381	387	PF00454	0.662
MOD_PIKK_1	435	441	PF00454	0.611
MOD_PIKK_1	459	465	PF00454	0.582
MOD_PIKK_1	571	577	PF00454	0.639
MOD_PIKK_1	9	15	PF00454	0.654
MOD_PKA_2	146	152	PF00069	0.749
MOD_PKA_2	285	291	PF00069	0.754
MOD_PKA_2	400	406	PF00069	0.613
MOD_PKA_2	9	15	PF00069	0.654
MOD_PKB_1	358	366	PF00069	0.605
MOD_Plk_1	107	113	PF00069	0.638
MOD_Plk_1	196	202	PF00069	0.597
MOD_Plk_1	49	55	PF00069	0.618
MOD_Plk_1	521	527	PF00069	0.642
MOD_Plk_1	68	74	PF00069	0.657
MOD_Plk_4	188	194	PF00069	0.661
MOD_Plk_4	670	676	PF00069	0.644
MOD_Plk_4	68	74	PF00069	0.618
MOD_Plk_4	753	759	PF00069	0.611
MOD_Plk_4	97	103	PF00069	0.693
MOD_ProDKin_1	151	157	PF00069	0.729
MOD_ProDKin_1	202	208	PF00069	0.647
MOD_ProDKin_1	224	230	PF00069	0.612
MOD_ProDKin_1	234	240	PF00069	0.563
MOD_ProDKin_1	254	260	PF00069	0.511
MOD_ProDKin_1	294	300	PF00069	0.629
MOD_ProDKin_1	304	310	PF00069	0.576
MOD_ProDKin_1	33	39	PF00069	0.666
MOD_ProDKin_1	343	349	PF00069	0.673
MOD_ProDKin_1	352	358	PF00069	0.602
MOD_ProDKin_1	362	368	PF00069	0.519
MOD_ProDKin_1	394	400	PF00069	0.766
MOD_ProDKin_1	484	490	PF00069	0.612
MOD_ProDKin_1	64	70	PF00069	0.656
MOD_ProDKin_1	662	668	PF00069	0.636
MOD_ProDKin_1	676	682	PF00069	0.535
MOD_ProDKin_1	718	724	PF00069	0.590
MOD_ProDKin_1	770	776	PF00069	0.631
MOD_ProDKin_1	844	850	PF00069	0.585
MOD_SUMO_rev_2	640	650	PF00179	0.607
TRG_DiLeu_BaLyEn_6	602	607	PF01217	0.529
TRG_ENDOCYTIC_2	178	181	PF00928	0.661
TRG_ENDOCYTIC_2	351	354	PF00928	0.615
TRG_ENDOCYTIC_2	43	46	PF00928	0.799
TRG_ENDOCYTIC_2	595	598	PF00928	0.542
TRG_ENDOCYTIC_2	603	606	PF00928	0.535
TRG_ENDOCYTIC_2	61	64	PF00928	0.828
TRG_ER_diArg_1	284	287	PF00400	0.578
TRG_ER_diArg_1	538	541	PF00400	0.676
TRG_NLS_MonoCore_2	533	538	PF00514	0.665
TRG_NLS_MonoCore_2	542	547	PF00514	0.620
TRG_NLS_MonoExtC_3	533	538	PF00514	0.674
TRG_NLS_MonoExtN_4	534	541	PF00514	0.674
TRG_Pf-PMV_PEXEL_1	605	609	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IID6	Leishmania donovani	97%	100%
A4H7P7	Leishmania braziliensis	62%	99%
E9APT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	93%
Q4QFP1	Leishmania major	85%	99%